Plum polyphenolics decrease oxidative stress and inflammation in vascular endothelial cells Academic Article uri icon


  • Previous studies have demonstrated that plums are rich in antioxidant polyphenolics which may have antiinflammatory effects. In this study we determined the antioxidant and antiinflammatory effects of polyphenolics extracted from Black Splendor (BS), a commercial variety of plum (Prunus salicina). BS concentrations of up to 10 mg gallic acid equiv./L did not significantly alter cell proliferation and therefore were selected for the determination of antioxidant and antiinflammatory effects in human umbilical vein endothelial cells (HUVEC). Reactive oxygen species (ROS) were induced with 10mM glucose for 30 min at 37C and BS (2 mg/L) decreased the induced oxidative stress by up to 70% upon treatment . Treatment of HUVEC cells with 10mM glucose significantly increased messengerRNA expression of inflammation biomarkers IL6, IL8, and NFB. An increase in transcription factor NFB upregulates other proinflammatory cytokines leading to increased vascular inflammation. Upon treatment with BS (4 mg/L), IL6, IL8, and NFB were decreased by 4.4, 7.4, and 3.1 fold, respectively. This data suggests that antioxidant polyphenolics found in plum extracts help control inflammation and inhibit oxidative stress in human umbilical vein endothelial cells.Grant Funding SourceTexas A&M University Vegetable and Fruit Improvment Center

published proceedings


author list (cited authors)

  • Townsley, E. D., Noratto, G., Angel, G., Del Follo, A., Byrne, D., & Mertens-Talcott, S.

citation count

  • 0

complete list of authors

  • Townsley, Emily D||Noratto, Giuliana||Angel, Gabriela||Del Follo, Armando||Byrne, David||Mertens-Talcott, Susanne

publication date

  • January 2009