HR job title
- Research Associate Professor
- Contact Info
- 1 979 845 1473
- ORCiD
- 0000-0002-8156-3651
Rijnkels, Monique Research Associate Professor
Positions
- Research Associate Professor, Veterinary Integrative Biosciences, School of Veterinary Medicine and Biomedical Sciences
We are studying transcriptional regulation and the genomics of the mammary gland and the role of epigenetic events during mammary gland development and lactation. We use various genomics approaches to mammary gland biology and my laboratory has been using ChIP-seq, DNase-seq, ATAC-seq and other epigenomic approaches to determine chromosomal states at different developmental time points to determine the role of epigenetic regulation in mammary gland development and understand gene regulation in the mammary gland in general. We use transgenic mouse models to study gene regulation in mammary gland development and lactation.
Research Areas
- Overview
- Publications
- Research
- Teaching
- Background
- Contact
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Overview
Publications
selected publications
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academic article
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Sanchez, L., Epps, J., Wall, S., McQueen, C., Pearson, S. J., Scribner, K., ... Porter, W. W.
(2023).
SIM2s directed Parkin-mediated mitophagy promotes mammary epithelial cell differentiation. Cell Death and Differentiation.
30(6), 1472-1487.
-
Wall, S. W., Sanchez, L., Tuttle, K. S., Pearson, S. J., Soma, S., Wyatt, G. L., ... Porter, W. W.
(2023).
Noncanonical role of singleminded-2s in mitochondrial respiratory chain formation in breast cancer. Experimental & Molecular Medicine.
55(5), 1046-1063.
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Fang, X., Ni, N., Wang, X., Tian, Y., Ivanov, I., Rijnkels, M., ... Li, Q.
(2022).
EZH2 and Endometrial Cancer Development: Insights from a Mouse Model. 11(5), 909-909.
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Elswood, J., Pearson, S. J., Payne, H. R., Barhoumi, R., Rijnkels, M., & W Porter, W.
(2021).
Autophagy regulates functional differentiation of mammary epithelial cells. Autophagy.
17(2), 420-438.
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Fang, X., Ni, N., Gao, Y., Lydon, J. P., Ivanov, I., Rijnkels, M., Bayless, K. J., & Li, Q.
(2020).
Transforming growth factor beta signaling and decidual integrity in mice. Biology of Reproduction.
103(6), 1186-1198.
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Pearson, S. J., Roy Sarkar, T., McQueen, C. M., Elswood, J., Schmitt, E. E., Wall, S. W., ... Porter, W. W.
(2019).
ATM-dependent activation of SIM2s regulates homologous recombination and epithelial-mesenchymal transition. Oncogene.
38(14), 2611-2626.
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Fang, X., Ni, N., Lydon, J. P., Ivanov, I., Bayless, K. J., Rijnkels, M., & Li, Q.
(2019).
Enhancer of Zeste 2 Polycomb Repressive Complex 2 Subunit Is Required for Uterine Epithelial Integrity. American Journal of Pathology.
189(6), 1212-1225.
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Pearson, S. J., Elswood, J., Barhoumi, R., Ming-Whitfield, B., Rijnkels, M., & Porter, W. W.
(2019).
Loss of SIM2s inhibits RAD51 binding and leads to unresolved replication stress. Breast Cancer Research.
21(1), 125.
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McQueen, C. M., Schmitt, E. E., Sarkar, T. R., Elswood, J., Metz, R. P., Earnest, D., Rijnkels, M., & Porter, W. W.
(2018).
PER2 regulation of mammary gland development. Development.
145(6), dev157966.
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Jerry, D. J., Shull, J. D., Hadsell, D. L., Rijnkels, M., Dunphy, K. A., Schneider, S. S., ... Trentham-Dietz, A.
(2018).
Genetic variation in sensitivity to estrogens and breast cancer risk. MAMMALIAN GENOME.
29(1-2), 24-37.
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Hadsell, D. L., Hadsell, L. A., Rijnkels, M., Carcamo-Bahena, Y., Wei, J., Williamson, P., & Grusak, M. A.
(2018).
In silico mapping of quantitative trait loci (QTL) regulating the milk ionome in mice identifies a milk iron locus on chromosome 1. MAMMALIAN GENOME.
29(9-10), 632-655.
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Rijnkels, M.
(2015).
TRIENNIAL LACTATION SYMPOSIUM: Nutrigenomics in dairy cows. Journal of Animal Science.
93(12), 5529-5530.
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Hadsell, D. L., Hadsell, L. A., Olea, W., Rijnkels, M., Creighton, C. J., Smyth, I., ... Cox, T. C.
(2015).
In-silico QTL mapping of postpubertal mammary ductal development in the mouse uncovers potential human breast cancer risk loci. MAMMALIAN GENOME.
26(1-2), 57-79.
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Beck, K., Turco, G., Bradnam, K., Rijnkels, M., NommsenRivers, L., Korf, I., & Lemay, D.
(2014).
Adjustment of RNASeq data for the effect of highly abundant transcripts: a case study in milk production (622.4). The FASEB Journal.
28(S1),
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Daniels, K. M., Farmer, C., Jimenez-Flores, R., & Rijnkels, M.
(2013).
LACTATION BIOLOGY SYMPOSIUM: The long-term impact of epigenetics and maternal influence on the neonate through milk-borne factors and nutrient status. Journal of Animal Science.
91(2), 673-675.
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Rijnkels, M., Freeman-Zadrowski, C., Hernandez, J., Potluri, V., Wang, L., Li, W., & Lemay, D. G.
(2013).
Epigenetic modifications unlock the milk protein gene loci during mouse mammary gland development and differentiation. PLoS ONE.
8(1), e53270-e53270.
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Lemay, D. G., Pollard, K. S., Martin, W. F., Freeman Zadrowski, C., Hernandez, J., Korf, I., German, J. B., & Rijnkels, M.
(2013).
From genes to milk: genomic organization and epigenetic regulation of the mammary transcriptome. PLoS ONE.
8(9), e75030-e75030.
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Lemay, D. G., Martin, W. F., Hinrichs, A. S., Rijnkels, M., German, J. B., Korf, I., & Pollard, K. S.
(2012).
G-NEST: a gene neighborhood scoring tool to identify co-conserved, co-expressed genes. BMC Bioinformatics.
13(1), 253.
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Neville, M. C., Anderson, S. M., McManaman, J. L., Badger, T. M., Bunik, M., Contractor, N., ... Williamson, P.
(2012).
Lactation and neonatal nutrition: defining and refining the critical questions. Journal of Mammary Gland Biology and Neoplasia.
17(2), 167-188.
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Rijnkels, M., Kabotyanski, E., Shore, A., & Rosen, J. M.
(2012).
The chromatin landscape of the casein gene locus. Hormone Molecular Biology and Clinical Investigation.
10(1), 201-205.
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Maningat, P. D., Sen, P., Rijnkels, M., Hadsell, D. L., Bray, M. S., & Haymond, M. W.
(2011).
Short-term administration of rhGH increases markers of cellular proliferation but not milk protein gene expression in normal lactating women. Physiological Genomics.
43(8), 381-391.
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Lemay, D. G., Rijnkels, M., German, J. B., & Pollard, K. S.
(2010).
From genes to milk: genomic organization of the mammary transcriptome. The FASEB Journal.
24(S1), 206.4-206.4.
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Martin, W. F., Lemay, D., Rijnkels, M., & German, B.
(2010).
Sitespecific evolution of casein proteins. 24(S1), 556.9-556.9.
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Lemay, D. G., Lange, M. C., Crook, S. C., Sela, D. A., Lefvre, C., Church, P., ... German, J. B.
(2010).
The International Milk Genomics Consortium Web Portal. The FASEB Journal.
24(S1), 556.8-556.8.
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Kress, C., Ballester, M., Devinoy, E., & Rijnkels, M.
(2010).
Epigenetic modifications in 3D: nuclear organization of the differentiating mammary epithelial cell. Journal of Mammary Gland Biology and Neoplasia.
15(1), 73-83.
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Devinoy, E., & Rijnkels, M.
(2010).
Epigenetics in mammary gland biology and cancer. Journal of Mammary Gland Biology and Neoplasia.
15(1), 1-4.
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Rijnkels, M., Kabotyanski, E., Montazer-Torbati, M. B., Hue Beauvais, C., Vassetzky, Y., Rosen, J. M., & Devinoy, E.
(2010).
The epigenetic landscape of mammary gland development and functional differentiation. Journal of Mammary Gland Biology and Neoplasia.
15(1), 85-100.
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Kabotyanski, E. B., Rijnkels, M., Freeman-Zadrowski, C., Buser, A. C., Edwards, D. P., & Rosen, J. M.
(2009).
Lactogenic hormonal induction of long distance interactions between beta-casein gene regulatory elements. Journal of Biological Chemistry.
284(34), 22815-22824.
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Bovine Genome Sequencing and Analysis Consortium, .., Elsik, C. G., Tellam, R. L., Worley, K. C., Gibbs, R. A., Muzny, D. M., ... Zhao, F.
(2009).
The genome sequence of taurine cattle: a window to ruminant biology and evolution. Science.
324(5926), 522-528.
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Maningat, P. D., Sen, P., Rijnkels, M., Sunehag, A. L., Hadsell, D. L., Bray, M., & Haymond, M. W.
(2009).
Gene expression in the human mammary epithelium during lactation: the milk fat globule transcriptome. Physiological Genomics.
37(1), 12-22.
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Lemay, D. G., Rijnkels, M., & German, J. B.
(2009).
Lessons from the bovine genome: implications for human nutrition and research. Journal of Nutrition.
139(7), 1271-1272.
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Lemay, D. G., Lynn, D. J., Martin, W. F., Neville, M. C., Casey, T. M., Rincon, G., ... Rijnkels, M.
(2009).
The bovine lactation genome: insights into the evolution of mammalian milk. 10(4), R43-R43.
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Montazer-Torbati, M. B., Hue-Beauvais, C., Droineau, S., Ballester, M., Coant, N., Aujean, E., ... Devinoy, E.
(2008).
Epigenetic modifications and chromatin loop organization explain the different expression profiles of the Tbrg4, WAP and Ramp3 genes. Experimental Cell Research.
314(5), 975-987.
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Kabotyanski, E. B., Huetter, M., Xian, W. a., Rijnkels, M., & Rosen, J. M.
(2006).
Integration of Prolactin and Glucocorticoid Signaling at the β-Casein Promoter and Enhancer by Ordered Recruitment of Specific Transcription Factors and Chromatin Modifiers. Molecular Endocrinology.
20(10), 2355-2368.
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Ginger, M. R., Shore, A. N., Contreras, A., Rijnkels, M., Miller, J., Gonzalez-Rimbau, M. F., & Rosen, J. M.
(2006).
A noncoding RNA is a potential marker of cell fate during mammary gland development. Proceedings of the National Academy of Sciences of the United States of America.
103(15), 5781-5786.
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International Chicken Genome Sequencing Consortium.
(2004).
Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution. Nature.
432(7018), 695-716.
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Rijnkels, M., Elnitski, L., Miller, W., & Rosen, J. M.
(2003).
Multispecies comparative analysis of a mammalian-specific genomic domain encoding secretory proteins. Genomics.
82(4), 417-432.
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Rijnkels, M.
(2002).
Multispecies comparison of the casein gene loci and evolution of casein gene family. Journal of Mammary Gland Biology and Neoplasia.
7(3), 327-345.
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Rijnkels, M., & Rosen, J. M.
(2001).
Adenovirus-Cre-mediated recombination in mammary epithelial early progenitor cells. Journal of Cell Science.
114(Pt 17), 3147-3153.
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Rijnkels, M., Kooiman, P. M., Platenburg, G. J., van Dixhoorn, M., Nuijens, J. H., de Boer, H. A., & Pieper, F. R.
(1998).
High-level expression of bovine alpha s1-casein in milk of transgenic mice. TRANSGENIC RESEARCH.
7(1), 5-14.
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Rijnkels, M., Kooiman, P. M., de Boer, H. A., & Pieper, F. R.
(1997).
Organization of the bovine casein gene locus. MAMMALIAN GENOME.
8(2), 148-152.
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Rijnkels, M., Meershoek, E., de Boer, H. A., & Pieper, F. R.
(1997).
Physical map and localization of the human casein gene locus. MAMMALIAN GENOME.
8(4), 285-286.
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Rijnkels, M., Wheeler, D. A., de Boer, H. A., & Pieper, F. R.
(1997).
Structure and expression of the mouse casein gene locus. MAMMALIAN GENOME.
8(1), 9-15.
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Rijnkels, M., Kooiman, P. M., Krimpenfort, P. J., de Boer, H. A., & Pieper, F. R.
(1995).
Expression analysis of the individual bovine beta-, alpha s2- and kappa-casein genes in transgenic mice. Biochemical Journal.
311 ( Pt 3)(Pt 3), 929-937.
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Sanchez, L., Epps, J., Wall, S., McQueen, C., Pearson, S. J., Scribner, K., ... Porter, W. W.
(2023).
SIM2s directed Parkin-mediated mitophagy promotes mammary epithelial cell differentiation. Cell Death and Differentiation.
30(6), 1472-1487.
-
chapter
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Rijnkels, M., & Pieper, F. R.
(1998).
Casein Gene-Based Mammary Gland-Specific Transgene Expression. Mammary Gland Transgenesis.
(pp. 41-64).
Springer Nature.
-
Rijnkels, M., & Pieper, F. R.
(1998).
Casein Gene-Based Mammary Gland-Specific Transgene Expression. Mammary Gland Transgenesis.
(pp. 41-64).
Springer Nature.
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institutional repository document
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Beiki, H., Murdoch, B. M., Park, C. A., Kern, C., Kontechy, D., Becker, G., ... Reecy, J. M.
(2022).
Functional genomics of cattle through integration of multi-omics data
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Beiki, H., Murdoch, B. M., Park, C. A., Kern, C., Kontechy, D., Becker, G., ... Reecy, J. M.
(2022).
Functional genomics of cattle through integration of multi-omics data
Research
principal investigator on
co-principal investigator on
investigator on
Teaching
teaching activities
- BIMS491 Hnr-research Instructor
- BIOT685 Directed Studies Instructor
- VIBS485 Directed Studies Instructor
- VIBS650 Educ Vet Med Bio Envir Instructor
- VIBS684 Professional Internship Instructor
- VIBS685 Directed Studies Instructor
Background
education and training
- Ph.D. in Medical Biotechnology, Leiden University - (Leiden, Netherlands) 1997
- M.S. in Biochemistry, Leiden University - (Leiden, Netherlands) 1988
- Baylor College of Medicine - (Houston, Texas, United States) , Postdoctoral Training 2001
Contact
first name
- Monique
has last name
- Rijnkels
mailing address
-
Texas A&M University
Veterinary Integrative Biosciences
4458 TAMU
College Station, TX 77843-4458
USA
Other
- mrijnkels@tamu.edu