Chondroitin sulfate "wobble motifs" modulate maintenance and differentiation of neural stem cells and their progeny. Academic Article uri icon

abstract

  • Chondroitin sulfate/dermatan sulfate (CS/DS) proteoglycans, major components of the central nervous system, have the potential to interact with a wide range of growth factors and neurotrophic factors that influence neuronal migration, axon guidance pathways, and neurite outgrowth. Recent studies have also revealed the role of CS/DS chains in the orchestration of the neural stem/progenitor cell micromilieu. Individual functional proteins recognize a set of multiple overlapping oligosaccharide sequences decorated to give different sulfation patterns, which are termed here "wobble CS/DS oligosaccharide motifs," and induce signaling pathways essential for the proliferation, self-renewal, and cell lineage commitment of neural stem/progenitor cells.

published proceedings

  • J Biol Chem

altmetric score

  • 1

author list (cited authors)

  • Purushothaman, A., Sugahara, K., & Faissner, A.

citation count

  • 89

publication date

  • January 2012