HR job title
- Professor
- Contact Info
Bolanos, Carlos Associate Professor
My research interests center on investigating how exposure to psychotropic drugs (e.g. stimulants, antidepressants), and stress (whether physical or emotional), modifies the biochemical integrity of neuronal pathways involved in the regulation of mood and motivated behaviors, and how these pharmacological and/or environmental manipulations early-in-life affect biochemical and behavioral functioning later in adulthood. Understanding the relationship(s) between brain and behavior from a developmental perspective can provide novel insights for the development of therapeutics for stress and drug dependence. As noted by my professional development and publication record below, I have been involved in research questions with high degree of translational relevance.
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Overview
Publications
selected publications
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academic article
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Cardona-Acosta, A. M., Sial, O. K., Parise, L. F., Gnecco, T., Enriquez Marti, G., & Bolaos-Guzmn, C. A.
(2023).
Alprazolam exposure during adolescence induces long-lasting dysregulation in reward sensitivity to morphine and second messenger signaling in the VTA-NAc pathway. Scientific Reports.
13(1), 10872.
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Cardona-Acosta, A. M., & Bolaos-Guzmn, C. A.
(2023).
Role of the mesolimbic dopamine pathway in the antidepressant effects of ketamine. Neuropharmacology.
225, 109374-109374.
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Henningfield, J. E., Fields, S., Anthony, J. C., Brown, L. S., Bolaos-Guzmn, C. A., Comer, S. D., ... Zarate, C. A.
(2021).
Advancing equity, diversity, and inclusion in the American College of Neuropsychopharmacology (ACNP): advances, challenges, and opportunities to accelerate progress. Neuropsychopharmacology.
46(5), 871-876.
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Henningfield, J. E., Fields, S., Anthony, J. C., Brown, L. S., Bolaos-Guzmn, C. A., Comer, S. D., ... Zarate, C. A.
(2021).
Reply to Drs. Hart and Cadet: we agree-the challenges of increasing equity, diversity and inclusion include societal issues and actions now are vital. Neuropsychopharmacology.
46(5), 878-879.
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Parise, E. M., Parise, L. F., Sial, O. K., Cardona-Acosta, A. M., Gyles, T. M., Juarez, B., ... Bolaos-Guzmn, C. A.
(2021).
The Resilient Phenotype Induced by Prophylactic Ketamine Exposure During Adolescence Is Mediated by the Ventral Tegmental Area-Nucleus Accumbens Pathway. Biological Psychiatry.
90(7), 482-493.
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Sial, O. K., Gnecco, T., Cardona-Acosta, A. M., Vieregg, E., Cardoso, E. A., Parise, L. F., & Bolaos-Guzmn, C. A.
(2021).
Exposure to Vicarious Social Defeat Stress and Western-Style Diets During Adolescence Leads to Physiological Dysregulation, Decreases in Reward Sensitivity, and Reduced Antidepressant Efficacy in Adulthood. Frontiers in Neuroscience.
15, 701919.
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Sial, O. K., Parise, E. M., Parise, L. F., Gnecco, T., & Bolaos-Guzmn, C. A.
(2020).
Ketamine: The final frontier or another depressing end?. Behavioural Brain Research.
383, 112508-112508.
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Parise, L. F., Sial, O. K., Warren, B. L., Sattler, C. R., Duperrouzel, J. C., Parise, E. M., & Bolaos-Guzmn, C. A.
(2020).
Nicotine treatment buffers negative behavioral consequences induced by exposure to physical and emotional stress in adolescent male mice. Psychopharmacology.
237(10), 3125-3137.
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Kokane, S. S., Armant, R. J., Bolaos-Guzmn, C. A., & Perrotti, L. I.
(2020).
Overlap in the neural circuitry and molecular mechanisms underlying ketamine abuse and its use as an antidepressant. Behavioural Brain Research.
384, 112548-112548.
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Alter, D., Beverley, J. A., Patel, R., Bolaos-Guzmn, C. A., & Steiner, H.
(2017).
The 5-HT1B serotonin receptor regulates methylphenidate-induced gene expression in the striatum: Differential effects on immediate-early genes. JOURNAL OF PSYCHOPHARMACOLOGY.
31(8), 1078-1087.
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Sial, O. K., Warren, B. L., Alcantara, L. F., Parise, E. M., & Bolaos-Guzmn, C. A.
(2016).
Vicarious social defeat stress: Bridging the gap between physical and emotional stress. Journal of Neuroscience Methods.
258, 94-103.
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McHenry, J. A., Robison, C. L., Bell, G. A., Vialou, V. V., Bolaos-Guzmn, C. A., Nestler, E. J., & Hull, E. M.
(2016).
The role of fosB in the medial preoptic area: Differential effects of mating and cocaine history. BEHAVIORAL NEUROSCIENCE.
130(5), 469-478.
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Bolaos-Guzmn, C. A., & Zarate, C. A.
(2016).
Underrepresented Minorities in Science: ACNP Strives to Increase Minority Representation and Inclusion. Neuropsychopharmacology.
41(10), 2421-2423.
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Bagot, R. C., Parise, E. M., Pea, C. J., Zhang, H., Maze, I., Chaudhury, D., ... Nestler, E. J.
(2015).
Corrigendum: Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression. Nature Communications.
6(1), 7626.
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Bagot, R. C., Parise, E. M., Pea, C. J., Zhang, H., Maze, I., Chaudhury, D., ... Nestler, E. J.
(2015).
Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression. Nature Communications.
6(1), 7062.
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Hodes, G. E., Pfau, M. L., Leboeuf, M., Golden, S. A., Christoffel, D. J., Bregman, D., ... Russo, S. J
(2014).
Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress. Proceedings of the National Academy of Sciences of the United States of America.
111(45), 16136-16141.
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Iiguez, S. D., Alcantara, L. F., Warren, B. L., Riggs, L. M., Parise, E. M., Vialou, V., ... Bolaos-Guzmn, C. A.
(2014).
Fluoxetine exposure during adolescence alters responses to aversive stimuli in adulthood. Journal of Neuroscience.
34(3), 1007-1021.
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Parise, E. M., & Bolaos-Guzmn, C. A.
(2014).
Chronic social defeat and intracranial self-stimulation: unmasking the many faces of depression?. Biological Psychiatry.
76(7), 513-514.
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Hodes, G. E., Pfau, M. L., Leboeuf, M., Golden, S. A., Christoffel, D. J., Bregman, D., ... Russo, S. J.
(2014).
Correction for Hodes et al., Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress. Proceedings of the National Academy of Sciences of the United States of America.
111(52), 18799-18799.
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Alcantara, L. F., Warren, B. L., Parise, E. M., Iiguez, S. D., & Bolaos-Guzmn, C. A.
(2014).
Effects of psychotropic drugs on second messenger signaling and preference for nicotine in juvenile male mice. Psychopharmacology.
231(8), 1479-1492.
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Warren, B. L., Sial, O. K., Alcantara, L. F., Greenwood, M. A., Brewer, J. S., Rozofsky, J. P., Parise, E. M., & Bolaos-Guzmn, C. A.
(2014).
Altered gene expression and spine density in nucleus accumbens of adolescent and adult male mice exposed to emotional and physical stress. Developmental Neuroscience.
36(3-4), 250-260.
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Steiner, H., Warren, B. L., Van Waes, V., & Bolaos-Guzmn, C. A.
(2014).
Life-long consequences of juvenile exposure to psychotropic drugs on brain and behavior. 211, 13-30.
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Parise, E. M., Alcantara, L. F., Warren, B. L., Wright, K. N., Hadad, R., Sial, O. K., ... Bolaos-Guzmn, C. A.
(2013).
Repeated ketamine exposure induces an enduring resilient phenotype in adolescent and adult rats. Biological Psychiatry.
74(10), 750-759.
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Warren, B. L., Vialou, V. F., Iiguez, S. D., Alcantara, L. F., Wright, K. N., Feng, J., ... Bolaos-Guzmn, C. A.
(2013).
Neurobiological sequelae of witnessing stressful events in adult mice. Biological Psychiatry.
73(1), 7-14.
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Iiguez, S. D., Charntikov, S., Baella, S. A., Herbert, M. S., Bolaos-Guzmn, C. A., & Crawford, C. A.
(2012).
Post-training cocaine exposure facilitates spatial memory consolidation in C57BL/6 mice. The Hippocampus.
22(4), 802-813.
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Warren, B. L., Iiguez, S. D., Alcantara, L. F., Wright, K. N., Parise, E. M., Weakley, S. K., & Bolaos-Guzmn, C. A.
(2011).
Juvenile administration of concomitant methylphenidate and fluoxetine alters behavioral reactivity to reward- and mood-related stimuli and disrupts ventral tegmental area gene expression in adulthood. Journal of Neuroscience.
31(28), 10347-10358.
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Iiguez, S. D., Vialou, V., Warren, B. L., Cao, J., Alcantara, L. F., Davis, L. C., ... Bolaos-Guzmn, C. A.
(2010).
Extracellular signal-regulated kinase-2 within the ventral tegmental area regulates responses to stress. Journal of Neuroscience.
30(22), 7652-7663.
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Vialou, V., Robison, A. J., Laplant, Q. C., Covington, H. E., Dietz, D. M., Ohnishi, Y. N., ... Nestler, E. J.
(2010).
DeltaFosB in brain reward circuits mediates resilience to stress and antidepressant responses. Nature Neuroscience.
13(6), 745-752.
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LaPlant, Q., Vialou, V., Covington, H. E., Dumitriu, D., Feng, J., Warren, B. L., ... Nestler, E. J.
(2010).
Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nature Neuroscience.
13(9), 1137-1143.
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Iiguez, S. D., Warren, B. L., & Bolaos-Guzmn, C. A.
(2010).
Short- and long-term functional consequences of fluoxetine exposure during adolescence in male rats. Biological Psychiatry.
67(11), 1057-1066.
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Iiguez, S. D., Warren, B. L., Neve, R. L., Russo, S. J., Nestler, E. J., & Bolaos-Guzmn, C. A.
(2010).
Viral-mediated expression of extracellular signal-regulated kinase-2 in the ventral tegmental area modulates behavioral responses to cocaine. Behavioural Brain Research.
214(2), 460-464.
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Iiguez, S. D., Warren, B. L., Parise, E. M., Alcantara, L. F., Schuh, B., Maffeo, M. L., Manojlovic, Z., & Bolaos-Guzmn, C. A.
(2009).
Nicotine exposure during adolescence induces a depression-like state in adulthood. Neuropsychopharmacology.
34(6), 1609-1624.
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Graham, D. L., Krishnan, V., Larson, E. B., Graham, A., Edwards, S., Bachtell, R. K., ... Self, D. W.
(2009).
Tropomyosin-related kinase B in the mesolimbic dopamine system: region-specific effects on cocaine reward. Biological Psychiatry.
65(8), 696-701.
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Wiley, M. D., Poveromo, L. B., Antapasis, J., Herrera, C. M., & Bolaos Guzmn, C. A.
(2009).
Kappa-opioid system regulates the long-lasting behavioral adaptations induced by early-life exposure to methylphenidate. Neuropsychopharmacology.
34(5), 1339-1350.
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Russo, S. J., Wilkinson, M. B., Mazei-Robison, M. S., Dietz, D. M., Maze, I., Krishnan, V., ... Nestler, E. J.
(2009).
Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward. Journal of Neuroscience.
29(11), 3529-3537.
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Wallace, D. L., Han, M., Graham, D. L., Green, T. A., Vialou, V., Iiguez, S. D., ... Nestler, E. J.
(2009).
CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits. Nature Neuroscience.
12(2), 200-209.
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Wallace, D. L., Vialou, V., Rios, L., Carle-Florence, T. L., Chakravarty, S., Kumar, A., ... Bolaos-Guzmn, C. A.
(2008).
The influence of DeltaFosB in the nucleus accumbens on natural reward-related behavior. Journal of Neuroscience.
28(41), 10272-10277.
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Bolaos, C. A., Willey, M. D., Maffeo, M. L., Powers, K. D., Kinka, D. W., Grausam, K. B., & Henderson, R. P.
(2008).
Antidepressant treatment can normalize adult behavioral deficits induced by early-life exposure to methylphenidate. Biological Psychiatry.
63(3), 309-316.
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Krishnan, V., Han, M., Mazei-Robison, M., Iiguez, S. D., Ables, J. L., Vialou, V., ... Nestler, E. J.
(2008).
AKT signaling within the ventral tegmental area regulates cellular and behavioral responses to stressful stimuli. Biological Psychiatry.
64(8), 691-700.
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Iiguez, S. D., Warren, B. L., Neve, R. L., Nestler, E. J., Russo, S. J., & Bolaos-Guzmn, C. A.
(2008).
Insulin receptor substrate-2 in the ventral tegmental area regulates behavioral responses to cocaine. BEHAVIORAL NEUROSCIENCE.
122(5), 1172-1177.
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Russo, S. J., Bolanos, C. A., Theobald, D. E., DeCarolis, N. A., Renthal, W., Kumar, A., ... Nestler, E. J.
(2007).
IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates. Nature Neuroscience.
10(1), 93-99.
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Han, M., Bolaos, C. A., Green, T. A., Olson, V. G., Neve, R. L., Liu, R., Aghajanian, G. K., & Nestler, E. J.
(2006).
Role of cAMP response element-binding protein in the rat locus ceruleus: regulation of neuronal activity and opiate withdrawal behaviors. Journal of Neuroscience.
26(17), 4624-4629.
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Berton, O., McClung, C. A., Dileone, R. J., Krishnan, V., Renthal, W., Russo, S. J., ... Nestler, E. J
(2006).
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science.
311(5762), 864-868.
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Zachariou, V., Bolanos, C. A., Selley, D. E., Theobald, D., Cassidy, M. P., Kelz, M. B., ... Nestler, E. J.
(2006).
An essential role for DeltaFosB in the nucleus accumbens in morphine action. Nature Neuroscience.
9(2), 205-211.
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Lagace, D. C., Yee, J. K., Bolaos, C. A., & Eisch, A. J.
(2006).
Juvenile administration of methylphenidate attenuates adult hippocampal neurogenesis. Biological Psychiatry.
60(10), 1121-1130.
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Olson, V. G., Zabetian, C. P., Bolanos, C. A., Edwards, S., Barrot, M., Eisch, A. J., ... Nestler, E. J.
(2005).
Regulation of drug reward by cAMP response element-binding protein: evidence for two functionally distinct subregions of the ventral tegmental area. 25(23), 5553-5562.
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Georgescu, D., Sears, R. M., Hommel, J. D., Barrot, M., Bolaos, C. A., Marsh, D. J., ... DiLeone, R. J.
(2005).
The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance. Journal of Neuroscience.
25(11), 2933-2940.
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Perrotti, L. I., Bolaos, C. A., Choi, K., Russo, S. J., Edwards, S., Ulery, P. G., ... Barrot, M.
(2005).
DeltaFosB accumulates in a GABAergic cell population in the posterior tail of the ventral tegmental area after psychostimulant treatment. European Journal of Neuroscience.
21(10), 2817-2824.
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Bolaos, C. A., Neve, R. L., & Nestler, E. J.
(2005).
Phospholipase C gamma in distinct regions of the ventral tegmental area differentially regulates morphine-induced locomotor activity. Synapse (New York).
56(3), 166-169.
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Barrot, M., Wallace, D. L., Bolaos, C. A., Graham, D. L., Perrotti, L. I., Neve, R. L., ... Nestler, E. J.
(2005).
Regulation of anxiety and initiation of sexual behavior by CREB in the nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America.
102(23), 8357-8362.
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Bolaos, C. A., & Nestler, E. J.
(2004).
Neurotrophic mechanisms in drug addiction. 5(1), 69-83.
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Bolaos, C. A., Perrotti, L. I., Edwards, S., Eisch, A. J., Barrot, M., Olson, V. G., ... Nestler, E. J.
(2003).
Phospholipase Cgamma in distinct regions of the ventral tegmental area differentially modulates mood-related behaviors. 23(20), 7569-7576.
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Eisch, A. J., Bolaos, C. A., de Wit, J., Simonak, R. D., Pudiak, C. M., Barrot, M., Verhaagen, J., & Nestler, E. J.
(2003).
Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression. Biological Psychiatry.
54(10), 994-1005.
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Bolaos, C. A., Barrot, M., Berton, O., Wallace-Black, D., & Nestler, E. J.
(2003).
Methylphenidate treatment during pre- and periadolescence alters behavioral responses to emotional stimuli at adulthood. Biological Psychiatry.
54(12), 1317-1329.
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Chao, J. R., Ni, Y. G., Bolaos, C. A., Rahman, Z., DiLeone, R. J., & Nestler, E. J.
(2002).
Characterization of the mouse adenylyl cyclase type VIII gene promoter: regulation by cAMP and CREB. European Journal of Neuroscience.
16(7), 1284-1294.
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Bolaos, C. A., Trksak, G. H., Cohen, O. S., & Jackson, D.
(2002).
Differential serotonergic inhibition of in vitro striatal [3H]acetylcholine release in prenatally cocaine-exposed male and female rats. Progress in Neuro-Psychopharmacology and Biological Psychiatry.
26(7-8), 1339-1348.
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Bolaos, C. A., Trksak, G. H., Glatt, S. J., & Jackson, D.
(2000).
Prenatal cocaine exposure increases serotonergic inhibition of electrically evoked acetylcholine release from rat striatal slices at adulthood. 36(1), 1-11.
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Glatt, S. J., Bolaos, C. A., Trksak, G. H., & Jackson, D.
(2000).
Effects of prenatal cocaine exposure on dopamine system development: a meta-analysis. NEUROTOXICOLOGY AND TERATOLOGY.
22(5), 617-629.
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Glatt, S. J., Bolaos, C. A., Trksak, G. H., Crowder-Dupont, C., & Jackson, D.
(2000).
Prenatal cocaine exposure alters behavioral and neurochemical sensitization to amphetamine in adult rats. Neuropharmacology.
39(4), 599-610.
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Bolanos, C. A., Glatt, S. J., & Jackson, D.
(1998).
Subsensitivity to dopaminergic drugs in periadolescent rats: a behavioral and neurochemical analysis. Brain research. Developmental brain research.
111(1), 25-33.
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Duke, M. A., Meier, T. L., Bolanos, C. A., Crawford, C. A., & McDougall, S. A.
(1997).
Paradoxical effects of kappa-opioid stimulation on the locomotor activity and Fos immunoreactivity of the preweanling rat: role of dopamine receptors. 111(5), 1114-1122.
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Bolanos, C. A., Garmsen, G. M., Clair, M. A., & McDougall, S. A.
(1996).
Effects of the kappa-opioid receptor agonist U-50,488 on morphine-induced place preference conditioning in the developing rat. European Journal of Pharmacology.
317(1), 1-8.
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Crawford, C. A., McDougall, S. A., Bolanos, C. A., Hall, S., & Berger, S. P.
(1995).
The effects of the kappa agonist U-50,488 on cocaine-induced conditioned and unconditioned behaviors and Fos immunoreactivity. Psychopharmacology.
120(4), 392-399.
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McDougall, S. A., & Bolanos, C. A.
(1995).
Behavioral effects of the reversible dopamine antagonist flupenthixol are not potentiated by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline in the preweanling rat. Pharmacology, Biochemistry and Behavior.
50(1), 127-131.
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Pruitt, D. L., Bolanos, C. A., & McDougall, S. A.
(1995).
Effects of dopamine D1 and D2 receptor antagonists on cocaine-induced place preference conditioning in preweanling rats. European Journal of Pharmacology.
283(1-3), 125-131.
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McDougall, S. A., Duke, M. A., Bolanos, C. A., & Crawford, C. A.
(1994).
Ontogeny of behavioral sensitization in the rat: effects of direct and indirect dopamine agonists. Psychopharmacology.
116(4), 483-490.
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Cardona-Acosta, A. M., Sial, O. K., Parise, L. F., Gnecco, T., Enriquez Marti, G., & Bolaos-Guzmn, C. A.
(2023).
Alprazolam exposure during adolescence induces long-lasting dysregulation in reward sensitivity to morphine and second messenger signaling in the VTA-NAc pathway. Scientific Reports.
13(1), 10872.
Teaching
teaching activities
- NRSC333 Bio Of Psych Disorders Instructor
- NRSC485 Directed Studies Instructor
- NRSC491 Hnr-research Instructor
- NRSC650 Clinical Psychopharm Instructor
- NRSC691 Research Instructor
- PBSI105 First Semester Experience Instructor
- PBSI235 Intro Beh & Cog Neuroscience Instructor
- PBSI333 Bio Of Psych Disorders Instructor
- PBSI485 Directed Studies Instructor
- PBSI491 Hnr-research Instructor
- PBSI650 Clinical Psychopharm Instructor
- PBSI685 Directed Studies Instructor
- PBSI691 Research Instructor
- PSYC333 Bio Of Psych Disorders Instructor
- PSYC489 Sptp: Clinical Psychopharm Instructor
- PSYC650 Clinical Psychopharm Instructor
Background
education and training
- Ph.D. in Experimental Psychology, Northeastern University - (Shenyang, China) 2000
- M.A. in Experimental Psychology, California State University, San Bernardino - (San Bernardino, California, United States) 1995
- B.A. in Psychology, California State University, San Bernardino - (San Bernardino, California, United States) 1993
awards and honors
Contact
first name
- Carlos
has last name
- Bolanos
mailing address
-
Texas A&M University
Psychology
4235 TAMU
College Station, TX 77843-4235
USA
Other
- bolanos-guzman@tamu.edu