Membrane Oxidation in Cell Delivery and Cell Killing Applications. Academic Article uri icon


  • Cell delivery or cell killing processes often involve the crossing or disruption of cellular membranes. We review how, by modifying the composition and properties of membranes, membrane oxidation can be exploited to enhance the delivery of macromolecular cargoes into live human cells. We also describe how membrane oxidation can be utilized to achieve efficient killing of bacteria by antimicrobial peptides. Finally, we present recent evidence highlighting how membrane oxidation is intimately engaged in natural biological processes such as antigen delivery in dendritic cells and in the killing of bacteria by antimicrobial peptides. Overall, the insights that have been recently gained in this area should facilitate the development of more effective delivery technologies and antimicrobial therapeutic approaches.

published proceedings

  • ACS Chem Biol

altmetric score

  • 10.05

author list (cited authors)

  • Wang, T., Libardo, M., Angeles-Boza, A. M., & Pellois, J.

citation count

  • 74

complete list of authors

  • Wang, Ting-Yi||Libardo, M Daben J||Angeles-Boza, Alfredo M||Pellois, Jean-Philippe

publication date

  • May 2017