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Tesh, Vernon Professor
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Overview
Publications
selected publications
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academic article
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Lee, K., Lee, J., Lee, P., Jeon, B. C., Song, M. Y., Kwak, S., ... Park, S.
(2022).
Inhibition of O-GlcNAcylation protects from Shiga toxin-mediated cell injury and lethality in host. EMBO Molecular Medicine.
14(1), e14678.
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Lee, M., Yoon, J. W., & Tesh, V. L.
(2020).
Editorial: Recent Advances in Understanding the Pathogenesis of Shiga Toxin-Producing Shigella and Escherichia coli. Frontiers in Cellular and Infection Microbiology.
10, 620703.
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Lee, K., Lee, J., Lee, P., Kim, C., Kim, D., Jeong, Y., ... Lee, M.
(2020).
Exosomes released from Shiga toxin 2a-treated human macrophages modulate inflammatory responses and induce cell death in toxin receptor expressing human cells. Cellular Microbiology.
22(11), e13249.
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Lee, M., & Tesh, V. L.
(2019).
Roles of Shiga Toxins in Immunopathology. Toxins.
11(4), 212-212.
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Tesh, V. L.
(2017).
Announcing the 2017 Toxins Travel Awards for Post-Doctoral Fellows and Ph.D. Students. Toxins.
9(1), 37-37.
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Park, J., Jeong, Y., Park, S., Yoon, S., Choi, S., Jeong, D. G., ... Park, Y.
(2017).
Shiga Toxins Induce Apoptosis and ER Stress in Human Retinal Pigment Epithelial Cells. Toxins.
9(10), 319-319.
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Xiao, C., & Tesh, V. L.
(2017).
Toxins: State of the Journal Report, 2017. Toxins.
9(2), 55-55.
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Tesh, V. L.
(2016).
Announcing the 2016 Toxins Travel Awards for Post-Doctoral Fellows and Ph.D. Students. Toxins.
8(2), 41-41.
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Lee, M., Kwon, H., Lee, E., Kim, D., Park, J., Tesh, V. L., Oh, T., & Kim, M. H.
(2016).
Shiga Toxins Activate the NLRP3 Inflammasome Pathway To Promote Both Production of the Proinflammatory Cytokine Interleukin-1 and Apoptotic Cell Death. Infection and Immunity.
84(1), 172-186.
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Tesh, V. L.
(2015).
Toxins Best Paper Award 2015. Toxins.
7(3), 971-973.
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Tesh, V. L., & Fry, B. G.
(2015).
Toxins: State of Journal Report, 2016. Toxins.
7(12), 5459-5461.
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Stearns-Kurosawa, D. J., Oh, S., Cherla, R. P., Lee, M., Tesh, V. L., Papin, J., Henderson, J., & Kurosawa, S.
(2013).
Distinct renal pathology and a chemotactic phenotype after enterohemorrhagic Escherichia coli shiga toxins in non-human primate models of hemolytic uremic syndrome. American Journal of Pathology.
182(4), 1227-1238.
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Lee, M., Kim, M. H., & Tesh, V. L.
(2013).
Shiga toxins expressed by human pathogenic bacteria induce immune responses in host cells. The Journal of Microbiology.
51(6), 724-730.
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Leyva-Illades, D., Cherla, R. P., Lee, M., & Tesh, V. L.
(2012).
Regulation of cytokine and chemokine expression by the ribotoxic stress response elicited by Shiga toxin type 1 in human macrophage-like THP-1 cells. Infection and Immunity.
80(6), 2109-2120.
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Tesh, V. L.
(2012).
Activation of cell stress response pathways by Shiga toxins. Cellular Microbiology.
14(1), 1-9.
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Zhang, Y., Zhang, G., Hendrix, L. R., Tesh, V. L., & Samuel, J. E.
(2012).
Coxiella burnetii induces apoptosis during early stage infection via a caspase-independent pathway in human monocytic THP-1 cells. PLoS One.
7(1), e30841-e30841.
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Lee, M., Cherla, R. P., Jenson, M. H., Leyva-Illades, D., Martinez-Moczygemba, M., & Tesh, V. L.
(2011).
Shiga toxins induce autophagy leading to differential signalling pathways in toxin-sensitive and toxin-resistant human cells. Cellular Microbiology.
13(10), 1479-1496.
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Lentz, E. K., Cherla, R. P., Jaspers, V., Weeks, B. R., & Tesh, V. L.
(2010).
Role of tumor necrosis factor alpha in disease using a mouse model of Shiga toxin-mediated renal damage. Infection and Immunity.
78(9), 3689-3699.
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Tesh, V. L.
(2010).
Induction of apoptosis by Shiga toxins. Future Microbiology.
5(3), 431-453.
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Cherla, R. P., Lee, S., Mulder, R. A., Lee, M., & Tesh, V. L.
(2009).
Shiga toxin 1-induced proinflammatory cytokine production is regulated by the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling pathway. Infection and Immunity.
77(9), 3919-3931.
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Lee, S., Lee, M., Cherla, R. P., & Tesh, V. L.
(2008).
Shiga toxin 1 induces apoptosis through the endoplasmic reticulum stress response in human monocytic cells. Cellular Microbiology.
10(3), 770-780.
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Lee, S., Cherla, R. P., & Tesh, V. L.
(2007).
Simultaneous induction of apoptotic and survival signaling pathways in macrophage-like THP-1 cells by Shiga toxin 1. Infection and Immunity.
75(3), 1291-1302.
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Cherla, R. P., Lee, S., Mees, P. L., & Tesh, V. L.
(2006).
Shiga toxin 1‐induced cytokine production is mediated by MAP kinase pathways and translation initiation factor eIF4E in the macrophage‐like THP‐1 cell line. 79(2), 397-407.
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Lee, S., Cherla, R. P., Caliskan, I., & Tesh, V. L.
(2005).
Shiga toxin 1 induces apoptosis in the human myelogenous leukemia cell line THP-1 by a caspase-8-dependent, tumor necrosis factor receptor-independent mechanism. Infection and Immunity.
73(8), 5115-5126.
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Harrison, L. M., Cherla, R. P., van den Hoogen, C., van Haaften, W., Lee, S., & Tesh, V. L.
(2005).
Comparative evaluation of apoptosis induced by Shiga toxin 1 and/or lipopolysaccharides in human monocytic and macrophage-like cells. Microbial Pathogenesis.
38(2-3), 63-76.
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Clayton, F., Pysher, T. J., Lou, R., Kohan, D. E., Denkers, N. D., Tesh, V. L., Taylor, F. B., & Siegler, R. L.
(2005).
Lipopolysaccharide upregulates renal shiga toxin receptors in a primate model of hemolytic uremic syndrome. American Journal of Nephrology.
25(6), 536-540.
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Siegler, R. L., Pysher, T. J., Tesh, V. L., Noris, M., Cassis, P., & Taylor, F. B.
(2005).
Reduced nitric oxide bioavailability in a baboon model of Shiga toxin mediated hemolytic uremic syndrome (HUS). Renal Failure.
27(5), 635-641.
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Harrison, L. M., van den Hoogen, C., van Haaften, W., & Tesh, V. L.
(2005).
Chemokine expression in the monocytic cell line THP-1 in response to purified shiga toxin 1 and/or lipopolysaccharides. Infection and Immunity.
73(1), 403-412.
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Harrison, L. M., van Haaften, W., & Tesh, V. L.
(2004).
Regulation of proinflammatory cytokine expression by Shiga toxin 1 and/or lipopolysaccharides in the human monocytic cell line THP-1. Infection and Immunity.
72(5), 2618-2627.
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Cherla, R. P., Lee, S., & Tesh, V. L.
(2003).
Shiga toxins and apoptosis. FEMS Microbiology Letters.
228(2), 159-166.
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Siegler, R. L., Obrig, T. G., Pysher, T. J., Tesh, V. L., Denkers, N. D., & Taylor, F. B.
(2003).
Response to Shiga toxin 1 and 2 in a baboon model of hemolytic uremic syndrome. Pediatric Nephrology.
18(2), 92-96.
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Pysher, T. J., Siegler, R. L., Tesh, V. L., & Taylor, F. B.
(2002).
von Willebrand Factor expression in a Shiga toxin-mediated primate model of hemolytic uremic syndrome. Pediatric and Developmental Pathology.
5(5), 472-479.
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Siegler, R. L., Pysher, T. J., Tesh, V. L., Denkers, N. D., & Taylor, F. B.
(2002).
Prophylactic heparinization is ineffective in a primate model of hemolytic uremic syndrome. Pediatric Nephrology.
17(12), 1053-1058.
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Siegler, R. L., Pysher, T. J., Tesh, V. L., & Taylor, F. B.
(2002).
Renal prostacyclin biosynthesis in a baboon model of Shiga toxin mediated hemolytic uremic syndrome. Nephron.
92(2), 363-368.
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Foster, G. H., & Tesh, V. L.
(2002).
Shiga toxin 1-induced activation of c-Jun NH(2)-terminal kinase and p38 in the human monocytic cell line THP-1: possible involvement in the production of TNF-alpha. 71(1), 107-114.
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Siegler, R. L., Pysher, T. J., Tesh, V. L., & Taylor, F. B.
(2001).
Response to single and divided doses of Shiga toxin-1 in a primate model of hemolytic uremic syndrome. 12(7), 1458-1467.
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Siegler, R. L., Pysher, T. J., Lou, R., Tesh, V. L., & Taylor, F. B.
(2001).
Response to Shiga toxin-1, with and without lipopolysaccharide, in a primate model of hemolytic uremic syndrome. American Journal of Nephrology.
21(5), 420-425.
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Tesh, V. L.
(2001).
Shiga toxins--not just cytotoxins anymore. TRENDS IN MICROBIOLOGY.
9(12), 584-585.
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Ramegowda, B., Samuel, J. E., & Tesh, V. L.
(1999).
Interaction of Shiga toxins with human brain microvascular endothelial cells: cytokines as sensitizing agents. Journal of Infectious Diseases.
180(4), 1205-1213.
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Taylor, F. B., Tesh, V. L., DeBault, L., Li, A., Chang, A. C., Kosanke, S. D., Pysher, T. J., & Siegler, R. L.
(1999).
Characterization of the baboon responses to Shiga-like toxin: descriptive study of a new primate model of toxic responses to Stx-1. American Journal of Pathology.
154(4), 1285-1299.
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Sakiri, R., Ramegowda, B., & Tesh, V. L.
(1998).
Shiga Toxin Type 1 Activates Tumor Necrosis Factor- Gene Transcription and Nuclear Translocation of the Transcriptional Activators Nuclear Factor-B and Activator Protein-1. Blood.
92(2), 558-566.
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Sakiri, R., Ramegowda, B., & Tesh, V. L.
(1998).
Shiga toxin type 1 activates tumor necrosis factor-alpha gene transcription and nuclear translocation of the transcriptional activators nuclear factor-kappaB and activator protein-1. Blood.
92(2), 558-566.
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Tesh, V. L.
(1998).
Virulence of enterohemorrhagic Escherichia coli: role of molecular crosstalk. TRENDS IN MICROBIOLOGY.
6(6), 228-233.
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Tesh, V. L., Ramegowda, B., & Samuel, J. E.
(1994).
Purified Shiga-like toxins induce expression of proinflammatory cytokines from murine peritoneal macrophages. Infection and Immunity.
62(11), 5085-5094.
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Schmitt, C. K., Darnell, S. C., Tesh, V. L., Stocker, B. A., & O'Brien, A. D.
(1994).
Mutation of flgM attenuates virulence of Salmonella typhimurium, and mutation of fliA represses the attenuated phenotype. JOURNAL OF BACTERIOLOGY.
176(2), 368-377.
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Tesh, V. L., Burris, J. A., Owens, J. W., Gordon, V. M., Wadolkowski, E. A., O'Brien, A. D., & Samuel, J. E.
(1993).
Comparison of the relative toxicities of Shiga-like toxins type I and type II for mice. Infection and Immunity.
61(8), 3392-3402.
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Tesh, V. L., & O'Brien, A. D.
(1992).
Adherence and colonization mechanisms of enteropathogenic and enterohemorrhagic Escherichia coli. Microbial Pathogenesis.
12(4), 245-254.
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Tesh, V. L., Samuel, J. E., Perera, L. P., Sharefkin, J. B., & O'Brien, A. D.
(1991).
Evaluation of the role of Shiga and Shiga-like toxins in mediating direct damage to human vascular endothelial cells. Journal of Infectious Diseases.
164(2), 344-352.
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Tesh, V. L., & O'Brien, A. D.
(1991).
The pathogenic mechanisms of Shiga toxin and the Shiga-like toxins. Molecular Microbiology.
5(8), 1817-1822.
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Tesh, V. L., Vukajlovich, S. W., & Morrison, D. C.
(1988).
Endotoxin interactions with serum proteins relationship to biological activity. Progress in clinical and biological research.
272, 47-62.
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Tesh, V. L., & Morrison, D. C.
(1988).
The interaction of Escherichia coli with normal human serum: factors affecting the capacity of serum to mediate lipopolysaccharide release. Microbial Pathogenesis.
4(3), 175-187.
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Tesh, V. L., & Morrison, D. C.
(1988).
The physical-chemical characterization and biologic activity of serum released lipopolysaccharides. JOURNAL OF IMMUNOLOGY.
141(10), 3523-3531.
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Tesh, V. L., Duncan, R. L., & Morrison, D. C.
(1986).
The interaction of Escherichia coli with normal human serum: the kinetics of serum-mediated lipopolysaccharide release and its dissociation from bacterial killing. JOURNAL OF IMMUNOLOGY.
137(4), 1329-1335.
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Lee, K., Lee, J., Lee, P., Jeon, B. C., Song, M. Y., Kwak, S., ... Park, S.
(2022).
Inhibition of O-GlcNAcylation protects from Shiga toxin-mediated cell injury and lethality in host. EMBO Molecular Medicine.
14(1), e14678.
-
chapter
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Tesh, V. L.
(2020).
Complement-Mediated Lipopolysaccharide Release. Endotoxin in Health and Disease.
(pp. 77-91).
Taylor & Francis.
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Lee, M., Cherla, R. P., & Tesh, V. L.
(2014).
Shiga Toxin and Shiga-Like Ribosome-Inactivating Proteins. MANUAL OF SECURITY SENSITIVE MICROBES AND TOXINS.
(pp. 519-532).
Taylor & Francis.
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Tesh, V. L.
(2012).
The induction of apoptosis by Shiga toxins and ricin. Current Topics in Microbiology and Immunology.
RICIN AND SHIGA TOXINS: PATHOGENESIS, IMMUNITY, VACCINES AND THERAPEUTICS.
(pp. 137-178).
Springer Nature.
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Tesh, V. L.
(2004).
Foodborne Enterohemorrhagic Escherichia Coli Infections. Preharvest and Postharvest Food Safety.
(pp. 27-42).
Wiley.
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O'Brien, A. D., Tesh, V. L., Donohue-Rolfe, A., Jackson, M. P., Olsnes, S., Sandvig, K., Lindberg, A. A., & Keusch, G. T.
(1992).
Shiga toxin: biochemistry, genetics, mode of action, and role in pathogenesis. Current Topics in Microbiology and Immunology.
Pathogenesis of Shigellosis.
(pp. 65-94).
Springer Nature.
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Duncan, R. L., Tesh, V., & Morrison, D. C.
(1986).
Characterization and Localization of Lipopolysaccharides Following the Ingestion of E. Coli by Murine Macrophages in Vitro. Immunobiology and Immunopharmacology of Bacterial Endotoxins.
(pp. 359-367).
Springer Nature.
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Tesh, V. L.
(2020).
Complement-Mediated Lipopolysaccharide Release. Endotoxin in Health and Disease.
(pp. 77-91).
Taylor & Francis.
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conference paper
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Decaluwe, H., Harrison, L. M., Mariscalco, M. M., Gendrel, D., Bohuon, C., Tesh, V. L., & Proulx, F.
(2006).
Procalcitonin in children with Escherichia coli O157:H7 associated hemolytic uremic syndrome. Pediatric Research.
579-583.
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Lee, S. Y., Caliskan, I., Cherla, R. P., & Tesh, V. L.
(2004).
Comparison of Shiga toxin-1 (Stx-1)-induced apoptosis mechanisms between monocytic and macrophage-like THP-1 cells. Journal of Leukocyte Biology.
59-59.
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Cherla, R. P., Lee, S. Y., & Tesh, V. L.
(2004).
Stx1 induced cytokine expression is mediated by MAP kinase pathways and through translation initiation factor eIF-4E in the macrophage-like cell line THP-1. Journal of Leukocyte Biology.
53-53.
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Siegler, R. L., Taylor, F. B., & Tesh, V. L.
(1996).
A baboon model of shiga-like toxin (SLT) mediated hemolytic uremic syndrome (HUS). Journal of the American Society of Nephrology.
A2937-A2937.
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Taylor, F. B., Chang, A., Li, A., Tesh, V. L., Pyscher, T., DeBault, L., & Siegler, R. L.
(1996).
Characterization of the baboon responses to Shiga-like toxin (descriptive study of new toxic and hemolytic uremic responses to SLT-1). Blood.
143-143.
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SIEGLER, R. L., TAYLOR, F. B., TESH, V. L., EDWIN, S. S., COOK, J. B., & DUDLEY, D. J.
(1995).
THE ENDOTHELIN-NITRIC OXIDE AXIS IN A PRIMATE MODEL OF SHIGA-LIKE TOXIN-INDUCED HEMOLYTIC-UREMIC SYNDROME. Journal of the American Society of Nephrology.
989-989.
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SIEGLER, R. L., TAYLOR, F. B., TESH, V. L., EDWIN, S. S., COOK, J. B., & DUDLEY, D. J.
(1995).
URINARY CYTOKINES IN A PRIMATE MODEL OF SHIGA-LIKE TOXIN-INDUCED HEMOLYTIC-UREMIC SYNDROME. Journal of the American Society of Nephrology.
990-990.
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SIEGLER, R. L., TAYLOR, F. B., TESH, V. L., EDWIN, S. S., COOK, J. B., & DUDLEY, D. J.
(1995).
URINARY PROSTAGLANDINS IN A PRIMATE MODEL OF SHIGA-LIKE TOXIN (SLT) INDUCED HEMOLYTIC-UREMIC SYNDROME. Journal of the American Society of Nephrology.
989-989.
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TESH, V. L., SAMUEL, J. E., BURRIS, J. A., OWENS, J. W., TAYLOR, F. B., & SIEGLER, R. L.
(1994).
QUANTITATION AND LOCALIZATION OF SHIGA TOXIN SHIGA-LIKE TOXIN-BINDING GLYCOLIPID RECEPTORS IN HUMAN AND BABOON TISSUES. International Congress Series.
189-192.
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Decaluwe, H., Harrison, L. M., Mariscalco, M. M., Gendrel, D., Bohuon, C., Tesh, V. L., & Proulx, F.
(2006).
Procalcitonin in children with Escherichia coli O157:H7 associated hemolytic uremic syndrome. Pediatric Research.
579-583.
-
institutional repository document
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Lee, M., Koo, S., Jeong, D. G., & Tesh, V. L.
(2016).
Shiga Toxins as Multi-Functional Proteins: Induction of Host Cellular Stress Responses, Role in Pathogenesis and Therapeutic Applications. Toxins.
-
Lentz, E. K., Leyva-Illades, D., Lee, M., Cherla, R. P., & Tesh, V. L.
(2011).
Differential response of the human renal proximal tubular epithelial cell line HK-2 to Shiga toxin types 1 and 2. Infection and Immunity.
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Lee, M., Cherla, R. P., Lentz, E. K., Leyva-Illades, D., & Tesh, V. L.
(2010).
Signaling through C/EBP homologous protein and death receptor 5 and calpain activation differentially regulate THP-1 cell maturation-dependent apoptosis induced by Shiga toxin type 1. Infection and Immunity.
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Stearns-Kurosawa, D. J., Collins, V., Freeman, S., Tesh, V. L., & Kurosawa, S.
(2010).
Distinct physiologic and inflammatory responses elicited in baboons after challenge with Shiga toxin type 1 or 2 from enterohemorrhagic Escherichia coli. Infection and Immunity.
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Leyva-Illades, D., Cherla, R. P., Galindo, C. L., Chopra, A. K., & Tesh, V. L.
(2010).
Global transcriptional response of macrophage-like THP-1 cells to Shiga toxin type 1. Infection and Immunity.
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Lee, M., Cherla, R. P., & Tesh, V. L.
(2010).
Shiga toxins: intracellular trafficking to the ER leading to activation of host cell stress responses. Toxins.
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Lee, M., Cherla, R. P., Leyva-Illades, D., & Tesh, V. L.
(2009).
Bcl-2 regulates the onset of shiga toxin 1-induced apoptosis in THP-1 cells. Infection and Immunity.
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Foster, G. H., Armstrong, C. S., Sakiri, R., & Tesh, V. L.
(2000).
Shiga toxin-induced tumor necrosis factor alpha expression: requirement for toxin enzymatic activity and monocyte protein kinase C and protein tyrosine kinases. Infection and Immunity.
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Ramegowda, B., & Tesh, V. L.
(1996).
Differentiation-associated toxin receptor modulation, cytokine production, and sensitivity to Shiga-like toxins in human monocytes and monocytic cell lines. Infection and Immunity.
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Lee, M., Koo, S., Jeong, D. G., & Tesh, V. L.
(2016).
Shiga Toxins as Multi-Functional Proteins: Induction of Host Cellular Stress Responses, Role in Pathogenesis and Therapeutic Applications. Toxins.
Contact
first name
- Vernon
has last name
- Tesh
Other
- vltesh@tamu.edu