selected publications academic article Dees, W. L., Hiney, J. K., & Srivastava, V. K. (2021). How alcohol affects insulin-like growth factor-1's influences on the onset of puberty: A critical review. Alcoholism: Clinical and Experimental Research. 45(11), 2196-2206. Dees, W. L., Hiney, J. K., & Srivastava, V. K. (2021). IGF-1 Influences Gonadotropin-Releasing Hormone Regulation of Puberty. 111(12), 1151-1163. Dearth, R., Hamilton, A., Srivastava, V., Hiney, J., & Dees, W. (2020). Manganese-Induced Central Precocious Puberty (MnPP) Increases Hormone Receptor Expression (HR+) in Proliferating Mammary Epithelial Cells in Adult Female Rats. The FASEB Journal. 34(S1), 1-1. Dees, W. L., Hiney, J. K., & Srivastava, V. K. (2019). Regulation of prepubertal dynorphin secretion in the medial basal hypothalamus of the female rat. Journal of Neuroendocrinology. 31(12), e12810. Srivastava, V. K., Hiney, J. K., & Dees, W. L. (2018). Alcohol Delays the Onset of Puberty in the Female Rat by Altering Key Hypothalamic Events. Alcoholism: Clinical and Experimental Research. 42(7), 1166-1176. Hiney, J. K., Srivastava, V. K., Vaden Anderson, D. N., Hartzoge, N. L., & Dees, W. L. (2018). Regulation of Kisspeptin Synthesis and Release in the Preoptic/Anterior Hypothalamic Region of Prepubertal Female Rats: Actions of IGF-1 and Alcohol. 42(1), 61-68. Dees, W. L., Hiney, J. K., & Srivastava, V. K. (2017). Influences of manganese on pubertal development. 235(1), R33-R42. Dees, W. L., Hiney, J. K., & Srivastava, V. K. (2017). Alcohol and Puberty. Alcohol research : current reviews. 38(2), 277-282. Dees, W. L., Hiney, J. K., & Srivastava, V. K. (2017). Alcohol and puberty: Mechanisms of delayed development. Alcohol research : current reviews. 38(2), e-1-e-6. Srivastava, V. K., Hiney, J. K., & Dees, W. L. (2016). Manganese-Stimulated Kisspeptin Is Mediated by the IGF-1/Akt/Mammalian Target of Rapamycin Pathway in the Prepubertal Female Rat. ENDOCRINOLOGY. 157(8), 3233-3241. Hiney, J. K., Srivastava, V. K., & Dees, W. L. (2016). Manganese protects against the effects of alcohol on hypothalamic puberty-related hormones. LIFE SCIENCES. 148, 106-111. Srivastava, V. K., Hiney, J. K., Stevener, K., & Dees, W. L. (2015). Differential Effects of Alcohol on Excitatory and Inhibitory Puberty-Related Peptides in the Basal Hypothalamus of the Female Rat. Alcoholism: Clinical and Experimental Research. 39(12), 2386-2393. Dees, W. L., Hiney, J. K., & Srivastava, V. K. (2015). Alcohol alters hypothalamic glial-neuronal communications involved in the neuroendocrine control of puberty: Invivo and invitro assessments. ALCOHOL. 49(7), 631-637. Dees, W. L., Hiney, J. K., & Srivastava, V. K. (2015). The Effects of Manganese on Female Pubertal Development. Issues in Toxicology. 22(22), 437-458. Hiney, J. K., Srivastava, V. K., Volz, C. E., & Dees, W. L. (2014). Alcohol alters insulin-like growth factor-1-induced transforming growth factor 1 synthesis in the medial basal hypothalamus of the prepubertal female rat. Alcoholism: Clinical and Experimental Research. 38(10), 2572-2578. Dearth, R. K., Hiney, J. K., Srivastava, V. K., Hamilton, A. M., & Dees, W. L. (2014). Prepubertal exposure to elevated manganese results in estradiol regulated mammary gland ductal differentiation and hyperplasia in female rats. EXPERIMENTAL BIOLOGY AND MEDICINE. 239(7), 871-882. Srivastava, V. K., Hiney, J. K., & Dees, W. L. (2014). Actions and interactions of alcohol and transforming growth factor 1 on prepubertal hypothalamic gonadotropin-releasing hormone. Alcoholism: Clinical and Experimental Research. 38(5), 1321-1329. Srivastava, V. K., Hiney, J. K., & Dees, W. L. (2013). Early life manganese exposure upregulates tumor-associated genes in the hypothalamus of female rats: relationship to manganese-induced precocious puberty. 136(2), 373-381. Srivastava, V. K., Hiney, J. K., & Dees, W. L. (2011). Hypothalamic actions and interactions of alcohol and IGF-1 on the expression of glial receptor protein tyrosine phosphatase- during female pubertal development. Alcoholism: Clinical and Experimental Research. 35(10), 1812-1821. Srivastava, V. K., Hiney, J. K., & Dees, W. L. (2011). Hypothalamic glial-to-neuronal signaling during puberty: influence of alcohol. International Journal of Environmental Research and Public Health. 8(7), 2876-2894. Hiney, J. K., Srivastava, V. K., & Dees, W. L. (2011). Manganese induces IGF-1 and cyclooxygenase-2 gene expressions in the basal hypothalamus during prepubertal female development. TOXICOLOGICAL SCIENCES. 121(2), 389-396. Srivastava, V. K., Hiney, J. K., & Dees, W. L. (2011). Prepubertal ethanol exposure alters hypothalamic transforming growth factor- and erbB1 receptor signaling in the female rat. ALCOHOL. 45(2), 173-181. Srivastava, V. K., Hiney, J. K., Mattison, J. A., Bartke, A., & Dees, W. L. (2007). The alcohol-induced suppression of ovarian insulin-like growth factor-1 gene transcription is independent of growth hormone and its receptor. Alcoholism: Clinical and Experimental Research. 31(5), 880-886. Srivastava, V. K., Dissen, G. A., Ojeda, S. R., Hiney, J. K., Pine, M. D., & Dees, W. L. (2007). Effects of alcohol on intraovarian nitric oxide synthase and steroidogenic acute regulatory protein in the prepubertal female rhesus monkey. 68(2), 182-191. Lee, B., Hiney, J. K., Pine, M. D., Srivastava, V. K., & Dees, W. L. (2007). Manganese stimulates luteinizing hormone releasing hormone secretion in prepubertal female rats: hypothalamic site and mechanism of action. 578(Pt 3), 765-772. Lee, B., Pine, M., Johnson, L., Rettori, V., Hiney, J. K., & Dees, W. L. (2006). Manganese acts centrally to activate reproductive hormone secretion and pubertal development in male rats. Reproductive Toxicology. 22(4), 580-585. Dees, W. L., Hiney, J. K., McArthur, N. H., Johnson, G. A., Dissen, G. A., & Ojeda, S. R. (2006). Origin and ontogeny of mammalian ovarian neurons. 147(8), 3789-3796. Pine, M. D., Hiney, J. K., Dearth, R. K., Bratton, G. R., & Dees, W. L. (2006). IGF-1 administration to prepubertal female rats can overcome delayed puberty caused by maternal Pb exposure. 21(1), 104-109. Lee, B., Pine, M., Johnson, L., Rettori, V., Hiney, J. K., & Dees, W. L. (2006). Manganese acts centrally to activate reproductive hormone secretion and pubertal development in male rats. Reproductive Toxicology. 22(4), 580-585. Srivastava, V. K., Vijayan, E., Hiney, J. K., & Dees, W. L. (2005). Effect of ethanol on follicle stimulating hormone-induced steroidogenic acute regulatory protein (StAR) in cultured rat granulosa cells. ALCOHOL. 37(2), 105-111. Pine, M., Lee, B., Dearth, R., Hiney, J. K., & Dees, W. L. (2005). Manganese acts centrally to stimulate luteinizing hormone secretion: a potential influence on female pubertal development. TOXICOLOGICAL SCIENCES. 85(2), 880-885. Dees, W. L., Srivastava, V. K., & Hiney, J. K. (2005). Alcohol alters insulin-like growth factor-1 activated oct 2 POU domain gene expression in the immature female hypothalamus. Journal of Studies on Alcohol and Drugs. 66(1), 35-45. Hiney, J. K., Srivastava, V., Dearth, R. K., & Dees, W. L. (2004). Influence of estradiol on insulin-like growth factor-1-induced luteinizing hormone secretion. BRAIN RESEARCH. 1013(1), 91-97. Dearth, R. K., Hiney, J. K., Srivastava, V., Les Dees, W., & Bratton, G. R. (2004). Low level lead (Pb) exposure during gestation and lactation: assessment of effects on pubertal development in Fisher 344 and Sprague-Dawley female rats. LIFE SCIENCES. 74(9), 1139-1148. Srivastava, V., Dearth, R. K., Hiney, J. K., Ramirez, L. M., Bratton, G. R., & Dees, W. L. (2004). The effects of low-level Pb on steroidogenic acute regulatory protein (StAR) in the prepubertal rat ovary. TOXICOLOGICAL SCIENCES. 77(1), 35-40. Hiney, J. K., Dearth, R. K., Srivastava, V., Rettori, V., & Dees, W. L. (2003). Actions of ethanol on epidermal growth factor receptor activated luteinizing hormone secretion. Journal of Studies on Alcohol and Drugs. 64(6), 809-816. Nahm, S., Frank, T. C., Browning, M. D., Sepulvado, J. M., Hiney, J. K., & Abbott, L. C. (2003). Insulin-like growth factor-I improves cerebellar dysfunction but does not prevent cerebellar neurodegeneration in the calcium channel mutant mouse, leaner. NEUROBIOLOGY OF DISEASE. 14(2), 157-165. Srivastava, V. K., Dearth, R. K., Hiney, J. K., Chandrashekar, V., Mattison, J. A., Bartke, A., & Dees, W. L. (2002). Alcohol suppresses insulin-like growth factor-1 gene expression in prepubertal transgenic female mice overexpressing the bovine growth hormone gene. Alcoholism: Clinical and Experimental Research. 26(11), 1697-1702. Dearth, R. K., Hiney, J. K., Srivastava, V., Burdick, S. B., Bratton, G. R., & Dees, W. L. (2002). Effects of lead (Pb) exposure during gestation and lactation on female pubertal development in the rat. Reproductive Toxicology. 16(4), 343-352. Hiney, J. K., Sower, S. A., Yu, W. H., McCann, S. M., & Dees, W. L. (2002). Gonadotropin-releasing hormone neurons in the preoptic-hypothalamic region of the rat contain lamprey gonadotropin-releasing hormone III, mammalian luteinizing hormone-releasing hormone, or both peptides. Proceedings of the National Academy of Sciences of USA. 99(4), 2386-2391. Srivastava, V. K., Hiney, J. K., Dearth, R. K., & Les Dees, W. (2002). Chronic effects of prepubertal ethanol administration on steroidogenic acute regulatory protein in the rat ovary. Alcoholism: Clinical and Experimental Research. 26(1), 107-113. Dees, W. L., Srivastava, V. K., & Hiney, J. K. (2001). Alcohol and female puberty: the role of intraovarian systems. Alcohol research : current reviews. 25(4), 271-275. Srivastava, V. K., Hiney, J. K., Dearth, R. K., & Les Dees, W. (2001). Acute effects of ethanol on steroidogenic acute regulatory protein (StAR) in the prepubertal rat ovary. 25(10), 1500-1505. Dees, W. L., Dissen, G. A., Hiney, J. K., Lara, F., & Ojeda, S. R. (2000). Alcohol ingestion inhibits the increased secretion of puberty-related hormones in the developing female rhesus monkey. ENDOCRINOLOGY. 141(4), 1325-1331. Dearth, R. K., Hiney, J. K., & Dees, W. L. (2000). Leptin acts centrally to induce the prepubertal secretion of luteinizing hormone in the female rat. Peptides. 21(3), 387-392. Dees, W. L., Dissen, G. A., Hiney, J. K., Lara, F., & Ojeda, S. R. (2000). Alcohol ingestion inhibits the increased secretion of puberty-related hormones in the developing female rhesus monkey. ENDOCRINOLOGY. 141(4), 1325-1331. Srivastava, V., Hiney, J. K., Nyberg, C. L., & Dees, W. L. (1995). Effect of ethanol on the synthesis of insulin-like growth factor 1 (IGF-1) and the IGF-1 receptor in late prepubertal female rats: a correlation with serum IGF-1. Alcoholism: Clinical and Experimental Research. 19(6), 1467-1473. DEES, W. L., HINEY, J. K., SCHULTEA, T. D., MAYERHOFER, A., DANILCHIK, M., DISSEN, G. A., & OJEDA, S. R. (1995). THE PRIMATE OVARY CONTAINS A POPULATION OF CATECHOLAMINERGIC NEURON-LIKE CELLS EXPRESSING NERVE GROWTH-FACTOR RECEPTORS. ENDOCRINOLOGY. 136(12), 5760-5768. Dees, W. L., Hiney, J. K., Schultea, T. D., Mayerhofer, A., Danilchik, M., Dissen, G. A., & Ojeda, S. R. (1995). The primate ovary contains a population of catecholaminergic neuron-like cells expressing nerve growth factor receptors. ENDOCRINOLOGY. 136(12), 5760-5768. NYBERG, C. L., SRIVASTAVA, V., HINEY, J. K., LARA, F., & DEES, W. L. (1995). N-METHYL-D-ASPARTIC ACID RECEPTOR MESSENGER-RIBONUCLEIC-ACID LEVELS AND LUTEINIZING-HORMONE RELEASE IN IMMATURE FEMALE RATS - EFFECTS OF STAGE OF PUBERTAL DEVELOPMENT AND EXPOSURE TO ETHANOL. ENDOCRINOLOGY. 136(7), 2874-2880. Nyberg, C. L., Srivastava, V., Hiney, J. K., Lara, F., & Dees, W. L. (1995). N-methyl-D-aspartic acid receptor messenger ribonucleic acid levels and luteinizing hormone release in immature female rats: effects of stage of pubertal development and exposure to ethanol. ENDOCRINOLOGY. 136(7), 2874-2880. Berg-von der Emde, K., Dees, W. L., Hiney, J. K., Hill, D. F., Dissen, G. A., Costa, M. E., Moholt-Siebert, M., & Ojeda, S. R. (1995). Neurotrophins and the neuroendocrine brain: different neurotrophins sustain anatomically and functionally segregated subsets of hypothalamic dopaminergic neurons. The Journal of Neuroscience. 15(6), 4223-4237. Rettori, V., Dees, W. L., Hiney, J. K., Lyson, K., & McCann, S. M. (1994). An interleukin-1-alpha-like neuronal system in the preoptic-hypothalamic region and its induction by bacterial lipopolysaccharide in concentrations which alter pituitary hormone release. 1(4), 251-258. Bratton, G. R., Hiney, J. K., & Dees, W. L. (1994). Lead (Pb) alters the norepinephrine-induced secretion of luteinizing hormone releasing hormone from the median eminence of adult male rats in vitro. LIFE SCIENCES. 55(8), 563-571. Nyberg, C. L., Hiney, J. K., Minks, J. B., & Dees, W. L. (1993). Ethanol alters N-methyl-DL-aspartic acid-induced secretion of luteinizing hormone releasing hormone and the onset of puberty in the female rat. 57(5), 863-868. Lara, H. E., Dees, W. L., Hiney, J. K., Dissen, G. A., Rivier, C., & Ojeda, S. R. (1991). Functional recovery of the developing rat ovary after transplantation: contribution of the extrinsic innervation. ENDOCRINOLOGY. 129(4), 1849-1860. Hiney, J. K., Ojeda, S. R., & Dees, W. L. (1991). Insulin-like growth factor I: a possible metabolic signal involved in the regulation of female puberty. Neuroendocrinology: international journal for basic and clinical studies on neuroendocrine relationships. 54(4), 420-423. Hiney, J. K., & Dees, W. L. (1991). Ethanol inhibits luteinizing hormone-releasing hormone release from the median eminence of prepubertal female rats in vitro: investigation of its actions on norepinephrine and prostaglandin-E2. ENDOCRINOLOGY. 128(3), 1404-1408. Gonzalez, D., Dees, W. L., Hiney, J. K., Ojeda, S. R., & Saneto, R. P. (1990). Expression of beta-nerve growth factor in cultured cells derived from the hypothalamus and cerebral cortex. 511(2), 249-258. Dees, W. L., Skelley, C. W., Hiney, J. K., & Johnston, C. A. (1990). Actions of ethanol on hypothalamic and pituitary hormones in prepubertal female rats. ALCOHOL. 7(1), 21-25. Dees, W. L., Hiney, J. K., Fuentes, F., & Forrest, D. W. (1990). Ethanol alters vasoactive intestinal peptide-induced steroid release from immature rat ovaries in vitro. LIFE SCIENCES. 46(3), 165-172. chapter Dees, W. L., Hiney, J. K., & Srivastava, V. K. (2018). Complimentary Methods for Assessing Hypothalamic Actions of Manganese During Pubertal Development. Methods in Pharmacology and Toxicology. (pp. 1-12). Springer Nature. Dees, W. L., Hiney, J. K., & Srivastava, V. K. (2014). Chapter 17 The Effects of Manganese on Female Pubertal Development. Manganese in Health and Disease. (pp. 437-458). Royal Society of Chemistry (RSC). Les Dees, W., Hiney, J. K., Dearth, R. K., & Srivastava, V. K. (2004). Use of Complimentary In Vitro and In Vivo Methods for Assessing Neuroendocrine Disruptors. In Vitro Neurotoxicology. (pp. 267-289). Springer Nature. Dees, W. L., Nyberg, C. L., & Hiney, J. K. (1995). Neuroendocrine Responses to Ethanol in the Prepubertal Female Rat. Alcohol and Hormones. (pp. 49-74). Springer Nature. conference paper Srivastava, V. K., Hiney, J. K., & Dees, W. L. (2018). ALCOHOL ALTERS THE SYNTHESIS OF KEY HYPOTHALAMIC NEUROMODULATORS ASSOCIATED WITH THE ONSET OF MAMMALIAN PUBERTAL DEVELOPMENT. Alcoholism: Clinical and Experimental Research. 211A-211A. Hiney, J. K., Srivastava, V. K., & Dees, W. L. (2017). ALCOHOL ALTERS THE IGF-1 STIMULATION OF KISSPEPTIN VIA THE INSULIN RECEPTOR SUBSTRATE-1/AKT/MTOR COMPLEX 1 SIGNALING PATHWAY. Alcoholism: Clinical and Experimental Research. 198A-198A. Srivastava, V. K., Hiney, J. K., & Dees, W. L. (2017). EFFECTS OF ALCOHOL ON SPECIFIC SIGNALING PROTEINS INVOLVED IN THE REGULATION OF THE MTOR/KISSPEPTIN PATHWAY IN THE HYPOTHALAMUS OF PREPUBERTAL FEMALE. Alcoholism: Clinical and Experimental Research. 198A-198A. Hamilton, A. M., Srivastava, V., Hiney, J. K., Dees, W. L., & Dearth, R. K. (2016). Utilizing The Novel Manganese-Induced Precocious Puberty Rat Model Identifies Progesterone Receptor as an Important Mediator Between Female Puberty and Breast Cancer. The FASEB Journal. Srivastava, V. K., Hiney, J. K., & Dees, W. L. (2014). EFFECTS OF ALCOHOL ON KEY HYPOTHALAMIC GENES CONTROLLING THE ONSET OF PUBERTY. Alcoholism: Clinical and Experimental Research. 152A-152A. Hiney, J. K., Srivastava, V. K., & Dees, W. L. (2012). ALCOHOL ALTERS INSULIN-LIKE GROWTH FACTOR-1 IGF-1 AND IGF-1/ESTRADIOL INDUCED TRANSFORMING GROWTH FACTOR beta 1 RELEASE FROM HYPOTHALAMIC ASTROCYTES. Alcoholism: Clinical and Experimental Research. 264A-264A. Srivastava, V. K., Hiney, J. K., Pine, M. D., & Dees, W. L. (2008). Actions and interactions of insulin-like growth factor-1 and alcohol on KISS-1 gene expression in juvenile female rats. Alcoholism: Clinical and Experimental Research. 20A-20A. Dees, W. L., Srivastava, V. K., Pine, M., & Hiney, J. K. (2007). Actions of alcohol and IGF-1 during female pubertal development. Alcoholism: Clinical and Experimental Research. 294A-294A. Srivastava, V. K., Hiney, J. K., Pine, M. D., & Dees, W. L. (2007). Effects of alcohol on the intraovarian insulin-like growth factor-1 in the prepubertal rhesus monkeys. Alcoholism: Clinical and Experimental Research. 335A-335A. Srivastava, V. K., Hiney, J. K., Pine, M. D., & Dees, W. L. (2006). Effects of alcohol on intraovarian systems in prepubertal female rhesus monkeys. Alcoholism: Clinical and Experimental Research. 75A-75A. Pine, M., Hiney, J. K., Lee, B., & Dees, W. L. (2005). Alcohol and puberty-related hormones: A protective effect of manganese. Alcoholism: Clinical and Experimental Research. 55A-55A.
investigator on Neuroendocrine Effects of Alcohol on Puberty- awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2015 - 2020
teaching activities BIMS481 Seminar In Biomed Sci Instructor BIMS485 Directed Studies Instructor VIBS305 Biomedical Anatomy Instructor VIBS485 Directed Studies Instructor
education and training Ph.D. in Veterinary Anatomy, Texas A&M University - (College Station, Texas, United States) 1996 M.S. in Veterinary Anatomy, Texas A&M University - (College Station, Texas, United States) 1990 B.S. in Animal Science, Texas A&M University - (College Station, Texas, United States) 1986
mailing address Texas A&M University Veterinary Integrative Biosciences 4458 TAMU College Station, TX 77843-4458 USA