selected publications academic article Dees, W. L., Hiney, J. K., & Srivastava, V. K. (2021). How alcohol affects insulin-like growth factor-1's influences on the onset of puberty: A critical review. Alcoholism: Clinical and Experimental Research. 45(11), 2196-2206. Dees, W. L., Hiney, J. K., & Srivastava, V. K. (2021). IGF-1 Influences Gonadotropin-Releasing Hormone Regulation of Puberty. 111(12), 1151-1163. Dearth, R., Hamilton, A., Srivastava, V., Hiney, J., & Dees, W. (2020). Manganese-Induced Central Precocious Puberty (MnPP) Increases Hormone Receptor Expression (HR+) in Proliferating Mammary Epithelial Cells in Adult Female Rats. The FASEB Journal. 34(S1), 1-1. Dees, W. L., Hiney, J. K., & Srivastava, V. K. (2019). Regulation of prepubertal dynorphin secretion in the medial basal hypothalamus of the female rat. Journal of Neuroendocrinology. 31(12), e12810. Srivastava, V. K., Hiney, J. K., & Dees, W. L. (2018). Alcohol Delays the Onset of Puberty in the Female Rat by Altering Key Hypothalamic Events. Alcoholism: Clinical and Experimental Research. 42(7), 1166-1176. Hiney, J. K., Srivastava, V. K., Vaden Anderson, D. N., Hartzoge, N. L., & Dees, W. L. (2018). Regulation of Kisspeptin Synthesis and Release in the Preoptic/Anterior Hypothalamic Region of Prepubertal Female Rats: Actions of IGF-1 and Alcohol. 42(1), 61-68. Dees, W. L., Hiney, J. K., & Srivastava, V. K. (2017). Influences of manganese on pubertal development. 235(1), R33-R42. Dees, W. L., Hiney, J. K., & Srivastava, V. K. (2017). Alcohol and Puberty. Alcohol research : current reviews. 38(2), 277-282. Dees, W. L., Hiney, J. K., & Srivastava, V. K. (2017). Alcohol and puberty: Mechanisms of delayed development. Alcohol research : current reviews. 38(2), e-1-e-6. Srivastava, V. K., Hiney, J. K., & Dees, W. L. (2016). Manganese-Stimulated Kisspeptin Is Mediated by the IGF-1/Akt/Mammalian Target of Rapamycin Pathway in the Prepubertal Female Rat. ENDOCRINOLOGY. 157(8), 3233-3241. Hiney, J. K., Srivastava, V. K., & Dees, W. L. (2016). Manganese protects against the effects of alcohol on hypothalamic puberty-related hormones. LIFE SCIENCES. 148, 106-111. Srivastava, V. K., Hiney, J. K., Stevener, K., & Dees, W. L. (2015). Differential Effects of Alcohol on Excitatory and Inhibitory Puberty-Related Peptides in the Basal Hypothalamus of the Female Rat. Alcoholism: Clinical and Experimental Research. 39(12), 2386-2393. Dees, W. L., Hiney, J. K., & Srivastava, V. K. (2015). Alcohol alters hypothalamic glial-neuronal communications involved in the neuroendocrine control of puberty: Invivo and invitro assessments. ALCOHOL. 49(7), 631-637. Dees, W. L., Hiney, J. K., & Srivastava, V. K. (2015). The Effects of Manganese on Female Pubertal Development. Issues in Toxicology. 22(22), 437-458. Hiney, J. K., Srivastava, V. K., Volz, C. E., & Dees, W. L. (2014). Alcohol alters insulin-like growth factor-1-induced transforming growth factor 1 synthesis in the medial basal hypothalamus of the prepubertal female rat. Alcoholism: Clinical and Experimental Research. 38(10), 2572-2578. Dearth, R. K., Hiney, J. K., Srivastava, V. K., Hamilton, A. M., & Dees, W. L. (2014). Prepubertal exposure to elevated manganese results in estradiol regulated mammary gland ductal differentiation and hyperplasia in female rats. EXPERIMENTAL BIOLOGY AND MEDICINE. 239(7), 871-882. Srivastava, V. K., Hiney, J. K., & Dees, W. L. (2014). Actions and interactions of alcohol and transforming growth factor 1 on prepubertal hypothalamic gonadotropin-releasing hormone. Alcoholism: Clinical and Experimental Research. 38(5), 1321-1329. Srivastava, V. K., Hiney, J. K., & Dees, W. L. (2013). Early life manganese exposure upregulates tumor-associated genes in the hypothalamus of female rats: relationship to manganese-induced precocious puberty. 136(2), 373-381. Srivastava, V. K., Hiney, J. K., & Dees, W. L. (2011). Hypothalamic actions and interactions of alcohol and IGF-1 on the expression of glial receptor protein tyrosine phosphatase- during female pubertal development. Alcoholism: Clinical and Experimental Research. 35(10), 1812-1821. Srivastava, V. K., Hiney, J. K., & Dees, W. L. (2011). Hypothalamic glial-to-neuronal signaling during puberty: influence of alcohol. International Journal of Environmental Research and Public Health. 8(7), 2876-2894. Hiney, J. K., Srivastava, V. K., & Dees, W. L. (2011). Manganese induces IGF-1 and cyclooxygenase-2 gene expressions in the basal hypothalamus during prepubertal female development. TOXICOLOGICAL SCIENCES. 121(2), 389-396. Srivastava, V. K., Hiney, J. K., & Dees, W. L. (2011). Prepubertal ethanol exposure alters hypothalamic transforming growth factor- and erbB1 receptor signaling in the female rat. ALCOHOL. 45(2), 173-181. Srivastava, V. K., Hiney, J. K., Mattison, J. A., Bartke, A., & Dees, W. L. (2007). The alcohol-induced suppression of ovarian insulin-like growth factor-1 gene transcription is independent of growth hormone and its receptor. Alcoholism: Clinical and Experimental Research. 31(5), 880-886. Srivastava, V. K., Dissen, G. A., Ojeda, S. R., Hiney, J. K., Pine, M. D., & Dees, W. L. (2007). Effects of alcohol on intraovarian nitric oxide synthase and steroidogenic acute regulatory protein in the prepubertal female rhesus monkey. 68(2), 182-191. Lee, B., Hiney, J. K., Pine, M. D., Srivastava, V. K., & Dees, W. L. (2007). Manganese stimulates luteinizing hormone releasing hormone secretion in prepubertal female rats: hypothalamic site and mechanism of action. 578(Pt 3), 765-772. Lee, B., Pine, M., Johnson, L., Rettori, V., Hiney, J. K., & Dees, W. L. (2006). Manganese acts centrally to activate reproductive hormone secretion and pubertal development in male rats. Reproductive Toxicology. 22(4), 580-585. Dees, W. L., Hiney, J. K., McArthur, N. H., Johnson, G. A., Dissen, G. A., & Ojeda, S. R. (2006). Origin and ontogeny of mammalian ovarian neurons. 147(8), 3789-3796. Pine, M. D., Hiney, J. K., Dearth, R. K., Bratton, G. R., & Dees, W. L. (2006). IGF-1 administration to prepubertal female rats can overcome delayed puberty caused by maternal Pb exposure. 21(1), 104-109. Lee, B., Pine, M., Johnson, L., Rettori, V., Hiney, J. K., & Dees, W. L. (2006). Manganese acts centrally to activate reproductive hormone secretion and pubertal development in male rats. Reproductive Toxicology. 22(4), 580-585. Srivastava, V. K., Vijayan, E., Hiney, J. K., & Dees, W. L. (2005). Effect of ethanol on follicle stimulating hormone-induced steroidogenic acute regulatory protein (StAR) in cultured rat granulosa cells. ALCOHOL. 37(2), 105-111. Pine, M., Lee, B., Dearth, R., Hiney, J. K., & Dees, W. L. (2005). Manganese acts centrally to stimulate luteinizing hormone secretion: a potential influence on female pubertal development. TOXICOLOGICAL SCIENCES. 85(2), 880-885. Dees, W. L., Srivastava, V. K., & Hiney, J. K. (2005). Alcohol alters insulin-like growth factor-1 activated oct 2 POU domain gene expression in the immature female hypothalamus. Journal of Studies on Alcohol and Drugs. 66(1), 35-45. Hiney, J. K., Srivastava, V., Dearth, R. K., & Dees, W. L. (2004). Influence of estradiol on insulin-like growth factor-1-induced luteinizing hormone secretion. BRAIN RESEARCH. 1013(1), 91-97. Dearth, R. K., Hiney, J. K., Srivastava, V., Les Dees, W., & Bratton, G. R. (2004). Low level lead (Pb) exposure during gestation and lactation: assessment of effects on pubertal development in Fisher 344 and Sprague-Dawley female rats. LIFE SCIENCES. 74(9), 1139-1148. Srivastava, V., Dearth, R. K., Hiney, J. K., Ramirez, L. M., Bratton, G. R., & Dees, W. L. (2004). The effects of low-level Pb on steroidogenic acute regulatory protein (StAR) in the prepubertal rat ovary. TOXICOLOGICAL SCIENCES. 77(1), 35-40. Hiney, J. K., Dearth, R. K., Srivastava, V., Rettori, V., & Dees, W. L. (2003). Actions of ethanol on epidermal growth factor receptor activated luteinizing hormone secretion. Journal of Studies on Alcohol and Drugs. 64(6), 809-816. Nahm, S., Frank, T. C., Browning, M. D., Sepulvado, J. M., Hiney, J. K., & Abbott, L. C. (2003). Insulin-like growth factor-I improves cerebellar dysfunction but does not prevent cerebellar neurodegeneration in the calcium channel mutant mouse, leaner. NEUROBIOLOGY OF DISEASE. 14(2), 157-165. Srivastava, V. K., Dearth, R. K., Hiney, J. K., Chandrashekar, V., Mattison, J. A., Bartke, A., & Dees, W. L. (2002). Alcohol suppresses insulin-like growth factor-1 gene expression in prepubertal transgenic female mice overexpressing the bovine growth hormone gene. Alcoholism: Clinical and Experimental Research. 26(11), 1697-1702. Dearth, R. K., Hiney, J. K., Srivastava, V., Burdick, S. B., Bratton, G. R., & Dees, W. L. (2002). Effects of lead (Pb) exposure during gestation and lactation on female pubertal development in the rat. Reproductive Toxicology. 16(4), 343-352. Hiney, J. K., Sower, S. A., Yu, W. H., McCann, S. M., & Dees, W. L. (2002). Gonadotropin-releasing hormone neurons in the preoptic-hypothalamic region of the rat contain lamprey gonadotropin-releasing hormone III, mammalian luteinizing hormone-releasing hormone, or both peptides. Proceedings of the National Academy of Sciences of USA. 99(4), 2386-2391. Srivastava, V. K., Hiney, J. K., Dearth, R. K., & Les Dees, W. (2002). Chronic effects of prepubertal ethanol administration on steroidogenic acute regulatory protein in the rat ovary. Alcoholism: Clinical and Experimental Research. 26(1), 107-113. Dees, W. L., Srivastava, V. K., & Hiney, J. K. (2001). Alcohol and female puberty: the role of intraovarian systems. Alcohol research : current reviews. 25(4), 271-275. Srivastava, V. K., Hiney, J. K., Dearth, R. K., & Les Dees, W. (2001). Acute effects of ethanol on steroidogenic acute regulatory protein (StAR) in the prepubertal rat ovary. 25(10), 1500-1505. Dees, W. L., Dissen, G. A., Hiney, J. K., Lara, F., & Ojeda, S. R. (2000). Alcohol ingestion inhibits the increased secretion of puberty-related hormones in the developing female rhesus monkey. ENDOCRINOLOGY. 141(4), 1325-1331. Dearth, R. K., Hiney, J. K., & Dees, W. L. (2000). Leptin acts centrally to induce the prepubertal secretion of luteinizing hormone in the female rat. Peptides. 21(3), 387-392. Dees, W. L., Dissen, G. A., Hiney, J. K., Lara, F., & Ojeda, S. R. (2000). Alcohol ingestion inhibits the increased secretion of puberty-related hormones in the developing female rhesus monkey. ENDOCRINOLOGY. 141(4), 1325-1331. Srivastava, V., Hiney, J. K., Nyberg, C. L., & Dees, W. L. (1995). Effect of ethanol on the synthesis of insulin-like growth factor 1 (IGF-1) and the IGF-1 receptor in late prepubertal female rats: a correlation with serum IGF-1. Alcoholism: Clinical and Experimental Research. 19(6), 1467-1473. DEES, W. L., HINEY, J. K., SCHULTEA, T. D., MAYERHOFER, A., DANILCHIK, M., DISSEN, G. A., & OJEDA, S. R. (1995). THE PRIMATE OVARY CONTAINS A POPULATION OF CATECHOLAMINERGIC NEURON-LIKE CELLS EXPRESSING NERVE GROWTH-FACTOR RECEPTORS. ENDOCRINOLOGY. 136(12), 5760-5768. Dees, W. L., Hiney, J. K., Schultea, T. D., Mayerhofer, A., Danilchik, M., Dissen, G. A., & Ojeda, S. R. (1995). The primate ovary contains a population of catecholaminergic neuron-like cells expressing nerve growth factor receptors. ENDOCRINOLOGY. 136(12), 5760-5768. NYBERG, C. L., SRIVASTAVA, V., HINEY, J. K., LARA, F., & DEES, W. L. (1995). N-METHYL-D-ASPARTIC ACID RECEPTOR MESSENGER-RIBONUCLEIC-ACID LEVELS AND LUTEINIZING-HORMONE RELEASE IN IMMATURE FEMALE RATS - EFFECTS OF STAGE OF PUBERTAL DEVELOPMENT AND EXPOSURE TO ETHANOL. ENDOCRINOLOGY. 136(7), 2874-2880. Nyberg, C. L., Srivastava, V., Hiney, J. K., Lara, F., & Dees, W. L. (1995). N-methyl-D-aspartic acid receptor messenger ribonucleic acid levels and luteinizing hormone release in immature female rats: effects of stage of pubertal development and exposure to ethanol. ENDOCRINOLOGY. 136(7), 2874-2880. Berg-von der Emde, K., Dees, W. L., Hiney, J. K., Hill, D. F., Dissen, G. A., Costa, M. E., Moholt-Siebert, M., & Ojeda, S. R. (1995). Neurotrophins and the neuroendocrine brain: different neurotrophins sustain anatomically and functionally segregated subsets of hypothalamic dopaminergic neurons. The Journal of Neuroscience. 15(6), 4223-4237. Rettori, V., Dees, W. L., Hiney, J. K., Lyson, K., & McCann, S. M. (1994). An interleukin-1-alpha-like neuronal system in the preoptic-hypothalamic region and its induction by bacterial lipopolysaccharide in concentrations which alter pituitary hormone release. 1(4), 251-258. Bratton, G. R., Hiney, J. K., & Dees, W. L. (1994). Lead (Pb) alters the norepinephrine-induced secretion of luteinizing hormone releasing hormone from the median eminence of adult male rats in vitro. LIFE SCIENCES. 55(8), 563-571. Nyberg, C. L., Hiney, J. K., Minks, J. B., & Dees, W. L. (1993). Ethanol alters N-methyl-DL-aspartic acid-induced secretion of luteinizing hormone releasing hormone and the onset of puberty in the female rat. 57(5), 863-868. Lara, H. E., Dees, W. L., Hiney, J. K., Dissen, G. A., Rivier, C., & Ojeda, S. R. (1991). Functional recovery of the developing rat ovary after transplantation: contribution of the extrinsic innervation. ENDOCRINOLOGY. 129(4), 1849-1860. Hiney, J. K., Ojeda, S. R., & Dees, W. L. (1991). Insulin-like growth factor I: a possible metabolic signal involved in the regulation of female puberty. Neuroendocrinology: international journal for basic and clinical studies on neuroendocrine relationships. 54(4), 420-423. Hiney, J. K., & Dees, W. L. (1991). Ethanol inhibits luteinizing hormone-releasing hormone release from the median eminence of prepubertal female rats in vitro: investigation of its actions on norepinephrine and prostaglandin-E2. ENDOCRINOLOGY. 128(3), 1404-1408. Gonzalez, D., Dees, W. L., Hiney, J. K., Ojeda, S. R., & Saneto, R. P. (1990). Expression of beta-nerve growth factor in cultured cells derived from the hypothalamus and cerebral cortex. 511(2), 249-258. Dees, W. L., Skelley, C. W., Hiney, J. K., & Johnston, C. A. (1990). Actions of ethanol on hypothalamic and pituitary hormones in prepubertal female rats. ALCOHOL. 7(1), 21-25. Dees, W. L., Hiney, J. K., Fuentes, F., & Forrest, D. W. (1990). Ethanol alters vasoactive intestinal peptide-induced steroid release from immature rat ovaries in vitro. LIFE SCIENCES. 46(3), 165-172. chapter Dees, W. L., Hiney, J. K., & Srivastava, V. K. (2018). Complimentary Methods for Assessing Hypothalamic Actions of Manganese During Pubertal Development. Methods in Pharmacology and Toxicology. (pp. 1-12). Springer Nature. Dees, W. L., Hiney, J. K., & Srivastava, V. K. (2014). Chapter 17 The Effects of Manganese on Female Pubertal Development. Manganese in Health and Disease. (pp. 437-458). Royal Society of Chemistry (RSC). Les Dees, W., Hiney, J. K., Dearth, R. K., & Srivastava, V. K. (2004). Use of Complimentary In Vitro and In Vivo Methods for Assessing Neuroendocrine Disruptors. In Vitro Neurotoxicology. (pp. 267-289). Springer Nature. Dees, W. L., Nyberg, C. L., & Hiney, J. K. (1995). Neuroendocrine Responses to Ethanol in the Prepubertal Female Rat. Alcohol and Hormones. (pp. 49-74). Springer Nature. conference paper Srivastava, V. K., Hiney, J. K., & Dees, W. L. (2018). ALCOHOL ALTERS THE SYNTHESIS OF KEY HYPOTHALAMIC NEUROMODULATORS ASSOCIATED WITH THE ONSET OF MAMMALIAN PUBERTAL DEVELOPMENT. Alcoholism: Clinical and Experimental Research. 211A-211A. Hiney, J. K., Srivastava, V. K., & Dees, W. L. (2017). ALCOHOL ALTERS THE IGF-1 STIMULATION OF KISSPEPTIN VIA THE INSULIN RECEPTOR SUBSTRATE-1/AKT/MTOR COMPLEX 1 SIGNALING PATHWAY. Alcoholism: Clinical and Experimental Research. 198A-198A. Srivastava, V. K., Hiney, J. K., & Dees, W. L. (2017). EFFECTS OF ALCOHOL ON SPECIFIC SIGNALING PROTEINS INVOLVED IN THE REGULATION OF THE MTOR/KISSPEPTIN PATHWAY IN THE HYPOTHALAMUS OF PREPUBERTAL FEMALE. Alcoholism: Clinical and Experimental Research. 198A-198A. Hamilton, A. M., Srivastava, V., Hiney, J. K., Dees, W. L., & Dearth, R. K. (2016). Utilizing The Novel Manganese-Induced Precocious Puberty Rat Model Identifies Progesterone Receptor as an Important Mediator Between Female Puberty and Breast Cancer. The FASEB Journal. Srivastava, V. K., Hiney, J. K., & Dees, W. L. (2014). EFFECTS OF ALCOHOL ON KEY HYPOTHALAMIC GENES CONTROLLING THE ONSET OF PUBERTY. Alcoholism: Clinical and Experimental Research. 152A-152A. Hiney, J. K., Srivastava, V. K., & Dees, W. L. (2012). ALCOHOL ALTERS INSULIN-LIKE GROWTH FACTOR-1 IGF-1 AND IGF-1/ESTRADIOL INDUCED TRANSFORMING GROWTH FACTOR beta 1 RELEASE FROM HYPOTHALAMIC ASTROCYTES. Alcoholism: Clinical and Experimental Research. 264A-264A. Srivastava, V. K., Hiney, J. K., Pine, M. D., & Dees, W. L. (2008). Actions and interactions of insulin-like growth factor-1 and alcohol on KISS-1 gene expression in juvenile female rats. Alcoholism: Clinical and Experimental Research. 20A-20A. Dees, W. L., Srivastava, V. K., Pine, M., & Hiney, J. K. (2007). Actions of alcohol and IGF-1 during female pubertal development. Alcoholism: Clinical and Experimental Research. 294A-294A. Srivastava, V. K., Hiney, J. K., Pine, M. D., & Dees, W. L. (2007). Effects of alcohol on the intraovarian insulin-like growth factor-1 in the prepubertal rhesus monkeys. Alcoholism: Clinical and Experimental Research. 335A-335A. Srivastava, V. K., Hiney, J. K., Pine, M. D., & Dees, W. L. (2006). Effects of alcohol on intraovarian systems in prepubertal female rhesus monkeys. Alcoholism: Clinical and Experimental Research. 75A-75A. Pine, M., Hiney, J. K., Lee, B., & Dees, W. L. (2005). Alcohol and puberty-related hormones: A protective effect of manganese. Alcoholism: Clinical and Experimental Research. 55A-55A.
investigator on Neuroendocrine Effects of Alcohol on Puberty- awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2015 - 2020
teaching activities BIMS481 Seminar In Biomed Sci Instructor BIMS485 Directed Studies Instructor BIMS491 Research Instructor VIBS305 Biomedical Anatomy Instructor VIBS485 Directed Studies Instructor VIBS685 Directed Studies Instructor
education and training Ph.D. in Veterinary Anatomy, Texas A&M University - (College Station, Texas, United States) 1996 M.S. in Veterinary Anatomy, Texas A&M University - (College Station, Texas, United States) 1990 B.S. in Animal Science, Texas A&M University - (College Station, Texas, United States) 1986
mailing address Texas A&M University Veterinary Integrative Biosciences 4458 TAMU College Station, TX 77843-4458 USA