Novel conformationally restricted tetracyclic analogs of Δ8-tetrahydrocannabinol Academic Article uri icon

abstract

  • Novel analogs of (-)-delta8-tetrahydrocannabinol (delta8-THC) in which the conformation of the side chain was restricted by incorporating the first one or two carbons into a six membered ring fused with the aromatic phenolic A ring were synthesized. The affinities of the novel ligands for CB1 and CB2 indicated that the "southbound" chain conformer retained the highest affinity for both receptors.

altmetric score

  • 3

author list (cited authors)

  • Khanolkar, A. D., Lu, D., Fan, P., Tian, X., & Makriyannis, A.

citation count

  • 27

publication date

  • August 1999