Polyunsaturated fatty acids (PUFA) regulate neurotransmitter contents in rat brain. Academic Article

abstract

• The effects of feeding of 6-propylthiouracil (6-PTU) and polyunsaturated fatty acids (PUFA) independently and in combination and administration (ip) of a single dose of triiodothyronine (T3) (2.5 microg/100 g body wt) along with feeding of 6-PTU and PUFA were studied in rat brain. Dopamine (DA), 5-hydroxytryptophan (5-HTP), serotonin (5-HT), 5-hydroxy indole acetic acid (5-HIAA), norepinephrine (NE) and epinephrine (EPI) contents were assayed in the hypothalamus and cerebral cortex regions. It was found that 6-PTU feeding resulted in decrease in dopamine, 5-HT, 5-HTP and 5-HIAA in both regions. In animals fed with PUFA followed by administration of T3, the DA level was found normal.

authors

• Bake, Shameena

published proceedings

• Indian J Biochem Biophys

author list (cited authors)

• Varghese, S., Shameena, B., Lakshmy, P. S., Biju, M. P., Easwar Shankar, P. N., Paulose, C. S., & Oommen, O. V

citation count

• 3

complete list of authors

• Varghese, S||Shameena, B||Lakshmy, PS||Biju, MP||Easwar Shankar, PN||Paulose, CS||Oommen, OV

publication date

• October 2001

published in

• n0301-1208ISSN  Journal

keywords

• Animals
• Biogenic Monoamines
• Brain
• Diet
• Drug Combinations
• Fatty Acids, Unsaturated
• Hormones
• Male
• Propylthiouracil
• Rats
• Rats, Wistar

PubMed Central ID

• 11886081

start page

• 327

end page

• 330

volume

• 38

issue

• 5