Novel conformationally restricted tetracyclic analogs of delta8-tetrahydrocannabinol.

abstract

• Novel analogs of (-)-delta8-tetrahydrocannabinol (delta8-THC) in which the conformation of the side chain was restricted by incorporating the first one or two carbons into a six membered ring fused with the aromatic phenolic A ring were synthesized. The affinities of the novel ligands for CB1 and CB2 indicated that the "southbound" chain conformer retained the highest affinity for both receptors.

authors

• Lu, Dai

published proceedings

• Bioorg Med Chem Lett

altmetric score

• 3

author list (cited authors)

• Khanolkar, A. D., Lu, D., Fan, P., Tian, X., & Makriyannis, A.

citation count

• 33

complete list of authors

• Khanolkar, AD||Lu, D||Fan, P||Tian, X||Makriyannis, A

publication date

• January 1999

publisher

• Elsevier  Publisher

published in

• Bioorganic and Medicinal Chemistry Letters  Journal

keywords

• Animals
• Brain
• Cell Membrane
• Dronabinol
• Mice
• Rats
• Receptor, Cannabinoid, Cb2
• Receptors, Cannabinoid
• Receptors, Drug
• Spleen
• Structure-Activity Relationship

Digital Object Identifier (DOI)

• 10.1016/s0960-894x(99)00355-8

start page

• 2119

end page

• 2124

volume

• 9

issue

• 15

URL

• http://dx.doi.org/10.1016/s0960-894x(99)00355-8

user-defined tag

• 3 Good Health and Well-Being