TOXICOLOGY AND APPLIED PHARMACOLOGY Journal

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Overview

publication venue for

• Lactational transfer of sulforaphane-N-acetylcysteine in vivo and in human breast milk..  482:116796-116796. 2023
• Exposure of environmental trace elements in prostate cancer patients: A multiple metal analysis..  479:116728-116728. 2023
• PBPK modeling of impact of nonalcoholic fatty liver disease on toxicokinetics of perchloroethylene in mice..  400:115069-115069. 2020
• Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes..  381:114711-114711. 2019
• Incorporation of the glutathione conjugation pathway in an updated physiologically-based pharmacokinetic model for perchloroethylene in mice..  352:142-152. 2018
• Decanoic acid suppresses proliferation and invasiveness of human trophoblast cells by disrupting mitochondrial function..  339:121-132. 2018
• Effects of pirfenidone in acute and sub-chronic liver fibrosis, and an initiation-promotion cancer model in the mouse..  339:1-9. 2018
• Inactivation of the orphan nuclear receptor NR4A1 contributes to apoptosis induction by fangchinoline in pancreatic cancer cells..  332:32-39. 2017
• In vitro cardiotoxicity assessment of environmental chemicals using an organotypic human induced pluripotent stem cell-derived model..  322:60-74. 2017
• The role of microRNAs in the development and progression of chemical-associated cancers..  312:3-10. 2016
• A mouse model of alcoholic liver fibrosis-associated acute kidney injury identifies key molecular pathways..  310:129-139. 2016
• 2,3,7,8-Tetrachlorodibenzo-p-dioxin has both pro-carcinogenic and anti-carcinogenic effects on neuroendocrine prostate carcinoma formation in TRAMP mice..  305:242-249. 2016
• Resveratrol protects the ovary against chromium-toxicity by enhancing endogenous antioxidant enzymes and inhibiting metabolic clearance of estradiol..  303:65-78. 2016
• Development and application of a rat PBPK model to elucidate kidney and liver effects induced by ETBE and tert-butanol..  288:439-452. 2015
• A fetal whole ovarian culture model for the evaluation of CrVI-induced developmental toxicity during germ cell nest breakdown..  289:58-69. 2015
• Prediction of binding affinity and efficacy of thyroid hormone receptor ligands using QSAR and structure-based modeling methods..  280:177-189. 2014
• Aspirin-triggered resolvin D1 down-regulates inflammatory responses and protects against endotoxin-induced acute kidney injury..  277:118-123. 2014
• Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity..  273:500-507. 2013
• NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells..  272:736-745. 2013
• Identification of putative estrogen receptor-mediated endocrine disrupting chemicals using QSAR- and structure-based virtual screening approaches..  272:67-76. 2013
• An approach for integrating toxicogenomic data in risk assessment: the dibutyl phthalate case study..  271:324-335. 2013
• Approaches to advancing quantitative human health risk assessment of environmental chemicals in the post-genomic era..  271:309-323. 2013
• Utilizing toxicogenomic data to understand chemical mechanism of action in risk assessment..  271:299-308. 2013
• Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: maternal diets rich in indole-3-carbinol versus sulforaphane..  270:60-69. 2013
• Sulfur mustard induces an endoplasmic reticulum stress response in the mouse ear vesicant model..  268:178-187. 2013
• Acetaminophen-induced acute liver injury in HCV transgenic mice..  266:224-232. 2013
• Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet..  262:52-59. 2012
• 3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells..  263:345-351. 2012
• Development and evaluation of a harmonized physiologically based pharmacokinetic (PBPK) model for perchloroethylene toxicokinetics in mice, rats, and humans..  253:203-234. 2011
• Hexavalent chromium-induced apoptosis of granulosa cells involves selective sub-cellular translocation of Bcl-2 members, ERK1/2 and p53..  251:253-266. 2011
• Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in a rat liver cell line..  253:45-56. 2011
• Evaluation of an in vitro toxicogenetic mouse model for hepatotoxicity..  249:208-216. 2010
• ATP7B detoxifies silver in ciliated airway epithelial cells..  243:315-322. 2010
• Role of retinoic acid in the modulation of benzo(a)pyrene-DNA adducts in human hepatoma cells: Implications for cancer prevention.  249:224-230. 2010
• Characterizing uncertainty and population variability in the toxicokinetics of trichloroethylene and metabolites in mice, rats, and humans using an updated database, physiologically based pharmacokinetic (PBPK) model, and Bayesian approach..  241:36-60. 2009
• Pharmacokinetic analysis of trichloroethylene metabolism in male B6C3F1 mice: Formation and disposition of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine..  238:90-99. 2009
• Development of an updated PBPK model for trichloroethylene and metabolites in mice, and its application to discern the role of oxidative metabolism in TCE-induced hepatomegaly..  236:329-340. 2009
• Time-course comparison of xenobiotic activators of CAR and PPARalpha in mouse liver..  235:199-207. 2009
• Disruption of period gene expression alters the inductive effects of dioxin on the AhR signaling pathway in the mouse liver..  234:370-377. 2009
• Metabolomic profiling of a modified alcohol liquid diet model for liver injury in the mouse uncovers new markers of disease..  232:236-243. 2008
• Chronic pharmacologic inhibition of EGFR leads to cardiac dysfunction in C57BL/6J mice..  228:315-325. 2008
• Ligand-dependent interactions of the Ah receptor with coactivators in a mammalian two-hybrid assay..  227:196-206. 2008
• Lactational exposure to hexavalent chromium delays puberty by impairing ovarian development, steroidogenesis and pituitary hormone synthesis in developing Wistar rats..  232:180-189. 2008
• Time course investigation of PPARalpha- and Kupffer cell-dependent effects of WY-14,643 in mouse liver using microarray gene expression..  225:267-277. 2007
• Cobaltous chloride and hypoxia inhibit aryl hydrocarbon receptor-mediated responses in breast cancer cells..  223:28-38. 2007
• Comparative non-cholinergic neurotoxic effects of paraoxon and diisopropyl fluorophosphate (DFP) on human neuroblastoma and astrocytoma cell lines..  219:162-171. 2007
• Isolation and characterization of two disintegrins inhibiting ADP-induced human platelet aggregation from the venom of Crotalus scutulatus scutulatus (Mohave Rattlesnake)..  212:59-68. 2006
• Physiological role of mGSTA4-4, a glutathione S-transferase metabolizing 4-hydroxynonenal: generation and analysis of mGsta4 null mouse..  194:296-308. 2004
• Neurotoxicity induced in differentiated SK-N-SH-SY5Y human neuroblastoma cells by organophosphorus compounds..  186:110-118. 2003
• The hidden effect of estrogenic/antiandrogenic methoxychlor on spermatogenesis..  180:129-135. 2002
• Cytotoxicity and aromatase (CYP19) activity modulation by organochlorines in human placental JEG-3 and JAR choriocarcinoma cells..  160:10-20. 1999
• Chlorophyllin chemoprevention in trout initiated by aflatoxin B(1) bath treatment: An evaluation of reduced bioavailability vs. target organ protective mechanisms..  158:141-151. 1999
• Benzo(a)pyrene-induced alterations in growth-related gene expression and signaling in precision-cut adult rat liver and kidney slices..  152:302-308. 1998
• Attenuation of gossypol cytotoxicity by cyclic AMP in a rat liver cell line..  151:311-318. 1998
• Comparative toxicity of eugenol and its quinone methide metabolite in cultured liver cells using kinetic fluorescence bioassays..  149:55-63. 1998
• Halogenated aromatic hydrocarbons suppress CA1 field excitatory postsynaptic potentials in rat hippocampal slices..  148:7-13. 1998
• Additive estrogenic activities of a binary mixture of 2',4',6'-trichloro- and 2',3',4',5'-tetrachloro-4-biphenylol..  147:93-100. 1997
• Hydroxylated polychlorinated biphenyls (PCBs) as estrogens and antiestrogens: structure-activity relationships..  145:111-123. 1997
• Antiestrogenic activity of hydroxylated polychlorinated biphenyl congeners identified in human serum..  142:160-168. 1997
• Effects of developmental exposure to indole-3-carbinol or 2,3,7,8-tetrachlorodibenzo-p-dioxin on reproductive potential of male rat offspring..  141:68-75. 1996
• Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on insulin-induced responses in MCF-7 human breast cancer cells..  138:242-250. 1996
• Eptastigmine-phosphotriesterase combination in DFP intoxication..  140:364-369. 1996
• Phosphotriesterase, pralidoxime-2-chloride (2-PAM) and eptastigmine treatments and their combinations in DFP intoxication..  141:555-560. 1996
• Alkyl polychlorinated dibenzofurans and related compounds as antiestrogens in the female rat uterus: structure-activity studies..  135:287-298. 1995
• Interaction of 2,3,7,8-tetrachlorodibenzo-p-dioxin and retinoic acid in MCF-7 human breast cancer cells..  127:1-8. 1994
• Encapsulation of phosphotriesterase within murine erythrocytes..  124:296-301. 1994
• Mechanism of action of alpha-naphthoflavone as an Ah receptor antagonist in MCF-7 human breast cancer cells..  120:179-185. 1993
• Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), and dibenzofurans (PCDFs) as antiestrogens in MCF-7 human breast cancer cells: quantitative structure-activity relationships..  120:55-61. 1993
• Phosphotriesterase decreases paraoxon toxicity in mice..  121:275-278. 1993
• 6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as an antiestrogen in human and rodent cancer cell lines: evidence for the role of the Ah receptor..  113:311-318. 1992
• The effect of 6-nitro-1,3,8-trichlorodibenzofuran as a partial estrogen in the female rat uterus..  113:55-63. 1992
• Patulin-induced cellular toxicity: a vital fluorescence study..  112:235-244. 1992
• Reply.  108:568-569. 1991
• Evaluation of the developmental toxicity of chlorinated phenols utilizing Hydra attenuata and postimplantation rat embryos in culture..  108:253-266. 1991
• Immunosuppressive and monooxygenase induction activities of polychlorinated diphenyl ether congeners in C57BL/6N mice: quantitative structure-activity relationships..  105:254-263. 1990
• Structure-dependent induction of aryl hydrocarbon hydroxylase activity in C57BL/6 mice by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related congeners: mechanistic studies..  105:243-253. 1990
• Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on I-compounds in hepatic DNA of Sprague-Dawley rats: sex-specific effects and structure-activity relationships..  103:271-280. 1990
• 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced porphyria in genetically inbred mice: partial antagonism and mechanistic studies..  100:208-216. 1989
• 2,2',4,4',5,5'-hexachlorobiphenyl as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6J mice..  97:561-571. 1989
• Comparative antiestrogenic activities of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 6-methyl-1,3,8-trichlorodibenzofuran in the female rat..  95:435-443. 1988
• Allylamine-induced vascular toxicity in vitro: prevention by semicarbazide-sensitive amine oxidase inhibitors..  95:61-71. 1988
• Immunosuppressive activities of polychlorinated dibenzofuran congeners: quantitative structure-activity relationships and interactive effects..  94:141-149. 1988
• Comparative activities of 2,3,7,8-tetrachlorodibenzo-p-dioxin and progesterone as antiestrogens in the female rat uterus..  92:368-380. 1988
• Modulation of diethylnitrosamine-induced hepatocarcinogenesis and O6-ethylguanine formation in rainbow trout by indole-3-carbinol, beta-naphthoflavone, and Aroclor 1254..  96:93-100. 1988
• Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic and uterine estrogen receptor levels in rats..  87:306-314. 1987
• Monoclonal antibodies to chlorinated dibenzo-p-dioxins..  82:256-263. 1986
• Comparative influences of different PB-type and 3-MC-type polychlorinated biphenyl-induced phenotypes on cytocidal hepatotoxicity of bromobenzene and acetaminophen..  76:118-127. 1984
• 2-hexanone potentiation of [14C]chloroform hepatotoxicity: covalent interaction of a reactive intermediate with rat liver phospholipid..  73:478-491. 1984
• Cytotoxicity of isoproterenol to cultured heart cells: effects of antioxidants on modifying membrane damage..  70:317-323. 1983
• The comparative biologic and toxic potencies of polychlorinated biphenyls and polybrominated biphenyls..  70:204-215. 1983
• The role of lysosomes in the pathogenesis of copper-induced hepatotoxicity. II. Intracellular distribution of copper in hepatocytes..  67:238-245. 1983
• Induction of drug-metabolizing enzymes by fractionated commercial polybrominated biphenyls (PBBs)..  57:254-262. 1981
• Effect of penicillic acid on adenosine triphosphatase activity in the mouse..  49:365-372. 1979
• Isomerically pure bromobiphenyl congeners and hepatic mono-oxygenase activities in the rat: influence of position and degree of bromination..  47:341-352. 1979
• COMPARATIVE METABOLISM OF HALOGENATED BIPHENYLS.  48:A181-A181. 1979
• In vitro and in vivo effects of penicillic acid on adenosine triphosphatase activities in mouse.  48. 1979
• Inhibitory characteristics of the mycotoxin penicillic acid on (Na⁺-K⁺)-activated adenosine triphosphatase.  48. 1979
• The comparative metabolism of halogenated biphenyls.  48. 1979
• Acute toxicity of patulin.  45. 1978
• Halogen substituents at the 4- and 4'-positions of biphenyl: influence on hepatic function in the rat..  42:359-366. 1977
• Effects of patulin on adenosine triphosphatase activities in the mouse..  42:175-187. 1977
• Effects of chronic lead treatment on some cardiovascular responses to norepinephrine in the rat..  40:407-413. 1977
• HALOGEN SUBSTITUENTS AT 4-POSITION AND 4'-POSITION OF BIPHENYL - INFLUENCE ON HEPATIC FUNCTION IN RAT.  41:220-220. 1977
• Detoxification of organophosphate nerve agents by bacterial phosphotriesterase. 2005
• Engineered variants of phosphotriesterase for enhanced detoxification of organophosphate nerve agents 2004

Identity

International Standard Serial Number (ISSN)

• 0041-008X