Therapeutic factors secreted by mesenchymal stromal cells and tissue repair. Academic Article uri icon

abstract

  • Systemic administration of MSCs resulted in remarkable functional improvements in injured tissues without either long-term engraftment or differentiation in many clinical and experimental situations. Emerging evidence suggest that most of the beneficial effects of MSCs could be explained by secretion of soluble factors that have multiple effects including modulation of inflammatory and immune reactions, protection from cell death, and stimulation of endogenous progenitor cells. In this review, we focus on the therapeutic factors that account for the beneficial effects of MSCs in animal models of human diseases.

published proceedings

  • J Cell Biochem

author list (cited authors)

  • Lee, R. H., Oh, J. Y., Choi, H., & Bazhanov, N

citation count

  • 73

complete list of authors

  • Lee, Ryang Hwa||Oh, Joo Youn||Choi, Hosoon||Bazhanov, Nikolay

publication date

  • October 2011

publisher