Red Sweet Cherry Ameliorates Inflammation in Obese Diabetic (db/db) Mice Conference Paper uri icon


  • We studied the possible protective effect of cherry intake on metabolic syndrome and diabetes complications using the obese diabetic (db/db) mouse model. Mice (45 week old) were fed an agarbased AIN93G diet supplemented with 0 (obese control), 5 or 10% cherry powder. Corn starch replaced cherry powder to maintain isocaloric content of the diets. In addition, a lean group fed same diet as obese control served as the lean control. At the end of 12 weeks, mice were euthanized; blood and organs were collected to analyze endpoint biomarkers of disease and inflammation using standard analytical protocols. Food intake, body mass index (BMI), body weight, and fasting blood glucose were similar among obese, 5% and 10% cherry groups and were higher than the lean group (p < 0.05). These results are consistent with liver, kidney, and heart weights and with mesenteric and epididymal fat. However, cecum tissue weight was higher (p < 0.05) in 10% cherry (0.3 0.1 g/animal) compared to obese, lean, and 5% cherry groups (0.110.19 g/animal); weight of cecum content was higher in the 5% and 10% cherry groups compared to obese and lean groups. This indicates an effect of cherry fiber and may suggest an improvement in circulating lipids.Plasma concentrations of monocyte chemoattractant protein (MCP)1, leptin, insulin, resistin, and plasminogen activator inhibitor (PAI)1 were generally similar among obese and cherry groups and higher than the lean group. Interestingly, plasma interleukin (IL)6 in obese mice (98 34 g/mL, mean SE) tended to be higher than in the 5 and 10% cherry groups (34 13.4 and 25 8 g/mL, respectively), but did not reach significance due to high variability among animal subjects. IL6 was higher (p< 0.05) in all db/db groups compared to lean group (13 2 g/mL).Therefore, cherry intake may help decrease inflammation induced by obesity and hyperglycemia. Further studies are needed to investigate the potential protective effect of cherries against obesity and diabetes complications.Support or Funding InformationWashington State Department of Agriculture and Washington State Fruit Commission

published proceedings


author list (cited authors)

  • Noratto, G., Chew, B. P., & Mertens-Talcott, S. U.

citation count

  • 0

complete list of authors

  • Noratto, Giuliana||Chew, Boon P||Mertens-Talcott, Susanne U

publication date

  • January 2017