Phospholipase C gamma in distinct regions of the ventral tegmental area differentially regulates morphine-induced locomotor activity.
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Neurotrophic factors and the signaling pathways they activate play a role in mediating long-term molecular, cellular, and behavioral adaptations associated with drug addiction. Here we mimicked the biological response of phospholipase C-gamma (PLC gamma) induction in the ventral tegmental area (VTA) observed after chronic morphine using viral-mediated gene transfer. Using a behavioral sensitization paradigm, we demonstrate that microinjections of PLC gamma 1 into distinct (rostral vs. caudal) regions of the VTA result in differential locomotor responses to morphine.
author list (cited authors)
Bolaos, C. A., Neve, R. L., & Nestler, E. J.