Novel conformationally restricted tetracyclic analogs of Δ8-tetrahydrocannabinol
- Additional Document Info
- View All
Novel analogs of (-)-delta8-tetrahydrocannabinol (delta8-THC) in which the conformation of the side chain was restricted by incorporating the first one or two carbons into a six membered ring fused with the aromatic phenolic A ring were synthesized. The affinities of the novel ligands for CB1 and CB2 indicated that the "southbound" chain conformer retained the highest affinity for both receptors.
author list (cited authors)
Khanolkar, A. D., Lu, D., Fan, P., Tian, X., & Makriyannis, A.