HR job title
- Retired Associate Professor
- Contact Info
- 1 979 845 7701
Mackenzie, Duncan Associate Professor
Positions
- Associate Professor, Biology, College of Arts and Sciences
Hormones secreted by the thyroid gland are of primary importance in the regulation of such fundamental physiological processes as growth, nutrient utilization, and reproduction. In my laboratory we examine the regulation of the secretion of thyroid hormones and their actions in poikilothermic vertebrates in order to understand the evolution of thyroid function. We are presently focusing on the regulation on thyroid hormone secretion and the mechanisms of iodine transport in commercially-important fish species such as the red drum (Sciaenops ocellatus), the channel catfish (Ictalurus punctatus), and even the zebrafish (Danio rerio).
This research is aimed at providing new insights into the potentially ancient role of thyroid hormones in nutrient assimilation, as well as elucidating evolutionary trends in the regulation of thyroid function. These studies may serve identify ways in which the pituitary-thyroid axis may be manipulated to enhance aquaculture production or endangered species conservation.
This research is aimed at providing new insights into the potentially ancient role of thyroid hormones in nutrient assimilation, as well as elucidating evolutionary trends in the regulation of thyroid function. These studies may serve identify ways in which the pituitary-thyroid axis may be manipulated to enhance aquaculture production or endangered species conservation.
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Overview
Publications
selected publications
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academic article
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Holloway, N., Riley, B., & MacKenzie, D. S.
(2021).
Expression of the sodium iodide symporter (NIS) in reproductive and neural tissues of teleost fish. General and Comparative Endocrinology.
300, 113632-113632.
-
Jones, R. A., Cohn, W. B., Wilkes, A. A., & MacKenzie, D. S.
(2017).
Negative feedback regulation of thyrotropin subunits and pituitary deiodinases in red drum, Sciaenops ocellatus. General and Comparative Endocrinology.
240, 19-26.
-
Martinez, B., Soanez-Organis, J. G., Viscarra, J. A., Jaques, J. T., MacKenzie, D. S., Crocker, D. E., & Ortiz, R. M.
(2016).
Glucose delays the insulin-induced increase in thyroid hormone-mediated signaling in adipose of prolong-fasted elephant seal pups. American Journal of Physiology. Regulatory Integrative and Comparative Physiology.
310(6), R502-R512.
-
Martinez, B., SoanezOrganis, J., MacKenzie, D., Crocker, D., & Ortiz, R.
(2015).
Thyroid Gland Remains Responsive to Thyroid Stimulating Hormone With Fasting Duration. The FASEB Journal.
29(S1),
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Pasupuleti, S., Sule, N., Cohn, W. B., MacKenzie, D. S., Jayaraman, A., & Manson, M. D.
(2014).
Chemotaxis of Escherichia coli to norepinephrine (NE) requires conversion of NE to 3,4-dihydroxymandelic acid. Journal of Bacteriology.
196(23), 3992-4000.
-
Martinez, B., SoanezOrganis, J., MacKenzie, D., Crocker, D., & Ortiz, R.
(2014).
Glucose infusion increases mRNA expression of deiodinase 1 & 2, and thyroid hormone receptor 1 in a fastingadapted mammal (1101.12). The FASEB Journal.
28(S1),
-
Martinez, B., Soanez-Organis, J. G., Vzquez-Medina, J. P., Viscarra, J. A., MacKenzie, D. S., Crocker, D. E., & Ortiz, R. M.
(2013).
Prolonged food deprivation increases mRNA expression of deiodinase 1 and 2, and thyroid hormone receptor -1 in a fasting-adapted mammal. Journal of Experimental Biology.
216(Pt 24), 4647-4654.
-
Browning, Z. S., Wilkes, A. A., Mackenzie, D. S., Patterson, R. M., & Lenox, M. W.
(2013).
Using PET/CT imaging to characterize 18F-fluorodeoxyglucose utilization in fish. Journal of Fish Diseases.
36(11), 911-919.
-
Jones, R. A., Cohn, W. B., Miller, T. C., Jaques, J. T., & Mackenzie, D. S.
(2013).
Cyclic mRNA expression of thyrotropin subunits and deiodinases in red drum, Sciaenops ocellatus. General and Comparative Endocrinology.
194, 248-256.
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Miller, T. C., Jaques, J. T., Szkudlinski, M. W., & Mackenzie, D. S.
(2012).
Thyrotropic activity of recombinant human glycoprotein hormone analogs and pituitary mammalian gonadotropins in goldfish (Carassius auratus): insights into the evolution of thyrotropin receptor specificity. General and Comparative Endocrinology.
177(1), 70-75.
-
Scobell, S. K., & Mackenzie, D. S.
(2011).
Reproductive endocrinology of Syngnathidae. Journal of Fish Biology.
78(6), 1662-1680.
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Cohn, W. B., Jones, R. A., Valverde, R. A., Leiner, K. A., & MacKenzie, D. S.
(2010).
Molecular cloning and regulation of mRNA expression of the thyrotropin and glycoprotein hormone subunits in red drum, Sciaenops ocellatus. Fish Physiology and Biochemistry.
36(4), 1277-1290.
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MacKenzie, D. S., Jones, R. A., & Miller, T. C.
(2009).
Thyrotropin in teleost fish. General and Comparative Endocrinology.
161(1), 83-89.
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Loter, T. C., MacKenzie, D. S., McLeese, J., & Eales, J. G.
(2007).
Seasonal changes in channel catfish thyroid hormones reflect increased magnitude of daily thyroid hormone cycles. AQUACULTURE.
262(2-4), 451-460.
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Mora, M. A., Musquiz, D., Bickham, J. W., Mackenzie, D. S., Hooper, M. J., Szabo, J. K., & Matson, C. W.
(2006).
Biomarkers of exposure and effects of environmental contaminants on swallows nesting along the Rio Grande, Texas, USA. Environmental Toxicology and Chemistry.
25(6), 1574-1584.
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Raine, J. C., Cameron, C., Vijayan, M. M., Mackenzie, D. S., & Leatherland, J. F.
(2005).
Effect of fasting on thyroid hormone levels, and TR(alpha) and TR(beta) mRNA accumulation in late-stage embryo and juvenile rainbow trout, Oncorhynchus mykiss. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
140(4), 452-459.
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Leiner, K. A., & Mackenzie, D. S.
(2003).
Central regulation of thyroidal status in a teleost fish: nutrient stimulation of T4 secretion and negative feedback of T3. 298(1), 32-43.
-
VanPutte, C. L., MacKenzie, D. S., & Eales, J. G.
(2001).
Characterization of hepatic low-K(m) outer-ring deiodination in red drum (Sciaenops ocellatus). Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology.
128(3), 413-423.
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Kohel, K. A., MacKenzie, D. S., Rostal, D. C., Grumbles, J. S., & Lance, V. A.
(2001).
Seasonality in plasma thyroxine in the desert tortoise, Gopherus agassizii. General and Comparative Endocrinology.
121(2), 214-222.
-
Leiner, K. A., & MacKenzie, D. S.
(2001).
The effects of photoperiod on growth rate and circulating thyroid hormone levels in the red drum, Sciaenops ocellatus: evidence for a free-running circadian rhythm of T(4) secretion. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
130(1), 141-149.
-
Ortiz, R. M., MacKenzie, D. S., & Worthy, G. A.
(2000).
Thyroid hormone concentrations in captive and free-ranging West Indian manatees (Trichechus manatus). Journal of Experimental Biology.
203(Pt 23), 3631-3637.
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Leiner, K. A., Han, G. S., & MacKenzie, D. S.
(2000).
The effects of photoperiod and feeding on the diurnal rhythm of circulating thyroid hormones in the red drum, Sciaenops ocellatus. General and Comparative Endocrinology.
120(1), 88-98.
-
Valverde, R. A., Owens, D. W., MacKenzie, D. S., & Amoss, M. S.
(1999).
Basal and stress-induced corticosterone levels in olive ridley sea turtles (Lepidochelys olivacea) in relation to their mass nesting behavior. Journal of Experimental Zoology.
284(6), 652-662.
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Moon, D. Y., Owens, D. W., & MacKenzie, D. S.
(1999).
The effects of fasting and increased feeding on plasma thyroid hormones, glucose, and total protein in sea turtles. Zoological Science: an international journal.
16(4), 579-586.
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Ortiz, R. M., Worthy, G. A., & MacKenzie, D. S.
(1998).
Osmoregulation in wild and captive West Indian manatees (Trichechus manatus). Physiological and Biochemical Zoology.
71(4), 449-457.
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Rostal, D. C., Owens, D. W., Grumbles, J. S., MacKenzie, D. S., & Amoss, M. S.
(1998).
Seasonal reproductive cycle of the Kemp's ridley sea turtle (Lepidochelys kempi). General and Comparative Endocrinology.
109(2), 232-243.
-
Moon, D., MacKenzie, D. S., & Owens, D. W.
(1998).
Serum thyroid hormone levels in wild and captive sea turtles. Animal Cells and Systems.
2(2), 177-181.
-
Moon, D. Y., MacKenzie, D. S., & Owens, D. W.
(1997).
Simulated hibernation of sea turtles in the laboratory: I. Feeding, breathing frequency, blood pH, and blood gases. Journal of Experimental Zoology.
278(6), 372-380.
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Heck, J., MacKenzie, D. S., Rostal, D., Medler, K., & Owens, D.
(1997).
Estrogen induction of plasma vitellogenin in the Kemp's ridley sea turtle (Lepidochelys kempi). General and Comparative Endocrinology.
107(2), 280-288.
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Figler, R. A., MacKenzie, D. S., Owens, D. W., Licht, P., & Amoss, M. S.
(1989).
Increased levels of arginine vasotocin and neurophysin during nesting in sea turtles. General and Comparative Endocrinology.
73(2), 223-232.
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MACKENZIE, D. S., THOMAS, P., & FARRAR, S. M.
(1989).
SEASONAL-CHANGES IN THYROID AND REPRODUCTIVE STEROID-HORMONES IN FEMALE CHANNEL CATFISH (ICTALURUS-PUNCTATUS) IN POND CULTURE. AQUACULTURE.
78(1), 63-80.
-
Mackenzie, D. S.
(1988).
Comparative endocrinology: hormones and reproduction in fishes, amphibians, and reptiles. Science.
239(4843), 1041-1041.
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MacKenzie, D. S., Sokolowska, M., Peter, R. E., & Breton, B.
(1987).
Increased gonadotropin levels in goldfish do not result in alterations in circulating thyroid hormone levels. General and Comparative Endocrinology.
67(2), 202-213.
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Chang, J. P., MacKenzie, D. S., Gould, D. R., & Peter, R. E.
(1984).
Effects of dopamine and norepinephrine on in vitro spontaneous and gonadotropin-releasing hormone-induced gonadotropin release by dispersed cells or fragments of the goldfish pituitary. LIFE SCIENCES.
35(20), 2027-2033.
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Stacey, N. E., MacKenzie, D. S., Marchant, T. A., Kyle, A. L., & Peter, R. E.
(1984).
Endocrine changes during natural spawning in the white sucker, Catostomus commersoni. I. Gonadotropin, growth hormone, and thyroid hormones. General and Comparative Endocrinology.
56(3), 333-348.
-
Scott, A. P., MacKenzie, D. S., & Stacey, N. E.
(1984).
Endocrine changes during natural spawning in the white sucker, Catostomus commersoni. II. Steroid hormones. General and Comparative Endocrinology.
56(3), 349-359.
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MacKenzie, D. S., Gould, D. R., Peter, R. E., Rivier, J., & Vale, W. W.
(1984).
Response of superfused goldfish pituitary fragments to mammalian and salmon gonadotropin-releasing hormones. LIFE SCIENCES.
35(20), 2019-2026.
-
MacKenzie, D. S., & Licht, P.
(1984).
Studies on the specificity of thyroid response to pituitary glycoprotein hormones. General and Comparative Endocrinology.
56(1), 156-166.
-
Papkoff, H., Licht, P., Bona-Gallo, A., MacKenzie, D. S., Oelofsen, W., & Oosthuizen, M. M.
(1982).
Biochemical and immunological characterization of pituitary hormones from the ostrich (Struthio camelus). General and Comparative Endocrinology.
48(2), 181-195.
-
MacKenzie, D. S.
(1982).
Stimulation of the thyroid gland of a teleost fish, Gillichthys mirabilis, by tetrapod pituitary glycoprotein hormones. Comparative Biochemistry and Physiology - A: Comparative Physiology.
72(3), 477-482.
-
MacKenzie, D. S., Licht, P., & Papkoff, H.
(1981).
Purification of thyrotropin from the pituitaries of two turtles: the green sea turtle and the snapping turtle. General and Comparative Endocrinology.
45(1), 39-48.
-
MacKenzie, D. S.
(1981).
In vivo thyroxine release in day-old cockerels in response to acute stimulation by mammalian and avian pituitary hormones. Poultry Science.
60(9), 2136-2143.
-
Bona-Gallo, A., Licht, P., MacKenzie, D. S., & Lofts, B.
(1980).
Annual cycles in levels of pituitary and plasma gonadotropin, gonadal steroids, and thyroid activity in the Chinese cobra (Naja naja). General and Comparative Endocrinology.
42(4), 477-493.
-
MacKenzie, D. S., Licht, P., & Papkoff, H.
(1978).
Thyrotropin from amphibian (Rana catesbeiana) pituitaries and evidence for heterothyrotropic activity of bullfrog luteinizing hormone in reptiles. General and Comparative Endocrinology.
36(4), 566-574.
-
Licht, P., MacKenzie, D. S., Papkoff, H., & Farmer, S.
(1977).
Immunological studies with the gonadotropins and their subunits from the green sea turtle Chelonia mydas. General and Comparative Endocrinology.
33(2), 231-241.
-
GATLIN, D. M., MACKENZIE, D. S., CRAIG, S. R., & NEILL, W. H.
EFFECTS OF DIETARY-SODIUM CHLORIDE ON RED DRUM JUVENILES IN WATERS OF VARIOUS SALINITIES. Progressive Fish-Culturist.
54(4), 220-227.
-
Pohlenz, C., Buentello, A., Miller, T., Small, B. C., MacKenzie, D. S., & Gatlin, D. M.
Effects of dietary arginine on endocrine growth factors of channel catfish, Ictalurus punctatus. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
166(2), 215-221.
-
Moon, H. L., Mackenzie, D. S., & Gatlin, D. M.
Effects of dietary thyroid hormones on the red drum (Sciaenops ocellatus). Fish Physiology and Biochemistry.
12(5), 369-380.
-
Gaylord, T. G., MacKenzie, D. S., & Gatlin, D. M.
Growth performance, body composition and plasma thyroid hormone status of channel catfish (Ictalurus punctatus) in response to short-term feed deprivation and refeeding. Fish Physiology and Biochemistry.
24(1), 73-79.
-
Garner, J. A., MacKenzie, D. S., & Gatlin, D.
Reproductive Biology of Atlantic Leatherback Sea Turtles at Sandy Point, St. Croix: The First 30 Years. Chelonian Conservation and Biology.
16(1), 29-43.
-
Craig, S. R., MacKenzie, D. S., Jones, G., & Gatlin, D. M.
Seasonal changes in the reproductive condition and body composition of free-ranging red drum, Sciaenops ocellatus. AQUACULTURE.
190(1-2), 89-102.
-
Holloway, N., Riley, B., & MacKenzie, D. S.
(2021).
Expression of the sodium iodide symporter (NIS) in reproductive and neural tissues of teleost fish. General and Comparative Endocrinology.
300, 113632-113632.
-
conference paper
-
Holloway, N. D., Mackenzie, D. S., & Riley, B. B.
(2020).
Evidence for expression of the sodium iodide symporter (NIS) in novel neural and ovarian locations in teleost fish. INTEGRATIVE AND COMPARATIVE BIOLOGY.
E104-E104.
-
Jones, R. A., Cohn, W. B., & Mackenzie, D. S.
(2014).
Regulation of Thyrotropin mRNA Expression in Red Drum, Sciaenops ocellatus. INTEGRATIVE AND COMPARATIVE BIOLOGY.
E103-E103.
-
Wilkes, A. A., Browning, Z., Lenox, M., Jaques, J., & Mackenzie, D. S.
(2014).
High Resolution Functional Imaging of Fish Endocrine Glands and Target Tissues Using Positron Emission Tomography-Computed Tomography. INTEGRATIVE AND COMPARATIVE BIOLOGY.
E369-E369.
-
Scobell, S. K., Mackenzie, D. S., Jaques, J. T., & Jones, A. G.
(2012).
Androgens and female intrasexual aggression in the sex-role reversed Gulf pipefish. INTEGRATIVE AND COMPARATIVE BIOLOGY.
E156-E156.
-
Raine, J. C., Cameron, C., Vijayan, M. M., Mackenzie, D. S., & Leatherland, J. F.
(2006).
A comparison of thyroid hormone receptor gene expression in food-deprived late-stage embryo and juvenile rainbow trout. 169-169.
-
MacKenzie, D. S., VanPutte, C. M., & Leiner, K. A.
(1998).
Nutrient regulation of endocrine function in fish. AQUACULTURE.
3-25.
-
MOON, D. Y., MACKENZIE, D. S., & OWENS, D. W.
(1990).
BEHAVIORAL AND METABOLIC RESPONSES OF CAPTIVE SEA-TURTLES TO COLD TEMPERATURE. AMERICAN ZOOLOGIST.
A123-A123.
-
HAYNES, S. P., & MACKENZIE, D. S.
(1990).
THYROID-HORMONE BINDING TO SERUM-PROTEINS IN SEA-TURTLES. AMERICAN ZOOLOGIST.
A124-A124.
-
HECK, J., MACKENZIE, D. S., & OWENS, D. W.
(1990).
VITELLOGENIN FROM THE KEMPS RIDLEY SEA-TURTLE. AMERICAN ZOOLOGIST.
A23-A23.
-
MACKENZIE, D. S., HAYNES, S. P., & MCKEE, J. W.
(1988).
SEASONAL PATTERNS OF THYROID-HORMONE PLASMA-PROTEIN BINDING IN THE CHANNEL CATFISH. AMERICAN ZOOLOGIST.
A149-A149.
-
WIBBELS, T., MACKENZIE, D. S., OWENS, D. W., AMOSS, M. S., & LIMPUS, C. J.
(1986).
ASPECTS OF THYROID PHYSIOLOGY IN LOGGERHEAD SEA-TURTLES, CARETTA-CARETTA. AMERICAN ZOOLOGIST.
A106-A106.
-
FIGLER, R. A., OWENS, D., MACKENZIE, D. S., & LICHT, P.
(1986).
CHANGES IN THE PLASMA-CONCENTRATION OF ARGININE VASOTOCIN DURING OVIPOSITION IN SEA-TURTLES. AMERICAN ZOOLOGIST.
A4-A4.
-
MACKENZIE, D. S.
(1986).
EFFECTS OF ESTRADIOL ON THYROID-HORMONE PLASMA-PROTEIN BINDING IN THE GOLDFISH. AMERICAN ZOOLOGIST.
A107-A107.
-
MACKENZIE, D. S., MARCHANT, T. A., CHANG, J. P., SOKOLOWSKA, M., & PETER, R. E.
(1984).
PLASMA THYROID-HORMONE LEVELS DURING INDUCED AND SPONTANEOUS OVULATION IN THE GOLDFISH (CARASSIUS-AURATUS). AMERICAN ZOOLOGIST.
A151-A151.
-
Mackenzie, D. S., Moon, H. Y., Gatlin, D. M., & Perez, L. R.
Dietary effects on thyroid hormones in the red drum, Sciaenops ocellatus. Fish Physiology and Biochemistry.
329-335.
-
Holloway, N. D., Mackenzie, D. S., & Riley, B. B.
(2020).
Evidence for expression of the sodium iodide symporter (NIS) in novel neural and ovarian locations in teleost fish. INTEGRATIVE AND COMPARATIVE BIOLOGY.
E104-E104.
Teaching
teaching activities
- ANSC491 Hnr-research Instructor
- BIOL112 Hnr-introductory Biology Ii Instructor
- BIOL291 Research Instructor
- BIOL405 Compar Endocrinology Instructor
- BIOL491 Hnr-research Instructor
- BIOL681 Seminar: Marine Biology Instructor
- BIOL685 Directed Studies Instructor
- BIOL691 Research Instructor
- NUTR491 Hnr-research Instructor
- SCEN289 Clsc Hullabaloo U Instructor
- SCEN289 Sptp: Hnr-sc First Yr Sch Instructor
- UGST485 Directed Studies Instructor
Works By Students
chaired theses and dissertations
-
Crawford, Jared Louis (2004-09). Seasonal variation in thyroxine in the American alligator (Alligator mississippiensis).
-
Garner, Jeanne (2012-07). Reproductive Endocrinology of Nesting Leatherback Sea Turtles in St. Croix, U.S. Virgin Islands.
-
Jones, Richard Alan (2012-10). Regulation of Thyrotropin mRNA Expression in Red Drum, Sciaenops ocellatus.
-
Miller, Thomas Charles (2012-07). Biological Activity of Thyrotropin in Two Teleost Fish, Red Drum (Sciaenops ocellatus) and Goldfish (Carassius auratus).
-
Romney, Sherdina Ericia (2017-05). A Species' Trait Based Approach to Climate Change Vulnerability Assessment in North Sea Fisheries Species.
-
Thronson, Amanda Mae (2009-05). Effect of variation in freshwater inflow on phytoplankton productivity and community composition in galveston bay, texas.
Background
education and training
- Ph.D. in Zoology, University of California, Berkeley - (Berkeley, California, United States) 1980
- B.S. in Zoology, University of California, Davis - (Davis, California, United States) 1975
- University of Alberta - (Edmonton, Alberta, Canada) , Postdoctoral Training 1983
awards and honors
- Association of Former Students University-Level Distinguished Achievement Award, The, conferred by Texas A&M University - (College Station, Texas, United States), 2019
- Association of Former Students College-Level Teaching Distinguished Achievement Award, The, conferred by Texas A&M University - (College Station, Texas, United States), 2002
- Association of Former Students College-Level Teaching Distinguished Achievement Award, The, conferred by Texas A&M University - (College Station, Texas, United States), 1989
Contact
first name
- Duncan
has last name
- Mackenzie
mailing address
-
Texas A&M University
Biology
3258 TAMU
College Station, TX 77843-3258
USA
Other
- d-mackenzie@tamu.edu