HR job title
- Associate Professor
- Contact Info
- 1 713 677 7565
Zhang, Dekai Associate Professor
Positions
- Associate Professor, Center for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology
- Associate Professor, Institute of Biosciences and Technology, School of Medicine
Our laboratory is studying the molecular mechanisms of innate immune recognition by identification and analysis of receptors involved in innate immune recognition and activated signaling pathways. We are particularly interested in the recently identified family of Toll-like receptors, which play a critical role in the mounting of innate immune responses. We wish to understand the mechanisms by which TLRs recognize different pathogen associate molecular patterns (PAMPs), as well as the regulatory mechanisms of TLR signal pathways that lead to NF- k B activation. We are also interested in studying the important links between chronic infection, inflammation and cancer by utilizing biochemical as well as whole animal approaches.
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Overview
Publications
selected publications
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academic article
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Du, B., Fan, Y. J., Zhao, L. X., Geng, X. Y., Li, D. L., Wu, X. W., Zhang, D. K., & Liu, B. R.
(2019).
A reliable detachable balloon that prevents abdominal cavity contamination during transrectal natural orifice transluminal endoscopic surgery. Journal of Digestive Diseases.
20(8), 383-390.
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Zhang, J., Zhang, J., Xu, S., Zhang, X., Wang, P., Wu, H., ... Pang, D. a.
(2018).
Hypoxia-Induced TPM2 Methylation is Associated with Chemoresistance and Poor Prognosis in Breast Cancer. Cellular Physiology and Biochemistry.
45(2), 692-705.
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Lu, Y., Li, X., Liu, S., Zhang, Y., & Zhang, D.
(2018).
Toll-like Receptors and Inflammatory Bowel Disease. Frontiers in Immunology.
9(JAN), 72.
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Xia, B., Shan, M., Wang, J. i., Zhong, Z., Geng, J., He, X., ... Pang, D. a.
(2017).
Homeobox A11 hypermethylation indicates unfavorable prognosis in breast cancer. Oncotarget.
8(6), 9794-9805.
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Sun, L., Li, Y., Jia, X., Wang, Q. i., Li, Y., Hu, M., ... Ren, H.
(2017).
Neuroprotection by IFN- via astrocyte-secreted IL-6 in acute neuroinflammation. Oncotarget.
8(25), 40065-40078.
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Shi, M., Zhang, Y., Liu, L., Zhang, T., Han, F., Cleveland, J., ... Zhang, D.
(2016).
MAP1S Protein Regulates the Phagocytosis of Bacteria and Toll-like Receptor (TLR) Signaling. 291(3), 1243-1250.
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Zhang, G., Xia, B., Liu, T., Zhang, J., Niu, M., Xu, S., ... Pang, D. a.
(2016).
A High-Quality Biobank Supports Breast Cancer Research in Harbin, China. Biopreservation and Biobanking.
14(5), 375-382.
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Jing, Y., Liang, H., Zhang, Y., Cleveland, J., Yan, J., & Zhang, D
(2015).
Up-regulation of Toll-like Receptor 9 in Osteosarcoma. Anticancer Research: international journal of cancer research and treatment.
35(11), 5839-5843.
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Song, W., Wang, J., Han, Z., Zhang, Y., Zhang, H., Wang, W., ... Chai, J.
(2015).
Structural basis for specific recognition of single-stranded RNA by Toll-like receptor 13. Nature Structural and Molecular Biology.
22(10), 782-787.
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Fan, Y., Mao, R., Yu, Y., Liu, S., Shi, Z., Cheng, J., ... Yang, J.
(2014).
USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase. 211(2), 313-328.
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Zhao, S., Zhang, Y., Zhang, Q., Wang, F., & Zhang, D.
(2014).
Toll-like receptors and prostate cancer. Frontiers in Immunology.
5(JUL), 352.
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Du, B., Luo, W., Li, R., Tan, B., Han, H., Lu, X., ... Liu, M.
(2013).
Lgr4/Gpr48 negatively regulates TLR2/4-associated pattern recognition and innate immunity by targeting CD14 expression. 288(21), 15131-15141.
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Zhao, S., Yang, H., Zhang, M., Zhang, D., Liu, Y., Liu, Y., ... Zhang, Q.
(2013).
Circulating tumor cells (CTCs) detected by triple-marker EpCAM, CK19, and hMAM RT-PCR and their relation to clinical outcome in metastatic breast cancer patients. Cell Biochemistry and Biophysics.
65(2), 263-273.
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Shi, Z., Cai, Z., Yu, J., Zhang, T., Zhao, S., Smeds, E., ... Zhang, D.
(2012).
Toll-like receptor 11 (TLR11) prevents Salmonella penetration into the murine Peyer patches. Journal of Biological Chemistry.
287(52), 43417-43423.
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Mathur, R., Oh, H., Zhang, D., Park, S., Seo, J., Koblansky, A., Hayden, M. S., & Ghosh, S.
(2012).
A mouse model of Salmonella typhi infection. Cell.
151(3), 590-602.
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Gorjestani, S., Yu, M., Tang, B., Zhang, D., Wang, D., & Lin, X.
(2011).
Phospholipase C2 (PLC2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses. 286(51), 43651-43659.
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Cai, Z., Sanchez, A., Shi, Z., Zhang, T., Liu, M., & Zhang, D.
(2011).
Activation of Toll-like receptor 5 on breast cancer cells by flagellin suppresses cell proliferation and tumor growth. Cancer Research.
71(7), 2466-2475.
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Shi, Z., Cai, Z., Sanchez, A., Zhang, T., Wen, S., Wang, J., ... Zhang, D.
(2011).
A novel Toll-like receptor that recognizes vesicular stomatitis virus. Journal of Biological Chemistry.
286(6), 4517-4524.
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Rao, P., Hayden, M. S., Long, M., Scott, M. L., West, A. P., Zhang, D., ... Ghosh, S.
(2010).
IkappaBbeta acts to inhibit and activate gene expression during the inflammatory response. Nature.
466(7310), 1115-1119.
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Sengupta, D., Koblansky, A., Gaines, J., Brown, T., West, A. P., Zhang, D., ... Ghosh, S.
(2010).
Subversion of innate immune responses by Brucella through the targeted degradation of the TLR signaling adapter, MAL. Journal of Immunology.
184(2), 956-964.
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Cai, Z., Shi, Z., Sanchez, A., Zhang, T., Liu, M., Yang, J., Wang, F., & Zhang, D.
(2009).
Transcriptional regulation of Tlr11 gene expression in epithelial cells. Journal of Biological Chemistry.
284(48), 33088-33096.
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Fan, Y., Mao, R., Zhao, Y., Yu, Y., Sun, W., Song, P., ... Yang, J.
(2009).
Tumor necrosis factor-alpha induces RelA degradation via ubiquitination at lysine 195 to prevent excessive nuclear factor-kappaB activation. Journal of Biological Chemistry.
284(43), 29290-29297.
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Shi, Z., Cai, Z., Wen, S., Chen, C., Gendron, C., Sanchez, A., ... Zhang, D.
(2009).
Transcriptional regulation of the novel Toll-like receptor Tlr13. 284(31), 20540-20547.
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Sun, W., Yu, Y., Dotti, G., Shen, T., Tan, X., Savoldo, B., ... Yang, J.
(2009).
PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation. Cellular Signalling.
21(1), 95-102.
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Yu, Y., Ge, N., Xie, M., Sun, W., Burlingame, S., Pass, A. K., ... Yang, J.
(2008).
Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop is required for interleukin (IL)-1-mediated optimal NFkappaB and AP-1 activation as well as IL-6 gene expression. 283(36), 24497-24505.
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Huang, X., Shi, Z., Wang, W., Bai, J., Chen, Z., Xu, J., Zhang, D., & Fu, S.
(2007).
Identification and characterization of a novel protein ISOC2 that interacts with p16INK4a. Biochemical and Biophysical Research Communications.
361(2), 287-293.
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Yarovinsky, F., Zhang, D., Andersen, J. F., Bannenberg, G. L., Serhan, C. N., Hayden, M. S., ... Sher, A
(2005).
TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science.
308(5728), 1626-1629.
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Zhang, D., Zhang, G., Hayden, M. S., Greenblatt, M. B., Bussey, C., Flavell, R. A., & Ghosh, S
(2004).
A toll-like receptor that prevents infection by uropathogenic bacteria. Science.
303(5663), 1522-1526.
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Cao, D., Russell, R. L., Zhang, D., Leffert, J. J., & Pizzorno, G
(2002).
Uridine phosphorylase (-/-) murine embryonic stem cells clarify the key role of this enzyme in the regulation of the pyrimidine salvage pathway and in the activation of fluoropyrimidines. Cancer Research.
62(8), 2313-2317.
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Pizzorno, G., Cao, D., Leffert, J. J., Russell, R. L., Zhang, D., & Handschumacher, R. E.
(2002).
Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
1587(2-3), 133-144.
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Zhang, D., Cao, D., Russell, R., & Pizzorno, G
(2001).
p53-dependent suppression of uridine phosphorylase gene expression through direct promoter interaction. Cancer Research.
61(18), 6899-6905.
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Russell, R. L., Cao, D., Zhang, D., Handschumacher, R. E., & Pizzorno, G.
(2001).
Uridine phosphorylase association with vimentin. Intracellular distribution and localization. 276(16), 13302-13307.
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Yang, X., Sham, J. S., Ng, M. H., Tsao, S. W., Zhang, D., Lowe, S. W., & Cao, L
(2000).
LMP1 of Epstein-Barr virus induces proliferation of primary mouse embryonic fibroblasts and cooperatively transforms the cells with a p16-insensitive CDK4 oncogene. Journal of Virology.
74(2), 883-891.
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Cao, D., Nimmakayalu, M. A., Wang, F., Zhang, D., Handschumacher, R. E., Bray-Ward, P., & Pizzorno, G
(1999).
Genomic structure, chromosomal mapping, and promoter region analysis of murine uridine phosphorylase gene. Cancer Research.
59(19), 4997-5001.
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Choo, C. K., Ling, M. T., Chan, K. W., Tsao, S. W., Zheng, Z., Zhang, D., Chan, L. C., & Wong, Y. C.
(1999).
Immortalization of human prostate epithelial cells by HPV 16 E6/E7 open reading frames. 40(3), 150-158.
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Cheung, A. N., Zhang, D. K., Liu, Y., Ngan, H. Y., Shen, D. H., & Tsao, S. W
(1999).
Telomerase activity in gestational trophoblastic disease. Journal of Clinical Pathology.
52(8), 588-592.
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Tu, W., Zhang, D. K., Cheung, P. T., Tsao, S. W., & Lau, Y. L
(1999).
Effect of insulin-like growth factor 1 on PHA-stimulated cord blood mononuclear cell telomerase activity. British Journal of Haematology.
104(4), 785-794.
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Zhang, D. K., Ngan, H. Y., Cheng, R. Y., Cheung, A. N., Liu, S. S., & Tsao, S. W.
(1999).
Clinical significance of telomerase activation and telomeric restriction fragment (TRF) in cervical cancer. European Journal of Cancer.
35(1), 154-160.
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Litaker, J. R., Pan, J., Cheung, Y., Zhang, D. K., Liu, Y., Wong, S. C., Wan, T. S., & Tsao, S. W
(1998).
Expression profile of senescence-associated beta-galactosidase and activation of telomerase in human ovarian surface epithelial cells undergoing immortalization. International Journal of Oncology.
13(5), 951-956.
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Tsao, S. W., Zhang, D. K., Cheng, R. Y., & Wan, T. S
(1998).
Telomerase activation in human cancers. Chinese Medical Journal.
111(8), 745-750.
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Lam, K. Y., Tsao, S. W., Zhang, D., Law, S., He, D., Ma, L., & Wong, J.
(1997).
Prevalence and predictive value of p53 mutation in patients with oesophageal squamous cell carcinomas: a prospective clinico-pathological study and survival analysis of 70 patients. 74(2), 212-219.
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Lam, K. Y., He, D., Ma, L., Zhang, D., Ngan, H. Y., Wan, T. S., & Tsao, S. W.
(1997).
Presence of human papillomavirus in esophageal squamous cell carcinomas of Hong Kong Chinese and its relationship with p53 gene mutation. Human Pathology.
28(6), 657-663.
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He, D., Zhang, D. K., Lam, K. Y., Ma, L., Ngan, H. Y., Liu, S. S., & Tsao, S. W.
(1997).
Prevalence of HPV infection in esophageal squamous cell carcinoma in Chinese patients and its relationship to the p53 gene mutation. International Journal of Cancer.
72(6), 959-964.
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Du, B., Fan, Y. J., Zhao, L. X., Geng, X. Y., Li, D. L., Wu, X. W., Zhang, D. K., & Liu, B. R.
(2019).
A reliable detachable balloon that prevents abdominal cavity contamination during transrectal natural orifice transluminal endoscopic surgery. Journal of Digestive Diseases.
20(8), 383-390.
Research
principal investigator on
Teaching
teaching activities
- IBST691 Research Credit: Medical Sci Instructor
Background
education and training
- Ph.D. in Oncology/Cell Biology, University of Hong Kong - (Hong Kong, Hong Kong, China) 1998
- M.D. in Internal Medicine, Harbin University - (Harbin, China) 1993
- B.S. in Medical Science, Harbin University - (Harbin, China) 1988
- Howard Hughes Medical Institute - (Chevy Chase, Maryland, United States) , Postdoctoral Training 2005
- Yale University - (New Haven, Connecticut, United States) , Postdoctoral Training 2001
Contact
first name
- Dekai
has last name
- Zhang
mailing address
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Texas A&M Health Science Center
Ibt-Ciid-Hook
1201 TAMUS
Houston, TX 77030-3303
USA
Other
- dekaizhang@tamu.edu