HR job title
- Research Scientist
- Contact Info
- 1 979 595 5691
Thaden, John Research Scientist
Positions
- Research Scientist, Center for Translational Research in Aging and Longevity, Kinesiology and Sport Management
Chromatography and mass spectrometry of small molecules in applications related to research on human metabolism and nutrition.
Research Areas
- Overview
- Publications
- Research
- Background
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Overview
Publications
selected publications
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academic article
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Deutz, N., Singer, P., Wierzchowska-McNew, R. A., Viana, M. V., Ben-David, I. A., Pantet, O., ... Berger, M. M.
(2023).
Females have a different metabolic response to critical illness, measured by comprehensive amino acid flux analysis. Metabolism: clinical and experimental.
142, 155400-155400.
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Kirschner, S. K., Ghane, P., Park, J. K., Simbo, S. Y., Ivanov, I., Braga-Neto, U. M., ... Deutz, N.
(2023).
Short-chain fatty acid production in accessible and inaccessible body pools as assessed by novel stable tracer pulse approach is reduced by aging independent of presence of COPD. 141, 155399-155399.
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Have, G., Thaden, J. J., Pereira, S. L., Engelen, M. P., & Deutz, N. E.
(2023).
-Hydroxy -Methylbutyric Acid (Hmb) Supplementation Stimulates Muscle Protein Synthesis In The Early Recovery Phase Of Sepsis In The Pig. Clinical nutrition ESPEN.
54, 482-483.
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Kang, M. C., Deutz, N. E., Have, G., Thaden, J. J., & Engelen, M. P.
(2023).
Aging In Older Adults Induces Changes In Arginine And Glutamine Kinetics, Partly Independent of The Presence of Comorbidities. Clinical nutrition ESPEN.
54, 474-474.
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Deutz, N. E., Singer, P., Wierzchowska-McNew, R. A., Viana, M. V., Ben-David, I. A., Pantet, O., ... Berger, M. M.
(2023).
Comprehensive Metabolic Amino Acid Flux Analysis In Critically Ill Male And Female Patients. Clinical nutrition ESPEN.
54, 464-464.
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Rice, S. A., Deutz, N. E., Thaden, J. J., Engelen, M. P., & Have, G.
(2023).
Enhanced Splanchnic Extraction Of Nutritional Arginine And Lower Citrulline Production Play A Role In The Reduced Systemic Availability Of Arginine In The Early Recovery Phase Of Sepsis In The Pig. Clinical nutrition ESPEN.
54, 496-496.
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Have, G., Rice, S., Hagve, M., Thaden, J. J., Engelen, M. P., & Deutz, N. E.
(2023).
L-Citrulline Supplementation Stimulates De Novo Arginine Synthesis In The Early Recovery Phase Of Sepsis In The Pig. Clinical nutrition ESPEN.
54, 483-483.
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Engelen, M. P., Have, G., Thaden, J. J., & Deutz, N. E.
(2023).
Sex Related Differences In Amino Acid Metabolism In Chronic Obstructive Pulmonary Disease. Clinical nutrition ESPEN.
54, 490-490.
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Wierzchowska-McNew, R. A., Engelen, M., Thaden, J. J., Ten Have, G., & Deutz, N.
(2022).
Obesity- and sex-related metabolism of arginine and nitric oxide in adults. 116(6), 1610-1620.
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Wierzchowska-McNew, R., Engelen, M., Cruthirds, C., Thaden, J., Have, G. T., & Deutz, N.
(2022).
Increased Amino Acid Turnover and Net Protein Breakdown but Preserved Muscle and Cognitive Function in Obese Middle-Age Adults. 6(Suppl 1), 1090-1090.
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Have, G. T., Thaden, J. J., Pereira, S. L., Engelen, M. P., & Deutz, N. E.
(2021).
-hydroxy -methylbutyric acid (hmb) supplementation reduced whole body protein breakdown in the early recovery phase of sepsis in the pig. Clinical nutrition ESPEN.
46, s549-S549.
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Wierzchowska-Mcnew, R. A., Deutz, N. E., Simbo, S. Y., Have, G., Thaden, J. J., & Engelen, M. P.
(2021).
Enhanced anabolic capacity, but unchanged anabolic threshold in clinically-stable normal weight patients with chronic obstructive pulmonary disease. Clinical nutrition ESPEN.
46, s666-S666.
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Viana, M. V., Becce, F., Pantet, O., Schmidt, S., Bagnoud, G., Thaden, J. J., ... Berger, M. M.
(2021).
Impact of -hydroxy--methylbutyrate (HMB) on muscle loss and protein metabolism in critically ill patients: A RCT. CLINICAL NUTRITION.
40(8), 4878-4887.
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De Wandel, S., Engelen, M., Wierzchowska-McNew, R., Thompson, J., Kirschner, S. K., Cruthirds, C. L., ... Deutz, N.
(2021).
Altered Glutamate and Glutamine Kinetics in Autism Spectrum Disorder. Current Developments in Nutrition.
5(Suppl 2), 5140845-845.
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Deutz, N., Singer, P., Wierzchowska-McNew, R. A., Viana, M. V., Ben-David, I. A., Pantet, O., ... Berger, M. M.
(2021).
Comprehensive metabolic amino acid flux analysis in critically ill patients. CLINICAL NUTRITION.
40(5), 2876-2897.
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Cross, K. M., Granados, J. Z., Ten Have, G., Thaden, J. J., Engelen, M., Lightfoot, J. T., & Deutz, N.
(2021).
Correction: Protein fractional synthesis rates within tissues of high- and low-active mice. PLoS ONE.
16(2), e0248081-e0248081.
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Have, G., Thaden, J. J., Engelen, M. P., Deutz, N. E., & Center for Translational Research in Aging Longevity, C. S.
(2020).
Excessive nitrogen uptake by the liver limits the anabolic response to enteral amino acids intervention during early sepsis-recovery. Clinical nutrition ESPEN.
40, 456-457.
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Wierzchowska-Mcnew, R. A., Engelen, M. P., Have, G., Thaden, J. J., & Deutz, N. E.
(2020).
Impaired whole-body arginine metabolism in type 2 diabetes. Clinical nutrition ESPEN.
40, 450-450.
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Wierzchowska-Mcnew, R. A., Engelen, M. P., Have, G., Thaden, J. J., & Deutz, N. E.
(2020).
Isoleucine supplementation for ten days does not modify protein and branched-chain amino acid turnover in type 2 diabetes. Clinical nutrition ESPEN.
40, 451-451.
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Cross, K. M., Granados, J. Z., Ten Have, G., Thaden, J. J., Engelen, M., Lightfoot, J. T., & Deutz, N.
(2020).
Protein fractional synthesis rates within tissues of high- and low-active mice. PLoS ONE.
15(11), e0242926-e0242926.
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Engelen, M., Jonker, R., Thaden, J. J., Ten Have, G., Jeon, M. S., Dasarathy, S., & Deutz, N.
(2020).
Comprehensive metabolic flux analysis to explain skeletal muscle weakness in COPD. CLINICAL NUTRITION.
39(10), 3056-3065.
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Ligthart-Melis, G. C., Engelen, M., Simbo, S. Y., Ten Have, G., Thaden, J. J., Cynober, L., & Deutz, N.
(2020).
Metabolic Consequences of Supplemented Methionine in a Clinical Context. 150(Suppl 1), 2538S-2547S.
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Cross, K., Granados, J., Barrington, W., Thaden, J., Have, G. T., Threadgill, D., Lightfoot, J. T., & Deutz, N.
(2020).
A Ketogenic Diet In Mice Reduces Cardiac Protein Synthesis Compared to a Western Diet. Current Developments in Nutrition.
4(Suppl 2), nzaa046_015-nzaa046_015.
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Granados, J. Z., Ten Have, G., Letsinger, A. C., Thaden, J. J., Engelen, M., Lightfoot, J. T., & Deutz, N.
(2020).
Activated whole-body arginine pathway in high-active mice. PLoS ONE.
15(6), e0235095-e0235095.
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Wierzchowska-McNew, A., Engelen, M., Have, G. T., Thaden, J., & Deutz, N.
(2020).
Age-Specific Differences in Whole-Body Amino Acid Kinetics. Current Developments in Nutrition.
4(Suppl 2), nzaa040_088-nzaa040_088.
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Wierzchowska-McNew, A., Engelen, M., Knoop, K., Have, G. T., & Thaden, J.
(2020).
Changes in Whole-Body Amino Acid Metabolism in Response to 2 Weeks of the Very-Low Calorie Diet Are Not Affected by Gender. Current Developments in Nutrition.
4(Suppl 2), nzaa063_098-nzaa063_098.
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Cross, K., Granados, J., Have, G. T., Thaden, J., Lightfoot, J. T., & Deutz, N.
(2020).
Comparable Organ Protein Fractional Synthesis Rate of High and Low-Active Mice. Current Developments in Nutrition.
4(Suppl 2), nzaa066_005-nzaa066_005.
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Engelen, M., Ten Have, G., Thaden, J. J., & Deutz, N.
(2019).
New advances in stable tracer methods to assess whole-body protein and amino acid metabolism. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE.
22(5), 337-346.
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Wierzchowska-McNew, A., Engelen, M. P., Knoop, K. D., Have, G., Thaden, J. J., & Deutz, N. E.
(2018).
Total weight loss obtained after 2 weeks of very low caloric diet is strongly associated with baseline (net) protein catabolic and glutamine production rates. CLINICAL NUTRITION.
37, s160-s161.
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Deutz, N., Thaden, J. J., Ten Have, G., Walker, D. K., & Engelen, M.
(2018).
Metabolic phenotyping using kinetic measurements in young and older healthy adults. Metabolism: clinical and experimental.
78, 167-178.
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Walker, D. K., Thaden, J. J., Wierzchowska-McNew, A., Engelen, M., & Deutz, N.
(2017).
Determination of -hydroxy--methylbutyrate concentration and enrichment in human plasma using chemical ionization gas chromatography tandem mass spectrometry. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences.
1040, 233-238.
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Engelen, M. P., Harrykissoon, R., Veley, E. A., Thaden, J. J., & Deutz, N. E.
(2015).
MON-PP121: Skeletal Muscle Weakness in Chronic Obstructive Pulmonary Disease is Associated with Disturbances in Glutamate Related Metabolism. CLINICAL NUTRITION.
34, s173-S173.
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Engelen, M. P., Jonker, R., Veley, E. A., Harrykissoon, R., Thaden, J. J., & Deutz, N. E.
(2015).
MON-PP282: Exhaled Concentration of Nitric Oxide (Feno) Does not Reflect the Upregulated Whole Body Nitric Oxide Synthesis in Patients with Chronic Obstructive Pulmonary Disease. CLINICAL NUTRITION.
34, s232-S232.
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Have, G., Engelen, M. P., Wolfe, R. R., Thaden, J., & Deutz, N. E.
(2015).
SUN-PP026: Reduced Protein Synthesis and Breakdown in Jejunal Mucosal Biopsies in a Live Bacteria Induced Hyperdynamic Sepsis Pig Model. CLINICAL NUTRITION.
34, s33-S33.
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Walker, D. K., Thaden, J. J., & Deutz, N.
(2015).
Application of gas chromatography-tandem mass spectrometry (GC/MS/MS) for the analysis of deuterium enrichment of water. Journal of Mass Spectrometry.
50(6), 838-843.
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Vertino, A., Ayyadevara, S., Thaden, J. J., & Shmookler Reis, R. J.
(2011).
A narrow quantitative trait locus in C. elegans coordinately affects longevity, thermotolerance, and resistance to paraquat. Frontiers in Genetics.
2(SEP), 63.
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Gupta, P. K., Brown, J., Biju, P. G., Thaden, J., Deutz, N. E., Kumar, S., Hauer-Jensen, M., & Hendrickson, H. P.
(2011).
Development of high-throughput HILIC-MS/MS methodology for plasma citrulline determination in multiple species. Analytical Methods.
3(8), 1759-1768.
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Shmookler Reis, R. J., Xu, L., Lee, H., Chae, M., Thaden, J. J., Bharill, P., ... Ayyadevara, S.
(2011).
Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants. Aging.
3(2), 125-147.
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Chae, M., Shmookler Reis, R. J., & Thaden, J. J.
(2008).
An iterative block-shifting approach to retention time alignment that preserves the shape and area of gas chromatography-mass spectrometry peaks. BMC Bioinformatics.
9 Suppl 9(Suppl 9), S15.
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Ayyadevara, S., Alla, R., Thaden, J. J., & Shmookler Reis, R. J.
(2008).
Remarkable longevity and stress resistance of nematode PI3K-null mutants. Aging Cell.
7(1), 13-22.
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Gurley, B. J., Swain, A., Hubbard, M. A., Hartsfield, F., Thaden, J., Williams, D. K., Gentry, W. B., & Tong, Y.
(2008).
Supplementation with goldenseal (Hydrastis canadensis), but not kava kava (Piper methysticum), inhibits human CYP3A activity in vivo. Clinical Pharmacology and Therapeutics.
83(1), 61-69.
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Sumner, L. W., Amberg, A., Barrett, D., Beale, M. H., Beger, R., Daykin, C. A., ... Viant, M. R.
(2007).
Proposed minimum reporting standards for chemical analysis Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI). Metabolomics.
3(3), 211-221.
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Gurley, B., Hubbard, M. A., Williams, D. K., Thaden, J., Tong, Y., Gentry, W. B., ... Cheboyina, S.
(2006).
Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: comparison of a milk thistle and black cohosh product to rifampin and clarithromycin. Journal of Clinical Pharmacology.
46(2), 201-213.
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Singh, S. P., Chen, T., Chen, L., Mei, N., McLain, E., Samokyszyn, V., ... Zimniak, P.
(2005).
Mutagenic effects of 4-hydroxynonenal triacetate, a chemically protected form of the lipid peroxidation product 4-hydroxynonenal, as assayed in L5178Y/Tk+/- mouse lymphoma cells. Journal of Pharmacology and Experimental Therapeutics.
313(2), 855-861.
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Ayyadevara, S., Ayyadevara, R., Vertino, A., Galecki, A., Thaden, J. J., & Shmookler Reis, R. J.
(2003).
Genetic loci modulating fitness and life span in Caenorhabditis elegans: categorical trait interval mapping in CL2a x Bergerac-BO recombinant-inbred worms. Genetics.
163(2), 557-570.
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Ayyadevara, S., Ayyadevara, R., Hou, S., Thaden, J. J., & Shmookler Reis, R. J.
(2001).
Genetic mapping of quantitative trait loci governing longevity of Caenorhabditis elegans in recombinant-inbred progeny of a Bergerac-BO x RC301 interstrain cross. Genetics.
157(2), 655-666.
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Ayyadevara, S., Thaden, J. J., & Shmookler Reis, R. J.
(2000).
Anchor polymerase chain reaction display: a high-throughput method to resolve, score, and isolate dimorphic genetic markers based on interspersed repetitive DNA elements. Analytical Biochemistry.
284(1), 19-28.
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Ayyadevara, S., Thaden, J. J., & Shmookler Reis, R. J.
(2000).
Discrimination of primer 3'-nucleotide mismatch by taq DNA polymerase during polymerase chain reaction. Analytical Biochemistry.
284(1), 11-18.
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Thaden, J. J., & Shmookler Reis, R. J.
(2000).
Ammonia, respiration, and longevity in nematodes: insights on metabolic regulation of life span from temporal rescaling. 23(2), 75-84.
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Benes, H., Weinstein, R. S., Zheng, W., Thaden, J. J., Jilka, R. L., Manolagas, S. C., & Shmookler Reis, R. J.
(2000).
Chromosomal mapping of osteopenia-associated quantitative trait loci using closely related mouse strains. Journal of Bone and Mineral Research.
15(4), 626-633.
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Redpath, J. L., Thaden, J. J., & Fong, R. L.
(1986).
Mutation induction in Escherichia coli WP2 uvrA by Cerenkov emission associated with 137Cs gamma irradiation. RADIATION RESEARCH.
105(1), 8-17.
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Deutz, N., Singer, P., Wierzchowska-McNew, R. A., Viana, M. V., Ben-David, I. A., Pantet, O., ... Berger, M. M.
(2023).
Females have a different metabolic response to critical illness, measured by comprehensive amino acid flux analysis. Metabolism: clinical and experimental.
142, 155400-155400.
-
conference paper
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McNew, A., Deutz, N., Simbo, S. Y., Thaden, J. J., ten Have, G., & Engelen, M.
(2019).
Protein Digestion, but Not Amino Acid Absorption, Is Compromised During Feeding in Chronic Obstructive Pulmonary Disease. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
a5730-a5730.
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Cruthirds, C., Thaden, J. J., Ten Have, G., Deutz, N., & Engelen, M.
(2019).
Skeletal Muscle Weakness Is Associated with Specific Alterations in Amino Acid Metabolism in Patients with Chronic Obstructive Pulmonary Disease. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
a2057-a2057.
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Granados, J. Z., Ten Have, G., Letsinger, A. C., Thaden, J. J., Lightfoot, J. T., & Deutz, N.
(2019).
High-active Mice Have Elevated Clearance Rate Of Bcaas Compared To Low-active Mice. Medicine & Science in Sports & Exercise.
998-999.
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Engelen, M. P., Com, G., Anderson, P. J., Thaden, J. J., Aarts, N., & Deutz, N. E.
(2012).
NOVEL METHOD TO MEASURE FAT AND PROTEIN DIGESTION RATE AND THE ACUTE RESPONSE TO PANCREATIC ENZYME INTAKE IN PEDIATRIC AND ADULT PATIENTS WITH CYSTIC FIBROSIS. PEDIATRIC PULMONOLOGY.
410-411.
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Reis, R., Ayyadevara, S., Tazearslan, C., & Thaden, J. J.
(2007).
Ten-fold extension of C. elegans longevity by mutations that also confer protection against oxidative and electrophilic stresses, but not hyperthermic stress. AGE.
119-120.
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Jilka, R. L., Wynne, R. A., Chen, X., Stewart, S., Xu, L., Thaden, J. J., Weinstein, R. S., & Manolagas, S. S.
(2005).
The pathogenesis of age-related bone loss in mice involves increased production of PPAR gamma-activating oxidized lipids derived from the lipoxygenase Alox15. Journal of Bone and Mineral Research.
S36-S36.
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Ayyadevara, S., Thaden, J. J., & Reis, R.
(1999).
Unbiased chromosomal mapping of loci governing longevity in C. elegans. AGE.
117-117.
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MILLER, P. S., CUSHMAN, C. D., KEAN, J. M., LEVIS, J. T., & THADEN, J. J.
(1993).
PSORALEN-CONJUGATED OLIGONUCLEOSIDE METHYLPHOSPHONATES - INTERACTION WITH RNA. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
6-MEDI.
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MILLER, P. S., CUSHMAN, C. D., KEAN, J. M., LEVIS, J. T., & THADEN, J. J.
(1993).
PSORALEN-DERIVATIZED ANTISENSE OLIGONUCLEOSIDE METHYLPHOSPHONATES. Journal of Cellular Biochemistry.
192-192.
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McNew, A., Deutz, N., Simbo, S. Y., Thaden, J. J., ten Have, G., & Engelen, M.
(2019).
Protein Digestion, but Not Amino Acid Absorption, Is Compromised During Feeding in Chronic Obstructive Pulmonary Disease. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
a5730-a5730.
Research
investigator on
Background
education and training
- Ph.D. in Biochemistry, Johns Hopkins University - (Baltimore, Maryland, United States) 1993
Contact
first name
- John
has last name
- Thaden
mailing address
-
Texas A&M University
Health And Kinesiology
4253 TAMU
College Station, TX 77843-4253
USA
Other
- jj.thaden@ctral.org