HR job title
- Associate Professor
- Contact Info
- 1 979 436 9646
Lee, Ryang Associate Professor
Positions
- Associate Professor, Cell Biology and Genetics, School of Medicine
Our group specializes in determining the cellular and molecular mechanisms of beneficial effects of mesenchymal stem cells (MSCs) in diseases that include heart disease, diabetes, and peritonitis. The goal is to develop a cellular therapy for human diseases either (a) with adult stem/progenitor cells (MSCs), or (b) with therapeutic factors that MSCs produce in response to signals from injured tissues.
- Overview
- Publications
- Research
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Overview
Publications
selected publications
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academic article
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Pacienza, N., Lee, R. H., Bae, E., Kim, D., Liu, Q., Prockop, D. J., & Yannarelli, G.
(2019).
InVitro Macrophage Assay Predicts the InVivo Anti-inflammatory Potential of Exosomes from Human Mesenchymal Stromal Cells. Molecular Therapy - Methods and Clinical Development.
13, 67-76.
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Song, H. B., Park, S. Y., Ko, J. H., Park, J. W., Yoon, C. H., Kim, D. H., ... Oh, J. Y.
(2018).
Mesenchymal Stromal Cells Inhibit Inflammatory Lymphangiogenesis in the Cornea by Suppressing Macrophage in a TSG-6-Dependent Manner. MOLECULAR THERAPY.
26(1), 162-172.
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Hai, B. o., Shigemoto-Kuroda, T., Zhao, Q., Lee, R. H., & Liu, F.
(2018).
Inhibitory Effects of iPSC-MSCs and Their Extracellular Vesicles on the Onset of Sialadenitis in a Mouse Model of Sjgren's Syndrome. Stem Cells International.
2018, 2092315-10.
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Prockop, D. J., Oh, J. Y., & Lee, R. H.
(2017).
Data against a Common Assumption: Xenogeneic Mouse Models Can Be Used to Assay Suppression of Immunity by Human MSCs. MOLECULAR THERAPY.
25(8), 1748-1756.
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Shigemoto-Kuroda, T., Oh, J. Y., Kim, D., Jeong, H. J., Park, S. Y., Lee, H. J., ... Lee, R. H.
(2017).
MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis. Stem Cell Reports.
8(5), 1214-1225.
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Ullah, M., Kuroda, Y., Bartosh, T. J., Liu, F., Zhao, Q., Gregory, C., ... Prockop, D. J.
(2017).
iPS-derived MSCs from an expandable bank to deliver a prodrug-converting enzyme that limits growth and metastases of human breast cancers. Cell Death Discovery.
3(1), 16064.
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Spees, J. L., Lee, R. H., & Gregory, C. A.
(2016).
Mechanisms of mesenchymal stem/stromal cell function. Stem Cell Research and Therapy.
7(1), 125-13.
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Yoon, N., Park, M. S., Shigemoto, T., Peltier, G., & Lee, R. H.
(2016).
Activated human mesenchymal stem/stromal cells suppress metastatic features of MDA-MB-231 cells by secreting IFN-. Cell Death and Disease.
7(4), e2191-e2191.
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Mohammadipoor, A., Lee, R. H., Prockop, D. J., & Bartosh, T. J.
(2016).
Stanniocalcin-1 attenuates ischemic cardiac injury and response of differentiating monocytes/macrophages to inflammatory stimuli. 177, 127-142.
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Kim, D., Choi, H., Nishida, H., Oh, J. Y., Gregory, C., Lee, R. H., ... Prockop, D. J.
(2016).
Scalable Production of a Multifunctional Protein (TSG-6) That Aggregates with Itself and the CHO Cells That Synthesize It. PLoS ONE.
11(1), e0147553-e0147553.
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Yoon, N., Park, M. S., Peltier, G. C., & Lee, R. H.
(2015).
Pre-activated human mesenchymal stromal cells in combination with doxorubicin synergistically enhance tumor-suppressive activity in mice. Cytotherapy.
17(10), 1332-1341.
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Zhao, Q., Gregory, C. A., Lee, R. H., Reger, R. L., Qin, L., Hai, B. o., ... Liu, F.
(2015).
MSCs derived from iPSCs with a modified protocol are tumor-tropic but have much less potential to promote tumors than bone marrow MSCs. Proceedings of the National Academy of Sciences of the United States of America.
112(2), 530-535.
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Lee, R. H., Yu, J. M., Foskett, A. M., Peltier, G., Reneau, J. C., Bazhanov, N., Oh, J. Y., & Prockop, D. J.
(2014).
TSG-6 as a biomarker to predict efficacy of human mesenchymal stem/progenitor cells (hMSCs) in modulating sterile inflammation in vivo. Proceedings of the National Academy of Sciences of the United States of America.
111(47), 16766-16771.
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Kim, J., Ko, J. H., Ko, A. Y., Lee, H. J., Kim, M. K., Wee, W. R., ... Oh, J. Y.
(2014).
TSG-6 protects corneal endothelium from transcorneal cryoinjury in rabbits. Investigative Ophthalmology and Visual Science.
55(8), 4905-4912.
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Kota, D. J., Wiggins, L. L., Yoon, N., & Lee, R. H.
(2013).
TSG-6 produced by hMSCs delays the onset of autoimmune diabetes by suppressing Th1 development and enhancing tolerogenicity. Diabetes.
62(6), 2048-2058.
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Oh, J. Y., Choi, H., Lee, R. H., Roddy, G. W., Ylstalo, J. H., Wawrousek, E., & Prockop, D. J.
(2012).
Identification of the HSPB4/TLR2/NF-B axis in macrophage as a therapeutic target for sterile inflammation of the cornea. EMBO Molecular Medicine.
4(5), 435-448.
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Roddy, G. W., Rosa, R. H., Oh, J. Y., Ylostalo, J. H., Bartosh, T. J., Choi, H., ... Prockop, D. J.
(2012).
Stanniocalcin-1 rescued photoreceptor degeneration in two rat models of inherited retinal degeneration. MOLECULAR THERAPY.
20(4), 788-797.
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Horie, M., Choi, H., Lee, R. H., Reger, R. L., Ylostalo, J., Muneta, T., Sekiya, I., & Prockop, D. J.
(2012).
Intra-articular injection of human mesenchymal stem cells (MSCs) promote rat meniscal regeneration by being activated to express Indian hedgehog that enhances expression of type II collagen. Osteoarthritis and Cartilage.
20(10), 1197-1207.
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Oh, J. Y., Lee, R. H., Yu, J. M., Ko, J. H., Lee, H. J., Ko, A. Y., Roddy, G. W., & Prockop, D. J.
(2012).
Intravenous mesenchymal stem cells prevented rejection of allogeneic corneal transplants by aborting the early inflammatory response. MOLECULAR THERAPY.
20(11), 2143-2152.
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Lee, R. H., Yoon, N., Reneau, J. C., & Prockop, D. J.
(2012).
Preactivation of human MSCs with TNF- enhances tumor-suppressive activity. Cell Stem Cell.
11(6), 825-835.
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Foraker, J. E., Oh, J. Y., Ylostalo, J. H., Lee, R. H., Watanabe, J., & Prockop, D. J.
(2011).
Cross-talk between human mesenchymal stem/progenitor cells (MSCs) and rat hippocampal slices in LPS-stimulated cocultures: the MSCs are activated to secrete prostaglandin E2. Journal of Neurochemistry.
119(5), 1052-1063.
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Lee, R. H., Oh, J. Y., Choi, H., & Bazhanov, N.
(2011).
Therapeutic factors secreted by mesenchymal stromal cells and tissue repair. Journal of Cellular Biochemistry.
112(11), 3073-3078.
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Roddy, G. W., Oh, J. Y., Lee, R. H., Bartosh, T. J., Ylostalo, J., Coble, K., Rosa, R. H., & Prockop, D. J.
(2011).
Action at a distance: systemically administered adult stem/progenitor cells (MSCs) reduce inflammatory damage to the cornea without engraftment and primarily by secretion of TNF- stimulated gene/protein 6. Stem Cells.
29(10), 1572-1579.
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Choi, H., Lee, R. H., Bazhanov, N., Oh, J. Y., & Prockop, D. J.
(2011).
Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-B signaling in resident macrophages. Blood.
118(2), 330-338.
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Oh, J. Y., Roddy, G. W., Choi, H., Lee, R. H., Ylstalo, J. H., Rosa, R. H., & Prockop, D. J.
(2010).
Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury. Proceedings of the National Academy of Sciences of the United States of America.
107(39), 16875-16880.
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Bartosh, T. J., Ylstalo, J. H., Mohammadipoor, A., Bazhanov, N., Coble, K., Claypool, K., ... Prockop, D. J.
(2010).
Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties. Proceedings of the National Academy of Sciences of the United States of America.
107(31), 13724-13729.
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Semon, J. A., Nagy, L. H., Llamas, C. B., Tucker, H. A., Lee, R. H., & Prockop, D. J.
(2010).
Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels. Cell and Tissue Research.
341(1), 147-158.
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Larson, B. L., Ylostalo, J., Lee, R. H., Gregory, C., & Prockop, D. J.
(2010).
Sox11 is expressed in early progenitor human multipotent stromal cells and decreases with extensive expansion of the cells. Tissue Engineering Part A.
16(11), 3385-3394.
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Lee, R. H., Pulin, A. A., Seo, M. J., Kota, D. J., Ylostalo, J., Larson, B. L., ... Prockop, D. J.
(2009).
Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6. Cell Stem Cell.
5(1), 54-63.
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Lee, R. H., Seo, M. J., Pulin, A. A., Gregory, C. A., Ylostalo, J., & Prockop, D. J.
(2009).
The CD34-like protein PODXL and alpha6-integrin (CD49f) identify early progenitor MSCs with increased clonogenicity and migration to infarcted heart in mice. Blood.
113(4), 816-826.
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Lee, R. H., Seo, M. J., Reger, R. L., Spees, J. L., Pulin, A. A., Olson, S. D., & Prockop, D. J.
(2006).
Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice. Proceedings of the National Academy of Sciences of the United States of America.
103(46), 17438-17443.
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Song, J. M., Lee, R. H., & Jung, J. S.
(2005).
Roles of NF-kappaB and bcl-2 in two differential modes of cell death of mouse cortical collecting duct cells. 28(2), 101-110.
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Lee, R. H., Kim, B., Choi, I., Kim, H., Choi, H. S., Suh, K., Bae, Y. C., & Jung, J. S.
(2004).
Characterization and expression analysis of mesenchymal stem cells from human bone marrow and adipose tissue. Cellular Physiology and Biochemistry.
14(4-6), 311-324.
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Lee, D. H., Kang, S. K., Lee, R. H., Ryu, J. M., Park, H. Y., Choi, H. S., ... Jung, J. S.
(2004).
Effects of peripheral benzodiazepine receptor ligands on proliferation and differentiation of human mesenchymal stem cells. Journal of Cellular Physiology.
198(1), 91-99.
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Hwang, S. M., Lee, R. H., Song, J. M., Yoon, S., Kim, Y. S., Lee, S. J., Kang, S. K., & Jung, J. S.
(2002).
Expression of aquaporin-5 and its regulation in skeletal muscle cells. Experimental & Molecular Medicine.
34(1), 69-74.
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Jung, J. S., Hwang, S. M., Lee, R. H., Kang, S. K., Woo, J. S., & Kim, Y. K.
(2001).
Extracellular ATP stimulates Na+ and Cl- transport through the activation of multiple purinergic receptors on the apical and basolateral membranes in M-1 mouse cortical collecting duct cells. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology.
5(3), 231-241.
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Kang, S. K., Lee, R. H., & Jung, J. S.
(2001).
Effect of brainderived neurotrophic factor in neural differentiation of mouse embryonic stem cells and neural precursor cells. Neuroscience Research Communications.
29(3), 183-192.
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Jung, J. S., Lee, R. H., Koh, S. H., & Kim, Y. K.
(2000).
Changes in expression of sodium cotransporters and aquaporin-2 during ischemia-reperfusion injury in rabbit kidney. Renal Failure.
22(4), 407-421.
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Jung, J. S., Park, M. Y., Lee, R. H., Jun, J. S., & Kim, Y. K.
(2000).
Protection against hydrogen peroxide induced injury in renal proximal tubule cell lines by inhibition of poly(ADP-ribose) synthase. Kidney and Blood Pressure Research.
23(1), 14-19.
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Park, M. Y., Lee, R. H., Lee, S. H., & Jung, J. S.
(1999).
Apoptosis induced by inhibition of contact with extracellular matrix in mouse collecting duct cells. Nephron.
83(4), 341-351.
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Pacienza, N., Lee, R. H., Bae, E., Kim, D., Liu, Q., Prockop, D. J., & Yannarelli, G.
(2019).
InVitro Macrophage Assay Predicts the InVivo Anti-inflammatory Potential of Exosomes from Human Mesenchymal Stromal Cells. Molecular Therapy - Methods and Clinical Development.
13, 67-76.
Research
principal investigator on
- Extracellular Vesicles Produced by Mesenchymal Stem Cells as Novel Therapy for Autoimmune Uveitis awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2019 - 2024
- Therapeutic Effects of MSC-Derived Extracellular Vesicles on Sjögren's Syndrome awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2018 - 2020
Teaching
teaching activities
- BICH491 Hnr-research Instructor
- BIOT684 Directed Prof Internship Instructor
- BIOT685 Directed Studies Instructor
- GENE491 Hnr-research Instructor
- MSCI630 Pathogenesis Of Human Disease Instructor
- MSCI691 Research Credit: Medical Sci Instructor
Background
education and training
- Ph.D. in Physiology, Pusan National University - (Busan, South Korea) 2003
- M.S. in Medicine, Pusan National University - (Busan, South Korea) 1999
- B.S. in Microbiology, Pusan National University - (Busan, South Korea) 1997
- Tulane University - (New Orleans, Louisiana, United States) , Postdoctoral Training 2008
Contact
first name
- Ryang
has last name
- Lee
mailing address
-
Texas A&M Health Science Center
Regenerative Medicine
1114 TAMUS
College Station, TX 77843-1114
USA
Other
- b4thesun@tamu.edu