Therapeutic factors secreted by mesenchymal stromal cells and tissue repair. Academic Article

abstract

• Systemic administration of MSCs resulted in remarkable functional improvements in injured tissues without either long-term engraftment or differentiation in many clinical and experimental situations. Emerging evidence suggest that most of the beneficial effects of MSCs could be explained by secretion of soluble factors that have multiple effects including modulation of inflammatory and immune reactions, protection from cell death, and stimulation of endogenous progenitor cells. In this review, we focus on the therapeutic factors that account for the beneficial effects of MSCs in animal models of human diseases.

authors

• Lee, Ryang

published proceedings

• J Cell Biochem

author list (cited authors)

• Lee, R. H., Oh, J. Y., Choi, H., & Bazhanov, N.

citation count

• 73

complete list of authors

• Lee, Ryang Hwa||Oh, Joo Youn||Choi, Hosoon||Bazhanov, Nikolay

publication date

• November 2011

publisher

• Wiley  Publisher

published in

• Journal of Cellular Biochemistry  Journal

keywords

• Apoptosis
• Humans
• Inflammation
• Mesenchymal Stem Cells
• Regeneration
• Wound Healing

PubMed Central ID

• 21748781

Digital Object Identifier (DOI)

• 10.1002/jcb.23250

start page

• 3073

end page

• 3078

volume

• 112

issue

• 11

URL

• http://dx.doi.org/10.1002/jcb.23250