Stimulation of the thyroid gland of a teleost fish, Gillichthys mirabilis, by tetrapod pituitary glycoprotein hormones. Academic Article

abstract

• 1. 1. Thyrotropins and gonadotropins purified from representatives of each tetrapod class and subunits of the mammalian hormones were tested for their ability to stimulate acute in vivo thyroxine release in a teleost fish. 2. 2. All intact hormones showed significant, intrinsic thyrotropic activity in this fish; subunits were inactive. 3. 3. Gonadotropins and thyrotropins capable of stimulating the teleost thyroid are therefore found in all tetrapod classes. 4. 4. Independent evolution of teleost fish has apparently led to an unusual situation in which the thyroid receptors for glycoprotein hormones are unable to distinguish between these structurally similar molecules from heterologous species. 1982.

authors

• Mackenzie, Duncan

published proceedings

• Comp Biochem Physiol A Comp Physiol

author list (cited authors)

• MacKenzie, D. S.

citation count

• 28

complete list of authors

• MacKenzie, DS

publication date

• January 1982

publisher

• Elsevier  Publisher

published in

• Comparative Biochemistry and Physiology - A: Comparative Physiology  Journal

keywords

• Animals
• Biological Evolution
• Female
• Fishes
• Follicle Stimulating Hormone
• Luteinizing Hormone
• Male
• Pituitary Hormones
• Species Specificity
• Thyroid Gland
• Thyrotropin
• Thyroxine

Digital Object Identifier (DOI)

• 10.1016/0300-9629(82)90111-6

start page

• 477

end page

• 482

volume

• 72

issue

• 3

URL

• http%3A%2F%2Fdx.doi.org%2F10.1016%2F0300-9629%2882%2990111-6