Red raspberry (Rubus idaeus L.) intake decreases oxidative stress in obese diabetic (db/db) mice. Academic Article

abstract

• Red raspberry fruit intake was investigated on obese diabetic (db/db) mice for 8weeks. Animals fed isocaloric diets (5.3% freeze-dried raspberry, or control) were assessed for obesity-diabetes-disease risk biomarkers. Results showed that raspberry intake improved antioxidant status and lessened plasma interleukin (IL)-6 (0.3-fold of control, p<0.1); most likely through enhancing glutathione peroxidase (GPx) activity in liver (4.3-fold of control), and in blood (2.1-fold of control). Other disease-risk biomarkers were similar between groups (p>0.05). Plasma levels of total cholesterol (T-CHL), low density lipoprotein-cholesterol (LDL-CHL), and resistin were higher in the raspberry group. Overall, the enhanced detoxifying cell defenses exerted by raspberry intake might be due to its polyphenolics and fibre. This study demonstrates in vivo that raspberry intake, at a dose that can be achieved by human consumption, might protect against diabetes-induced oxidative stress.

authors

• Noratto, Giuliana

published proceedings

• Food Chem

altmetric score

• 0.5

author list (cited authors)

• Noratto, G. D., Chew, B. P., & Atienza, L. M.

citation count

• 61

complete list of authors

• Noratto, Giuliana D||Chew, Boon P||Atienza, Liezl M

publication date

• July 2017

publisher

• Elsevier  Publisher

published in

• Food Chemistry  Journal

keywords

• Animals
• Antioxidants
• Cholesterol
• Cholesterol, LDL
• Diabetes
• Diabetes Mellitus
• Humans
• Interleukin-6
• Liver
• Male
• Mice
• Mice, Obese
• Obesity
• Oxidative Stress
• Plant Extracts
• Polyphenolics-fibre
• Raspberry
• Rubus
• Rubus Idaeus L.

Digital Object Identifier (DOI)

• 10.1016/j.foodchem.2017.01.097

start page

• 305

end page

• 314

volume

• 227

URL

• http://dx.doi.org/10.1016/j.foodchem.2017.01.097