A mouse model of Salmonella typhi infection. Academic Article uri icon

abstract

  • Salmonella spp. are gram-negative flagellated bacteria that can cause food- and waterborne gastroenteritis and typhoid fever in humans. We now report that flagellin from Salmonella spp. is recognized in mouse intestine by Toll-like receptor 11 (TLR11). Absence of TLR11 renders mice more susceptible to infection by S.Typhimurium, with increased dissemination of the bacteria and enhanced lethality. Unlike S.Typhimurium, S.Typhi, a human obligatory pathogen that causes typhoid fever, is normally unable to infect mice. TLR11 is expressed in mice, but not in humans, and remarkably, we find that tlr11(-/-) mice are efficiently infected with orally administered S.Typhi. We also find that tlr11(-/-) mice can be immunized against S.Typhi. Therefore, tlr11(-/-) mice represent a small-animal model for the study of the immune response to S.Typhi and for the development of vaccines against this important human pathogen.

published proceedings

  • Cell

altmetric score

  • 29.35

author list (cited authors)

  • Mathur, R., Oh, H., Zhang, D., Park, S., Seo, J., Koblansky, A., Hayden, M. S., & Ghosh, S.

citation count

  • 164

complete list of authors

  • Mathur, Ramkumar||Oh, Hyunju||Zhang, Dekai||Park, Sung-Gyoo||Seo, Jin||Koblansky, Alicia||Hayden, Matthew S||Ghosh, Sankar

publication date

  • January 2012

published in