HR job title
- Research Scientist
- Contact Info
Kodali, Maheedhar Research Scientist
Positions
- Research Scientist, Cell Biology and Genetics, Texas A&M University Naresh K. Vashisht College of Medicine
Research Interests: Understanding pathophysiology and developing treatment strategies for neurodegenerative conditions including Gulf War Illness, Traumatic Brain Injury, Aging, Alzheimer's Disease and Temporal Lobe Epilepsy,
Expertise: Developing experimental models for Gulf War Illness, Traumatic Brain Injury, and Temporal Lobe Epilepsy, Survival surgeries for transplantation of cells and chronic EEG recordings, isolation of microglia and astrocytes from rodent brains, functional assessment in rodents by neurocognitive tests, investigation of modulation of neuroinflammation and neurogenesis at the cellular and molecular level, human mesenchymal stem cell cultures and isolation of extracellular Vesicles.
Expertise: Developing experimental models for Gulf War Illness, Traumatic Brain Injury, and Temporal Lobe Epilepsy, Survival surgeries for transplantation of cells and chronic EEG recordings, isolation of microglia and astrocytes from rodent brains, functional assessment in rodents by neurocognitive tests, investigation of modulation of neuroinflammation and neurogenesis at the cellular and molecular level, human mesenchymal stem cell cultures and isolation of extracellular Vesicles.
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Overview
Publications
selected publications
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academic article
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Kodali, M., Jankay, T., Shetty, A. K., & Reddy, D. S.
(2023).
Pathophysiological basis and promise of experimental therapies for Gulf War Illness, a chronic neuropsychiatric syndrome in veterans. Psychopharmacology.
240(4), 673-697.
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Kodali, M., Madhu, L. N., Reger, R. L., Milutinovic, B., Upadhya, R., Gonzalez, J. J., ... Shetty, A. K.
(2023).
Intranasally administered human MSC-derived extracellular vesicles inhibit NLRP3-p38/MAPK signaling after TBI and prevent chronic brain dysfunction. 108, 118-134.
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Attaluri, S., Arora, M., Madhu, L. N., Kodali, M., Shuai, B., Melissari, L., ... Shetty, A. K.
(2022).
Oral Nano-Curcumin in a Model of Chronic Gulf War Illness Alleviates Brain Dysfunction with Modulation of Oxidative Stress, Mitochondrial Function, Neuroinflammation, Neurogenesis, and Gene Expression. Aging and Disease.
13(2), 583-613.
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Madhu, L. N., Kodali, M., & Shetty, A. K.
(2022).
Promise of metformin for preventing age-related cognitive dysfunction. NEURAL REGENERATION RESEARCH.
17(3), 503-507.
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Attaluri, S., Upadhya, R., Kodali, M., Madhu, L. N., Upadhya, D., Shuai, B., & Shetty, A. K.
(2022).
Brain-Specific Increase in Leukotriene Signaling Accompanies Chronic Neuroinflammation and Cognitive Impairment in a Model of Gulf War Illness. Frontiers in Immunology.
13, 853000.
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Bryant, J. D., Kodali, M., Shuai, B., Menissy, S. S., Graves, P. J., Phan, T. T., ... West, A. P.
(2021).
Neuroimmune mechanisms of cognitive impairment in a mouse model of Gulf War illness. Brain, Behavior, and Immunity.
97, 204-218.
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Madhu, L. N., Kodali, M., Attaluri, S., Shuai, B., Melissari, L., Rao, X., & Shetty, A. K.
(2021).
Melatonin improves brain function in a model of chronic Gulf War Illness with modulation of oxidative stress, NLRP3 inflammasomes, and BDNF-ERK-CREB pathway in the hippocampus. Redox Biology.
43, 101973-101973.
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Kodali, M., Attaluri, S., Madhu, L. N., Shuai, B., Upadhya, R., Gonzalez, J. J., Rao, X., & Shetty, A. K.
(2021).
Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus. Aging Cell.
20(2), e13277.
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Kodali, M., Mishra, V., Hattiangady, B., Attaluri, S., Gonzalez, J. J., Shuai, B., & Shetty, A. K.
(2021).
Moderate, intermittent voluntary exercise in a model of Gulf War Illness improves cognitive and mood function with alleviation of activated microglia and astrocytes, and enhanced neurogenesis in the hippocampus. Brain, Behavior, and Immunity.
97, 135-149.
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Gita, D., Dos Santos, Y., Upadhya, R., Kodali, M., Madhu, L. N., & Shetty, A. K.
(2020).
Extracellular Vesicles in the Forebrain Display Reduced miR-346 and miR-331-3p in a Rat Model of Chronic Temporal Lobe Epilepsy. Molecular Neurobiology.
57(3), 1674-1687.
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Upadhya, R., Madhu, L. N., Attaluri, S., Gita, D., Pinson, M. R., Kodali, M., ... Shetty, A. K.
(2020).
Extracellular vesicles from human iPSC-derived neural stem cells: miRNA and protein signatures, and anti-inflammatory and neurogenic properties. Journal of Extracellular Vesicles.
9(1), 1809064-1809064.
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Shetty, A. K., Attaluri, S., Kodali, M., Shuai, B., Shetty, G. A., Upadhya, D., ... Rao, X.
(2020).
Monosodium luminol reinstates redox homeostasis, improves cognition, mood and neurogenesis, and alleviates neuro- and systemic inflammation in a model of Gulf War Illness. Redox Biology.
28, 101389-101389.
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Upadhya, D., Kodali, M., Gitai, D., Castro, O. W., Zanirati, G., Upadhya, R., ... Shetty, A. K.
(2019).
A Model of Chronic Temporal Lobe Epilepsy Presenting Constantly Rhythmic and Robust Spontaneous Seizures, Co-morbidities and Hippocampal Neuropathology. Aging and Disease.
10(5), 915-936.
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Shetty, A. K., Upadhya, R., Madhu, L. N., & Kodali, M.
(2019).
Novel Insights on Systemic and Brain Aging, Stroke, Amyotrophic Lateral Sclerosis, and Alzheimer's Disease. Aging and Disease.
10(2), 470-482.
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Kodali, M., Castro, O. W., Kim, D., Thomas, A., Shuai, B., Attaluri, S., ... Shetty, A. K.
(2019).
Intranasally Administered Human MSC-Derived Extracellular Vesicles Pervasively Incorporate into Neurons and Microglia in both Intact and Status Epilepticus Injured Forebrain. International Journal of Molecular Sciences.
21(1), 181-181.
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Madhu, L. N., Attaluri, S., Kodali, M., Shuai, B., Upadhya, R., Gitai, D., & Shetty, A. K.
(2019).
Neuroinflammation in Gulf War Illness is linked with HMGB1 and complement activation, which can be discerned from brain-derived extracellular vesicles in the blood. Brain, Behavior, and Immunity.
81, 430-443.
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Hussain, T., Kil, H., Hattiangady, B., Lee, J., Kodali, M., Shuai, B., ... Aldaz, C. M.
(2019).
Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus. NEUROBIOLOGY OF DISEASE.
121, 163-176.
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Upadhya, D., Hattiangady, B., Castro, O. W., Shuai, B., Kodali, M., Attaluri, S., ... Shetty, A. K.
(2019).
Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration. Proceedings of the National Academy of Sciences of the United States of America.
116(1), 287-296.
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Shetty, A. K., Kodali, M., Upadhya, R., & Madhu, L. N.
(2018).
Emerging Anti-Aging Strategies - Scientific Basis and Efficacy. Aging and Disease.
9(6), 1165-1184.
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Kodali, M., Hattiangady, B., Shetty, G. A., Bates, A., Shuai, B., & Shetty, A. K.
(2018).
Curcumin treatment leads to better cognitive and mood function in a model of Gulf War Illness with enhanced neurogenesis, and alleviation of inflammation and mitochondrial dysfunction in the hippocampus. Brain, Behavior, and Immunity.
69, 499-514.
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Petrescu, A. D., Grant, S., Frampton, G., McMillin, M., Kain, J., Kodali, M., Shetty, A. K., & DeMorrow, S.
(2018).
Gulf war illness-related chemicals increase CD11b/c+ monocyte infiltration into the liver and aggravate hepatic cholestasis in a rodent model. Scientific Reports.
8(1), 13147.
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Matos, H., Koike, B., Pereira, W., de Andrade, T. G., Castro, O. W., Duzzioni, M., ... Gita, D.
(2018).
Rhythms of Core Clock Genes and Spontaneous Locomotor Activity in Post-Status Epilepticus Model of Mesial Temporal Lobe Epilepsy. Frontiers in Neurology.
9(AUG), 632.
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McMillin, M., Grant, S., Frampton, G., Kodali, M., Shetty, A., & DeMorrow, S.
(2017).
CHOLESTATIC LIVER INJURY IS EXACERBATED BY PRIOR EXPOSURE TO GULF WAR ILLNESS-RELATED CHEMICALS. Gastroenterology.
152(5), S1064-S1064.
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Shetty, G. A., Hattiangady, B., Upadhya, D., Bates, A., Attaluri, S., Shuai, B., Kodali, M., & Shetty, A. K.
(2017).
Chronic Oxidative Stress, Mitochondrial Dysfunction, Nrf2 Activation and Inflammation in the Hippocampus Accompany Heightened Systemic Inflammation and Oxidative Stress in an Animal Model of Gulf War Illness. Frontiers in Molecular Neuroscience.
10, 182.
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Castro, O. W., Upadhya, D., Kodali, M., & Shetty, A. K.
(2017).
Resveratrol for Easing Status Epilepticus Induced Brain Injury, Inflammation, Epileptogenesis, and Cognitive and Memory Dysfunction-Are We There Yet?. Frontiers in Neurology.
8(NOV), 603.
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Kodali, M., Megahed, T., Mishra, V., Shuai, B., Hattiangady, B., & Shetty, A. K.
(2016).
Voluntary Running Exercise-Mediated Enhanced Neurogenesis Does Not Obliterate Retrograde Spatial Memory. Journal of Neuroscience.
36(31), 8112-8122.
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Upadhya, D., Hattiangady, B., Shetty, G. A., Zanirati, G., Kodali, M., & Shetty, A. K.
(2016).
Neural Stem Cell or Human Induced Pluripotent Stem Cell-Derived GABA-ergic Progenitor Cell Grafting in an Animal Model of Chronic Temporal Lobe Epilepsy. Current Protocols in Stem Cell Biology.
38(1), 2D.7.1-2D.7.47.
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Mishra, V., Shuai, B., Kodali, M., Shetty, G. A., Hattiangady, B., Rao, X., & Shetty, A. K.
(2015).
Resveratrol Treatment after Status Epilepticus Restrains Neurodegeneration and Abnormal Neurogenesis with Suppression of Oxidative Stress and Inflammation. Scientific Reports.
5(1), 17807.
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Kodali, M., Parihar, V. K., Hattiangady, B., Mishra, V., Shuai, B., & Shetty, A. K.
(2015).
Resveratrol prevents age-related memory and mood dysfunction with increased hippocampal neurogenesis and microvasculature, and reduced glial activation. Scientific Reports.
5(1), 8075.
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Shetty, A. K., Mishra, V., Kodali, M., & Hattiangady, B.
(2014).
Blood brain barrier dysfunction and delayed neurological deficits in mild traumatic brain injury induced by blast shock waves. Frontiers in Cellular Neuroscience.
8(AUG), 232.
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Hattiangady, B., Mishra, V., Kodali, M., Shuai, B., Rao, X., & Shetty, A. K.
(2014).
Object location and object recognition memory impairments, motivation deficits and depression in a model of Gulf War illness. Frontiers in Behavioral Neuroscience.
8(MAR), 78.
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Kodali, M., Hattiangady, B., Watanabe, J., Rao, X., & Shetty, A. K.
(2014).
Unilateral Moderate Controlled Cortical Impact Traumatic Brain Injury Induces Enduring Deficits in Spatial, Object Location, Object Recognition and Pattern Separation Memory, and Mood Function. Cell Transplantation.
23(6), 774-775.
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Vidyasagar, M. S., Kodali, M., Prakash Saxena, P. u., Upadhya, D., Murali Krishna, C., Vadhiraja, B. M., Fernandes, D. J., & Bola Sadashiva, S. R.
(2010).
Predictive and prognostic significance of glutathione levels and DNA damage in cervix cancer patients undergoing radiotherapy. International Journal of Radiation: Oncology - Biology - Physics.
78(2), 343-349.
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Vidyasagar, M. S., Kodali, M., Balu, P. N., Baijal, G., Vadhiraja, B. M., Bhat, R. A., Fernandes, D. J., & Krishna, C. M.
(2009).
Serum protein profile studies of cervical cancers in monitoring of tumor response to radiotherapy using HPLC-LIF: A pilot study. Photonics & Lasers in Medicine.
24(3), 165-174.
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Kodali, M., Madhu, L. N., Reger, R. L., Milutinovic, B., Upadhya, R., Attaluri, S., ... Shetty, A. K.
A single intranasal dose of human mesenchymal stem cell-derived extracellular vesicles after traumatic brain injury eases neurogenesis decline, synapse loss, and BDNF-ERK-CREB signaling. Frontiers in Molecular Neuroscience.
16, 1185883.
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Ayyubova, G., Kodali, M., Upadhya, R., Madhu, L. N., Attaluri, S., Somayaji, Y., ... Shetty, A. K.
Extracellular vesicles from hiPSC-NSCs can prevent peripheral inflammation-induced cognitive dysfunction with inflammasome inhibition and improved neurogenesis in the hippocampus. Journal of Neuroinflammation.
20(1), 297.
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Kodali, M., Madhu, L. N., Kolla, V., Attaluri, S., Huard, C., Somayaji, Y., ... Shetty, A. K.
FDA-approved cannabidiol [Epidiolex] alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and declined neurogenesis. Military Medical Research.
11(1), 61.
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Attaluri, S., Jaimes Gonzalez, J., Kirmani, M., Vogel, A. D., Upadhya, R., Kodali, M., ... Shetty, A. K.
Intranasally administered extracellular vesicles from human induced pluripotent stem cell-derived neural stem cells quickly incorporate into neurons and microglia in 5xFAD mice. Frontiers in Aging Neuroscience.
15, 1200445.
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Kodali, M., Madhu, L. N., Somayaji, Y., Attaluri, S., Huard, C., Panda, P. K., ... Shetty, A. K.
Residual Microglia Following Short-term PLX5622 Treatment in 5xFAD Mice Exhibit Diminished NLRP3 Inflammasome and mTOR Signaling, and Enhanced Autophagy. 5(07-26), 2024.07.11.603157.
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Kodali, M., Gonzalez, J. J., Oake, C., Huard, C., Somayaji, Y., Shuai, B., ... Shetty, A. K.
Transient CSF1R Inhibition in the Early Stage of AD Retains Homeostatic Microglia with Reduced Inflammasomes and Increased autophagy in the 5XFAD Model. Alzheimer's and Dementia.
19(S13),
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Kodali, M., Jankay, T., Shetty, A. K., & Reddy, D. S.
(2023).
Pathophysiological basis and promise of experimental therapies for Gulf War Illness, a chronic neuropsychiatric syndrome in veterans. Psychopharmacology.
240(4), 673-697.
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conference paper
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Madhu, L. N., Attaluri, S., Kodali, M., Melissari, L., Shuai, B., Upadhya, R., & Shetty, A. K.
(2019).
Brain Dysfunction in a Model of Gulf War Illness Continues into Middle Age with Elevated Oxidative Stress and Waned Mitochondrial Activity. Cell Transplantation.
476-477.
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Atobiloye, M. A., Attaluri, S., Gitai, D., Kodali, M., Kim, D., Prockop, D. J., & Shetty, A. K.
(2019).
Intranasal Administration of MSC-Derived Exosomes Modulate Status Epilepticus Induced Abnormal Plasticity of Newly Born Neurons and Microglial Activation in the Hippocampus. The FASEB Journal.
557.4-557.4.
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Kain, J., Petrescu, A., Grant, S., Frampton, G. A., McMillin, M., Wyatt, A., ... DeMorrow, S.
(2017).
Exposure to gulf war illness-related chemicals increases susceptibility to cholestatic liver injury by enhancing CD11b+macrophage/monocyte infiltration into the liver. HEPATOLOGY.
942A-942A.
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DeMorrow, S., Kain, J., Grant, S., Frampton, G., McMillin, M., Wyatt, A., ... Petrescu, A.
(2017).
Prolonged Low-Level Inflammation Due to Exposure to Gulf War Illness Related Chemicals Increases Susceptibility to Cholestatic Liver Injury by Enhancing CD11b(+) Macrophage/Monocyte Infiltration into the Liver. American Journal of Pathology.
2368-2368.
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Kodali, M., Shuai, B., Mishra, V., Attaluri, S., Hattiangady, B., & Shetty, A. K.
(2016).
Moderate Running Exercise Improves Cognitive, Memory, and Mood Function With Increased Neurogenesis in a Gulf War Illness Model. Cell Transplantation.
764-765.
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Shetty, A., Kodali, M., Rao, S., Madhu, L. N., & Cai, J.
A SINGLE INTRANASAL DOSE OF HUMAN NSC-DERIVED EXTRACELLULAR VESICLES AFTER TBI INHIBITS PROINFLAMMATORY TRANSCRIPTOMIC SIGNATURES IN ASTROCYTES. JOURNAL OF NEUROTRAUMA.
A92-A92.
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Somayaji, Y., Madhu, L. N., Kodali, M., Attaluri, S., Shuai, B., & Shetty, A. K.
Montelukast Treatment Attenuates Cognitive Dysfunction in a Model of Chronic Gulf War Illness With Modulation of Leukotriene Signaling and NLRP3-Inflammasome Activation. Cell Transplantation.
24-25.
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Kodali, M., Upadhya, R., Attaluri, S., Madhu, N. L., Shuai, B., & Shetty, K. A.
REPEATED CLOSED HEAD INJURY LEADS TO LONGTERM COGNITIVE AND MOOD IMPAIRMENTS WITH ELEVATED OXIDATIVE STRESS, NEUROINFLAMMATION AND REDUCED HIPPOCAMPAL NEUROGENESIS. JOURNAL OF NEUROTRAUMA.
A79-A80.
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Madhu, L. N., Attaluri, S., Kodali, M., Melissari, L., Shuai, B., Upadhya, R., & Shetty, A. K.
(2019).
Brain Dysfunction in a Model of Gulf War Illness Continues into Middle Age with Elevated Oxidative Stress and Waned Mitochondrial Activity. Cell Transplantation.
476-477.
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institutional repository document
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Bryant, J. D., Kodali, M., Shuai, B., Menissy, S. S., Graves, P. J., Shetty, A. K., West, L. C., & West, A. P.
(2020).
Innate immune signaling and sex differences contribute to neurocognitive impairment, neuroinflammation, and mitochondrial rewiring in a mouse model of Gulf War illness
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Madhu, L. N., Kodali, M., Upadhya, R., Rao, S., Shuai, B., Somayaji, Y., ... Shetty, A. K.
Intranasally Administered EVs from hiPSC-derived NSCs Alter the Transcriptomic Profile of Activated Microglia and Conserve Brain Function in an Alzheimer's Model
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Bryant, J. D., Kodali, M., Shuai, B., Menissy, S. S., Graves, P. J., Shetty, A. K., West, L. C., & West, A. P.
(2020).
Innate immune signaling and sex differences contribute to neurocognitive impairment, neuroinflammation, and mitochondrial rewiring in a mouse model of Gulf War illness
Background
education and training
- Ph.D. in Cancer Cell Biology, Kasturba Medical College - (Manipala, Karnataka, India) 2010
- M.Sc. in (Medical) Biochemistry, Kasturba Medical College - (Manipala, Karnataka, India) 2000
- B.Sc. in Biochemistry, Microbiology, First class, Acharya Nagarjuna University - (Guntur, Andhra Pradesh, India) 1997
Contact
first name
- Maheedhar
has last name
- Kodali
Other
- kodali@tamu.edu