HR job title
- Associate Professor
- Contact Info
- 1 979 845 7990
- Websites
Trache, Andreea Associate Professor
Positions
- Associate Professor, Medical Physiology, Texas A&M University Naresh K. Vashisht College of Medicine
The research in my laboratory focuses on the study of cellular responses to mechano-chemical stresses from a biophysical perspective. Biophysics research represents an applied field of science at the interface of physics, biology, engineering, and medicine. Our lab uses live vascular cells as a model system because endothelial and smooth muscle cells reside 'in vivo' in a mechanically active environment that is continuously changing. Using real-time imaging of live cells is the only way to directly monitor cellular responses to mechano-chemical stimulation. Moreover, single-cell imaging experiments allow discrete measurements of transient microscopic events that may be masked by a macroscopic average behavior, and will aid in understanding such behavior.
- Overview
- Publications
- Research
- Teaching
- Works By Students
- Background
- Contact
- Other
- View All
Overview
Publications
selected publications
-
academic article
-
Ojha, K. R., Kim, H., Padgham, S., Hopkins, L., Zamen, R. J., Chattopadhyay, A., ... Trache, A.
(2023).
Smooth Muscle-Alpha Actin R149C Pathogenic Variant Downregulates Integrin Recruitment at Cell-Matrix Adhesions and Decreases Cellular Contractility. 24(11), 9616-9616.
-
Ni, H., Ni, Q., Papoian, G. A., Trache, A., & Jiang, Y. i.
(2023).
Myosin and alpha-actinin regulation of stress fiber contractility under tensile stress. Scientific Reports.
13(1), 8662-8662.
-
Mohajeri, A., Padgham, S., Woodman, C., & Trache, A.
(2023).
Stretch-induced mechanical stimulation effects on vascular smooth muscle contractility in aged resistance arteries. Physiology.
38(S1), 5795299.
-
Shin, S. Y., Ojha, K. R., Padgham, S., Trache, A., & Woodman, C.
(2022).
Aging Alters Integrinmediated Vascular Smooth Muscle Function in Soleus Feed Arteries. The FASEB Journal.
36(S1),
-
Ojha, K. R., Shin, S. Y., Padgham, S., Leon Olmedo, F., Guo, B., Han, G., Woodman, C., & Trache, A.
(2022).
Age-Associated Dysregulation of Integrin Function in Vascular Smooth Muscle. Frontiers in Physiology.
13, 913673.
-
Bywaters, B. C., Pedraza, G., Trache, A., & Rivera, G. M.
(2022).
Endothelial NCK2 promotes atherosclerosis progression in male but not female Nck1-null atheroprone mice. Frontiers in Cardiovascular Medicine.
9, 955027.
-
Shin, S. Y., Woodman, C., & Trache, A.
(2021).
Effects of Aging on IntegrinMediated Vascular Smooth Muscle Contractility in Soleus Muscle Feed Arteries. The FASEB Journal.
35(S1),
-
Li, X., Ni, Q., He, X., Kong, J., Lim, S., Papoian, G. A., ... Jiang, Y. i.
(2020).
Tensile force-induced cytoskeletal remodeling: Mechanics before chemistry. PLoS Computational Biology.
16(6), e1007693-e1007693.
-
Massett, M. P., Bywaters, B. C., Gibbs, H. C., Trzeciakowski, J. P., Padgham, S., Chen, J., ... Trache, A.
(2020).
Loss of smooth muscle -actin effects on mechanosensing and cell-matrix adhesions. Experimental Biology and Medicine.
245(4), 374-384.
-
Shin, S. Y., Trache, A., & Woodman, C.
(2019).
Integrinmediated Vasoconstrictor Function Declines with Age in Skeletal Muscle Resistance Arteries. The FASEB Journal.
33(S1), 518.4-518.4.
-
Woodman, C. R., Seawright, J. W., Luttrell, M. J., Shin, S. Y., & Trache, A.
(2018).
Importance of mechanical signals in promoting exercise-induced improvements in vasomotor function of aged skeletal muscle resistance arteries. American Journal of Physiology. Heart and Circulatory Physiology.
315(3), H602-H609.
-
Seawright, J. W., Sreenivasappa, H., Gibbs, H. C., Padgham, S., Shin, S. Y., Chaponnier, C., ... Trache, A.
(2018).
Vascular Smooth Muscle Contractile Function Declines With Age in Skeletal Muscle Feed Arteries. Frontiers in Physiology.
9, 856.
-
Seawright, J. W., Luttrell, M., Trache, A., & Woodman, C. R.
(2016).
Short-term increases in pressure and shear stress attenuate age-related declines in endothelial function in skeletal muscle feed arteries. European Journal of Applied Physiology.
116(7), 1305-1311.
-
Seawright, J. W., Trache, A., Wilson, E., & Woodman, C. R.
(2016).
Short-duration increases in intraluminal pressure improve vasoconstrictor responses in aged skeletal muscle feed arteries. European Journal of Applied Physiology.
116(5), 931-937.
-
Sreenivasappa, H., Chaki, S. P., Lim, S., Trzeciakowski, J. P., Davidson, M. W., Rivera, G. M., & Trache, A.
(2014).
Selective regulation of cytoskeletal tension and cell-matrix adhesion by RhoA and Src. Integrative Biology: interdisciplinary approaches for molecular and cellular life sciences.
6(8), 743-754.
-
Papke, C. L., Cao, J., Kwartler, C. S., Villamizar, C., Byanova, K. L., Lim, S., ... Milewicz, D. M.
(2013).
Smooth muscle hyperplasia due to loss of smooth muscle -actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-. Human Molecular Genetics.
22(15), 3123-3137.
-
Chaki, S. P., Barhoumi, R., Berginski, M. E., Sreenivasappa, H., Trache, A., Gomez, S. M., & Rivera, G. M.
(2013).
Nck enables directional cell migration through the coordination of polarized membrane protrusion with adhesion dynamics. Journal of Cell Science.
126(Pt 7), 1637-1649.
-
Lim, S., Trzeciakowski, J. P., Sreenivasappa, H., Dangott, L. J., & Trache, A.
(2012).
RhoA-induced cytoskeletal tension controls adaptive cellular remodeling to mechanical signaling. Integrative Biology: interdisciplinary approaches for molecular and cellular life sciences.
4(6), 615-627.
-
Hayenga, H. N., Trache, A., Trzeciakowski, J., & Humphrey, J. D.
(2011).
Regional atherosclerotic plaque properties in ApoE-/- mice quantified by atomic force, immunofluorescence, and light microscopy. Journal of Vascular Research.
48(6), 495-504.
-
Lim, S., Trzeciakowski, J. P., & Trache, A.
(2011).
Effect of Tensile Stress on Smooth Muscle Cells. Biophysical Journal.
100(3), 447a-447a.
-
Lim, S., Kreipe, B. A., Trzeciakowski, J., Dangott, L., & Trache, A.
(2010).
Extracellular matrix effect on RhoA signaling modulation in vascular smooth muscle cells. Experimental Cell Research.
316(17), 2833-2848.
-
Trache, A., & Lim, S.
(2010).
Live cell response to mechanical stimulation studied by integrated optical and atomic force microscopy. Journal of Visualized Experiments.
2072.
-
Trache, A., Trzeciakowski, J. P., & Meininger, G. A.
(2010).
Mg2+ modulates integrin-extracellular matrix interaction in vascular smooth muscle cells studied by atomic force microscopy. Journal of Molecular Recognition.
23(3), 316-321.
-
Trache, A., & Lim, S.
(2009).
Integrated microscopy for real-time imaging of mechanotransduction studies in live cells. Journal of Biomedical Optics.
14(3), 034024-1.
-
Na, S., Trache, A., Trzeciakowski, J., Sun, Z., Meininger, G. A., & Humphrey, J. D.
(2008).
Time-dependent changes in smooth muscle cell stiffness and focal adhesion area in response to cyclic equibiaxial stretch. Annals of Biomedical Engineering.
36(3), 369-380.
-
Trache, A.
(2007).
Integrated Imaging Techniques Applied to Live Cell Biophysics. jmd1-jmd1.
-
Hawkins, D. M., Trache, A., Ellis, E. A., Stevenson, D., Holzenburg, A., Meininger, G. A., & Reddy, S. M.
(2006).
Quantification and confocal imaging of protein specific molecularly imprinted polymers. Biomacromolecules.
7(9), 2560-2564.
-
Chowdhury, M. H., Gant, V. A., Trache, A., Baldwin, A., Meininger, G. A., & Cot, G. L.
(2006).
Use of surface-enhanced Raman spectroscopy for the detection of human integrins. Journal of Biomedical Optics.
11(2), 024004-024004.
-
Sun, Z., Martinez-Lemus, L. A., Trache, A., Trzeciakowski, J. P., Davis, G. E., Pohl, U., & Meininger, G. A.
(2005).
Mechanical properties of the interaction between fibronectin and alpha5beta1-integrin on vascular smooth muscle cells studied using atomic force microscopy. American Journal of Physiology. Heart and Circulatory Physiology.
289(6), H2526-H2535.
-
Trache, A., & Meininger, G. A.
(2005).
Atomic force-multi-optical imaging integrated microscope for monitoring molecular dynamics in live cells. Journal of Biomedical Optics.
10(6), 064023-064023.
-
Trache, A., Trzeciakowski, J. P., Gardiner, L., Sun, Z., Muthuchamy, M., Guo, M., Yuan, S. Y., & Meininger, G. A.
(2005).
Histamine effects on endothelial cell fibronectin interaction studied by atomic force microscopy. Biophysical Journal.
89(4), 2888-2898.
-
Martinez-Lemus, L. A., Sun, Z., Trache, A., Trzciakowski, J. P., & Meininger, G. A.
(2005).
Integrins and regulation of the microcirculation: from arterioles to molecular studies using atomic force microscopy. Microcirculation.
12(1), 99-112.
-
Tong, C. W., Kolomenskii, A., Lioubimov, V. A., Schuessler, H. A., Trache, A., Granger, H. J., & Muthuchamy, M.
(2001).
Measurements of the cross-bridge attachment/detachment process within intact sarcomeres by surface plasmon resonance. Biochemistry.
40(46), 13915-13924.
-
Dinca, A., Miclea, P. T., Lupei, V., Skettrup, T., & Dinca, M.
(1998).
Multiple solutions provided by analytical synthesis in admittance matching; application to dichroic mirrors. Journal of Modern Optics.
45(3), 605-618.
-
Dinca, A., Trifan, M. E., Lupei, V., & Dinca, M. P.
(1996).
Admittance-matched interference polarizers. Journal of Modern Optics.
43(8), 1615-1620.
-
Dinca, A., Trifan, M. E., Lupei, V., & Dinca, M. P.
(1996).
Variable reflectivity mirrors with all profiled layers. Optics Communications.
127(4-6), 176-182.
-
Dinca, A., Trifan, M. E., Lupei, V., & Dinca, M.
(1996).
Dichroic mirror design by complete admittance matching. Optical Engineering.
35(5), 1284-1287.
-
DINCA, A., LUPEI, V., & DINCA, M. P.
(1994).
DESIGN OF GRADED REFLECTIVITY MIRRORS FOR YAG ND LASERS. Proceedings of SPIE.
2206, 554-562.
-
Trache, A., & Lim, S.
Live Cell Response to Mechanical Stimulation Studied by Integrated Optical and Atomic Force Microscopy. Journal of Visualized Experiments.
-
Ojha, K. R., Kim, H., Padgham, S., Hopkins, L., Zamen, R. J., Chattopadhyay, A., ... Trache, A.
(2023).
Smooth Muscle-Alpha Actin R149C Pathogenic Variant Downregulates Integrin Recruitment at Cell-Matrix Adhesions and Decreases Cellular Contractility. 24(11), 9616-9616.
-
chapter
-
Trache, A., Massett, M. P., & Woodman, C. R.
(2020).
Vascular smooth muscle stiffness and its role in aging. Current Topics in Membranes.
MEMBRANE BIOMECHANICS.
(pp. 217-253).
Elsevier.
-
Trache, A., Xie, L., Huang, H., Glinsky, V. V., & Meininger, G. A.
(2018).
Applications of Atomic Force Microscopy for Adhesion Force Measurements in Mechanotransduction. Methods in molecular biology (Clifton, N.J.).
NANOSCALE IMAGING: METHODS AND PROTOCOLS.
(pp. 515-528).
Springer Nature.
-
Sun, Z., Trache, A., Meissner, K., & Meininger, G. A.
(2012).
Integration of AFM with Optical Microscopy Techniques. Atomic Force Microscopy in Liquid.
(pp. 211-229).
Wiley.
-
Trache, A., & Meininger, G. A.
(2008).
Total internal reflection fluorescence (TIRF) microscopy. Current protocols in microbiology.
(pp. Unit 2A.2.1-2A.2.22-2a.2.22).
Wiley.
-
Trache, A., & Meininger, G. A.
(2008).
Atomic force microscopy (AFM). Current protocols in microbiology.
(pp. Unit-2C.2).
Wiley.
-
Trache, A., Massett, M. P., & Woodman, C. R.
(2020).
Vascular smooth muscle stiffness and its role in aging. Current Topics in Membranes.
MEMBRANE BIOMECHANICS.
(pp. 217-253).
Elsevier.
-
conference paper
-
Ojha, K. R., Kim, H., Padgham, S., Hopkins, L., Chattopadhyay, A., Han, G., ... Trache, A.
(2023).
Contractility and adhesion to the matrix is impaired in vascular smooth muscle from Acta2 R149C mice. Molecular Biology of the Cell.
317-317.
-
Ni, H., Ni, Q., Papoian, G. A., Jiang, Y., & Trache, A.
(2023).
Mechanochemical simulation of stress fiber. Molecular Biology of the Cell.
877-877.
-
Ojha, K. R., Padgham, S., Shin, S. Y., Woodman, C. R., & Trache, A.
(2022).
LPA effect on integrin recruitment and actin remodeling in aged vascular smooth muscle cells. Biophysical Journal.
491A-492A.
-
Li, X., Ni, Q., He, X., Kong, J., Lim, S., Papoian, G. A., ... Jiang, Y. i.
(2022).
Tensile force-induced cytoskeletal remodeling: mechanics before chemistry. Biophysical Journal.
519A-519A.
-
Shin, S., Seawright, J., Trache, A., & Woodman, C.
(2020).
Effect of Aging on Vascular Smooth Muscle Myogenic Contractility in Soleus Muscle Feed Arteries. The FASEB Journal.
1-1.
-
Sreenivasappa, H., Bywaters, B., Padgham, S., Shin, S. Y., Trzeciakowski, J. P., Woodman, C. R., & Trache, A.
(2019).
Aging Alters Functional Properties of Cell-Matrix Adhesions in Vascular Smooth Muscle Cells. Biophysical Journal.
261A-261A.
-
Trache, A., Sreenivasappa, H., Padgham, S., Shin, S., Trzeciakowski, J., & Woodman, C.
(2019).
Vascular smooth muscle cells: Key players in arterial aging. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
-
Woodman, C., Seawright, J., Shin, S. Y., & Trache, A.
(2017).
Effect of aging on vascular smooth muscle contractility in skeletal muscle resistance arteries. The FASEB Journal.
705.8-705.8.
-
Shin, S. Y., Seawright, J., Trache, A., & Woodman, C.
(2017).
Exercise-like mechanical stimulation improves myogenic responses in aged skeletal muscle resistance arteries. The FASEB Journal.
-
Massett, M. P., Gibbs, H., Padgham, S., Sreenivasappa, H., Chen, J., Yeh, A., Milewicz, D. M., & Trache, A.
(2017).
Matrix remodeling and stress relaxation are impaired in vascular smooth muscle from Acta2-/mice. Molecular Biology of the Cell.
-
Sreenivasappa, H., Lim, S., Trzeciakowski, J. P., Davidson, M. W., & Trache, A.
(2014).
Extracellular matrix modulates mechanical characteristics of cell-matrix adhesions. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
-
Sreenivasappa, H., Chaki, S. P., Lim, S., Trzeciakowski, J. P., Davidson, M. W., Rivera, G. M., & Trache, A.
(2014).
Functional coupling between adhesion strength and cell stiffness depends on cytoskeletal tension modulation. Molecular Biology of the Cell.
-
Sreenivasappa, H., Lim, S., Chaki, S., Trzeciakowski, J. P., Davidson, M. W., Rivera, G., & Trache, A.
(2013).
RhoA-src crosstalk modulates cell stiffness and adhesion to the matrix. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
-
Sreenivasappa, H., Lim, S., Trzeciakowski, J. P., Rivera, G., Davidson, M. W., & Trache, A.
(2012).
Effect of cytoskeletal tension on vascular smooth muscle cell adhesion. Molecular Biology of the Cell.
-
Trache, A.
(2012).
From ligand-receptor interaction to whole cell manipulation using atomic force microscopy. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
-
Sreenivasappa, H., Lim, S., Trzeciakowski, J. P., Rivera, G., Davidson, M., & Trache, A.
(2012).
Modulation of Integrin-Extracellular Matrix Adhesions by RhoA and Src. Biophysical Journal.
177A-177A.
-
Lim, S., Trzeciakowski, J., Sreenivasappa, H., & Trache, A.
(2011).
Cytoskeletal tension modulates cellular responses to mechanical stimuli. Molecular Biology of the Cell.
-
Trache, A.
(2011).
Real-time mechanically-induced cellular remodeling. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
-
Lim, S., Trzeciakowski, J., & Trache, A.
(2010).
Mechanically Induced Cell Signaling Stimulates Real-Time Cytoskeleton Remodeling. Biophysical Journal.
190A-190A.
-
Trache, A., & Lim, S.
(2009).
Force Transduction In Smooth Muscle Cells. Biophysical Journal.
397A-397A.
-
Bridenbaugh, E. A., Chowdury, U., Jamroz, R. C., Trache, A., Gashev, A. A., & Zawieja, D. C.
(2005).
Upregulated expression of immune function genes in rat lymphatic vessels. The FASEB Journal.
A167-A167.
-
Sun, Z., Trzeciakowski, J. P., Martinez, L. A., Trache, A., & Meininger, G. A.
(2004).
Application of force with an atomic force microscope to a fibronectin - Alpha5 betal integrin focal contact in vascular smooth muscle cells (VSMC) induces a force generating response. Biophysical Journal.
389A-389A.
-
Trache, A., Trzeciakowski, J., Gant, A., Cote, G., Sun, Z., Wilson, E., & Meininger, G. A.
(2004).
Influence of cell stiffness on adhesion force between 51 integrin and fibronectin in intact cells using atomic force microscopy. Biophysical Journal.
477A-477A.
-
Sun, Z., Martinez, L. A., Trache, A., Trzeciakowski, J. P., & Meminger, G. A.
(2004).
Vascular smooth muscle cells (VSMC) mechanically respond to application of force to the fibronectin-51 integrin bond. The FASEB Journal.
A655-A655.
-
Trache, A., Reeves, L., Sun, Z., Guo, M., Wilson, E., Yuan, S., & Meininger, G. A.
(2003).
Demonstration of differences in adhesion to fibronectin (FN) after histamine (HIST) in endothelial cells using the atomic force microscope (AFM). Biophysical Journal.
470A-470A.
-
Reeves, L., Trache, A., Sun, Z., Gu, M. Z., Yuan, S., & Meininger, G. A.
(2003).
Demonstration of differences in adhesion to fibronectin (FN)after histamine (HIST) in endothelial cells using the atomic force microscope (AFM). The FASEB Journal.
A1246-A1246.
-
Sarin, V., Gaffin, R., Trache, A., Muthuchamy, M., & Meininger, G.
(2003).
Inhibition of cardiac contractility by RGD-dependent integrins. The FASEB Journal.
A848-A848.
-
Sun, Z., Trache, A., Pohl, U., & Meininger, G. A.
(2003).
Regulation of fibronectin (FN) adhesion to vascular smooth muscle (VSM) 5l integrin:: a study using atomic force microscopy (AFM). Biophysical Journal.
470A-470A.
-
Morton, D. E., & Dinca, A.
(1999).
Ion-assisted deposition of E-gun evaporated ITO films at low substrate temperatures. Proceedings of the Annual Technical Conference- Society of Vacuum Coaters.
250-254.
-
Dinca, A., Lupei, V., & Dinca, M.
(1998).
Interferential filter design with continuously variable refractive index. Proceedings of SPIE.
1173-1177.
-
Dinca, A., Miclea, P., Lupei, V., & Dinca, M.
(1998).
On the solutions of the single layer synthesis with symmetrical three layer periods. Proceedings of SPIE.
1162-1166.
-
Dinca, A., Dinca, M., & Lupei, V.
(1997).
Dielectric mirrors coating of the active medium for diode pumped Erbium laser. Proceedings of SPIE.
203-212.
-
Dinca, A., Lupei, V., Miclea, P. T., & Dinca, M. P.
(1996).
Dichroic mirror for high power Nd:YAG laser. Proceedings of SPIE.
418-427.
-
Dinca, A., Trifan, M. E., Lupei, V., Skettrup, T., & Dinca, M. P.
(1996).
Dichroic mirror for diode pumped YAG:Nd laser. Proceedings of SPIE.
262-269.
-
DINCA, A.
(1995).
EDGE FILTERS WITH THIN DIELECTRIC LAYERS. Proceedings of SPIE.
588-590.
-
Trache, A., Lupei, V., & Dinca, M. P.
(1994).
Design of broadband dichroic mirrors using admittance matching. Proceedings of SPIE.
120-129.
-
Trache, A., Lupei, V., & Dinca, M. P.
(1994).
Design of graded-reflectivity mirrors using rotating masks. Proceedings of SPIE.
130-139.
-
Trache, A., Lupei, V., & Dinca, M. P.
(1994).
Thin films for variable reflectance laser mirrors. Proceedings of SPIE.
196-204.
-
Ojha, K. R., Kim, H., Padgham, S., Hopkins, L., Chattopadhyay, A., Han, G., ... Trache, A.
(2023).
Contractility and adhesion to the matrix is impaired in vascular smooth muscle from Acta2 R149C mice. Molecular Biology of the Cell.
317-317.
Research
principal investigator on
- Integrins as regulators of vascular contractility in aged resistance arteries awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2019 - 2021
- Cytoskeleton remodeling regulates contractile function and mechanosensing in vascular smooth muscle awarded by American Heart Association - (New York, New York, United States) 2018 - 2021
- Career: Integrated Scanning and Optical Imaging Techniques To Enable Understanding of Live Cell Dynamics-From Molecular Biology awarded by National Science Foundation - (Arlington, Virginia, United States) 2008 - 2015
Teaching
teaching activities
- BMEN491 Hnr-research Instructor
- BMEN491 Hnr-research Instructor
- BMEN691 Research Instructor
- MPHY603 Applied Microscopy Biomed Res Instructor
- MSCI612 Current Tpcs In Cell Signaling Instructor
- MSCI689 Sptp:appl Microsc Biomed Res Instructor
- MSCI691 Research Credit: Medical Sci Instructor
Works By Students
chaired theses and dissertations
-
Sreenivasappa, Harini Bytaraya (2014-12). Mechanical Signaling Induced Cellular Remodeling Studied By Integrated Optical And Atomic Force Microscopy.
Background
education and training
- Ph.D. in Physics, Institutul de Fizica Atomica - (MÄgurele, Romania) 1996
- B.S. in Physics, University of Bucharest - (Bucharest, Romania) 1989
- Texas A&M Health Science Center - (College Station, Texas, United States) , Postdoctoral Training 2005
- Texas A&M University - (College Station, Texas, United States) , Postdoctoral Training 2001
- Rice University - (Houston, Texas, United States) , Postdoctoral Training 2000
awards and honors
Contact
first name
- Andreea
has last name
- Trache
mailing address
-
Texas A&M Health Science Center
Medical Physiology
1114 TAMUS
College Station, TX 77843-1114
USA
Other
In the News
- trache@tamu.edu