Effects of chronic lead treatment on some cardiovascular responses to norepinephrine in the rat. Academic Article

abstract

• Rats were treated with lead via the mother's milk from birth to weaning. After a lead-free period of approximately 4 months, responses to norepinephrine were tested. Neither the pressor effect nor the enhancement of myocardial cAMP accumulation caused by norepinephrine was altered by prior lead treatment. However, norepinephrine caused significantly more cardiac arrhythmias in lead-treated animals than in controls. Even doses of norepinephrine which caused no significant ECG abnormalities in control animals were arrhythmogenic in lead-treated rats. It is concluded that lead treatment causes changes in cardiac conduction which are not readily reversed by termination of lead exposure. 1977.

authors

• Griffith, William

published proceedings

• Toxicol Appl Pharmacol

author list (cited authors)

• Williams, B. J., Griffith, W. H., Albrecht, C. M., Pirch, J. H., & Hejtmancik, M. R.

citation count

• 30

complete list of authors

• Williams, BJ||Griffith, WH||Albrecht, CM||Pirch, JH||Hejtmancik, MR

publication date

• June 1977

publisher

• Elsevier  Publisher

published in

• TOXICOLOGY AND APPLIED PHARMACOLOGY  Journal

keywords

• Animals
• Arrhythmias, Cardiac
• Blood Pressure
• Cyclic AMP
• Drug Interactions
• Female
• Hemodynamics
• Lead
• Male
• Myocardium
• Norepinephrine
• Rats
• Time Factors

PubMed Central ID

• 196361

Digital Object Identifier (DOI)

• 10.1016/0041-008x(77)90068-0

start page

• 407

end page

• 413

volume

• 40

issue

• 3

URL

• http://dx.doi.org/10.1016/0041-008x(77)90068-0