Part 3: Notch-sparing γ-secretase inhibitors: SAR studies of 2-substituted aminopyridopyrimidinones Academic Article uri icon

abstract

  • In search for novel lead compounds as γ-secretase inhibitors, analogs of aminopyrido[2,3-d]pyrimidin-7-ones (I) were synthesized and evaluated for inhibitory effects on amyloid-β-peptide production and cleavage of the Notch1 receptor mediated by γ-secretase. Selected pyridopyrimidines, such as 1, 8, 9, 10, 11 and 16 are γ-secretase inhibitors that did not have an effect on Notch1 receptor processing.

altmetric score

  • 12.5

author list (cited authors)

  • Zhang, J., Lu, D., Wei, H., Gu, Y., Selkoe, D. J., Wolfe, M. S., & Augelli-Szafran, C. E.

citation count

  • 2

publication date

  • May 2016