A study of maternal Diet interventions on offspring obesity and non-alcoholic fatty liver disease.
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The applicant's research is focused on evaluating different maternal diet interventions on preventing offspring obesity and fatty liver disease and understanding why. It has been realized that maternal overfeeding and obesity cause higher risks of obesity in the secondary generation. Thus, to prevent obesity of the child, the mother needs to carefully monitor what she eats before pregnancy, during pregnancy and lactation. However, there are no detailed guidelines that the nurse and the dieticians can follow to guide a heathy diet or healthy life style for obese women, due to very limited data from either human or mouse study. We aim to answer if maternal diet intervention could effectively reduce the risk for obesity in children, by focusing on study different durations of diet transition period. Using a mouse model, we will test if and how switching from a high fat diet to a normal fat diet before pregnancy could prevent offspring obesity.