Curcuminoids from tumeric (Curcuma longa) target microRNA148 and microRNA146 in their anti-inflammatory effects in non-cancer colon cells Academic Article uri icon


  • The antiinflammatory properties of tumeric have been investigated in multiple studies, however the involvement of microRNAs in antiinflammatory properties of natural compounds has not been much investigated yet. We studied the potential protective effects of a standardized curcuminoid extract against inflammation induced by lipopolysacharide (LPS) in CCD18Co colon cells and investigated underlying miRNA based mechanisms. We investigated miRNAs 146, which is regulated by NFkB and involved in the regulation of the TLR4 pathway and also microRNA148a which is a regulator of pregnane X receptor (PXR) a transcription factor involved in the regulation of drugmetabolizing enzymes and drug transporters as well as in the suppression of NFkB. LPS significantly induced the expression of all inflammatory biomarkers by up to 2 fold. The extract significantly reduced the expression of inflammatory biomarkers including NFkB, IL6, IL8, TRAF6, TLR4 up to 0.9, 0.2, 0.4, 0.32, and 0.1 fold of control cells. The expression of microRNA146 and 148a were increased by LPS up to 30% and reduced by curcuminoids by 30 and 25% respectively. Overall, these data confirm the antiinflammatory effects of curcuminoids in colon and indicate the involvement of microRNAs 146 and 148a in the antiinflammatory effects of curcuminoids.Grant Funding Source: ASN

published proceedings


author list (cited authors)

  • Noratto, G., Angel-Morales, G., Del Follo, A., Tian, Y., & Mertens-Talcott, S.

citation count

  • 0

complete list of authors

  • Noratto, Giuliana||Angel-Morales, Gabriela||Del Follo, Armando||Tian, Yanan||Mertens-Talcott, Susanne

publication date

  • January 2010