selected publications academic article Lee, K., Lee, J., Lee, P., Jeon, B. C., Song, M. Y., Kwak, S., ... Park, S. (2022). Inhibition of O‐GlcNAcylation protects from Shiga toxin‐mediated cell injury and lethality in host. EMBO Molecular Medicine. 14(1), e14678. Lee, M., Yoon, J. W., & Tesh, V. L. (2020). Editorial: Recent Advances in Understanding the Pathogenesis of Shiga Toxin-Producing Shigella and Escherichia coli. Frontiers in Cellular and Infection Microbiology. 10, 620703. Lee, K., Lee, J., Lee, P., Kim, C., Kim, D., Jeong, Y., ... Lee, M. (2020). Exosomes released from Shiga toxin 2a-treated human macrophages modulate inflammatory responses and induce cell death in toxin receptor expressing human cells. Cell Microbiol. 22(11), e13249. Lee, M., & Tesh, V. L. (2019). Roles of Shiga Toxins in Immunopathology. Toxins. 11(4), 212-212. Park, J., Jeong, Y., Park, S., Yoon, S., Choi, S., Jeong, D. G., ... Park, Y. (2017). Shiga Toxins Induce Apoptosis and ER Stress in Human Retinal Pigment Epithelial Cells. Toxins. 9(10), 319-319. Xiao, C., & Tesh, V. L. (2017). Toxins: State of the Journal Report, 2017. Toxins. 9(2), 55-55. Tesh, V. L. (2017). Announcing the 2017 Toxins Travel Awards for Post-Doctoral Fellows and Ph.D. Students. Toxins. 9(1), 37-37. Lee, M., Kwon, H., Lee, E., Kim, D., Park, J., Tesh, V. L., Oh, T., & Kim, M. H. (2016). Shiga Toxins Activate the NLRP3 Inflammasome Pathway To Promote Both Production of the Proinflammatory Cytokine Interleukin-1β and Apoptotic Cell Death. INFECTION AND IMMUNITY. 84(1), 172-186. Tesh, V. (2015). Toxins Best Paper Award 2015. Toxins. 7(3), 971-973. Tesh, V., & Fry, B. (2015). Toxins: State of Journal Report, 2016. Toxins. 7(12), 5459-5461. Stearns-Kurosawa, D. J., Oh, S., Cherla, R. P., Lee, M., Tesh, V. L., Papin, J., Henderson, J., & Kurosawa, S. (2013). Distinct renal pathology and a chemotactic phenotype after enterohemorrhagic Escherichia coli shiga toxins in non-human primate models of hemolytic uremic syndrome. American Journal of Pathology. 182(4), 1227-1238. Lee, M., Cherla, R. P., Jenson, M. H., Leyva-Illades, D., Martinez-Moczygemba, M., & Tesh, V. L (2011). Shiga toxins induce autophagy leading to differential signalling pathways in toxin-sensitive and toxin-resistant human cells. Cell Microbiol. 13(10), 1479-1496. Tesh, V. L. (2010). Induction of apoptosis by Shiga toxins. Future Microbiol. 5(3), 431-453. Lee, S., Lee, M., Cherla, R. P., & Tesh, V. L (2008). Shiga toxin 1 induces apoptosis through the endoplasmic reticulum stress response in human monocytic cells. Cell Microbiol. 10(3), 770-780. Cherla, R. P., Lee, S., Mees, P. L., & Tesh, V. L (2006). Shiga toxin 1-induced cytokine production is mediated by MAP kinase pathways and translation initiation factor eIF4E in the macrophage-like THP-1 cell line. Journal of Leukocyte Biology. 79(2), 397-407. Clayton, F., Pysher, T. J., Lou, R., Kohan, D. E., Denkers, N. D., Tesh, V. L., Taylor, F. B., & Siegler, R. L. (2005). Lipopolysaccharide upregulates renal shiga toxin receptors in a primate model of hemolytic uremic syndrome. Am J Nephrol. 25(6), 536-540. Lee, S., Cherla, R. P., Caliskan, I., & Tesh, V. L (2005). Shiga toxin 1 induces apoptosis in the human myelogenous leukemia cell line THP-1 by a caspase-8-dependent, tumor necrosis factor receptor-independent mechanism. INFECTION AND IMMUNITY. 73(8), 5115-5126. Harrison, L. M., Cherla, R. P., van den Hoogen, C., van Haaften, W., Lee, S., & Tesh, V. L (2005). Comparative evaluation of apoptosis induced by Shiga toxin 1 and/or lipopolysaccharides in human monocytic and macrophage-like cells. Microbial Pathogenesis. 38(2-3), 63-76. Harrison, L. M., van den Hoogen, C., van Haaften, W., & Tesh, V. L. (2005). Chemokine expression in the monocytic cell line THP-1 in response to purified shiga toxin 1 and/or lipopolysaccharides. INFECTION AND IMMUNITY. 73(1), 403-412. Siegler, R. L., Pysher, T. J., Tesh, V. L., Noris, M., Cassis, P., & Taylor, F. B. (2005). Reduced nitric oxide bioavailability in a baboon model of Shiga toxin mediated hemolytic uremic syndrome (HUS). Ren Fail. 27(5), 635-641. Harrison, L. M., van Haaften, W., & Tesh, V. L. (2004). Regulation of proinflammatory cytokine expression by Shiga toxin 1 and/or lipopolysaccharides in the human monocytic cell line THP-1. INFECTION AND IMMUNITY. 72(5), 2618-2627. Siegler, R. L., Pysher, T. J., Tesh, V. L., & Taylor, F. B. (2002). Renal prostacyclin biosynthesis in a baboon model of Shiga toxin mediated hemolytic uremic syndrome. Nephron. 92(2), 363-368. Foster, G. H., & Tesh, V. L. (2002). Shiga toxin 1-induced activation of c-Jun NH(2)-terminal kinase and p38 in the human monocytic cell line THP-1: possible involvement in the production of TNF-alpha. Journal of Leukocyte Biology. 71(1), 107-114. Pysher, T. J., Siegler, R. L., Tesh, V. L., & Taylor, F. B. (2002). von Willebrand Factor expression in a Shiga toxin-mediated primate model of hemolytic uremic syndrome. Pediatric and Developmental Pathology. 5(5), 472-479. Siegler, R. L., Pysher, T. J., Lou, R., Tesh, V. L., & Taylor, F. B. (2001). Response to Shiga toxin-1, with and without lipopolysaccharide, in a primate model of hemolytic uremic syndrome. Am J Nephrol. 21(5), 420-425. Siegler, R. L., Pysher, T. J., Tesh, V. L., & Taylor, F. B. (2001). Response to single and divided doses of Shiga toxin-1 in a primate model of hemolytic uremic syndrome. Journal of the American Society of Nephrology. 12(7), 1458-1467. Tesh, V. L. (2001). Shiga toxins--not just cytotoxins anymore. TRENDS IN MICROBIOLOGY. 9(12), 584-585. Ramegowda, B., Samuel, J. E., & Tesh, V. L (1999). Interaction of Shiga toxins with human brain microvascular endothelial cells: cytokines as sensitizing agents. J Infect Dis. 180(4), 1205-1213. Taylor, F. B., Tesh, V. L., DeBault, L., Li, A., Chang, A. C., Kosanke, S. D., Pysher, T. J., & Siegler, R. L. (1999). Characterization of the baboon responses to Shiga-like toxin: descriptive study of a new primate model of toxic responses to Stx-1. American Journal of Pathology. 154(4), 1285-1299. Sakiri, R., Ramegowda, B., & Tesh, V. L. (1998). Shiga toxin type 1 activates tumor necrosis factor-alpha gene transcription and nuclear translocation of the transcriptional activators nuclear factor-kappaB and activator protein-1. BLOOD. 92(2), 558-566. Tesh, V. L. (1998). Virulence of enterohemorrhagic Escherichia coli: role of molecular crosstalk. TRENDS IN MICROBIOLOGY. 6(6), 228-233. Tesh, V. L., Ramegowda, B., & Samuel, J. E (1994). Purified Shiga-like toxins induce expression of proinflammatory cytokines from murine peritoneal macrophages. INFECTION AND IMMUNITY. 62(11), 5085-5094. conference paper Decaluwe, H., Harrison, L. M., Mariscalco, M. M., Gendrel, D., Bohuon, C., Tesh, V. L., & Proulx, F. (2006). Procalcitonin in children with Escherichia coli O157:H7 associated hemolytic uremic syndrome. Pediatric Research. 579-583. Taylor, F. B., Chang, A., Li, A., Tesh, V. L., Pyscher, T., DeBault, L., & Siegler, R. L. (1996). Characterization of the baboon responses to Shiga-like toxin (descriptive study of new toxic and hemolytic uremic responses to SLT-1). BLOOD. 143-143. Siegler, R. L., Taylor, F. B., & Tesh, V. L. (1996). A baboon model of shiga-like toxin (SLT) mediated hemolytic uremic syndrome (HUS). Journal of the American Society of Nephrology. A2937-A2937. SIEGLER, R. L., TAYLOR, F. B., TESH, V. L., EDWIN, S. S., COOK, J. B., & DUDLEY, D. J. (1995). THE ENDOTHELIN-NITRIC OXIDE AXIS IN A PRIMATE MODEL OF SHIGA-LIKE TOXIN-INDUCED HEMOLYTIC-UREMIC SYNDROME. Journal of the American Society of Nephrology. 989-989. SIEGLER, R. L., TAYLOR, F. B., TESH, V. L., EDWIN, S. S., COOK, J. B., & DUDLEY, D. J. (1995). URINARY CYTOKINES IN A PRIMATE MODEL OF SHIGA-LIKE TOXIN-INDUCED HEMOLYTIC-UREMIC SYNDROME. Journal of the American Society of Nephrology. 990-990. SIEGLER, R. L., TAYLOR, F. B., TESH, V. L., EDWIN, S. S., COOK, J. B., & DUDLEY, D. J. (1995). URINARY PROSTAGLANDINS IN A PRIMATE MODEL OF SHIGA-LIKE TOXIN (SLT) INDUCED HEMOLYTIC-UREMIC SYNDROME. Journal of the American Society of Nephrology. 989-989. TESH, V. L., SAMUEL, J. E., BURRIS, J. A., OWENS, J. W., TAYLOR, F. B., & SIEGLER, R. L. (1994). QUANTITATION AND LOCALIZATION OF SHIGA TOXIN SHIGA-LIKE TOXIN-BINDING GLYCOLIPID RECEPTORS IN HUMAN AND BABOON TISSUES. International Congress Series. 189-192. Lee, S. Y., Caliskan, I., Cherla, R. P., & Tesh, V. L. Comparison of Shiga toxin-1 (Stx-1)-induced apoptosis mechanisms between monocytic and macrophage-like THP-1 cells. Journal of Leukocyte Biology. 59-59. Cherla, R. P., Lee, S. Y., & Tesh, V. L. Stx1 induced cytokine expression is mediated by MAP kinase pathways and through translation initiation factor eIF-4E in the macrophage-like cell line THP-1. Journal of Leukocyte Biology. 53-53. institutional repository document Stearns-Kurosawa, D. J., Collins, V., Freeman, S., Tesh, V. L., & Kurosawa, S. (2019). Distinct physiologic and inflammatory responses elicited in baboons after challenge with Shiga toxin type 1 or 2 from enterohemorrhagic Escherichia coli. INFECTION AND IMMUNITY. Lee, M., Koo, S., Jeong, D. G., & Tesh, V. L (2016). Shiga Toxins as Multi-Functional Proteins: Induction of Host Cellular Stress Responses, Role in Pathogenesis and Therapeutic Applications. Toxins. Lentz, E. K., Leyva-Illades, D., Lee, M., Cherla, R. P., & Tesh, V. L. (2011). Differential response of the human renal proximal tubular epithelial cell line HK-2 to Shiga toxin types 1 and 2. INFECTION AND IMMUNITY. Lee, M., Cherla, R. P., & Tesh, V. L. (2010). Shiga toxins: intracellular trafficking to the ER leading to activation of host cell stress responses. Toxins. Leyva-Illades, D., Cherla, R. P., Galindo, C. L., Chopra, A. K., & Tesh, V. L. (2010). Global transcriptional response of macrophage-like THP-1 cells to Shiga toxin type 1. INFECTION AND IMMUNITY. Lee, M., Cherla, R. P., Lentz, E. K., Leyva-Illades, D., & Tesh, V. L. (2010). Signaling through C/EBP homologous protein and death receptor 5 and calpain activation differentially regulate THP-1 cell maturation-dependent apoptosis induced by Shiga toxin type 1. INFECTION AND IMMUNITY. Lee, M., Cherla, R. P., Leyva-Illades, D., & Tesh, V. L. (2009). Bcl-2 regulates the onset of shiga toxin 1-induced apoptosis in THP-1 cells. INFECTION AND IMMUNITY. Foster, G. H., Armstrong, C. S., Sakiri, R., & Tesh, V. L. (2000). Shiga toxin-induced tumor necrosis factor alpha expression: requirement for toxin enzymatic activity and monocyte protein kinase C and protein tyrosine kinases. INFECTION AND IMMUNITY. Ramegowda, B., & Tesh, V. L. (1996). Differentiation-associated toxin receptor modulation, cytokine production, and sensitivity to Shiga-like toxins in human monocytes and monocytic cell lines. INFECTION AND IMMUNITY.