HR job title
- Research Assistant Professor
- Contact Info
Purushothaman, Anurag Research Assistant Professor
Positions
- Research Assistant Professor, Biomedical Engineering, College of Engineering
- Overview
- Publications
- Background
- Contact
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Overview
Publications
selected publications
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academic article
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Purushothaman, A., Mohajeri, M., & Lele, T. P.
(2023).
The role of glycans in the mechanobiology of cancer. 299(3), 102935-102935.
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Bandari, S. K., Purushothaman, A., Ramani, V. C., Brinkley, G. J., Chandrashekar, D. S., Varambally, S., ... Sanderson, R. D.
(2018).
Chemotherapy induces secretion of exosomes loaded with heparanase that degrades extracellular matrix and impacts tumor and host cell behavior. Matrix Biology.
65, 104-118.
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Purushothaman, A., Bandari, S. K., Chandrashekar, D. S., Jones, R. J., Lee, H. C., Weber, D. M., & Orlowski, R. Z.
(2017).
Chondroitin sulfate proteoglycan serglycin influences protein cargo loading and functions of tumor-derived exosomes. Oncotarget.
8(43), 73723-73732.
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Jung, O., Trapp-Stamborski, V., Purushothaman, A., Jin, H., Wang, H., Sanderson, R. D., & Rapraeger, A. C.
(2016).
Heparanase-induced shedding of syndecan-1/CD138 in myeloma and endothelial cells activates VEGFR2 and an invasive phenotype: prevention by novel synstatins. Oncogenesis.
5(2), e202-e202.
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Purushothaman, A., Bandari, S. K., Liu, J., Mobley, J. A., Brown, E. E., & Sanderson, R. D.
(2016).
Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions. 291(4), 1652-1663.
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Yoshida, C. A., Kawane, T., Moriishi, T., Purushothaman, A., Miyazaki, T., Komori, H., ... Komori, T.
(2014).
Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin-type O-glycans and reduction of glycosaminoglycans. 289(38), 26584-26596.
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Purushothaman, A., & Toole, B. P.
(2014).
Serglycin proteoglycan is required for multiple myeloma cell adhesion, in vivo growth, and vascularization. 289(9), 5499-5509.
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Ramani, V. C., Purushothaman, A., Stewart, M. D., Thompson, C. A., Vlodavsky, I., Au, J., & Sanderson, R. D.
(2013).
The heparanase/syndecan-1 axis in cancer: mechanisms and therapies. The FEBS Journal.
280(10), 2294-2306.
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Thompson, C. A., Purushothaman, A., Ramani, V. C., Vlodavsky, I., & Sanderson, R. D.
(2013).
Heparanase regulates secretion, composition, and function of tumor cell-derived exosomes. 288(14), 10093-10099.
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Purushothaman, A., Babitz, S. K., & Sanderson, R. D.
(2012).
Heparanase enhances the insulin receptor signaling pathway to activate extracellular signal-regulated kinase in multiple myeloma. 287(49), 41288-41296.
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Purushothaman, A., Sugahara, K., & Faissner, A.
(2012).
Chondroitin sulfate "wobble motifs" modulate maintenance and differentiation of neural stem cells and their progeny. 287(5), 2935-2942.
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Ma, X., Chen, M., Li, X., Purushothaman, A., & Li, F.
(2012).
Electrochemical Detection of Norepinephrine in the Presence of Epinephrine, Uric Acid and Ascorbic Acid Using a Graphene-modified Electrode. International Journal of Electrochemical Science.
7, 991-1000.
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Purushothaman, A., & Sanderson, R. D.
(2011).
SDC1 (syndecan 1)
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Purushothaman, A., Hurst, D. R., Pisano, C., Mizumoto, S., Sugahara, K., & Sanderson, R. D.
(2011).
Heparanase-mediated loss of nuclear syndecan-1 enhances histone acetyltransferase (HAT) activity to promote expression of genes that drive an aggressive tumor phenotype. 286(35), 30377-30383.
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Basappa, .., Murugan, S., Kavitha, C. V., Purushothaman, A., Nevin, K. G., Sugahara, K., & Rangappa, K. S.
(2010).
A small oxazine compound as an anti-tumor agent: a novel pyranoside mimetic that binds to VEGF, HB-EGF, and TNF-. Cancer Letters.
297(2), 231-243.
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Purushothaman, A., Uyama, T., Kobayashi, F., Yamada, S., Sugahara, K., Rapraeger, A. C., & Sanderson, R. D.
(2010).
Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis. Blood.
115(12), 2449-2457.
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Ten Dam, G. B., Yamada, S., Kobayashi, F., Purushothaman, A., van de Westerlo, E., Bulten, J., ... van Kuppevelt, T. H.
(2009).
Dermatan sulfate domains defined by the novel antibody GD3A12, in normal tissues and ovarian adenocarcinomas. Histochemistry and Cell Biology.
132(1), 117-127.
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Purushothaman, A., Chen, L., Yang, Y., & Sanderson, R. D.
(2008).
Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma. 283(47), 32628-32636.
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ten Dam, G. B., van de Westerlo, E., Purushothaman, A., Stan, R. V., Bulten, J., Sweep, F., ... van Kuppevelt, T. H.
(2007).
Antibody GD3G7 selected against embryonic glycosaminoglycans defines chondroitin sulfate-E domains highly up-regulated in ovarian cancer and involved in vascular endothelial growth factor binding. American Journal of Pathology.
171(4), 1324-1333.
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Purushothaman, A., Fukuda, J., Mizumoto, S., ten Dam, G. B., van Kuppevelt, T. H., Kitagawa, H., Mikami, T., & Sugahara, K.
(2007).
Functions of chondroitin sulfate/dermatan sulfate chains in brain development. Critical roles of E and iE disaccharide units recognized by a single chain antibody GD3G7. 282(27), 19442-19452.
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Anurag, P., & Rajamohan, T.
(2003).
Cardioprotective effect of tender coconut water in experimental myocardial infarction. Plant Foods for Human Nutrition.
58(3), 1-12.
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Anurag, P., & Anuradha, C. V.
(2002).
Metformin improves lipid metabolism and attenuates lipid peroxidation in high fructose-fed rats. Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics.
4(1), 36-42.
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Purushothaman, A., Mohajeri, M., & Lele, T. P.
(2023).
The role of glycans in the mechanobiology of cancer. 299(3), 102935-102935.
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chapter
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Purushothaman, A., & Sanderson, R. D.
(2020).
Heparanase: A Dynamic Promoter of Myeloma Progression. Advances in Experimental Medicine and Biology.
Heparanase.
(pp. 331-349).
Springer Nature.
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Purushothaman, A.
(2019).
Exosomes from Cell Culture-Conditioned Medium: Isolation by Ultracentrifugation and Characterization. Methods in molecular biology (Clifton, N.J.).
Vigetti, D., & Theocharis, A. D. (Eds.),
The Extracellular Matrix.
(pp. 233-244).
Springer Nature.
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Sanderson, R. D., Yang, Y., Purushothaman, A., Khotskaya, Y. B., Ritchie, J. P., & Ramani, V. C.
(2010).
Proteoglycans and Cancer. Cell-Extracellular Matrix Interactions in Cancer.
(pp. 191-215).
Springer Nature.
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Purushothaman, A., & Sanderson, R. D.
(2020).
Heparanase: A Dynamic Promoter of Myeloma Progression. Advances in Experimental Medicine and Biology.
Heparanase.
(pp. 331-349).
Springer Nature.
Background
education and training
- Ph.D. in Biochemistry, University of Kerala - (Thiruvananthapuram, India) 2003
- M.Phil. in Biochemistry, Annamalai University - (Chidambaram, Tamil Nadu, India) 1999
- M.Sc. in Biochemistry, Annamalai University - (Chidambaram, Tamil Nadu, India) 1997
- B.Sc. in Chemistry, University of Kerala - (Thiruvananthapuram, India) 1995
Contact
first name
- Anurag
has last name
- Purushothaman
Other
- anuragp@tamu.edu