HR job title
- Assistant Professor
- Contact Info
- 9794583126
- Websites
- ORCiD
- 0000-0002-4631-7762
Raghavan, Shreya Assistant Professor
Positions
- Assistant Professor, Biomedical Engineering, College of Engineering
The Raghavan lab utilizes biomaterials and regenerative engineering strategies to create engineered microenvironments - these engineered niches allow the study of cancer stem cell, neural cell and immune interactions as it pertains to cancer metastasis and inflammation.
Research Areas
- Overview
- Publications
- Research
- Teaching
- Background
- Contact
- Other
- View All
Overview
Publications
selected publications
-
academic article
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VandenHeuvel, S. N., Chau, E., Mohapatra, A., Dabbiru, S., Roy, S., O'Connell, C., ... Raghavan, S. A.
(2024).
Macrophage Checkpoint Nanoimmunotherapy Has the Potential to Reduce Malignant Progression in Bioengineered In Vitro Models of Ovarian Cancer. ACS Applied Bio Materials.
-
Clevenger, A. J., McFarlin, M. K., Gorley, J., Solberg, S. C., Madyastha, A. K., & Raghavan, S. A.
(2024).
Advances in cancer mechanobiology: Metastasis, mechanics, and materials. APL Bioengineering.
8(1), 011502.
-
Donehoo, D. A., Collier, C. A., VandenHeuvel, S. N., Roy, S., Solberg, S. C., & Raghavan, S. A.
(2024).
Degrees of macrophage-facilitated healing in aneurysm occlusion devices. Journal of Biomedical Materials Research - Part B Applied Biomaterials.
112(2), e35385.
-
Oropeza, E., Seker, S., Carrel, S., Mazumder, A., Lozano, D., Jimenez, A., ... Haricharan, S.
(2023).
Molecular portraits of cell cycle checkpoint kinases in cancer evolution, progression, and treatment responsiveness. Science Advances.
9(26), eadf2860.
-
Collier, C. A., Foncerrada, S., Clevenger, A. J., Shetty, A., & Raghavan, S. A.
(2023).
Acute Exposure to Pyridostigmine Bromide Disrupts Cholinergic Myenteric Neuroimmune Function in Mice. 7(5), e2200254.
-
Tasmim, S., Yousuf, Z., Rahman, F. S., Seelig, E., Clevenger, A. J., VandenHeuvel, S. N., ... Ware, T. H.
(2023).
Liquid crystal elastomer based dynamic device for urethral support: Potential treatment for stress urinary incontinence. 292, 121912-121912.
-
Clevenger, A. J., McFarlin, M. K., Collier, C. A., Sheshadri, V. S., Madyastha, A. K., Gorley, J., ... Raghavan, S. A.
(2023).
Peristalsis-Associated Mechanotransduction Drives Malignant Progression of Colorectal Cancer. Cellular and Molecular Bioengineering.
1-21.
-
Clevenger, A. J., Crawford, L. Z., Noltensmeyer, D., Babaei, H., Mabbott, S. B., Avazmohammadi, R., & Raghavan, S.
(2023).
Rapid Prototypable Biomimetic Peristalsis Bioreactor Capable of Concurrent Shear and Multi-Axial Strain. Cells, Tissues, Organs: in vivo, in vitro.
212(1), 96-110.
-
Walsh, A. J., & Raghavan, S.
(2022).
Design and Implementation of Privilege for Sale, a JEDI Activity for a Biomedical Engineering Introductory Course. 2(2), 183-188.
-
Raghavan, S.
(2022).
Inclusive Engagement in an Undergraduate Core Biomaterials Course for Enhanced Reflective Learning. 2(2), 151-156.
-
VandenHeuvel, S. N., Farris, H. A., Noltensmeyer, D. A., Roy, S., Donehoo, D. A., Kopetz, S., ... Raghavan, S.
(2022).
Decellularized organ biomatrices facilitate quantifiable in vitro 3D cancer metastasis models. SOFT MATTER.
18(31), 5791-5806.
-
Raghavan, S.
(2022).
How inclusive are cell lines in preclinical engineered cancer models?. DMM Disease Models and Mechanisms.
15(5), dmm049520.
-
Chau, S. M., Herting, S. M., Noltensmeyer, D. A., Ahmed, H., Maitland, D. J., & Raghavan, S.
(2022).
Macrophage activation in response to shape memory polymer foam-coated aneurysm occlusion devices. Journal of Biomedical Materials Research - Part B Applied Biomaterials.
110(7), 1535-1544.
-
Bent, A., Raghavan, S., Dasari, A., & Kopetz, S.
(2022).
The Future of ctDNA-Defined Minimal Residual Disease: Personalizing Adjuvant Therapy in Colorectal Cancer. Clinical Colorectal Cancer.
21(2), 89-95.
-
O'Connell, C., VandenHeuvel, S., Kamat, A., Raghavan, S., & Godin, B.
(2022).
The Proteolytic Landscape of Ovarian Cancer: Applications in Nanomedicine. International Journal of Molecular Sciences.
23(17), 9981-9981.
-
Collier, C. A., Mendiondo, C., & Raghavan, S.
(2022).
Tissue engineering of the gastrointestinal tract: the historic path to translation. Journal of Biological Engineering.
16(1), 9.
-
Raghavan, S., Snyder, C. S., Wang, A., McLean, K., Zamarin, D., Buckanovich, R. J., & Mehta, G.
(2020).
Carcinoma-Associated Mesenchymal Stem Cells Promote Chemoresistance in Ovarian Cancer Stem Cells via PDGF Signaling. Cancers.
12(8), 2063-2063.
-
Rivera-Bez, L., Lohse, I., Lin, E., Raghavan, S., Owen, S., Harouaka, R., ... Nagrath, S.
(2020).
Expansion of Circulating Tumor Cells from Patients with Locally Advanced Pancreatic Cancer Enable Patient Derived Xenografts and Functional Studies for Personalized Medicine. Cancers.
12(4), 1011-1011.
-
Frieboes, H. B., Raghavan, S., & Godin, B.
(2020).
Modeling of Nanotherapy Response as a Function of the Tumor Microenvironment: Focus on Liver Metastasis. 8, 1011.
-
Bregenzer, M. E., Davis, C., Horst, E. N., Mehta, P., Novak, C. M., Raghavan, S., Snyder, C. S., & Mehta, G.
(2019).
Physiologic Patient Derived 3D Spheroids for Anti-neoplastic Drug Screening to Target Cancer Stem Cells. Journal of Visualized Experiments.
-
Bregenzer, M. E., Davis, C., Horst, E. N., Mehta, P., Novak, C. M., Raghavan, S., Snyder, C. S., & Mehta, G.
(2019).
Physiologic Patient Derived 3D Spheroids for Anti-neoplastic Drug Screening to Target Cancer Stem Cells. Journal of Visualized Experiments.
-
Novak, C. M., Horst, E. N., Raghavan, S., & Mehta, G.
(2019).
Upregulation of COX-2 in MCF7 Breast Cancer Cells When Exposed to Shear Stress. OBM Genetics.
3(3), 1-1.
-
Raghavan, S., & Bitar, K. N.
(2019).
114 Tissue-Engineered Intestines Can Neo-Innervate Experimentally Denervated Intestines with Functional Nitrergic Neurons. Gastroenterology.
156(6), s-30.
-
Zakhem, E., Raghavan, S., Suhar, R. A., & Bitar, K. N.
(2019).
Bioengineering and regeneration of gastrointestinal tissue: where are we now and what comes next?. Expert Opinion on Biological Therapy.
19(6), 527-537.
-
Ward Rashidi, M. R., Mehta, P., Bregenzer, M., Raghavan, S., Fleck, E. M., Horst, E. N., ... Mehta, G.
(2019).
Engineered 3D Model of Cancer Stem Cell Enrichment and Chemoresistance. Neoplasia.
21(8), 822-836.
-
Raghavan, S., Mehta, P., Xie, Y., Lei, Y. L., & Mehta, G.
(2019).
Ovarian cancer stem cells and macrophages reciprocally interact through the WNT pathway to promote pro-tumoral and malignant phenotypes in 3D engineered microenvironments. Journal for ImmunoTherapy of Cancer.
7(1), 190.
-
Bregenzer, M. E., Horst, E. N., Mehta, P., Novak, C. M., Raghavan, S., Snyder, C. S., & Mehta, G.
(2019).
Integrated cancer tissue engineering models for precision medicine. 14(5), e0216564-e0216564.
-
Raghavan, S., & Mehta, G.
(2018).
Immuno-modulation of macrophages by ovarian cancer stem cells in an in vitro 3D spheroid platform. Cancer Research.
78(13), 118-118.
-
Raghavan, S., Mehta, P., Ward, M. R., Bregenzer, M. E., Fleck, E., Tan, L., ... Mehta, G.
(2017).
Personalized Medicine-Based Approach to Model Patterns of Chemoresistance and Tumor Recurrence Using Ovarian Cancer Stem Cell Spheroids. 23(22), 6934-6945.
-
Rego, S. L., Raghavan, S., Zakhem, E., & Bitar, K. N.
(2017).
Enteric neural differentiation in innervated, physiologically functional, smooth muscle constructs is modulated by bone morphogenic protein 2 secreted by sphincteric smooth muscle cells. 11(4), 1251-1261.
-
Shalev, O., Raghavan, S., Mazzara, J. M., Senabulya, N., Sinko, P. D., Fleck, E., ... Shtein, M.
(2017).
Printing of small molecular medicines from the vapor phase. Nature Communications.
8(1), 711.
-
Raghavan, S., Mehta, P., Horst, E. N., Ward, M. R., Rowley, K. R., & Mehta, G.
(2016).
Comparative analysis of tumor spheroid generation techniques for differential in vitro drug toxicity. Oncotarget.
7(13), 16948-16961.
-
Zakhem, E., Murphy, S. V., Davis, M. L., Raghavan, S., & Lam, M. T.
(2016).
IMAGE AND VIDEO ACQUISITION AND PROCESSING FOR CLINICAL APPLICATIONS. 7(Suppl 1), 35-38.
-
Bitar, K. N., Bohl, J., Fortunato, J. E., Somara, S., Raghavan, S., Zakhem, E., Rego, S. L., & Koch, K. L.
(2015).
600 In Situ Implantation of Autologous Biosphincter Re-Instates Continence in a Large Animal Model of Passive Fecal Incontinence. Gastroenterology.
148(4), s-117.
-
Zakhem, E., Rego, S. L., Raghavan, S., & Bitar, K. N.
(2015).
601 The Appendix As a Viable Source of Neural Progenitor Cells to Functionally Innervate Bioengineered Gastrointestinal Smooth Muscle Tissues. Gastroenterology.
148(4), s-117.
-
Raghavan, S., Ward, M. R., Rowley, K. R., Wold, R. M., Takayama, S., Buckanovich, R. J., & Mehta, G.
(2015).
Formation of stable small cell number three-dimensional ovarian cancer spheroids using hanging drop arrays for preclinical drug sensitivity assays. Gynecologic Oncology.
138(1), 181-189.
-
Zakhem, E., Rego, S. L., Raghavan, S., & Bitar, K. N.
(2015).
The appendix as a viable source of neural progenitor cells to functionally innervate bioengineered gastrointestinal smooth muscle tissues. Stem cells translational medicine.
4(6), 548-554.
-
Bitar, K. N., & Raghavan, S.
(2014).
Stem cell therapy for GI neuromuscular disorders. Current Colorectal Cancer Reports.
16(12), 419.
-
Gilmont, R. R., Raghavan, S., Somara, S., & Bitar, K. N.
(2014).
Bioengineering of physiologically functional intrinsically innervated human internal anal sphincter constructs. 20(11-12), 1603-1611.
-
Raghavan, S., & Bitar, K. N.
(2014).
264 Extracellular Matrix Directs Differentiation of Motor Neuronal Subtypes in Tissue Engineered Innervated Intestinal Smooth Muscle. Gastroenterology.
146(5), s-63.
-
Zakhem, E., Raghavan, S., & Bitar, K. N.
(2014).
Neo-innervation of a bioengineered intestinal smooth muscle construct around chitosan scaffold. Biomaterials.
35(6), 1882-1889.
-
Raghavan, S., Miyasaka, E. A., Gilmont, R. R., Somara, S., Teitelbaum, D. H., & Bitar, K. N.
(2014).
Perianal implantation of bioengineered human internal anal sphincter constructs intrinsically innervated with human neural progenitor cells. Surgery.
155(4), 668-674.
-
Mohs, A. M., Gilmont, R. R., Raghavan, S., Somara, S., Marini, F. C., Srinivasan, S., & Bitar, K. N.
(2014).
Su2010 Near Infrared Labeling and Detection of Enteric Nerves: Tracking of Differentiating Neural Progenitor Cells and Tissue Innervation. Gastroenterology.
146(5), s-521-s-522.
-
Raghavan, S., & Bitar, K. N.
(2014).
The influence of extracellular matrix composition on the differentiation of neuronal subtypes in tissue engineered innervated intestinal smooth muscle sheets. Biomaterials.
35(26), 7429-7440.
-
Bitar, K. N., Raghavan, S., & Zakhem, E.
(2014).
Tissue engineering in the gut: developments in neuromusculature. Gastroenterology.
146(7), 1614-1624.
-
Somara, S., Zakhem, E., Raghavan, S., Gilmont, R. R., & Bitar, K. N.
(2013).
Mo1826 FISH Oil Aids in Treatment of Colonic Dysmotility in Mice With DSS-Induced Colitis. Gastroenterology.
144(5), s-672-s-673.
-
Raghavan, S., Gilmont, R. R., & Bitar, K. N.
(2013).
Neuroglial differentiation of adult enteric neuronal progenitor cells as a function of extracellular matrix composition. Biomaterials.
34(28), 6649-6658.
-
Raghavan, S., Gilmont, R. R., & Bitar, K. N.
(2013).
Sa2054 Modulation of Adult Enteric Neuroglial Differentiation by Varying Extracellular Matrix Composition. Gastroenterology.
144(5), s-370.
-
Gilmont, R. R., Somara, S., Varadarajan, S., Zakhem, E., Raghavan, S., & Bitar, K. N.
(2013).
Sa2055 Neuronal Progenitor Cells Undergo Oxidant Injury Following Cryopreservation. Gastroenterology.
144(5), s-370-s-371.
-
Zakhem, E., Raghavan, S., Somara, S., Gilmont, R. R., & Bitar, K. N.
(2013).
Su1874 Tubular Esophageal Tissue Construct Bioengineered From Isolated Esophageal Circular Smooth Muscle Cells. Gastroenterology.
144(5), s-497-s-498.
-
Somara, S., Varadarajan, S., Zakhem, E., Raghavan, S., Gilmont, R. R., & Bitar, K. N.
(2013).
Su2060 HSP27 Mediated Maintenance of Neural Integrity in Aged Transgenic Mice Expressing Phosphomimic HSP27. Gastroenterology.
144(5), s-544-s-545.
-
Fang, Y. u., Frampton, J. P., Raghavan, S., Sabahi-Kaviani, R., Luker, G., Deng, C. X., & Takayama, S.
(2012).
Rapid generation of multiplexed cell cocultures using acoustic droplet ejection followed by aqueous two-phase exclusion patterning. 18(9), 647-657.
-
Gilmont, R. R., Raghavan, S., Miyasaka, E. A., Varadarajan, S., Somara, S., Teitelbaum, D. H., & Bitar, K. N.
(2012).
72 In Situ Implanted Bioengineered Human Internal Anal Sphincter Innervated With Human Enteric Neuronal Progenitor Cells Maintain Myogenic and Neurogenic Physiological Functionality. Gastroenterology.
142(5), s-17.
-
Zakhem, E., Gilmont, R. R., Raghavan, S., & Bitar, K. N.
(2012).
857 Neo-Innervation of a Bioengineered Smooth Muscle Construct by an Intrinsically Innervated Construct Located on the Same Scaffold. Gastroenterology.
142(5), s-147.
-
Zakhem, E., Raghavan, S., Gilmont, R. R., & Bitar, K. N.
(2012).
Chitosan-based scaffolds for the support of smooth muscle constructs in intestinal tissue engineering. Biomaterials.
33(19), 4810-4817.
-
Bitar, K. N., & Raghavan, S.
(2012).
Intestinal tissue engineering: current concepts and future vision of regenerative medicine in the gut. NEUROGASTROENTEROLOGY AND MOTILITY.
24(1), 7-19.
-
Zakhem, E., Raghavan, S., Varadarajan, S., Somara, S., Gilmont, R. R., & Bitar, K. N.
(2012).
Tu1368 A Bioengineered Segment of Colonic Smooth Muscle Tissue Demonstrates the Capabilities of Expansion and Decompression Similar to Native Tissue. Gastroenterology.
142(5), s-813.
-
Zakhern, E., Raghavan, S., Gilmont, R. R., & Bitar, K. N.
(2011).
Manufacturing a Gastrointestinal Hollow Organ Using Novel Biodegradable Chitosan Scaffold With Physiologically Functional Circular Smooth Muscle Layer. Gastroenterology.
140(5), S160-S161.
-
Raghavan, S., Miyasaka, E. A., Gilmont, R. R., Teitelbaum, D. H., & Bitar, K. N.
(2011).
Comparison of Angiogenic Growth Factors to Optimize Physiological Function of Implanted Tissue Engineered Internal Anal Sphincter (IAS). Gastroenterology.
140(5), s-161.
-
Raghavan, S., Gilmont, R. R., Miyasaka, E. A., Herman, R., Teitelbaum, D. H., & Bitar, K. N.
(2011).
In Situ Implantation Preserves Myogenic and Neuronal Characteristics of Intrinsically Innervated Bioengineered Human Internal Anal Sphincter (IAS). Gastroenterology.
140(5), s-138.
-
Miyasaka, E. A., Raghavan, S., Gilmont, R. R., Mittal, K., Somara, S., Bitar, K. N., & Teitelbaum, D. H.
(2011).
In vivo growth of a bioengineered internal anal sphincter: comparison of growth factors for optimization of growth and survival. Pediatric Surgery International.
27(2), 137-143.
-
Somara, S., Musaka, D., Raghavan, S., Gilmont, R. R., & Bitar, K. N.
(2011).
Restoration of Adult-Like Colonic Motility in Aged Transgenic Mice Expressing Phosphomimic HSP27. Gastroenterology.
140(5), s-103.
-
Raghavan, S., Gilmont, R. R., Miyasaka, E. A., Somara, S., Srinivasan, S., Teitelbaum, D. H., & Bitar, K. N.
(2011).
Successful implantation of bioengineered, intrinsically innervated, human internal anal sphincter. Gastroenterology.
141(1), 310-319.
-
Raghavan, S., Lam, M. T., Foster, L. L., Gilmont, R. R., Somara, S., Takayama, S., & Bitar, K. N.
(2010).
Bioengineered three-dimensional physiological model of colonic longitudinal smooth muscle in vitro. 16(5), 999-1009.
-
Raghavan, S., Miyasaka, E. A., Hashish, M., Somara, S., Gilmont, R. R., Teitelbaum, D. H., & Bitar, K. N.
(2010).
Successful implantation of physiologically functional bioengineered mouse internal anal sphincter. American Journal of Physiology - Gastrointestinal and Liver Physiology.
299(2), G430-G439.
-
Raghavan, S., Miyasaka, E. A., Gilmont, R. R., Somara, S., Srinivasan, S., Teitelbaum, D. H., & Bitar, K.
(2010).
166 Successful Implantation of Intrinsically Innervated Physiologically Functional Bioengineered Human Internal Anal Sphincter (IAS). Gastroenterology.
138(5), s-30.
-
Raghavan, S., Gilmont, R. R., Somara, S., Srinivasan, S., & Bitar, K.
(2010).
171 Physiology of Intrinsically Innervated Bioengineered Construct From Human Internal Anal Sphincter Smooth Muscle Cells. Gastroenterology.
138(5), s-31.
-
Somara, S., Musaka, D., Raghavan, S., Gilmont, R. R., & Bitar, K.
(2010).
576 Contraction of Colonic Longitudinal Smooth Muscle is Dependent on PKC-Mediated Phosphorylation of Tropomyosin. Gastroenterology.
138(5), s-81.
-
Gilmont, R. R., Somara, S., Srinivasan, S., Raghavan, S., & Bitar, K.
(2010).
785 IAS Smooth Muscle Cells Direct the Differentiation of Neuronal Progenitor Cells Into Mature Neurons. Gastroenterology.
138(5), s-110.
-
Somara, S., Musaka, D., Raghavan, S., Gilmont, R. R., & Bitar, K.
(2010).
M2032 Longitudinal Muscle Physiological Specificity Correlates With the Differences in Expression and Phosphorylation of Contractile Proteins. Gastroenterology.
138(5), s-462-s-463.
-
Gilmont, R. R., Somara, S., Raghavan, S., & Bitar, K.
(2010).
S2071 Phosphorylated Heat Shock Protein 20 (HSP20) Inhibits PKC and Non-PKC Mediated Force Generation in Bioengineered Colonic Circular Smooth Muscle Constructs. Gastroenterology.
138(5), s-313-s-314.
-
Hashish, M., Raghavan, S., Somara, S., Gilmont, R. R., Miyasaka, E., Bitar, K. N., & Teitelbaum, D. H.
(2010).
Surgical implantation of a bioengineered internal anal sphincter. Journal of Pediatric Surgery.
45(1), 52-58.
-
Raghavan, S., Hashish, M., Miyasaka, E. A., Somara, S., Gilmont, R. R., Teitelbaum, D. H., & Bitar, K. N.
(2009).
660 Successful Implantation of Physiologically Functional Bioengineered Mouse Internal Anal Sphincter. Gastroenterology.
136(5), a-101.
-
Raghavan, S., Lam, M., Foster, L. L., Gilmont, R. R., Somara, S., Takayama, S., & Bitar, K. N.
(2009).
S1241 Development of a Three-Dimensional Physiological Model of Colonic Longitudinal Smooth Muscle In Vitro Lined Up in Longitudinal Axis. Gastroenterology.
136(5), a-220.
-
Gilmont, R. R., Somara, S., Srinivasan, S., Raghavan, S., & Bitar, K. N.
(2009).
S1797 Co-Culture of Enteric Neuronal Cells with Bioengineered Three-Dimensional Colonic Circular Smooth Muscle Constructs. Gastroenterology.
136(5), a-272.
-
Collier, C. A., Salikhova, A., Sabir, S., Foncerrada, S., & Raghavan, S. A.
Crisis in the gut: navigating gastrointestinal challenges in Gulf War Illness with bioengineering. Military Medical Research.
11(1), 45.
-
Moore, E., & Raghavan, S. A.
Introduction to Biomaterials in Innate Immunity. Materials Advances.
-
Clevenger, A. J., Jha, A., Moore, E., & Raghavan, S. A.
Manipulating immune activity of macrophages: a materials and mechanics perspective. Trends in Biotechnology.
S0167-7799(24)00187-2.
-
Jones, S., VandenHeuvel, S., Martinez, A. L., Birur, R., Burgeson, E., Gilbert, I., ... Cosgriff-Hernandez, E.
Suspension electrospinning of decellularized extracellular matrix: A new method to preserve bioactivity. Bioactive Materials.
41, 640-656.
-
VandenHeuvel, S. N., Chau, E., Mohapatra, A., Dabbiru, S., Roy, S., O'Connell, C., ... Raghavan, S. A.
(2024).
Macrophage Checkpoint Nanoimmunotherapy Has the Potential to Reduce Malignant Progression in Bioengineered In Vitro Models of Ovarian Cancer. ACS Applied Bio Materials.
-
chapter
-
Clevenger, A. J., VandenHeuvel, S. N., & Raghavan, S.
(2022).
The Intersection of Biomaterials, Tissue Engineering and Immuno-Oncology. Biomaterial Based Approaches to Study the Tumour Microenvironment.
-
Clevenger, A. J., VandenHeuvel, S. N., & Raghavan, S.
(2022).
Chapter 13 The Intersection of Biomaterials, Tissue Engineering, and Immuno-oncology. Biomaterial Based Approaches to Study the Tumour Microenvironment.
(pp. 342-383).
Royal Society of Chemistry (RSC).
-
Mehta, P., Novak, C., Raghavan, S., Ward, M., & Mehta, G.
(2018).
Self-Renewal and CSCs In Vitro Enrichment: Growth as Floating Spheres. Methods in molecular biology (Clifton, N.J.).
Papaccio, G., & Desiderio, V. (Eds.),
CANCER STEM CELLS: METHODS AND PROTOCOLS.
(pp. 61-75).
Springer Nature.
-
Bitar, K. N., Raghavan, S., Somara, S., Zakhem, E., & Rego, S.
(2015).
Chapter 35 Advances in Neo-Innervation of the Gut. Translational Regenerative Medicine.
(pp. 485-493).
Elsevier.
-
Bitar, K. N., & Raghavan, S.
(2014).
Chapter 34 Intestinal Regeneration The Bioengineering Approach. Regenerative Medicine Applications in Organ Transplantation.
(pp. 505-513).
Elsevier.
-
Bitar, K. N., Gilmont, R. R., Raghavan, S., & Somara, S.
(2012).
Chapter 17 Cellular Physiology of Gastrointestinal Smooth Muscle. Physiology of the Gastrointestinal Tract.
(pp. 489-509).
Elsevier.
-
Clevenger, A. J., VandenHeuvel, S. N., & Raghavan, S.
(2022).
The Intersection of Biomaterials, Tissue Engineering and Immuno-Oncology. Biomaterial Based Approaches to Study the Tumour Microenvironment.
-
conference paper
-
Mehta, P., Bregenzer, M., Rashidi, M. W., Raghavan, S., Fleck, E., Horst, E., ... Mehta, G.
(2020).
Abstract A52: Serially passaging ovarian cancer spheroids as an in situ model for emergence of chemoresistance and enrichment of cancer stem cells. CLINICAL CANCER RESEARCH.
a52-a52.
-
Hwang, W. L., Jagadeesh, K., Ashenberg, O., Drokhlyansky, E., Eng, G., Wittenberghe, N. V., ... Jacks, T. E.
(2019).
Dissecting Transcriptomic Heterogeneity in Patient-Derived Pancreatic Ductal Adenocarcinoma With Single-Nucleus RNA-seq. Pancreas.
1448-1448.
-
Raghavan, S., & Bitar, K. N.
(2019).
TISSUE-ENGINEERED INTESTINES CAN NEO-INNERVATE EXPERIMENTALLY DENERVATED INTESTINES WITH FUNCTIONAL NITRERGIC NEURONS. Gastroenterology.
S30-S30.
-
Novak, C., Horst, E., Raghavan, S., & Mehta, G.
(2018).
Breast cancer cells exhibit enhanced proliferation, invasion, PLAU expression and chemoresistance when exposed to fluid shear stress in an innovative 3D bioreactor. Cancer Research.
187-187.
-
Raghavan, S., Mehta, P., Bregenzer, M., Rashidi, M. W., Fleck, E., Tan, L., ... Mehta, G.
(2018).
Abstract A33: Patient-specific evaluation of chemoresistance and tumor recurrence using ovarian cancer stem cell spheroids. CLINICAL CANCER RESEARCH.
a33-a33.
-
Raghavan, S., Ward, M., Mehta, P., Buckanovich, R. J., & Mehta, G.
(2017).
Abstract AP22: CHEMORESISTANCE, TUMOR INITIATION AND TUMOR REEMERGENCE TRENDS IN MALIGNANT ASCITESDERIVED OVARIAN CANCER STEM CELL SPHEROIDS. CLINICAL CANCER RESEARCH.
ap22-ap22.
-
Bitar, K. N., Bohl, J., Fortunato, J. E., Somara, S., Raghavan, S., Zakhem, E., Rego, S. L., & Koch, K. L.
(2015).
In Situ Implantation of Autologous Biosphincter (TM) Re-Instates Continence in a Large Animal Model of Passive Fecal Incontinence. Gastroenterology.
S117-S117.
-
Zakhem, E., Rego, S. L., Raghavan, S., & Bitar, K. N.
(2015).
The Appendix As a Viable Source of Neural Progenitor Cells to Functionally Innervate Bioengineered Gastrointestinal Smooth Muscle Tissues. Gastroenterology.
S117-S117.
-
Raghavan, S., & Bitar, K. N.
(2014).
Extracellular Matrix Directs Differentiation of Motor Neuronal Subtypes in Tissue Engineered Innervated Intestinal Smooth Muscle. Gastroenterology.
S63-S63.
-
Mohs, A. M., Gilmont, R. R., Raghavan, S., Somara, S., Marini, F. C., Srinivasan, S., & Bitar, K. N.
(2014).
Near Infrared Labeling and Detection of Enteric Nerves: Tracking of Differentiating Neural Progenitor Cells and Tissue Innervation. Gastroenterology.
S521-S522.
-
Somara, S., Zakhem, E., Raghavan, S., Gilmont, R. R., & Bitar, K. N.
(2013).
FISH Oil Aids in Treatment of Colonic Dysmotility in Mice With DSS- Induced Colitis. Gastroenterology.
S672-S673.
-
Somara, S., Varadarajan, S., Zakhem, E., Raghavan, S., Gilmont, R. R., & Bitar, K. N.
(2013).
HSP27 Mediated Maintenance of Neural Integrity in Aged Transgenic Mice Expressing Phosphomimic HSP27. Gastroenterology.
S544-S545.
-
Raghavan, S., Gilmont, R. R., & Bitar, K. N.
(2013).
Modulation of Adult Enteric Neuroglial Differentiation by Varying Extracellular Matrix Composition. Gastroenterology.
S370-S370.
-
Gilmont, R. R., Somara, S., Varadarajan, S., Zakhem, E., Raghavan, S., & Bitar, K. N.
(2013).
Neuronal Progenitor Cells Undergo Oxidant Injury Following Cryopreservation. Gastroenterology.
S370-S370.
-
Zakhem, E., Raghavan, S., Somara, S., Gilmont, R. R., & Bitar, K. N.
(2013).
Tubular Esophageal Tissue Construct Bioengineered From Isolated Esophageal Circular Smooth Muscle Cells. Gastroenterology.
S497-S498.
-
Zakhem, E., Raghavan, S., Varadarajan, S., Somara, S., Gilmont, R. R., & Bitar, K. N.
(2012).
A Bioengineered Segment of Colonic Smooth Muscle Tissue Demonstrates the Capabilities of Expansion and Decompression Similar to Native Tissue. Gastroenterology.
S813-S813.
-
Gilmont, R. R., Raghavan, S., Miyasaka, E. A., Varadarajan, S., Somara, S., Teitelbaum, D. H., & Bitar, K. N.
(2012).
In Situ Implanted Bioengineered Human Internal Anal Sphincter Innervated With Human Enteric Neuronal Progenitor Cells Maintain Myogenic and Neurogenic Physiological Functionality. Gastroenterology.
S17-S17.
-
Zakhem, E., Gilmont, R. R., Raghavan, S., & Bitar, K. N.
(2012).
Neo-Innervation of a Bioengineered Smooth Muscle Construct by an Intrinsically Innervated Construct Located on the Same Scaffold. Gastroenterology.
S147-S147.
-
Raghavan, S., Miyasaka, E. A., Gilmont, R. R., Teitelbaum, D. H., & Bitar, K. N.
(2011).
Comparison of Angiogenic Growth Factors to Optimize Physiological Function of Implanted Tissue Engineered Internal Anal Sphincter (IAS). Gastroenterology.
S161-S161.
-
Raghavan, S., Gilmont, R. R., Miyasaka, E. A., Herman, R., Teitelbaum, D. H., & Bitar, K. N.
(2011).
In Situ Implantation Preserves Myogenic and Neuronal Characteristics of Intrinsically Innervated Bioengineered Human Internal Anal Sphincter (IAS). Gastroenterology.
S138-S138.
-
Somara, S., Musaka, D., Raghavan, S., Gilmont, R. R., & Bitar, K. N.
(2011).
Restoration of Adult-Like Colonic Motility in Aged Transgenic Mice Expressing Phosphomimic HSP27. Gastroenterology.
S103-S103.
-
Somara, S., Musaka, D., Raghavan, S., Gilmont, R. R., & Bitar, K.
(2010).
Contraction of Colonic Longitudinal Smooth Muscle is Dependent on PKC-Mediated Phosphorylation of Tropomyosin. Gastroenterology.
S81-S81.
-
Gilmont, R. R., Somara, S., Srinivasan, S., Raghavan, S., & Bitar, K.
(2010).
IAS Smooth Muscle Cells Direct the Differentiation of Neuronal Progenitor Cells Into Mature Neurons. Gastroenterology.
S110-S110.
-
Somara, S., Musaka, D., Raghavan, S., Gilmont, R. R., & Bitar, K.
(2010).
Longitudinal Muscle Physiological Specificity Correlates With the Differences in Expression and Phosphorylation of Contractile Proteins. Gastroenterology.
S462-S463.
-
Gilmont, R. R., Somara, S., Raghavan, S., & Bitar, K.
(2010).
Phosphorylated Heat Shock Protein 20 (HSP20) Inhibits PKC and Non-PKC Mediated Force Generation in Bioengineered Colonic Circular Smooth Muscle Constructs. Gastroenterology.
S313-S314.
-
Raghavan, S., Gilmont, R. R., Somara, S., Srinivasan, S., & Bitar, K.
(2010).
Physiology of Intrinsically Innervated Bioengineered Construct From Human Internal Anal Sphincter Smooth Muscle Cells. Gastroenterology.
S31-S31.
-
Raghavan, S., Miyasaka, E. A., Gilmont, R. R., Somara, S., Srinivasan, S., Teitelbaum, D. H., & Bitar, K.
(2010).
Successful Implantation of Intrinsically Innervated Physiologically Functional Bioengineered Human Internal Anal Sphincter (IAS). Gastroenterology.
S30-S30.
-
Gilmont, R. R., Somara, S., Srinivasan, S., Raghavan, S., & Bitar, K. N.
(2009).
Co-Culture of Enteric Neuronal Cells with Bioengineered Three-Dimensional Colonic Circular Smooth Muscle Constructs. Gastroenterology.
A272-A272.
-
Raghavan, S., Lam, M., Foster, L. L., Gilmont, R. R., Somara, S., Takayama, S., & Bitar, K. N.
(2009).
Development of a Three-Dimensional Physiological Model of Colonic Longitudinal Smooth Muscle In Vitro Lined Up in Longitudinal Axis. Gastroenterology.
A220-A220.
-
Raghavan, S., Hashish, M., Miyasaka, E. A., Somara, S., Gilmont, R. R., Teitelbaum, D. H., & Bitar, K. N.
(2009).
Successful Implantation of Physiologically Functional Bioengineered Mouse Internal Anal Sphincter. Gastroenterology.
A101-A101.
-
Raghavan, S., Hjulstrom, M., Holmgren, J., & Svennerholm, A. M.
(2000).
Protection by therapeutic oral vaccination with inactivated bacteria in a mouse model Helicobacter pylori infection. GUT.
A64-A64.
-
Mehta, P., Bregenzer, M., Rashidi, M. W., Raghavan, S., Fleck, E., Horst, E., ... Mehta, G.
(2020).
Abstract A52: Serially passaging ovarian cancer spheroids as an in situ model for emergence of chemoresistance and enrichment of cancer stem cells. CLINICAL CANCER RESEARCH.
a52-a52.
-
institutional repository document
-
Abello, J., Yin, Y., Zhao, Y., Maurer, J., Lee, J., Bodell, C., ... Stratman, A. N.
(2024).
Endothelial cell Piezo1 promotes vascular smooth muscle cell differentiation on large arteries
-
Clevenger, A. J., Collier, C. A., Gorley, J., McFarlin, M. K., Solberg, S. C., Kopetz, E. S., Stratman, A. N., & Raghavan, S. A.
(2024).
Oncogenic KRAS Mutations Confer a Unique Mechanotransduction Response to Peristalsis in Colorectal Cancer Cells
-
Jones, S., VandenHeuval, S., Martinez, A. L., Burgeson, E., Raghavan, S., Rogers, S., & Cosgriff-Hernandez, E.
(2024).
Suspension Electrospinning of Decellularized Extracellular Matrix
-
Oropeza, E., Seker, S., Carrel, S., Mazumder, A., Jimenez, A., VandenHeuvel, .., ... Haricharan, S.
(2020).
Molecular portraits of cell cycle checkpoint kinases in cancer evolution, progression, and treatment responsiveness
-
Abello, J., Yin, Y., Zhao, Y., Maurer, J., Lee, J., Bodell, C., ... Stratman, A. N.
(2024).
Endothelial cell Piezo1 promotes vascular smooth muscle cell differentiation on large arteries
Research
principal investigator on
- Bioengineered intestines can evaluate neuro-immune pathobiology of Gulf War Illness-related gastrointestinal dysfunction awarded by Congressionally Directed Medical Research Programs - (Frederick, Maryland, United States)
- Engineered enteric nerve plexi to improve predictive preclinical screens in early-stage colorectal adenocarcinomas awarded by National Institutes of Health - (Bethesda, Maryland, United States)
- Longitudinal macrophage immunomodulation in 3D tumor organoids for immunotherapy screening awarded by Texas A&M University - (College Station, Texas, United States)
co-principal investigator on
- Microphysiological Leads Optimization and Toxicity Screening facility awarded by Cancer Prevention and Research Institute of Texas - (Austin, Texas, United States)
- Nano-immunotherapy targeting macrophages to arrest liver metastasis in ovarian cancer awarded by Houston Methodist - (Houston, Texas, United States)
Teaching
teaching activities
- BIOT685 Directed Studies Instructor
- BMEN291 Hnr-research Instructor
- BMEN343 Intro To Biomaterials Instructor
- BMEN489 Sptp: Cancer Bioengineering Instructor
- BMEN491 Hnr-research Instructor
- BMEN689 Sptp: Cancer Bioengineering Instructor
- BMEN691 Research Instructor
Background
education and training
- Cert. in High-Impact Principles and Practices for STEM Education, University of Michigan-Ann Arbor - (Ann Arbor, Michigan, United States) 2015
- Ph.D. in Biomedical Engineering, Virginia Tech - Wake Forest University - (Blacksburg, Virginia, United States) 2014
- M.S.E. in Biomedical Engineering (Biotechnology), University of Michigan-Ann Arbor - (Ann Arbor, Michigan, United States) 2008
- B.E. in Instrumentation and Control Systems Engineering, Anna University, Chennai - (Chennai, Tamil Nadu, India) 2006
awards and honors
- Cells, Tissues, Organs - Young Investigator Award, conferred by Karger Publishers - (Basel, Switzerland), 2021
- Scholar of Color, conferred by AtKisson Training Group, LLC - (Massachusetts, United States), 2021
- ADVANCE NCFDD Faculty Success Fellow, conferred by Texas A&M University - (College Station, Texas, United States), 2020
Contact
first name
- Shreya
has last name
- Raghavan
mailing address
-
3120 TAMU
5016 Emerging Technologies Building
College Station, TX 77843
USA
Other
In the News
- sraghavan@tamu.edu