Comparison of anti-Campylobacter activity of free thymol and thymol--D-glucopyranoside in absence or presence of -glycoside-hydrolysing gut bacteria.
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abstract
Thymol is a natural product that exhibits antimicrobial activity in vitro but in vivo results indicate that absorption within the proximal alimentary tract precludes its delivery to the distal gut. Presently, the anti-Campylobacter activity of thymol was compared against that of thymol--D-glucopyranoside, the latter being resistant to absorption. When treated with 1 mM thymol, Campylobacter coli and jejuni were reduced during pure or co-culture with a -glycoside-hydrolysing Parabacteroides distasonis. Thymol--D-glucopyranoside treatment (1 mM) did not reduce C. coli and jejuni during pure culture but did during co-culture with P. distasonis or during mixed culture with porcine or bovine faecal microbes possessing -glycoside-hydrolysing activity. Fermentation acid production was reduced by thymol--D-glucopyranoside treatment, indicating that fermentation was inhibited, which may limit its application to just before harvest. Results suggest that thymol--D-glucopyranoside or similar -glycosides may be able to escape absorption within the proximal gut and become activated by bacterial -glycosidases in the distal gut.
Epps, S., Petrujki, B. T., Sedej, I., Krueger, N. A., Harvey, R. B., Beier, R. C., ... Nisbet, D. J.
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Epps, Sharon VR||Petrujkić, Branko T||Sedej, Ivana||Krueger, Nathan A||Harvey, Roger B||Beier, Ross C||Stanton, Thad B||Phillips, Timothy D||Anderson, Robin C||Nisbet, David J
