Blood platelet uptake of serotonin in episodic aggression. Academic Article

abstract

• Blood platelet uptake of 3H-serotonin (5HT uptake), a potential marker of serotonergic function, was determined in male outpatients with episodic aggression (n = 15) and in age- and sex-matched nonaggressive controls (n = 15). Correlations with rating scales of "impulsivity" (Barratt Impulsivity Scale, 10th revision) and "anger" (Spielberger Anger Expression Scale) were performed. Mean 5HT uptake was 18% lower in patients with episodic aggression. A significant negative correlation between % difference in platelet 5HT uptake and impulsivity score was observed, but the correlation between 5HT uptake and anger was not significant. These results support the hypothesis of disturbed serotonergic function in aggression and suggest that the primary relationship is in the "control" of aggression. The blood platelet may be useful in identifying impulsive subtypes.

authors

• Kent, Thomas

published proceedings

• Psychiatry Res

altmetric score

• 3

author list (cited authors)

• Brown, C. S., Kent, T. A., Bryant, S. G., Gevedon, R. M., Campbell, J. L., Felthous, A. R., Barratt, E. S., & Rose, R. M.

citation count

• 77

complete list of authors

• Brown, CS||Kent, TA||Bryant, SG||Gevedon, RM||Campbell, JL||Felthous, AR||Barratt, ES||Rose, RM

publication date

• January 1989

publisher

• Elsevier  Publisher

published in

• Psychiatry Research  Journal

keywords

• Adolescent
• Adult
• Aggression
• Blood Platelets
• Circadian Rhythm
• Humans
• Impulsive Behavior
• Male
• Middle Aged
• Psychological Tests
• Seasons
• Serotonin
• Violence

PubMed Central ID

• 2922444

Digital Object Identifier (DOI)

• 10.1016/0165-1781(89)90003-6

start page

• 5

end page

• 12

volume

• 27

issue

• 1

URL

• http://dx.doi.org/10.1016/0165-1781(89)90003-6