Non-anthocyanin phenolics in cherry (Prunus avium L.) modulate IL-6, liver lipids and expression of PPAR and LXRs in obese diabetic (db/db) mice. Academic Article uri icon


  • Anthocyanin-rich cherries are known for preventing/decreasing risk factors associated with obesity; however, the specific benefits exerted by cherry non-anthocyanin phenolics are not clear. Obese diabetic (db/db) mice fed a diet supplemented with anthocyanin-depleted cherry powder (cherry) were compared to db/db (obese) or lean counterparts (lean) fed a control isocaloric diet for 12 weeks. The reduced plasma interleukin (IL)-6 and improved liver health may be mediated by cherry fibre and non-anthocyanin phenolics. Benefits for liver health included reduction of lipids and protein carbonyls, and modulation of peroxisome proliferator-activated receptor (PPAR)δ mRNA to resemble levels in lean. Lack of plasma antilipidemic, improvement of antioxidant defenses, and PPARα/γ mRNA modulation in liver suggest cherry anthocyanins specific benefits. This is the first study to elucidate in vivo the potential benefits of cherry non-anthocyanin phenolics for diabetes-induced liver disorders and the importance of choosing processing technologies that preserve anthocyanins and health benefits of whole cherries.

published proceedings

  • Food Chem

author list (cited authors)

  • Noratto, G. D., Lage, N. N., Chew, B. P., Mertens-Talcott, S. U., Talcott, S. T., & Pedrosa, M. L.

citation count

  • 25

complete list of authors

  • Noratto, Giuliana D||Lage, Nara N||Chew, Boon P||Mertens-Talcott, Susanne U||Talcott, Stephen T||Pedrosa, Maria L

publication date

  • November 2018