In vitro digestion, absorption and biological activities of acylated anthocyanins from purple sweet potatoes (Ipomoea batatas). Academic Article uri icon


  • Purple sweet potatoes (PSP) are widely used as color enhancers in food formulations. Investigations on the stability of PSP polyphenolics during simulated digestion and subsequent absorption in a Caco-2 cell monolayer model were accomplished. Measures of bioactive activities were also assessed in vitro. PSP whole polyphenolic extracts as a control (WC) were compared to isolates enriched in anthocyanins (AC) or non-anthocyanin phenolics (NAP). Anthocyanins were also alkali-hydrolyzed to remove acylated moieties. Compounds were subjected to simulated gastro-intestinal digestions where non-hydrolyzed anthocyanins showed higher stability compared to alkali-hydrolyzed. For many alkali-hydrolyzed anthocyanins, the transport through a Caco-2 cell monolayer was reduced. PSP fractions significantly increased the generation of reactive oxygen species in HT-29 cells and was suppressive in the CCD-18Co cells while down-regulated mRNA expression of inflammatory markers. Results indicate the importance of PSP composition and the effects of acyl moieties on anthocyanin stability and functional properties for food colors.

published proceedings

  • Food Chem

author list (cited authors)

  • de Aguiar Cipriano, P., Kim, H., Fang, C., Paula Venancio, V., Mertens-Talcott, S. U., & Talcott, S. T.

citation count

  • 2

complete list of authors

  • de Aguiar Cipriano, Paula||Kim, Hyemee||Fang, Chuo||Paula Venancio, Vinicius||Mertens-Talcott, Susanne U||Talcott, Stephen T

publication date

  • January 2022