Complexity of the Neurospora crassa circadian clock system: multiple loops and oscillators. Academic Article uri icon


  • Organisms from bacteria to humans use a circadian clock to control daily biochemical, physiological, and behavioral rhythms. We review evidence from Neurospora crassa that suggests that the circadian clock is organized as a network of genes and proteins that form coupled evening- and morning-specific oscillatory loops that can function autonomously, respond differently to environmental inputs, and regulate phase-specific outputs. There is also evidence for coupled morning and evening oscillator loops in plants, insects, and mammals, suggesting conservation of clock organization. From a systems perspective, fungi provide a powerful model organism for investigating oscillator complexity, communication between oscillators, and addressing reasons why the system has evolved to be so complex.

published proceedings

  • Cold Spring Harb Symp Quant Biol

altmetric score

  • 3

author list (cited authors)

  • de Paula, R. M., Vitalini, M. W., Gomer, R. H., & Bell-Pedersen, D.

citation count

  • 18

complete list of authors

  • de Paula, RM||Vitalini, MW||Gomer, RH||Bell-Pedersen, D

publication date

  • January 2007