Sacha inchi (Plukenetia volubillis L.) oil as novel source of dietary fat to prevent inflammation and cardiovascular disease risk Conference Paper uri icon


  • Cardiovascularrelated diseases (CVD) are the main cause of death around the world and the largest economic burden. Western diets have adopted a pattern in which ratios omega6 (n6): omega3 (n 3) fatty acids (FA) are 15:116:1, which promotes inflammation and CVD. Sacha inchi seeds, native to Peru and source of dietary oil (SIO) contain a FA profile of n3: n6 1, characteristic in Mediterranean diet. However, the composition of SIO varies by cultivar and the health benefits have not been investigated. Our goal was to characterize SIO in 16 cultivars and the antiinflammatory properties using human endothelial vein cells (HUVEC). SIO were analyzed by gas chromatography and HPLC, and antioxidant activity (AOX) by ABTS. A commercial SIO was assessed in HUVEC using the dichlorofluorescein diacetate (DCFHDA) assay for reactive oxygen species (ROS), and qRTPCR for mRNA. Results showed that SIO from different cultivars are rich in (n6) linoleic (36.140.9%) and (n3) linolenic acids (37.243.9%), (702.61601.3 g/g), and tocopherols (0.8 y 925.9 g/g) and exerted AOX (7.710.3 mol TE/g). SIO decreased H2O2induced ROS (0.73fold) and downregulated LPSinduced expression of NFkB (0.84fold), TNF (0.72fold), VCAM1(0.68fold), and ICAM1 (0.64fold). Overall, these results suggest the health cardioprotective benefits of SIO as a novel source of dietary fat.Grant Funding Source : ASN

published proceedings


author list (cited authors)

  • Noratto, G. D., Chirinos, R., Campos, D., Larondelle, Y., Arbizu, S., Dos Santos, M. M., & Mertens-Talcott, S.

citation count

  • 1

complete list of authors

  • Noratto, Giuliana Doris||Chirinos, Rosana||Campos, David||Larondelle, Yvan||Arbizu, Shirley||Dos Santos, Manoela Maciel||Mertens-Talcott, Susanne

publication date

  • January 2012