HR job title
- Professor
- Contact Info
McGregor, Alistair Associate Professor
Positions
- Associate Professor, Microbial Pathogenesis and Immunology, School of Medicine
Our lab studies various herpesviruses but the major focus of our research is on the study of cytomegalovirus (CMV) which is a common pathogen that establish a life long infection in a mainly latent state. CMV causes disease in transplant patients and is a leading cause of congenital disease in newborns where the virus crosses the placenta and infects the fetus in utero. Congenitally infected newborns can have severe disease that causes cognitive impairment, hearing loss and vision problems. There is no vaccine against congenital CMV and our research seeks to understand the disease and develop interventions strategies.
Research Areas
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- Publications
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Overview
Publications
selected publications
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academic article
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Choi, K. Y., El-Hamdi, N. S., & McGregor, A.
(2022).
Cross Strain Protection against Cytomegalovirus Reduces DISC Vaccine Efficacy against CMV in the Guinea Pig Model. Viruses.
14(4), 760-760.
-
Choi, K. Y., El-Hamdi, N., & McGregor, A.
(2022).
Endothelial Cell Infection by Guinea Pig Cytomegalovirus Is a Lytic or Persistent Infection Depending on Tissue Origin but Requires Viral Pentamer Complex and pp65 Tegument Protein. Journal of Virology.
96(17), e0083122-e00822.
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Choi, K. Y., & McGregor, A.
(2021).
A Fully Protective Congenital CMV Vaccine Requires Neutralizing Antibodies to Viral Pentamer and gB Glycoprotein Complexes but a pp65 T-Cell Response Is Not Necessary. Viruses.
13(8), 1467-1467.
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Choi, K. Y., El-Hamdi, N., Hornig, J., & McGregor, A.
(2021).
Guinea pig cytomegalovirus protective T cell antigen GP83 is a functional pp65 homolog for innate immune evasion and pentamer dependent virus tropism. Journal of Virology.
95(10), JVI.00324-JVI.00321.
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Choi, K. Y., El-Hamdi, N. S., & McGregor, A.
(2021).
A trimeric capable gB CMV vaccine provides limited protection against a highly cell associated and epithelial tropic strain of cytomegalovirus in guinea pigs. JOURNAL OF GENERAL VIROLOGY.
102(3),
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Choi, K. Y., El-Hamdi, N. S., & McGregor, A.
(2020).
Convalescent Immunity to Guinea Pig Cytomegalovirus Induces Limited Cross Strain Protection against Re-Infection but High-Level Protection against Congenital Disease. International Journal of Molecular Sciences.
21(17), 5997-5997.
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Choi, K. Y., El-Hamdi, N. S., & McGregor, A.
(2020).
Requirements for guinea pig cytomegalovirus tropism and antibody neutralization on placental amniotic sac cells. JOURNAL OF GENERAL VIROLOGY.
101(4), 426-439.
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El-Hamdi, N. S., Choi, K. Y., & McGregor, A.
(2020).
Guinea pig cytomegalovirus trimer complex gH/gL/gO uses PDGFRA as universal receptor for cell fusion and entry. Virology.
548, 236-249.
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Choi, K. Y., El-Hamdi, N. S., & McGregor, A.
(2020).
Neutralizing antibodies to gB based CMV vaccine requires full length antigen but reduced virus neutralization on non-fibroblast cells limits vaccine efficacy in the guinea pig model. Vaccine.
38(10), 2340-2349.
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Choi, K. Y., El-Hamdi, N. S., & McGregor, A.
(2019).
Inclusion of the Viral Pentamer Complex in a Vaccine Design Greatly Improves Protection against Congenital Cytomegalovirus in the Guinea Pig Model. Journal of Virology.
93(22), e01442-e01419.
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Hornig, J., Choi, K. Y., & McGregor, A.
(2017).
The essential role of guinea pig cytomegalovirus (GPCMV) IE1 and IE2 homologs in viral replication and IE1-mediated ND10 targeting. Virology.
504, 122-140.
-
Coleman, S., Choi, K. Y., & McGregor, A.
(2017).
Cytomegalovirus UL128 homolog mutants that form a pentameric complex produce virus with impaired epithelial and trophoblast cell tropism and altered pathogenicity in the guinea pig. Virology.
509, 205-221.
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Choi, K. Y., Root, M., & McGregor, A.
(2016).
A Novel Non-Replication-Competent Cytomegalovirus Capsid Mutant Vaccine Strategy Is Effective in Reducing Congenital Infection. Journal of Virology.
90(17), 7902-7919.
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Coleman, S., Choi, K. Y., Root, M., & McGregor, A.
(2016).
A Homolog Pentameric Complex Dictates Viral Epithelial Tropism, Pathogenicity and Congenital Infection Rate in Guinea Pig Cytomegalovirus. PLOS Pathogens.
12(7), e1005755-e1005755.
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Coleman, S., Hornig, J., Maddux, S., Choi, K. Y., & McGregor, A.
(2015).
Correction: Viral Glycoprotein Complex Formation, Essential Function and Immunogenicity in the Guinea Pig Model for Cytomegalovirus. PLoS ONE.
10(9), e0137942-e0137942.
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Coleman, S., Hornig, J., Maddux, S., Choi, K. Y., & McGregor, A.
(2015).
Viral Glycoprotein Complex Formation, Essential Function and Immunogenicity in the Guinea Pig Model for Cytomegalovirus. PLoS ONE.
10(8), e0135567-e0135567.
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Coleman, S. M., & McGregor, A.
(2015).
A bright future for bioluminescent imaging in viral research. Future Virology.
10(2), 169-183.
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Hornig, J., & McGregor, A.
(2014).
Design and development of antivirals and intervention strategies against human herpesviruses using high-throughput approach. Expert Opinion on Drug Discovery.
9(8), 891-915.
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Schleiss, M. R., Buus, R., Choi, K. Y., & McGregor, A.
(2013).
An Attenuated CMV Vaccine with a Deletion in Tegument Protein GP83 (pp65 Homolog) Protects against Placental Infection and Improves Pregnancy Outcome in a Guinea Pig Challenge Model. Future Virology.
8(12), 1151-1160.
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McGregor, A. C., Waddington, C. S., & Pollard, A. J.
(2013).
Prospects for prevention of Salmonella infection in children through vaccination. Current Opinion in Infectious Diseases.
26(3), 254-262.
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McGregor, A., & Choi, K. Y.
(2011).
Cytomegalovirus antivirals and development of improved animal models. Expert Opinion on Drug Metabolism and Toxicology.
7(10), 1245-1265.
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McGregor, A., Choi, K. Y., & Schleiss, M. R.
(2011).
Guinea pig cytomegalovirus GP84 is a functional homolog of the human cytomegalovirus (HCMV) UL84 gene that can complement for the loss of UL84 in a chimeric HCMV. Virology.
410(1), 76-87.
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McGregor, A., Leibelt, J., Bouska, C., & Schleiss, M.
(2010).
A Chimeric Guinea Pig Cytomegalovirus (GPCMV) Encoding Wild Type or Mutant HCMV UL97 Renders GPCMV Susceptible or Resistant to Ganciclovir while Retaining an Ability to Disseminate in the Animal Host. ANTIVIRAL RESEARCH.
86(1), A23-A24.
-
McGregor, A.
(2010).
Current and new cytomegalovirus antivirals and novel animal model strategies. Inflammation and Allergy: Drug Targets.
9(4), 286-299.
-
Cui, X., McGregor, A., Schleiss, M. R., & McVoy, M. A.
(2009).
The impact of genome length on replication and genome stability of the herpesvirus guinea pig cytomegalovirus. Virology.
386(1), 132-138.
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Schleiss, M. R., McGregor, A., Choi, K. Y., Date, S. V., Cui, X., & McVoy, M. A.
(2008).
Analysis of the nucleotide sequence of the guinea pig cytomegalovirus (GPCMV) genome. Virology Journal.
5(1), 139-139.
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Bradley, A. J., Kovcs, I. J., Gatherer, D., Dargan, D. J., Alkharsah, K. R., Chan, P., ... Davison, A. J.
(2008).
Genotypic analysis of two hypervariable human cytomegalovirus genes. Journal of Medical Virology.
80(9), 1615-1623.
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McGregor, A., Choi, K. Y., Cui, X., McVoy, M. A., & Schleiss, M. R.
(2008).
Expression of the human cytomegalovirus UL97 gene in a chimeric guinea pig cytomegalovirus (GPCMV) results in viable virus with increased susceptibility to ganciclovir and maribavir. ANTIVIRAL RESEARCH.
78(3), 250-259.
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Cui, X., McGregor, A., Schleiss, M. R., & McVoy, M. A.
(2008).
Cloning the complete guinea pig cytomegalovirus genome as an infectious bacterial artificial chromosome with excisable origin of replication. Journal of Virological Methods.
149(2), 231-239.
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Schleiss, M. R., McGregor, A., Choi, Y., Anderson, J., Leviton, M., Cui, X., & McVoy, M.
(2008).
Genetically engineered live-attenuated cytomegalovirus (CMV) vaccines improve pregnancy outcome in the guinea-pig model of congenital CMV infection. Retrovirology.
5(Suppl 1), p4-P4.
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Schleiss, M., Lacayo, J., Belkaid, Y., McGregor, A., Stroup, G., Rayner, J., ... Smith, J.
(2007).
Vaccination as an Antiviral Strategy for Control of Cytomegalovirus (CMV) Disease: A Vectored Vaccine Approach Targeting the UL83 (pp65) Homolog Protects Against Congenital CMV Disease in the Guinea Pig Model. ANTIVIRAL RESEARCH.
74(3), a42-A42.
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Schleiss, M. R., Lacayo, J. C., Belkaid, Y., McGregor, A., Stroup, G., Rayner, J., ... Smith, J. F.
(2007).
Preconceptual administration of an alphavirus replicon UL83 (pp65 homolog) vaccine induces humoral and cellular immunity and improves pregnancy outcome in the guinea pig model of congenital cytomegalovirus infection. Journal of Infectious Diseases.
195(6), 789-798.
-
Schleiss, M. R., Anderson, J. L., & McGregor, A.
(2006).
Cyclic cidofovir (cHPMPC) prevents congenital cytomegalovirus infection in a guinea pig model. 3(1), 9.
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Schleiss, M. R., Stroup, G., Pogorzelski, K., & McGregor, A.
(2006).
Protection against congenital cytomegalovirus (CMV) disease, conferred by a replication-disabled, bacterial artificial chromosome (BAC)-based DNA vaccine. Vaccine.
24(37-39), 6175-6186.
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Schleiss, M. R., Bernstein, D. I., McVoy, M. A., Stroup, G., Bravo, F., Creasy, B., ... Hallenberger, S.
(2005).
The non-nucleoside antiviral, BAY 38-4766, protects against cytomegalovirus (CMV) disease and mortality in immunocompromised guinea pigs. ANTIVIRAL RESEARCH.
65(1), 35-43.
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McGregor, A., Liu, F., & Schleiss, M. R.
(2004).
Molecular, biological, and in vivo characterization of the guinea pig cytomegalovirus (CMV) homologs of the human CMV matrix proteins pp71 (UL82) and pp65 (UL83). Journal of Virology.
78(18), 9872-9889.
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McGregor, A., Liu, F., & Schleiss, M. R.
(2004).
Identification of essential and non-essential genes of the guinea pig cytomegalovirus (GPCMV) genome via transposome mutagenesis of an infectious BAC clone. Virus Research.
101(2), 101-108.
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McGregor, A., & Schleiss, M. R.
(2004).
Herpesvirus genome mutagenesis by transposon-mediated strategies. Methods in molecular biology (Clifton, N.J.).
256, 281-302.
-
McGregor, A.
(2003).
Transposon and transposome mutagenesis of plasmids, cosmids, and BACs. Methods in molecular biology (Clifton, N.J.).
235, 233-245.
-
McGregor, A., & Schleiss, M. R.
(2001).
Molecular cloning of the guinea pig cytomegalovirus (GPCMV) genome as an infectious bacterial artificial chromosome (BAC) in Escherichia coli. Molecular Genetics and Metabolism.
72(1), 15-26.
-
McGregor, A., & Schleiss, M. R.
(2001).
Recent advances in herpesvirus genetics using bacterial artificial chromosomes. Molecular Genetics and Metabolism.
72(1), 8-14.
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McGregor, A., Bourne, N., Bravo, F. J., Viera, J., Bernstein, D. I., & Schleiss, M. R.
(1999).
Insertional Mutagenesis of the Guinea Pig Cytomegalovirus (GPCMV) Genome: Stable Expression of the Green Fluorescent Protein (GFP) Gene and Application to In Vivo Pathogenesis Studies. Pediatric Research.
45(7), 271-271.
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Schleiss, M. R., McGregor, A., Jensen, N. J., Erdem, G., & Aktan, L.
(1999).
Molecular characterization of the guinea pig cytomegalovirus UL83 (pp65) protein homolog. Virus Genes.
19(3), 205-221.
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Rixon, F. J., Addison, C., McGregor, A., Macnab, S. J., Nicholson, P., Preston, V. G., & Tatman, J. D.
(1996).
Multiple interactions control the intracellular localization of the herpes simplex virus type 1 capsid proteins. JOURNAL OF GENERAL VIROLOGY.
77 ( Pt 9)(9), 2251-2260.
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Choi, K. Y., El-Hamdi, N. S., & McGregor, A.
(2022).
Cross Strain Protection against Cytomegalovirus Reduces DISC Vaccine Efficacy against CMV in the Guinea Pig Model. Viruses.
14(4), 760-760.
-
chapter
-
Mcgregor, A., McVoy, M. A., & Schleiss, M. R.
(2013).
The Guinea Pig Model of Congenital Cytomegalovirus Infection. Reddehase, M. J. (Eds.),
Cytomegaloviruses: From Molecular Pathogenesis to Intervention (Vol. 2).
(pp. 88-118).
Caister Academic Press.
-
McGregor, A., Choi, K. Y., Schachtele, S., & Lokensgard, J.
(2013).
Chapter 37 Human Herpesviruses and Animal Models. Animal Models for the Study of Human Disease.
(pp. 905-925).
Elsevier.
-
McGregor, A., Choi, K. Y., Schachtele, S., & Lokensgard, J.
(2013).
Human Herpesviruses and Animal Models. ANIMAL MODELS FOR THE STUDY OF HUMAN DISEASE.
(pp. 905-925).
Elsevier.
-
McGregor, A., Yeon Choi, K., & Sung, H.
(2012).
Antiviral and vaccine strategies against cytomegalovirus: Current therapies and future directions. Cytomegalovirus Infections: Risk Factors, Causes and Management.
(pp. 77-118).
-
McGregor, A., & Schleiss, M. R.
(2004).
Herpesvirus Genome Mutagenesis by Transposon-Mediated Strategies. Methods in molecular biology (Clifton, N.J.).
Bacterial Artificial Chromosomes.
(pp. 281-302).
Springer Nature.
-
McGregor, A.
(2003).
Transposon and Transposome Mutagenesis of Plasmids, Cosmids, and BACs. Methods in molecular biology (Clifton, N.J.).
E. coli Plasmid Vectors.
(pp. 233-245).
Springer Nature.
-
Mcgregor, A., McVoy, M. A., & Schleiss, M. R.
(2013).
The Guinea Pig Model of Congenital Cytomegalovirus Infection. Reddehase, M. J. (Eds.),
Cytomegaloviruses: From Molecular Pathogenesis to Intervention (Vol. 2).
(pp. 88-118).
Caister Academic Press.
Research
principal investigator on
- Development of a universal DISC vaccine strategy against congenital cytomegalovirus awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2021 - 2026
- CMV Pentameric Complex Based Vaccine Strategies for Prevention of Congenital CMV awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2017 - 2022
- Development of an Effective DISC Vaccine Strategy Against Congenital CMV awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2013 - 2018
- Placental Trophoblast Infection and TLR Mediated Response to Congenital CMV awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2013 - 2018
Teaching
teaching activities
- MEID708 Integument/musculoskeletal Instructor
- MSCI691 Research Credit: Medical Sci Instructor
Background
education and training
- Ph.D. in Virology, University of Glasgow - (Glasgow, United Kingdom) 1994
- Cincinnati Children's Hospital Medical Center - (Cincinnati, Ohio, United States) , Postdoctoral Training 1999
- University of Glasgow - (Glasgow, United Kingdom) , Postdoctoral Training 1997
Contact
first name
- Alistair
has last name
- McGregor
mailing address
-
Dept. Microbial Path & Immunol. COM
8447 Riverside Pkwy, MREB2, Rm 3209
Dept. Microbial Path & Immunol. COM, 8447 Riverside Pkwy, MREB2, Rm 3209
Bryan, Texas 77801-3260
USA
Other
- mcgalistair2013@tamu.edu