HR job title
- Associate Professor
- Contact Info
- 1 979 436 9421
- ORCiD
- 0000-0001-6423-8585
Brinkmeyer-Langford, Candice Associate Professor
Positions
- Associate Professor, Environmental and Occupational Health, School of Public Health
My research focuses on the roles of genetic diversity on neurological conditions resulting from environmental agents, such as viral infections. We use Theiler's Murine Encephalomyelitis virus (TMEV), a neurotropic virus affecting mice, and the genetically diverse Collaborative Cross mouse resource, to study the mechanisms underlying neuropathological outcomes to infection.
Research Areas
- Overview
- Publications
- Research
- Teaching
- Contact
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Overview
Publications
selected publications
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academic article
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Karmakar, M., Prez Gmez, A. A., Carroll, R. J., Lawley, K. S., Amstalden, K., Welsh, C. J., Threadgill, D. W., & Brinkmeyer-Langford, C.
(2023).
Baseline Gait and Motor Function Predict Long-Term Severity of Neurological Outcomes of Viral Infection. International Journal of Molecular Sciences.
24(3), 2843-2843.
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Prez Gmez, A. A., Wang, M., Kochan, K., Amstalden, K., Young, C. R., Welsh, C. J., Phillips, T. D., & Brinkmeyer-Langford, C. L.
(2023).
C57BL/6J mice exposed to perfluorooctanoic acid demonstrate altered immune responses and increased seizures after Theiler's murine encephalomyelitis virus infection. Frontiers in Immunology.
14, 1228509.
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Lawley, K. S., Rech, R. R., Perez Gomez, A. A., Hopkins, L., Han, G., Amstalden, K., ... Brinkmeyer-Langford, C. L.
(2022).
Viral Clearance and Neuroinflammation in Acute TMEV Infection Vary by Host Genetic Background. International Journal of Molecular Sciences.
23(18), 10482-10482.
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Perez Gomez, A. A., Karmakar, M., Carroll, R. J., Lawley, K. S., Amstalden, K., Young, C. R., ... Brinkmeyer-Langford, C.
(2021).
Genetic and immunological contributors to virus-induced paralysis. Brain, Behavior, and Immunity - Health.
18, 100395-100395.
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Brinkmeyer-Langford, C., Amstalden, K., Konganti, K., Hillhouse, A., Lawley, K., Perez-Gomez, A., ... Threadgill, D. W.
(2021).
Resilience in Long-Term Viral Infection: Genetic Determinants and Interactions. International Journal of Molecular Sciences.
22(21), 11379-11379.
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Lawley, K. S., Rech, R. R., Elenwa, F., Han, G., Perez Gomez, A. A., Amstalden, K., ... Brinkmeyer-Langford, C. L.
(2021).
Host genetic diversity drives variable central nervous system lesion distribution in chronic phase of Theiler's Murine Encephalomyelitis Virus (TMEV) infection. PLoS ONE.
16(8), e0256370-e0256370.
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Eldridge, R., Osorio, D., Amstalden, K., Edwards, C., Young, C. R., Cai, J. J., ... Brinkmeyer-Langford, C.
(2020).
Antecedent presentation of neurological phenotypes in the Collaborative Cross reveals four classes with complex sex-dependencies. Scientific Reports.
10(1), 7918.
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Brinkmeyer-Langford, C., Chu, C., Balog-Alvarez, C., Yu, X., Cai, J. J., Nabity, M., & Kornegay, J. N.
(2018).
Expression profiling of disease progression in canine model of Duchenne muscular dystrophy. PLoS ONE.
13(3), e0194485-e0194485.
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Chu, C. P., Hokamp, J. A., Cianciolo, R. E., Dabney, A. R., Brinkmeyer-Langford, C., Lees, G. E., & Nabity, M. B.
(2017).
RNA-seq of serial kidney biopsies obtained during progression of chronic kidney disease from dogs with X-linked hereditary nephropathy. Scientific Reports.
7(1), 16776.
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Markham, L. W., Brinkmeyer-Langford, C. L., Soslow, J. H., Gupte, M., Sawyer, D. B., Kornegay, J. N., & Galindo, C. L.
(2017).
GRMD cardiac and skeletal muscle metabolism gene profiles are distinct. BMC Medical Genomics.
10(1), 21.
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Brinkmeyer-Langford, C. L., Rech, R., Amstalden, K., Kochan, K. J., Hillhouse, A. E., Young, C., Welsh, C. J., & Threadgill, D. W.
(2017).
Host genetic background influences diverse neurological responses to viral infection in mice. Scientific Reports.
7(1), 12194.
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Kornegay, J. N., Bogan, D. J., Bogan, J. R., Dow, J. L., Wang, J., Fan, Z., ... Wagner, K. R.
(2016).
Dystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures. 6(1), 14.
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Brinkmeyer-Langford, C., Balog-Alvarez, C., Cai, J. J., Davis, B. W., & Kornegay, J. N.
(2016).
Genome-wide association study to identify potential genetic modifiers in a canine model for Duchenne muscular dystrophy. BMC GENOMICS.
17(1), 665.
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Galindo, C. L., Soslow, J. H., Brinkmeyer-Langford, C. L., Gupte, M., Smith, H. M., Sengsayadeth, S., ... Markham, L. W.
(2016).
Translating golden retriever muscular dystrophy microarray findings to novel biomarkers for cardiac/skeletal muscle function in Duchenne muscular dystrophy. Pediatric Research.
79(4), 629-636.
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Brinkmeyer-Langford, C. L., Guan, J., Ji, G., & Cai, J. J.
(2016).
Aging Shapes the Population-Mean and -Dispersion of Gene Expression in Human Brains. Frontiers in Aging Neuroscience.
8(AUG), 183.
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Zeng, Y., Wang, G., Yang, E., Ji, G., Brinkmeyer-Langford, C. L., & Cai, J. J.
(2015).
Aberrant gene expression in humans. PLOS Genetics.
11(1), e1004942-e1004942.
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Wang, G., Yang, E., Mandhan, I., Brinkmeyer-Langford, C. L., & Cai, J. J.
(2014).
Population-level expression variability of mitochondrial DNA-encoded genes in humans. European Journal of Human Genetics.
22(9), 1093-1099.
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Fritz, K. L., Kaese, H. J., Valberg, S. J., Hendrickson, J. A., Rendahl, A. K., Bellone, R. R., ... McCue, M. E.
(2014).
Genetic risk factors for insidious equine recurrent uveitis in Appaloosa horses. Animal Genetics.
45(3), 392-399.
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Wang, G., Yang, E., Brinkmeyer-Langford, C. L., & Cai, J. J.
(2014).
Additive, epistatic, and environmental effects through the lens of expression variability QTL in a twin cohort. Genetics.
196(2), 413-425.
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Brinkmeyer-Langford, C., Rodrigues, A., Kochan, K. J., Haney, R., Rassu, F., Steelman, A. J., ... Welsh, C. J.
(2014).
Consequences of perinatal bisphenol A exposure in a mouse model of multiple sclerosis. Autoimmunity.
47(1), 57-66.
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Kornegay, J. N., Spurney, C. F., Nghiem, P. P., Brinkmeyer-Langford, C. L., Hoffman, E. P., & Nagaraju, K.
(2014).
Pharmacologic management of Duchenne muscular dystrophy: target identification and preclinical trials. Institute for Laboratory Animal Research (ILAR) Journal.
55(1), 119-149.
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Brinkmeyer-Langford, C. L., Cai, J. J., Gill, C. A., & Skow, L. C.
(2013).
Microsatellite variation in the equine MHC. Animal Genetics.
44(3), 267-275.
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Brinkmeyer-Langford, C., & Kornegay, J. N.
(2013).
Comparative Genomics of X-linked Muscular Dystrophies: The Golden Retriever Model. Current Genomics.
14(5), 330-342.
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Bovine Genome Sequencing and Analysis Consortium, .., Elsik, C. G., Tellam, R. L., Worley, K. C., Gibbs, R. A., Muzny, D. M., ... Zhao, F.
(2009).
The genome sequence of taurine cattle: a window to ruminant biology and evolution. Science.
324(5926), 522-528.
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Brinkmeyer-Langford, C. L., Childers, C. P., Fritz, K. L., Gustafson-Seabury, A. L., Cothran, M., Raudsepp, T., Womack, J. E., & Skow, L. C.
(2009).
A high resolution RH map of the bovine major histocompatibility complex. BMC GENOMICS.
10(1), 182.
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Brinkmeyer-Langford, C., Raudsepp, T., Gustafson-Seabury, A., & Chowdhary, B. P.
(2008).
A BAC contig map over the proximal approximately 3.3 Mb region of horse chromosome 21. Cytogenetic and Genome Research.
120(1-2), 164-172.
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Raudsepp, T., Gustafson-Seabury, A., Durkin, K., Wagner, M. L., Goh, G., Seabury, C. M., ... Chowdhary, B. P.
(2008).
A 4,103 marker integrated physical and comparative map of the horse genome. Cytogenetic and Genome Research.
122(1), 28-36.
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Wagner, M. L., Raudsepp, T., Goh, G., Agarwala, R., Schaffer, A. A., Dranchak, P. K., ... Mickelson, J. R.
(2006).
A 1.3-Mb interval map of equine homologs of HSA2. Cytogenetic and Genome Research.
112(3-4), 227-234.
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Brinkmeyer-Langford, C., Raudsepp, T., Lee, E., Goh, G., Schffer, A. A., Agarwala, R., ... Chowdhary, B. P.
(2005).
A high-resolution physical map of equine homologs of HSA19 shows divergent evolution compared with other mammals. MAMMALIAN GENOME.
16(8), 631-649.
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Raudsepp, T., Lee, E., Kata, S. R., Brinkmeyer, C., Mickelson, J. R., Skow, L. C., Womack, J. E., & Chowdhary, B. P.
(2004).
Exceptional conservation of horse-human gene order on X chromosome revealed by high-resolution radiation hybrid mapping. Proceedings of the National Academy of Sciences of the United States of America.
101(8), 2386-2391.
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Brinkmeyer-Langford, C. L., Murphy, W. J., Childers, C. P., & Skow, L. C.
A conserved segmental duplication within ELA
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Karmakar, M., Prez Gmez, A. A., Carroll, R. J., Lawley, K. S., Amstalden, K., Welsh, C. J., Threadgill, D. W., & Brinkmeyer-Langford, C.
(2023).
Baseline Gait and Motor Function Predict Long-Term Severity of Neurological Outcomes of Viral Infection. International Journal of Molecular Sciences.
24(3), 2843-2843.
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chapter
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Brinkmeyer-Langford, C., Li, J., Welsh, C. J., & Tiffany-Castiglioni, E.
(2018).
Myelin and Myelination. Comprehensive Toxicology.
(pp. 120-140).
Elsevier.
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Skow, L. C., & BrinkmeyerLangford, C. L.
(2013).
Unexpected Structural Features of the Equine Major Histocompatibility Complex. Equine Genomics.
(pp. 93-101).
Wiley.
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Brinkmeyer-Langford, C., Li, J., Welsh, C. J., & Tiffany-Castiglioni, E.
(2018).
Myelin and Myelination. Comprehensive Toxicology.
(pp. 120-140).
Elsevier.
Research
principal investigator on
co-principal investigator on
investigator on
- Comprehensive Tools and Models for Addressing Exposure to Mixtures During Environmental Emergency-Related Contamination Events awarded by National Institute of Environmental Health Sciences - (Durham, North Carolina, United States) 2017 - 2022
- Regulatory Science in Environmental Health and Toxicology awarded by National Institute of Environmental Health Sciences - (Durham, North Carolina, United States) 2016 - 2021
- TEX-VAL: Texas A&M Tissue Chip Validation Consortium awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2018 - 2020
Teaching
teaching activities
- BICH491 Hnr-research Instructor
- BIMS291 Research Instructor
- BIMS491 Hnr-research Instructor
- GENE491 Hnr-research Instructor
- NRSC277 Essential Neuroscience Instructor
- VIBS277 Essential Neuroscience Instructor
- VIBS285 Directed Studies Instructor
- VIBS485 Directed Studies Instructor
- VIBS691 Research Instructor
Contact
first name
- Candice
has last name
- Brinkmeyer-Langford
mailing address
-
Texas A&M University School of Public Health
Environmental and Occupational Health
1266 TAMU
College Station, TX 77843-1266
USA
Other
- brinkmeyer@tamu.edu