HR job title
- Professor
- Contact Info
Li, Zhenyu Professor
Positions
My research focuses on the mechanism of platelet activation and arterial thrombotic diseases such as heart attack and stroke. We are also interested in the crosstalk between thrombosis and inflammation in sepsis.
Research Areas
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Overview
Publications
selected publications
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academic article
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Pandeya, A., Zhang, Y., Cui, J., Yang, L., Li, J., Zhang, G., ... Wei, Y.
(2023).
Inflammasome activation and pyroptosis mediate coagulopathy and inflammation in Salmonella systemic infection. 275, 127460-127460.
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He, H., Yang, W. u., Su, N., Zhang, C., Dai, J., Han, F., ... Hu, J.
(2023).
Activating NO-sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury. 220(2), e20211422.
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Zhang, Y., Wu, C., Li, L., Pandeya, A., Zhang, G., Cui, J., ... Li, Z.
(2022).
Extracellular Histones Trigger Disseminated Intravascular Coagulation by Lytic Cell Death. International Journal of Molecular Sciences.
23(12), 6800-6800.
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Wei, Y., Yang, L., Pandeya, A., Cui, J., Zhang, Y., & Li, Z.
(2022).
Pyroptosis-Induced Inflammation and Tissue Damage. Journal of Molecular Biology.
434(4), 167301-167301.
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Yang, L., Pandeya, A., Li, L., Ojo, I., Li, Z., & Wei, Y.
(2022).
Transport Across Two Membrane Bilayers in E. coli by Efflux Pumps of Different Dimensions. Journal of Molecular Biology.
434(2), 167376-167376.
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Zhang, Y., Cui, J., Zhang, G., Wu, C., Abdel-Latif, A., Smyth, S. S., ... Li, Z.
(2021).
Inflammasome activation promotes venous thrombosis through pyroptosis. Blood Advances.
5(12), 2619-2623.
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Pandeya, A., Yang, L., Alegun, O., Karunasena, C., Risko, C., Li, Z., & Wei, Y.
(2021).
Biotinylation as a tool to enhance the uptake of small molecules in Gram-negative bacteria. PLoS ONE.
16(11), e0260023-e0260023.
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Xiang, B., Zhang, G., Zhang, Y., Wu, C., Joshi, S., Morris, A. J., ... Li, Z.
(2021).
Calcium Ion Chelation Preserves Platelet Function During Cold Storage. 41(1), 234-249.
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Zhang, R., Liu, Y., Zhang, B., Wu, C., Zhou, J., Zhang, Y. u., ... Shi, S.
(2021).
Coagulopathy is associated with multiple organ damage and prognosis of COVID-19. EXCLI Journal.
20, 174-191.
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Wu, C., Ye, D., Mullick, A. E., Li, Z., Danser, A., Daugherty, A., & Lu, H. S.
(2020).
Effects of Renin-Angiotensin Inhibition on ACE2 (Angiotensin-Converting Enzyme 2) and TMPRSS2 (Transmembrane Protease Serine 2) Expression: Insights Into COVID-19. 76(4), e29-e30.
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Xiong, G., Chen, J., Zhang, G., Wang, S., Kawasaki, K., Zhu, J., ... Xu, R.
(2020).
Hsp47 promotes cancer metastasis by enhancing collagen-dependent cancer cell-platelet interaction. Proceedings of the National Academy of Sciences of the United States of America.
117(7), 3748-3758.
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Zhang, Y., Zhang, G., Jian, C., Wu, C., Mackman, N., Smyth, S., Wei, Y., & Li, Z.
(2019).
Inflammasome Activation Promotes Deep Vein Thrombosis through Pyroptosis. Blood.
134(Supplement_1), 3644-3644.
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Wu, C., Lu, W., Zhang, Y., Zhang, G., Shi, X., Hisada, Y., ... Li, Z.
(2019).
Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis. Immunity.
50(6), 1401-1411.e4.
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Pandeya, A., Li, L., Li, Z., & Wei, Y.
(2019).
Gasdermin D (GSDMD) as a new target for the treatment of infection. MedChemComm.
10(5), 660-667.
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Sexton, T. R., Zhang, G., Macaulay, T. E., Callahan, L. A., Charnigo, R., Vsevolozhskaya, O. A., Li, Z., & Smyth, S.
(2018).
Ticagrelor Reduces ThromboinflammatoryMarkersin PatientsWithPneumonia. JACC: Basic to Translational Science.
3(4), 435-449.
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Wu, C., Wei, Y., & Li, Z.
(2018).
Abstract 038: Inflammasome Activation Triggers Blood Coagulation Through Pyroptosis. Arteriosclerosis, Thrombosis and Vascular Biology.
38(Suppl_1),
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Wang, S., Li, Z., & Xu, R.
(2018).
Human Cancer and Platelet Interaction, a Potential Therapeutic Target. International Journal of Molecular Sciences.
19(4), 1246-1246.
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Gao, X., Wu, X., Yan, J., Zhang, J., Zhao, W., DeMarco, D., ... Ai, X.
(2018).
Transcriptional regulation of stress kinase JNK2 in pro-arrhythmic CaMKII expression in the aged atrium. Cardioscience.
114(5), 737-746.
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Zhang, R., Zhang, G., Xiang, B., Chen, X., Tang, L., Shi, S., ... Li, Z.
(2017).
TRAF3 negatively regulates platelet activation and thrombosis. Scientific Reports.
7(1), 17112.
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Liu, Y. i., Zhang, C., Li, Z., Wang, C., Jia, J., Gao, T., ... Liang, Y.
(2017).
Latexin Inactivation Enhances Survival and Long-Term Engraftment ofHematopoietic Stem Cells and Expands the Entire Hematopoietic System in Mice. Stem Cell Reports.
8(4), 991-1004.
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Zhang, Y., Zhang, J., Yan, R., Tian, J., Zhang, Y., Zhang, J., ... Dai, K.
(2017).
Receptor-interacting protein kinase 3 promotes platelet activation and thrombosis. Proceedings of the National Academy of Sciences of the United States of America.
114(11), 2964-2969.
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Dong, C., Li, B. o., Li, Z., Shetty, S., & Fu, J.
(2016).
Dasatinib-loaded albumin nanoparticles possess diminished endothelial cell barrier disruption and retain potent anti-leukemia cell activity. Oncotarget.
7(31), 49699-49709.
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Guo, L., Morin, E. E., Yuan, Y., Zhan, C., Gong, M., Li, Z., ... Li, X.
(2016).
Abstract 159: Synthetic High Density Lipoprotein - a Potential Therapy for Sepsis. 36(suppl_1),
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Zhang, R., Zhang, G., Xiang, B., Xie, P., & Li, Z.
(2016).
Abstract 55: Traf3 Negatively Regulates Platelet Activation and Thrombosis. 36(suppl_1),
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Huang, Y., Joshi, S., Xiang, B., Kanaho, Y., Li, Z., Bouchard, B. A., Moncman, C. L., & Whiteheart, S. W.
(2016).
Arf6 controls platelet spreading and clot retraction via integrin IIb3 trafficking. Blood.
127(11), 1459-1467.
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Xiang, B., Zhang, G., Ye, S., Zhang, R., Huang, C., Liu, J., ... Li, Z.
(2015).
Characterization of a Novel Integrin Binding Protein, VPS33B, Which Is Important for Platelet Activation and In Vivo Thrombosis and Hemostasis. 132(24), 2334-2344.
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Ouseph, M. M., Huang, Y., Banerjee, M., Joshi, S., MacDonald, L., Zhong, Y. u., ... Wang, Q. J.
(2015).
Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis. Blood.
126(10), 1224-1233.
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Xiang, B., Zhang, G., Ye, S., Huang, C., Liu, J., Tao, M., ... Li, Z.
(2015).
Abstract 45: Characterization of a Novel Integrin Binding Protein that is Essential for IIb3 Outside-in Signaling and Hemostasis. 35(suppl_1),
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Zhang, Y., Zhang, J., Yan, R., Zhang, J., Chen, M., Jiang, M., ... Dai, K.
(2014).
Impaired Platelet Responses to Thromboxane a2 and Thrombin in Mice Lacking Receptor-Interacting Protein Kinase 3. Blood.
124(21), 2762-2762.
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Xiang, B., Zhang, G., Ye, S., Huang, C., Liu, J., Ruan, C., ... Li, Z.
(2014).
VPS33B, a Member of the Sec1/Munc18 Protein Family, Binds to Integrin Beta Subunits and Is Required for IIb3 Outside-in Signaling. Blood.
124(21), 340-340.
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Chen, J., Shetty, S., Zhang, P., Gao, R., Hu, Y., Wang, S., Li, Z., & Fu, J.
(2014).
Aspirin-triggered resolvin D1 down-regulates inflammatory responses and protects against endotoxin-induced acute kidney injury. TOXICOLOGY AND APPLIED PHARMACOLOGY.
277(2), 118-123.
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Gao, R., Chen, J., Hu, Y., Li, Z., Wang, S., Shetty, S., & Fu, J.
(2014).
Sirt1 deletion leads to enhanced inflammation and aggravates endotoxin-induced acute kidney injury. 9(6), e98909-e98909.
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Han, J., Zhang, G., Welch, E. J., Liang, Y., Fu, J., Vogel, S. M., ... Li, Z.
(2013).
A critical role for Lyn kinase in strengthening endothelial integrity and barrier function. Blood.
122(25), 4140-4149.
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Gross, A. K., Dunn, S. P., Feola, D. J., Martin, C. A., Charnigo, R., Li, Z., Abdel-Latif, A., & Smyth, S. S.
(2013).
Clopidogrel treatment and the incidence and severity of community acquired pneumonia in a cohort study and meta-analysis of antiplatelet therapy in pneumonia and critical illness. Journal of Thrombosis and Thrombolysis.
35(2), 147-154.
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Wei, S., Wang, H., Zhang, G., Lu, Y., An, X., Ren, S., ... Huo, Y.
(2013).
Platelet IB kinase- deficiency increases mouse arterial neointima formation via delayed glycoprotein Ib shedding. Arteriosclerosis, Thrombosis and Vascular Biology.
33(2), 241-248.
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Xiang, B., Zhang, G., Guo, L., Li, X., Morris, A. J., Daugherty, A., ... Li, Z.
(2013).
Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway. 4(1), 2657.
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Xiang, B., Zhang, G., Stefanini, L., Bergmeier, W., Gartner, T. K., Whiteheart, S. W., & Li, Z.
(2012).
The Src family kinases and protein kinase C synergize to mediate Gq-dependent platelet activation. 287(49), 41277-41287.
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Xiang, B., Zhang, G., Li, X., Morris, A. J., Daugherty, A., Whiteheart, S. W., Smyth, S. S., & Li, Z.
(2012).
Platelets Protect From Lipopolysaccharide-Induced Lethal Endotoxemia by Inhibiting Macrophage-Dependent Inflammation Via the Cyclooxygenase 1 (COX1) Signaling Pathway. Blood.
120(21), 93-93.
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Li, Z., & Du, X.
(2012).
Response: yes, cGMP plays a stimulatory role in platelet activation. Blood.
119(22), 5336-5337.
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Cheng, H., Dong, A., Panchatcharam, M., Mueller, P., Yang, F., Li, Z., ... Smyth, S. S.
(2012).
Lysophosphatidic acid signaling protects pulmonary vasculature from hypoxia-induced remodeling. 32(1), 24-32.
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Xiang, B., Zhang, G., Ren, H., Sunkara, M., Morris, A. J., Gartner, T. K., Smyth, S. S., & Li, Z.
(2012).
The P2Y(12) antagonists, 2MeSAMP and cangrelor, inhibit platelet activation through P2Y(12)/G(i)-dependent mechanism. 7(12), e51037-e51037.
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Zhang, G., Xiang, B., Ye, S., Chrzanowska-Wodnicka, M., Morris, A. J., Gartner, T. K., ... Li, Z.
(2011).
Distinct roles for Rap1b protein in platelet secretion and integrin IIb3 outside-in signaling. 286(45), 39466-39477.
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Zhang, G., Xiang, B., Shaojing, Y. e., Chrzanowska-Wodnicka, M., Morris, A. J., Gartner, T. K., ... Li, Z.
(2011).
DISTINCT ROLES for Rap1b In PLATELET SECRETION and INTEGRIN aIIBb3 OUTSIDE-In SIGNALING. Blood.
118(21), 2200-2200.
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Xiang, B., Zhang, G., & Li, Z.
(2011).
Src Family Kinases Contribute to GI and Gq-Mediated Platelet Activation. Blood.
118(21), 5263-5263.
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Zhang, G., Xiang, B., Dong, A., Skoda, R. C., Daugherty, A., Smyth, S. S., Du, X., & Li, Z.
(2011).
Biphasic roles for soluble guanylyl cyclase (sGC) in platelet activation. Blood.
118(13), 3670-3679.
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Li, Z., & Smyth, S. S.
(2011).
Connexin 37 counteracts clotting. Circulation.
124(8), 873-875.
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Li, Z., Yang, F., Dunn, S., Gross, A. K., & Smyth, S. S.
(2011).
Platelets as immune mediators: their role in host defense responses and sepsis. 127(3), 184-188.
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Li, Z., Delaney, M. K., O'Brien, K. A., & Du, X.
(2010).
Signaling during platelet adhesion and activation. Arteriosclerosis, Thrombosis and Vascular Biology.
30(12), 2341-2349.
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Xiang, B., Zhang, G., Liu, J., Morris, A. J., Smyth, S. S., Gartner, T. K., & Li, Z.
(2010).
A novel P2Y12-Independent Signaling Pathway Mediating Akt Phosphorylation In Response to Thrombin Receptors. Blood.
116(21), 3191-3191.
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Zhang, G., Xiang, B., Skoda, R. C., Smyth, S. S., Du, X., & Li, Z.
(2010).
Biphasic Roles for the Soluble Guanylyl Cyclase (sGC) In Platelet Activation In Mice. Blood.
116(21), 486-486.
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Xiang, B., Zhang, G., Liu, J., Morris, A. J., Smyth, S. S., Gartner, T. K., & Li, Z.
(2010).
A G(i) -independent mechanism mediating Akt phosphorylation in platelets. 8(9), 2032-2041.
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Feng, H., Guo, L., Song, Z., Gao, H., Wang, D., Fu, W., ... Li, X.
(2010).
Caveolin-1 protects against sepsis by modulating inflammatory response, alleviating bacterial burden, and suppressing thymocyte apoptosis. 285(33), 25154-25160.
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Li, Z., Zhang, G., Liu, J., Stojanovic, A., Ruan, C., Lowell, C. A., & Du, X.
(2010).
An important role of the SRC family kinase Lyn in stimulating platelet granule secretion. 285(17), 12559-12570.
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Zhang, G., Han, J., Welch, E. J., Ye, R. D., Voyno-Yasenetskaya, T. A., Malik, A. B., Du, X., & Li, Z.
(2009).
Lipopolysaccharide stimulates platelet secretion and potentiates platelet aggregation via TLR4/MyD88 and the cGMP-dependent protein kinase pathway. Journal of Immunology.
182(12), 7997-8004.
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Welch, E. J., Naikawadi, R. P., Li, Z., Lin, P., Ishii, S., Shimizu, T., ... Ye, R. D.
(2009).
Opposing effects of platelet-activating factor and lyso-platelet-activating factor on neutrophil and platelet activation. 75(1), 227-234.
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Flevaris, P., Li, Z., Zhang, G., Zheng, Y. i., Liu, J., & Du, X.
(2009).
Two distinct roles of mitogen-activated protein kinases in platelets and a novel Rac1-MAPK-dependent integrin outside-in retractile signaling pathway. Blood.
113(4), 893-901.
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Yin, H., Liu, J., Li, Z., Berndt, M. C., Lowell, C. A., & Du, X.
(2008).
Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway. Blood.
112(4), 1139-1146.
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Li, Z., Zhang, G., Feil, R., Han, J., & Du, X.
(2006).
Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3. Blood.
107(3), 965-972.
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Marjanovic, J. A., Li, Z., Stojanovic, A., & Du, X.
(2005).
Stimulatory roles of nitric-oxide synthase 3 and guanylyl cyclase in platelet activation. 280(45), 37430-37438.
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Li, Z., Zhang, G., Yin, H., Feil, R., Hofmann, F., & Du, X.
(2005).
The Role of the cGMP-Dependent Protein Kinase II in Platelet Activation and In Vivo Thrombosis. Blood.
106(11), 653-653.
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Li, Z., Zhang, G., Marjanovic, J. A., Ruan, C., & Du, X.
(2004).
A platelet secretion pathway mediated by cGMP-dependent protein kinase. 279(41), 42469-42475.
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Du, X., Marjanovic, J. A., & Li, Z.
(2004).
On the roles of cGMP and glycoprotein Ib in platelet activation. 103(11), 4371-4372.
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Li, Z., Zhang, G., Le Breton, G. C., Gao, X., Malik, A. B., & Du, X.
(2003).
Two waves of platelet secretion induced by thromboxane A2 receptor and a critical role for phosphoinositide 3-kinases. 278(33), 30725-30731.
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Li, Z., Ajdic, J., Eigenthaler, M., & Du, X.
(2003).
A predominant role for cAMP-dependent protein kinase in the cGMP-induced phosphorylation of vasodilator-stimulated phosphoprotein and platelet inhibition in humans. Blood.
101(11), 4423-4429.
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Xi, X., Bodnar, R. J., Li, Z., Lam, S., & Du, X.
(2003).
Critical roles for the COOH-terminal NITY and RGT sequences of the integrin beta3 cytoplasmic domain in inside-out and outside-in signaling. Journal of Cell Biology.
162(2), 329-339.
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Li, Z., Xi, X., Gu, M., Feil, R., Ye, R. D., Eigenthaler, M., Hofmann, F., & Du, X.
(2003).
A stimulatory role for cGMP-dependent protein kinase in platelet activation. Cell.
112(1), 77-86.
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Bodnar, R. J., Xi, X., Li, Z., Berndt, M. C., & Du, X.
(2002).
Regulation of glycoprotein Ib-IX-von Willebrand factor interaction by cAMP-dependent protein kinase-mediated phosphorylation at Ser 166 of glycoprotein Ib(beta). 277(49), 47080-47087.
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Li, Z., Xi, X., & Du, X.
(2001).
A mitogen-activated protein kinase-dependent signaling pathway in the activation of platelet integrin alpha IIbbeta3. 276(45), 42226-42232.
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Englund, G. D., Bodnar, R. J., Li, Z., Ruggeri, Z. M., & Du, X.
(2001).
Regulation of von Willebrand factor binding to the platelet glycoprotein Ib-IX by a membrane skeleton-dependent inside-out signal. 276(20), 16952-16959.
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Bodnar, R. J., Gu, M., Li, Z., Englund, G. D., & Du, X.
(1999).
The cytoplasmic domain of the platelet glycoprotein Ibalpha is phosphorylated at serine 609. Journal of Biological Chemistry.
274(47), 33474-33479.
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Pandeya, A., Zhang, Y., Cui, J., Yang, L., Li, J., Zhang, G., ... Wei, Y.
(2023).
Inflammasome activation and pyroptosis mediate coagulopathy and inflammation in Salmonella systemic infection. 275, 127460-127460.
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chapter
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Li, Z., & Smyth, S. S.
(2019).
16 Interactions Between Platelets, Leukocytes, and the Endothelium. Platelets.
(pp. 295-310).
Elsevier.
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Xiang, B., & Li, Z.
(2017).
Defects of Platelet Signal Transduction. Platelets in Thrombotic and Non-Thrombotic Disorders.
(pp. 923-936).
Springer Nature.
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Li, Z., & Smyth, S. S.
(2019).
16 Interactions Between Platelets, Leukocytes, and the Endothelium. Platelets.
(pp. 295-310).
Elsevier.
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institutional repository document
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Ye, D., Howatt, D. A., Li, Z., Daugherty, A., Lu, H. S., & Wu, C.
(2021).
GSDMD Deficiency Protects Against Aortic Rupture
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Li, Z., Liang, Y., wang, c., Zhang, G., Schlossmann, J., Baron, M., ... Du, X.
(2020).
AN IMPORTANT STIMULATORY ROLE FOR THE cGMP-DEPENDENT PROTEIN KINASE II IN PLATELET ACTIVATION, IN VIVO THROMBOSIS AND HAEMOSTASIS
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Wu, C., Ye, D., Mullick, A. E., Li, Z., Danser, A., Daugherty, A., & Lu, H. S.
(2020).
Effects of Renin-Angiotensin Inhibition on ACE2 and TMPRSS2 Expression: Insights into COVID-19
-
Xiang, B., Zhang, G., Zhang, Y., Wu, C., Joshi, S., Morris, A. J., ... Li, Z.
(2020).
Calcium ion chelation preserves platelet function during cold storage
-
Wu, C., Zhang, Y., Li, L., Pandeya, A., Zhang, G., Cui, J., ... Li, Z.
(2020).
Extracellular histones trigger disseminated intravascular coagulation by lytic cell death
-
Ye, D., Howatt, D. A., Li, Z., Daugherty, A., Lu, H. S., & Wu, C.
(2021).
GSDMD Deficiency Protects Against Aortic Rupture
Teaching
teaching activities
- PHSC685 Directed Studies Instructor
- PHSC689 Sptp: Reseach Techniques Instructor
- PHSC691 Research Instructor
Contact
first name
- Zhenyu
has last name
- Li
Other
- zli21@tamu.edu