2018 Elsevier Ltd All rights reserved. A compound may be neurotoxic by perturbing a metabolic, structural, or functional property characteristic of myelin or myelinating cells. Perturbations of these properties during nervous system development are more deleterious than those occurring after maturation of the nervous system. Myelin and myelination are described in this section, with emphasis on points relevant to neurotoxic mechanisms of chemicals that target myelin. More information is readily available in more specialized reviews of subtopics on myelin development and biology.
