Characterization of the baboon responses to Shiga-like toxin: descriptive study of a new primate model of toxic responses to Stx-1. Academic Article uri icon


  • The baboon response to intravenous infusion of Shiga toxin 1 (Stx-1) varied from acute renal failure, proteinuria, hyperkalemia, and melena with minimal perturbation of host inflammatory and hemostatic systems (high-dose group, 2.0 microg/kg; n = 5) to renal failure with hematuria, proteinuria, thrombocytopenia, schistocytosis, anemia, and melena (low-dose group, 0.05 to 0.2 microg/kg; n = 8). Both groups exhibited renal shutdown and died in 57 hours or less. Both groups produced urine that was positive for tumor necrosis factor and interleukin-6 although neither of these cytokines was detectable (

published proceedings

  • Am J Pathol

author list (cited authors)

  • Taylor, F. B., Tesh, V. L., DeBault, L., Li, A., Chang, A. C., Kosanke, S. D., Pysher, T. J., & Siegler, R. L.

citation count

  • 125

publication date

  • April 1999