HR job title
- Research Assistant Professor
- Contact Info
- 1 979 846 0337
Bake, Shameena Assistant Professor
Positions
- Assistant Professor, Neuroscience and Experimental Therapeutics, College of Medicine
I have developed an independent line of research to investigate effects of maternal ethanol consumption on adult health, with particular emphasis on cerebral blood flow and stroke severity in adults.
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Overview
Publications
selected publications
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academic article
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Bake, S., Pinson, M. R., Pandey, S., Chambers, J. P., Mota, R., Fairchild, A. E., Miranda, R. C., & Sohrabji, F.
(2021).
Prenatal alcohol-induced sex differences in immune, metabolic and neurobehavioral outcomes in adult rats. Brain, Behavior, and Immunity.
98, 86-100.
-
Bake, S., Okoreeh, A., Khosravian, H., & Sohrabji, F.
(2019).
Insulin-like Growth Factor (IGF)-1 treatment stabilizes the microvascular cytoskeleton under ischemic conditions. Experimental Neurology.
311, 162-172.
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Okoreeh, A. K., Bake, S., & Sohrabji, F.
(2017).
Astrocyte-specific insulin-like growth factor-1 gene transfer in aging female rats improves stroke outcomes. Glia.
65(7), 1043-1058.
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Bake, S., Gardner, R., Tingling, J. D., Miranda, R. C., & Sohrabji, F.
(2017).
Fetal Alcohol Exposure Alters Blood Flow and Neurological Responses to Transient Cerebral Ischemia in Adult Mice. Alcoholism: Clinical and Experimental Research.
41(1), 117-127.
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Lunde, E. R., Washburn, S. E., Golding, M. C., Bake, S., Miranda, R. C., & Ramadoss, J.
(2016).
Alcohol-Induced Developmental Origins of Adult-Onset Diseases. Alcoholism: Clinical and Experimental Research.
40(7), 1403-1414.
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Maldonado-Bouchard, S., Peters, K., Woller, S. A., Madahian, B., Faghihi, U., Patel, S., Bake, S., & Hook, M. A.
(2016).
Inflammation is increased with anxiety- and depression-like signs in a rat model of spinal cord injury. Brain, Behavior, and Immunity.
51, 176-195.
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Bake, S., Okoreeh, A. K., Alaniz, R. C., & Sohrabji, F.
(2016).
Insulin-Like Growth Factor (IGF)-I Modulates Endothelial Blood-Brain Barrier Function in Ischemic Middle-Aged Female Rats. ENDOCRINOLOGY.
157(1), 61-69.
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Tsai, P., Bake, S., Balaraman, S., Rawlings, J., Holgate, R. R., Dubois, D., & Miranda, R. C.
(2014).
MiR-153 targets the nuclear factor-1 family and protects against teratogenic effects of ethanol exposure in fetal neural stem cells. Biology Open.
3(8), 741-758.
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Bake, S., Selvamani, A., Cherry, J., & Sohrabji, F.
(2014).
Blood brain barrier and neuroinflammation are critical targets of IGF-1-mediated neuroprotection in stroke for middle-aged female rats. PLoS ONE.
9(3), e91427-e91427.
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Sohrabji, F., Bake, S., & Lewis, D. K.
(2013).
Age-related changes in brain support cells: Implications for stroke severity. Neurochemistry International: the journal for the publication of cellular and molecular aspects of neurochemistry.
63(4), 291-301.
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Tingling, J. D., Bake, S., Holgate, R., Rawlings, J., Nagsuk, P. P., Chandrasekharan, J., Schneider, S. L., & Miranda, R. C.
(2013).
CD24 expression identifies teratogen-sensitive fetal neural stem cell subpopulations: evidence from developmental ethanol exposure and orthotopic cell transfer models. PLoS ONE.
8(7), e69560-e69560.
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Sudheendran, N., Bake, S., Miranda, R. C., & Larin, K. V.
(2013).
Comparative assessments of the effects of alcohol exposure on fetal brain development using optical coherence tomography and ultrasound imaging. Journal of Biomedical Optics.
18(2), 20506-020506.
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Bake, S., Tingling, J. D., & Miranda, R. C.
(2012).
Ethanol exposure during pregnancy persistently attenuates cranially directed blood flow in the developing fetus: evidence from ultrasound imaging in a murine second trimester equivalent model. Alcoholism: Clinical and Experimental Research.
36(5), 748-758.
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Lewis, D. K., Bake, S., Thomas, K., Jezierski, M. K., & Sohrabji, F.
(2010).
A high cholesterol diet elevates hippocampal cytokine expression in an age and estrogen-dependent manner in female rats. JOURNAL OF NEUROIMMUNOLOGY.
223(1-2), 31-38.
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Bake, S., Friedman, J. A., & Sohrabji, F.
(2009).
Reproductive age-related changes in the blood brain barrier: expression of IgG and tight junction proteins. Microvascular Research.
78(3), 413-424.
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Bake, S., Ma, L., & Sohrabji, F.
(2008).
Estrogen receptor-alpha overexpression suppresses 17beta-estradiol-mediated vascular endothelial growth factor expression and activation of survival kinases. ENDOCRINOLOGY.
149(8), 3881-3889.
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Camarillo, C., Kumar, L. S., Bake, S., Sohrabji, F., & Miranda, R. C.
(2007).
Ethanol regulates angiogenic cytokines during neural development: evidence from an in vitro model of mitogen-withdrawal-induced cerebral cortical neuroepithelial differentiation. Alcoholism: Clinical and Experimental Research.
31(2), 324-335.
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Johnson, A. B., Bake, S., Lewis, D. K., & Sohrabji, F.
(2006).
Temporal expression of IL-1beta protein and mRNA in the brain after systemic LPS injection is affected by age and estrogen. JOURNAL OF NEUROIMMUNOLOGY.
174(1-2), 82-91.
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Sohrabji, F., & Bake, S.
(2006).
Age-related changes in neuroprotection: is estrogen pro-inflammatory for the reproductive senescent brain?. Endocrine.
29(2), 191-197.
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Nordell, V. L., Lewis, D. K., Bake, S., & Sohrabji, F.
(2005).
The neurotrophin receptor p75NTR mediates early anti-inflammatory effects of estrogen in the forebrain of young adult rats. BMC Neuroscience.
6(1), 58.
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Bake, S., & Sohrabji, F.
(2004).
17beta-estradiol differentially regulates blood-brain barrier permeability in young and aging female rats. ENDOCRINOLOGY.
145(12), 5471-5475.
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Varghese, S., Shameena, B., Lakshmy, P. S., Biju, M. P., Easwar Shankar, P. N., Paulose, C. S., & Oommen, O. V
(2001).
Polyunsaturated fatty acids (PUFA) regulate neurotransmitter contents in rat brain. 38(5), 327-330.
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Varghese, S., Shameena, B., Sudhakaran, P. R., & Oommen, O. V
(2001).
Short-term effects of thyroid hormones on lipogenic enzymes and 14C-acetate incorporation into various lipid classes: in vivo and in vitro studies. Indian Journal of Experimental Biology.
39(5), 431-435.
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Shameena, B., Renuka, T. R., Varghese, S., Paulose, C. S., & Oommen, O. V.
(2001).
Hypothyroidism and nutritional status alter 3,5,3'-triiodothyronine (T3) receptors in isolated liver nuclei of Anabas testudineus (Bloch). Endocrine Research.
27(3), 329-336.
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Leena, S., Shameena, B., & Oommen, O. V.
(2001).
In vivo and in vitro effects of prolactin and growth hormone on lipid metabolism in a teleost, Anabas testudineus (Bloch). Comparative Biochemistry and Physiology B: Biochemistry and Molecular Biology.
128(4), 761-766.
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Varghese, S., Shameena, B., & Oommen, O. V.
(2001).
Thyroid hormones regulate lipid peroxidation and antioxidant enzyme activities in Anabas testudineus (Bloch). Comparative Biochemistry and Physiology B: Biochemistry and Molecular Biology.
128(1), 165-171.
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Shameena, B., Varghese, S., Leena, S., & Oommen, O. V.
(2000).
3,5,3'-triiodothyronine (T3) and 3',5'-diiodothyrone (T2) have short-term effects on lipid metabolism in a teleost Anabas testudineus (Bloch): evidence from enzyme activities. Endocrine Research.
26(3), 431-444.
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Leena, S., Shameena, B., & Oommen, O. V.
(1999).
Studies on the effect of growth hormone in vivo and in vitro on lipogenic enzymes and transaminases in a teleost Anabas testudineus (BLOCH). Endocrine Research.
25(3-4), 341-355.
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Bake, S., Pinson, M. R., Pandey, S., Chambers, J. P., Mota, R., Fairchild, A. E., Miranda, R. C., & Sohrabji, F.
(2021).
Prenatal alcohol-induced sex differences in immune, metabolic and neurobehavioral outcomes in adult rats. Brain, Behavior, and Immunity.
98, 86-100.
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conference paper
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Bake, S., Miranda, R. C., & Sohrabji, F
(2021).
HEALTH OUTCOMES OF ADULTS WITH FETAL ALCOHOL SPECTRUM DISORDERS: A FETAL BASIS TO ADULT DISEASE. Alcoholism: Clinical and Experimental Research.
69A-69A.
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Pinson, M. R., Bake, S., Adams, A. M., Pandey, S., Sohrabji, F., & Miranda, R. C
(2021).
PRENATAL ALCOHOL-INDUCED SEX DIFFERENCES IN POST-STROKE IMMUNE RESPONSE OUTCOMES IN ADULT RATS. Alcoholism: Clinical and Experimental Research.
101A-101A.
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Bake, S., Miranda, R., & Sohrabji, F
(2019).
Prenatal Alcohol Exposure Induces Glucose Intolerance and Exacerbates Stroke Severity in Middle-Aged Rats. Stroke.
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Okoreeh, A. K., Bake, S., & Sohrabji, F
(2016).
Astrocyte Specific rAAV-mediated Insulin-Like Growth Factor-1 Expression in Aging Female Rats Increases Post-Stroke Survival and Sensory Motor Performance. Stroke.
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Bake, S., Miranda, R., & Sohrabji, F
(2016).
Effect of Fetal Alcohol Exposure on Stroke Severity and Blood Flow in Adult Mice. Stroke.
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Sudheendran, N., Bake, S., Miranda, R. C., & Larin, K. V.
(2014).
Binge consumption of ethanol during pregnancy leads to significant developmental delay of mouse embryonic brain. Proceedings of SPIE.
89530d-89530d-5.
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Miranda, R. C., Bake, S., Tingling, J. D., & Tsai, P
(2013).
ETHANOL EFFECTS ON THE MATERNAL/FETAL INTERFACE AND ON CELL-AUTONOMOUS FETAL NEURAL STEM CELL PROGRAMMING, CONVERGENTLY INFLUENCE NEURAL DEVELOPMENT. Alcoholism: Clinical and Experimental Research.
267A-267A.
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Sudheendran, N., Bake, S., Miranda, R. C., & Larin, K. V.
(2013).
Effect of Alcohol Exposure on Fetal Brain Development. Proceedings of SPIE.
85930i-85930i-5.
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Bake, S., Tingling, J., Sharma, S., & Miranda, R. C
(2011).
ACUTE ETHANOL EXPOSURE DECREASES MURINE FETAL BLOOD FLOW: EVIDENCE FROM ULTRASOUND IMAGING. Alcoholism: Clinical and Experimental Research.
126A-126A.
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Bake, S., Miranda, R. C., & Sohrabji, F
(2021).
HEALTH OUTCOMES OF ADULTS WITH FETAL ALCOHOL SPECTRUM DISORDERS: A FETAL BASIS TO ADULT DISEASE. Alcoholism: Clinical and Experimental Research.
69A-69A.
Research
investigator on
- Prenatal Alcohol and Stroke Susceptibility in the Aging Adult with FASD awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2018 - 2023
- Prenatal microRNA Neuro-Therapeutics for Fetal Alcohol Exposure awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2016 - 2021
- Neuroprotection In the Aging Female Brain awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2012 - 2019
Teaching
teaching activities
- MEID605 Foundations Of Medicine I Instructor
- MSCI691 Research Credit: Medical Sci Instructor
Background
education and training
- Ph.D. in Zoology, University of Kerala - (Thiruvananthapuram, India) 2001
- M.S. in Zoology, Madurai Kamaraj University - (Madurai, Tamil Nadu, India) 1995
- Texas A&M Health Science Center - (College Station, Texas, United States) , Postdoctoral Training 2005
Contact
first name
- Shameena
has last name
- Bake
mailing address
-
Texas A&M Health Science Center
Neuroscience & Experimental Therapeutics
1359 TAMUS
Bryan, TX 77807-1359
USA
Other
- sbake@tamu.edu