The Neurospora Transcription Factor ADV-1 Transduces Light Signals and Temporal Information to Control Rhythmic Expression of Genes Involved in Cell Fusion. Academic Article uri icon

abstract

  • Light and the circadian clock have a profound effect on the biology of organisms through the regulation of large sets of genes. Toward understanding how light and the circadian clock regulate gene expression, we used genome-wide approaches to identify the direct and indirect targets of the light-responsive and clock-controlled transcription factor ADV-1 in Neurospora crassa A large proportion of ADV-1 targets were found to be light- and/or clock-controlled, and enriched for genes involved in development, metabolism, cell growth, and cell fusion. We show that ADV-1 is necessary for transducing light and/or temporal information to its immediate downstream targets, including controlling rhythms in genes critical to somatic cell fusion. However, while ADV-1 targets are altered in predictable ways in adv-1 cells in response to light, this is not always the case for rhythmic target gene expression. These data suggest that a complex regulatory network downstream of ADV-1 functions to generate distinct temporal dynamics of target gene expression relative to the central clock mechanism.

published proceedings

  • G3 (Bethesda)

altmetric score

  • 5.1

author list (cited authors)

  • Dekhang, R., Wu, C., Smith, K. M., Lamb, T. M., Peterson, M., Bredeweg, E. L., ... Bell-Pedersen, D.

citation count

  • 21

complete list of authors

  • Dekhang, Rigzin||Wu, Cheng||Smith, Kristina M||Lamb, Teresa M||Peterson, Matthew||Bredeweg, Erin L||Ibarra, Oneida||Emerson, Jillian M||Karunarathna, Nirmala||Lyubetskaya, Anna||Azizi, Elham||Hurley, Jennifer M||Dunlap, Jay C||Galagan, James E||Freitag, Michael||Sachs, Matthew S||Bell-Pedersen, Deborah

publication date

  • January 2017