HR job title
- Research Scientist
- Contact Info
- 1 979 595 5691
Thaden, John Research Scientist
Positions
- Research Scientist, Center for Translational Research in Aging and Longevity, Health and Kinesiology
Chromatography and mass spectrometry of small molecules in applications related to research on human metabolism and nutrition.
Research Areas
- Overview
- Publications
- Research
- Background
- Contact
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Overview
Publications
selected publications
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academic article
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De Wandel, S., Engelen, M. P., Wierzchowska-McNew, R., Thompson, J., Kirschner, S. K., Cruthirds, C. L., ... Deutz, N. E.
(2021).
Altered Glutamate and Glutamine Kinetics in Autism Spectrum Disorder. Current Developments in Nutrition.
5(Supplement_2), 845-845.
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Deutz, N., Singer, P., Wierzchowska-McNew, R. A., Viana, M. V., Ben-David, I. A., Pantet, O., ... Berger, M. M.
(2021).
Comprehensive metabolic amino acid flux analysis in critically ill patients. CLINICAL NUTRITION.
40(5), 2876-2897.
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Cross, K. M., Granados, J. Z., Ten Have, G., Thaden, J. J., Engelen, M., Lightfoot, J. T., & Deutz, N.
(2021).
Correction: Protein fractional synthesis rates within tissues of high- and low-active mice. PLOS ONE.
16(2), e0248081-e0248081.
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Viana, M. V., Becce, F., Pantet, O., Schmidt, S., Bagnoud, G., Thaden, J. J., ... Berger, M. M.
(2021).
Impact of β−hydroxy-β−methylbutyrate (HMB) on muscle loss and protein metabolism in critically ill patients: A RCT. CLINICAL NUTRITION.
40(8), 4878-4887.
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Have, G., Thaden, J. J., Engelen, M. P., Deutz, N. E., & Center for Translational Research in Aging Longevity, C. S.
(2020).
Excessive nitrogen uptake by the liver limits the anabolic response to enteral amino acids intervention during early sepsis-recovery. Clinical Nutrition ESPEN.
40, 456-457.
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Wierzchowska-Mcnew, R. A., Engelen, M. P., Have, G., Thaden, J. J., & Deutz, N. E.
(2020).
Impaired whole-body arginine metabolism in type 2 diabetes. Clinical Nutrition ESPEN.
40, 450-450.
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Wierzchowska-Mcnew, R. A., Engelen, M. P., Have, G., Thaden, J. J., & Deutz, N. E.
(2020).
Isoleucine supplementation for ten days does not modify protein and branched-chain amino acid turnover in type 2 diabetes. Clinical Nutrition ESPEN.
40, 451-451.
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Ligthart-Melis, G. C., Engelen, M., Simbo, S. Y., Have, G., Thaden, J. J., Cynober, L., & Deutz, N.
(2020).
Metabolic Consequences of Supplemented Methionine in a Clinical Context. JOURNAL OF NUTRITION.
150(Supplement_1), 2538s-2547s.
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Granados, J. Z., Ten Have, G., Letsinger, A. C., Thaden, J. J., Engelen, M., Lightfoot, J. T., & Deutz, N.
(2020).
Activated whole-body arginine pathway in high-active mice. PLOS ONE.
15(6), e0235095-e0235095.
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Cross, K., Granados, J., Barrington, W., Thaden, J., Have, G. T., Threadgill, D., Lightfoot, J. T., & Deutz, N.
(2020).
A Ketogenic Diet In Mice Reduces Cardiac Protein Synthesis Compared to a Western Diet. Current Developments in Nutrition.
4(Supplement_2), 515-515.
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Wierzchowska-McNew, A., Engelen, M., Have, G. T., Thaden, J., & Deutz, N.
(2020).
Age-Specific Differences in Whole-Body Amino Acid Kinetics. Current Developments in Nutrition.
4(Supplement_2), 88-88.
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Wierzchowska-McNew, A., Engelen, M., Knoop, K., Have, G. T., & Thaden, J.
(2020).
Changes in Whole-Body Amino Acid Metabolism in Response to 2 Weeks of the Very-Low Calorie Diet Are Not Affected by Gender. Current Developments in Nutrition.
4(Supplement_2), 1700-1700.
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Cross, K., Granados, J., Have, G. T., Thaden, J., Lightfoot, J. T., & Deutz, N.
(2020).
Comparable Organ Protein Fractional Synthesis Rate of High and Low-Active Mice. Current Developments in Nutrition.
4(Supplement_2), 1750-1750.
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Cross, K. M., Granados, J. Z., Ten Have, G., Thaden, J. J., Engelen, M., Lightfoot, J. T., & Deutz, N.
(2020).
Protein fractional synthesis rates within tissues of high- and low-active mice. PLOS ONE.
15(11), e0242926-e0242926.
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Engelen, M., Jonker, R., Thaden, J. J., Ten Have, G., Jeon, M. S., Dasarathy, S., & Deutz, N.
(2020).
Comprehensive metabolic flux analysis to explain skeletal muscle weakness in COPD. CLINICAL NUTRITION.
39(10), 3056-3065.
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Engelen, M., Ten Have, G., Thaden, J. J., & Deutz, N.
(2019).
New advances in stable tracer methods to assess whole-body protein and amino acid metabolism. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE.
22(5), 337-346.
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Wierzchowska-McNew, A., Engelen, M. P., Knoop, K. D., Have, G., Thaden, J. J., & Deutz, N. E.
(2018).
Total weight loss obtained after 2 weeks of very low caloric diet is strongly associated with baseline (net) protein catabolic and glutamine production rates. CLINICAL NUTRITION.
37, s160-s161.
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Deutz, N., Thaden, J. J., Ten Have, G., Walker, D. K., & Engelen, M.
(2018).
Metabolic phenotyping using kinetic measurements in young and older healthy adults. Metabolism.
78, 167-178.
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Walker, D. K., Thaden, J. J., Wierzchowska-McNew, A., Engelen, M., & Deutz, N.
(2016).
Determination of β-hydroxy-β-methylbutyrate concentration and enrichment in human plasma using chemical ionization gas chromatography tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci.
1040, 233-238.
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Engelen, M. P., Harrykissoon, R., Veley, E. A., Thaden, J. J., & Deutz, N. E.
(2015).
MON-PP121: Skeletal Muscle Weakness in Chronic Obstructive Pulmonary Disease is Associated with Disturbances in Glutamate Related Metabolism. CLINICAL NUTRITION.
34, s173-S173.
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Engelen, M. P., Jonker, R., Veley, E. A., Harrykissoon, R., Thaden, J. J., & Deutz, N. E.
(2015).
MON-PP282: Exhaled Concentration of Nitric Oxide (Feno) Does not Reflect the Upregulated Whole Body Nitric Oxide Synthesis in Patients with Chronic Obstructive Pulmonary Disease. CLINICAL NUTRITION.
34, s232-S232.
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Have, G., Engelen, M. P., Wolfe, R. R., Thaden, J., & Deutz, N. E.
(2015).
SUN-PP026: Reduced Protein Synthesis and Breakdown in Jejunal Mucosal Biopsies in a Live Bacteria Induced Hyperdynamic Sepsis Pig Model. CLINICAL NUTRITION.
34, s33-S33.
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Walker, D. K., Thaden, J. J., & Deutz, N.
(2015).
Application of gas chromatography–tandem mass spectrometry (GC/MS/MS) for the analysis of deuterium enrichment of water. JOURNAL OF MASS SPECTROMETRY.
50(6), 838-843.
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Shmookler Reis, R. J., Xu, L., Lee, H., Chae, M., Thaden, J. J., Bharill, P., ... Ayyadevara, S.
(2011).
Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants. Aging.
3(2), 125-147.
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Vertino, A., Ayyadevara, S., Thaden, J. J., & Reis, R.
(2011).
A Narrow Quantitative Trait Locus in C. elegans Coordinately Affects Longevity, Thermotolerance, and Resistance to Paraquat. Frontiers in Genetics.
2(SEP), 63.
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Gupta, P. K., Brown, J., Biju, P. G., Thaden, J., Deutz, N. E., Kumar, S., Hauer-Jensen, M., & Hendrickson, H. P.
(2011).
Development of high-throughput HILIC-MS/ MS methodology for plasma citrulline determination in multiple species. Analytical Methods.
3(8), 1759-1768.
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Chae, M., Reis, R., & Thaden, J. J.
(2008).
An iterative block-shifting approach to retention time alignment that preserves the shape and area of gas chromatography-mass spectrometry peaks. BMC Bioinformatics.
9(Suppl 9), s15-s15.
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Ayyadevara, S., Alla, R., Thaden, J. J., & Reis, R.
(2008).
Remarkable longevity and stress resistance of nematode PI3K‐null mutants. Aging Cell.
7(1), 13-22.
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Sumner, L. W., Amberg, A., Barrett, D., Beale, M. H., Beger, R., Daykin, C. A., ... Viant, M. R.
(2007).
Proposed minimum reporting standards for chemical analysis. Metabolomics.
3(3), 211-221.
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Gurley, B. J., Swain, A., Hubbard, M. A., Hartsfield, F., Thaden, J., Williams, D. K., Gentry, W. B., & Tong, Y.
(2007).
Supplementation With Goldenseal (Hydrastis canadensis), but not Kava Kava (Piper methysticum), Inhibits Human CYP3A Activity In Vivo. CLINICAL PHARMACOLOGY & THERAPEUTICS.
83(1), 61-69.
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Gurley, B., Hubbard, M. A., Williams, D. K., Thaden, J., Tong, Y., Gentry, W. B., ... Cheboyina, S.
(2006).
Assessing the Clinical Significance of Botanical Supplementation on Human Cytochrome P450 3A Activity: Comparison of a Milk Thistle and Black Cohosh Product to Rifampin and Clarithromycin. The Journal of Clinical Pharmacology.
46(2), 201-213.
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Singh, S. P., Chen, T., Chen, L., Mei, N., McLain, E., Samokyszyn, V., ... Zimniak, P.
(2005).
Mutagenic Effects of 4-Hydroxynonenal Triacetate, a Chemically Protected Form of the Lipid Peroxidation Product 4-Hydroxynonenal, as Assayed in L5178Y/Tk+/– Mouse Lymphoma Cells. Journal of Pharmacology and Experimental Therapeutics.
313(2), 855-861.
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Ayyadevara, S., Ayyadevara, R., Vertino, A., Galecki, A., Thaden, J. J., & Reis, R.
(2003).
Genetic loci modulating fitness and life span in Caenorhabditis elegans: categorical trait interval mapping in CL2a x Bergerac-BO recombinant-inbred worms. GENETICS.
163(2), 557-570.
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Ayyadevara, S., Ayyadevara, R., Hou, S., Thaden, J. J., & Reis, R.
(2001).
Genetic Mapping of Quantitative Trait Loci Governing Longevity of Caenorhabditis elegans in Recombinant-Inbred Progeny of a Bergerac-BO × RC301 Interstrain Cross. GENETICS.
157(2), 655-666.
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Ayyadevara, S., Thaden, J. J., & Reis, R.
(2000).
Anchor Polymerase Chain Reaction Display: A High-Throughput Method to Resolve, Score, and Isolate Dimorphic Genetic Markers Based on Interspersed Repetitive DNA Elements. ANALYTICAL BIOCHEMISTRY.
284(1), 19-28.
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Ayyadevara, S., Thaden, J. J., & Reis, R.
(2000).
Discrimination of Primer 3′-Nucleotide Mismatch by Taq DNA Polymerase during Polymerase Chain Reaction. ANALYTICAL BIOCHEMISTRY.
284(1), 11-18.
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Thaden, J. J., & Shmookler Reis, R. J.
(2000).
Ammonia, respiration, and longevity in nematodes: insights on metabolic regulation of life span from temporal rescaling. GeroScience.
23(2), 75-84.
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Beneš, H., Weinstein, R. S., Zheng, W., Thaden, J. J., Jilka, R. L., Manolagas, S. C., & Reis, R.
(2000).
Chromosomal Mapping of Osteopenia‐Associated Quantitative Trait Loci Using Closely Related Mouse Strains. JOURNAL OF BONE AND MINERAL RESEARCH.
15(4), 626-633.
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Redpath, J. L., Thaden, J. J., & Fong, R. L.
(1986).
Mutation induction in Escherichia coli WP2 uvrA by Cerenkov emission associated with 137Cs gamma irradiation. RADIATION RESEARCH.
105(1), 8-17.
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De Wandel, S., Engelen, M. P., Wierzchowska-McNew, R., Thompson, J., Kirschner, S. K., Cruthirds, C. L., ... Deutz, N. E.
(2021).
Altered Glutamate and Glutamine Kinetics in Autism Spectrum Disorder. Current Developments in Nutrition.
5(Supplement_2), 845-845.
-
conference paper
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Granados, J. Z., Ten Have, G., Letsinger, A. C., Thaden, J. J., Lightfoot, J. T., & Deutz, N.
(2019).
High-active Mice Have Elevated Clearance Rate Of Bcaas Compared To Low-active Mice. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE.
998-999.
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McNew, A., Deutz, N., Simbo, S. Y., Thaden, J. J., ten have, G., & Engelen, M.
(2019).
Protein Digestion, but Not Amino Acid Absorption, Is Compromised During Feeding in Chronic Obstructive Pulmonary Disease. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
a5730-a5730.
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Cruthirds, C., Thaden, J. J., Ten Have, G., Deutz, N., & Engelen, M.
(2019).
Skeletal Muscle Weakness Is Associated with Specific Alterations in Amino Acid Metabolism in Patients with Chronic Obstructive Pulmonary Disease. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
a2057-a2057.
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Engelen, M. P., Com, G., Anderson, P. J., Thaden, J. J., Aarts, N., & Deutz, N. E.
(2012).
NOVEL METHOD TO MEASURE FAT AND PROTEIN DIGESTION RATE AND THE ACUTE RESPONSE TO PANCREATIC ENZYME INTAKE IN PEDIATRIC AND ADULT PATIENTS WITH CYSTIC FIBROSIS. PEDIATRIC PULMONOLOGY.
410-411.
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Reis, R., Ayyadevara, S., Tazearslan, C., & Thaden, J. J.
(2007).
Ten-fold extension of C. elegans longevity by mutations that also confer protection against oxidative and electrophilic stresses, but not hyperthermic stress. AGE.
119-120.
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Jilka, R. L., Wynne, R. A., Chen, X., Stewart, S., Xu, L., Thaden, J. J., Weinstein, R. S., & Manolagas, S. S.
(2005).
The pathogenesis of age-related bone loss in mice involves increased production of PPAR gamma-activating oxidized lipids derived from the lipoxygenase Alox15. JOURNAL OF BONE AND MINERAL RESEARCH.
S36-S36.
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Ayyadevara, S., Thaden, J. J., & Reis, R.
(1999).
Unbiased chromosomal mapping of loci governing longevity in C. elegans. AGE.
117-117.
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MILLER, P. S., CUSHMAN, C. D., KEAN, J. M., LEVIS, J. T., & THADEN, J. J.
(1993).
PSORALEN-CONJUGATED OLIGONUCLEOSIDE METHYLPHOSPHONATES - INTERACTION WITH RNA. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
6-MEDI.
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MILLER, P. S., CUSHMAN, C. D., KEAN, J. M., LEVIS, J. T., & THADEN, J. J.
(1993).
PSORALEN-DERIVATIZED ANTISENSE OLIGONUCLEOSIDE METHYLPHOSPHONATES. JOURNAL OF CELLULAR BIOCHEMISTRY.
192-192.
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Granados, J. Z., Ten Have, G., Letsinger, A. C., Thaden, J. J., Lightfoot, J. T., & Deutz, N.
(2019).
High-active Mice Have Elevated Clearance Rate Of Bcaas Compared To Low-active Mice. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE.
998-999.
Research
investigator on
Background
education and training
- Ph.D. in Biochemistry, Johns Hopkins University - (Baltimore, Maryland, United States) 1993
Contact
first name
- John
has last name
- Thaden
mailing address
-
Texas A&M University
Health And Kinesiology
4253 TAMU
College Station, TX 77843-4253
USA
Other
- jj.thaden@ctral.org