A retro-inverso TAT-like peptide designed to deliver cysteamine to cells. Academic Article uri icon


  • A retro-inverso, TAT-like peptide wherein lysine residues are replaced with cysteine residues bearing a disulfide-linked cysteamine group is found to engage in thiol-disulfide exchange with cysteine. These peptides are transported into cells and localize to lysosomes. Cellular uptake is enhanced in peptides bearing two cysteamine groups over those with one or none, by factors of approximately 1.5 and 12, respectively.

published proceedings

  • Bioorg Med Chem Lett

altmetric score

  • 0.25

author list (cited authors)

  • Lim, J., Pellois, J., & Simanek, E. E.

citation count

  • 2

complete list of authors

  • Lim, Jongdoo||Pellois, Jean-Philippe||Simanek, Eric E

publication date

  • January 2010