HR job title
- Research Professor
- Contact Info
- ORCiD
- 0000-0002-0872-5060
Young, Keith Research Professor
Positions
- Research Professor, Psychiatry and Behavioral Sciences, College of Medicine
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Overview
Publications
selected publications
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academic article
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Nievergelt, C. M., Maihofer, A. X., Atkinson, E. G., Chen, C., Choi, K. W., Coleman, J. R., ... Koenen, K. C.
(2023).
Discovery of 95 PTSD loci provides insight into genetic architecture and neurobiology of trauma and stress-related disorders. 4(09-08), 2023.08.31.23294915.
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Jaffe, A. E., Tao, R., Page, S. C., Maynard, K. R., Pattie, E. A., Nguyen, C. V., ... Kleinman, J. E.
(2022).
Decoding Shared Versus Divergent Transcriptomic Signatures Across Cortico-Amygdala Circuitry in PTSD and Depressive Disorders. American Journal of Psychiatry.
179(9), 673-686.
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Young, K. A.
(2022).
Matthew J. Friedman and the VA National PTSD Brain Bank: New Transcriptomic Insight into PTSD Pathophysiology. Psychiatry (New York).
85(2), 171-182.
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Maihofer, A. X., Choi, K. W., Coleman, J., Daskalakis, N. P., Denckla, C. A., Ketema, E., ... Nievergelt, C. M.
(2022).
Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information. 91(7), 626-636.
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Peterson, A. L., Young-McCaughan, S., Roache, J. D., Mintz, J., Litz, B. T., Williamson, D. E., ... STRONG STAR Consortium and the Consortium to Alleviate PTSD.
(2021).
STRONG STAR and the Consortium to Alleviate PTSD: Shaping the future of combat PTSD and related conditions in military and veteran populations. 110, 106583-106583.
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Logue, M. W., Zhou, Z., Morrison, F. G., Wolf, E. J., Daskalakis, N. P., Chatzinakos, C., ... Miller, M. W.
(2021).
Gene expression in the dorsolateral and ventromedial prefrontal cortices implicates immune-related gene networks in PTSD. Neurobiology of Stress.
15, 100398-100398.
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Morrow, K., Choi, S., Young, K., Haidar, M., Boduch, C., & Bourgeois, J. A.
(2021).
Amantadine for the treatment of childhood and adolescent psychiatric symptoms. Baylor University Medical Center Proceedings.
34(5), 566-570.
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Girgenti, M. J., Wang, J., Ji, D., Cruz, D. A., Traumatic Stress Brain Research Group, .., Stein, M. B., ... Duman, R. S.
(2021).
Transcriptomic organization of the human brain in post-traumatic stress disorder. Nature Neuroscience.
24(1), 24-33.
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Morrow, K., Young, K. A., Spencer, S., Medina, E. S., Marziale, M. A., Sanchez, A., & Bourgeois, J. A.
(2020).
Utility of oxcarbazepine in the treatment of childhood and adolescent psychiatric symptoms. Baylor University Medical Center Proceedings.
34(1), 34-39.
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Nguyen, A., Young, K. A., & Bourgeois, J. A.
(2020).
Psychiatric Prodrome in Anti-NMDAR-Associated Encephalopathy: Clinical and Pathophysiologic Considerations. The primary care companion for CNS disorders.
22(3), 19r02563.
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Lavasani, S., Lipsitt, A., Young, K. A., & Bourgeois, J. A.
(2020).
Psychiatric Presentation of Probable Seronegative Autoimmune Encephalitis in a Late Middle-Aged Woman With Ovarian Teratoma. 61(3), 288-295.
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Girgenti, M., Wang, J., Ji, D., Cruz, D., Group, T., Program, M. V., ... Duman, R.
(2020).
Transcriptomic Organization of Human Posttraumatic Stress Disorder. Biological Psychiatry.
87(9), s122-S122.
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Nievergelt, C. M., Maihofer, A. X., Klengel, T., Atkinson, E. G., Chen, C., Choi, K. W., ... Koenen, K. C.
(2019).
International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci. Nature Communications.
10(1), 4558.
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Selemon, L. D., Young, K. A., Cruz, D. A., & Williamson, D. E.
(2019).
Frontal Lobe Circuitry in Posttraumatic Stress Disorder. 3, 2470547019850166-247054701985016.
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Young, K. A., Morissette, S. B., Jamroz, R., Meyer, E. C., Stanford, M. S., Wan, L. i., & Kimbrel, N. A.
(2017).
5-HTTLPR and DISC1 risk genotypes for elevated PTSD symptoms in US military veterans. World Psychiatry.
16(1), 109-110.
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Gadad, B. S., Li, W., Yazdani, U., Grady, S., Johnson, T., Hammond, J., ... German, D. C.
(2015).
Administration of thimerosal-containing vaccines to infant rhesus macaques does not result in autism-like behavior or neuropathology. Proceedings of the National Academy of Sciences of the United States of America.
112(40), 12498-12503.
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Kimbrel, N. A., Morissette, S. B., Meyer, E. C., Chrestman, R., Jamroz, R., Silvia, P. J., Beckham, J. C., & Young, K. A.
(2015).
Effect of the 5-HTTLPR polymorphism on posttraumatic stress disorder, depression, anxiety, and quality of life among Iraq and Afghanistan veterans. 28(4), 456-466.
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Kimbrel, N. A., DeBeer, B. B., Meyer, E. C., Silvia, P. J., Beckham, J. C., Young, K. A., & Morissette, S. B.
(2015).
An examination of the broader effects of warzone experiences on returning Iraq/Afghanistan veterans' psychiatric health. Psychiatry Research.
226(1), 78-83.
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Wilson, L. C., Kimbrel, N. A., Meyer, E. C., Young, K. A., & Morissette, S. B.
(2015).
Do child abuse and maternal care interact to predict military sexual trauma?. JOURNAL OF CLINICAL PSYCHOLOGY.
71(4), 378-386.
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Young, K. A., Thompson, P. M., Cruz, D. A., Williamson, D. E., & Selemon, L. D.
(2015).
BA11 FKBP5 expression levels correlate with dendritic spine density in postmortem PTSD and controls. Neurobiology of Stress.
2, 67-72.
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Gadad, B. S., Hewitson, L., Young, K. A., & German, D. C.
(2013).
Neuropathology and animal models of autism: genetic and environmental factors. Autism Research and Treatment.
2013, 731935-12.
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Dolan, S., Martindale, S., Robinson, J., Kimbrel, N. A., Meyer, E. C., Kruse, M. I., ... Gulliver, S. B.
(2012).
Neuropsychological sequelae of PTSD and TBI following war deployment among OEF/OIF veterans. Neuropsychology Review.
22(1), 21-34.
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Robinson, J. L., Laird, A. R., Glahn, D. C., Blangero, J., Sanghera, M. K., Pessoa, L., ... Fox, P. T.
(2012).
The functional connectivity of the human caudate: an application of meta-analytic connectivity modeling with behavioral filtering. NEUROIMAGE.
60(1), 117-129.
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Anderson, N. E., Stanford, M. S., Wan, L. i., & Young, K. A.
(2011).
High psychopathic trait females exhibit reduced startle potentiation and increased p3 amplitude. Behavioral Sciences and the Law.
29(5), 649-666.
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Anderson, N. E., Wan, L. i., Young, K. A., & Stanford, M. S.
(2011).
Psychopathic traits predict startle habituation but not modulation in an emotional faces task. Personality and Individual Differences.
50(5), 712-716.
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Castiglioni, J. A., Russell, M. I., Setlow, B., Young, K. A., Welsh, J. C., & Steele-Russell, I.
(2009).
An animal model of hypnotic pain attenuation. Behavioural Brain Research.
197(1), 198-204.
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Dhanasekaran, M., Holcomb, L. A., Hitt, A. R., Tharakan, B., Porter, J. W., Young, K. A., & Manyam, B. V.
(2009).
Centella asiatica extract selectively decreases amyloid beta levels in hippocampus of Alzheimer's disease animal model. Phytotherapy Research.
23(1), 14-19.
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Young, K. A., Bonkale, W. L., Holcomb, L. A., Hicks, P. B., & German, D. C.
(2008).
Major depression, 5HTTLPR genotype, suicide and antidepressant influences on thalamic volume. British Journal of Psychiatry.
192(4), 285-289.
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Young, K. A., Holcomb, L. A., Bonkale, W. L., Hicks, P. B., Yazdani, U., & German, D. C.
(2007).
5HTTLPR polymorphism and enlargement of the pulvinar: unlocking the backdoor to the limbic system. Biological Psychiatry.
61(6), 813-818.
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Dhanasekaran, M., Tharakan, B., Holcomb, L. A., Hitt, A. R., Young, K. A., & Manyam, B. V.
(2007).
Neuroprotective mechanisms of ayurvedic antidementia botanical Bacopa monniera. Phytotherapy Research.
21(10), 965-969.
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Holcomb, L. A., Dhanasekaran, M., Hitt, A. R., Young, K. A., Riggs, M., & Manyam, B. V.
(2006).
Bacopa monniera extract reduces amyloid levels in PSAPP mice. Journal of Alzheimer's Disease.
9(3), 243-251.
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Schubert, M. H., Young, K. A., & Hicks, P. B.
(2006).
Galantamine improves cognition in schizophrenic patients stabilized on risperidone. Biological Psychiatry.
60(6), 530-533.
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Faraone, S. V., Skol, A. D., Tsuang, D. W., Young, K. A., Haverstock, S. L., Prabhudesai, S., ... Schellenberg, G. D.
(2005).
Genome scan of schizophrenia families in a large Veterans Affairs Cooperative Study sample: evidence for linkage to 18p11.32 and for racial heterogeneity on chromosomes 6 and 14. American Journal of Medical Genetics, Part B, Neuropsychiatric Genetics.
139B(1), 91-100.
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Browning, J. L., Patel, T., Brandt, P. C., Young, K. A., Holcomb, L. A., & Hicks, P. B.
(2005).
Clozapine and the mitogen-activated protein kinase signal transduction pathway: implications for antipsychotic actions. Biological Psychiatry.
57(6), 617-623.
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Surs, A. M., Lind, L. M., Kashner, M. T., Bernstein, I. H., Young, K., & Worchel, J.
(2005).
Aggression and Impulsivity Instruments: An Examination in Veterans. Military Psychology.
17(4), 283-297.
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Young, K. A., Holcomb, L. A., Yazdani, U., Hicks, P. B., & German, D. C.
(2004).
Elevated neuron number in the limbic thalamus in major depression. American Journal of Psychiatry.
161(7), 1270-1277.
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Skol, A. D., Young, K. A., Tsuang, D. W., Faraone, S. V., Haverstock, S. L., Bingham, S., ... Tsuang, M. T.
(2003).
Modest evidence for linkage and possible confirmation of association between NOTCH4 and schizophrenia in a large Veterans Affairs Cooperative Study sample. 118B(1), 8-15.
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Faraone, S. V., Skol, A. D., Tsuang, D. W., Bingham, S., Young, K. A., Prabhudesai, S., ... Schellenberg, G. D.
(2002).
Linkage of chromosome 13q32 to schizophrenia in a large veterans affairs cooperative study sample. American Journal of Medical Genetics Part A.
114(6), 598-604.
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Tsuang, D. W., Skol, A. D., Faraone, S. V., Bingham, S., Young, K. A., Prabhudesai, S., ... Veterans Affairs Cooperative Study.
(2001).
Examination of genetic linkage of chromosome 15 to schizophrenia in a large Veterans Affairs Cooperative Study sample. American Journal of Medical Genetics Part A.
105(8), 662-668.
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Wadenberg, M. G., Browning, J. L., Young, K. A., & Hicks, P. B.
(2001).
Antagonism at 5-HT(2A) receptors potentiates the effect of haloperidol in a conditioned avoidance response task in rats. Pharmacology, Biochemistry and Behavior.
68(3), 363-370.
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Young, K. A., Smith, M., Rawls, T., Elliott, D. B., Russell, I. S., & Hicks, P. B.
(2001).
N100 evoked potential latency variation and startle in schizophrenia. NeuroReport.
12(4), 767-773.
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Petty, F., Brannan, S., Casada, J., Davis, L. L., Gajewski, V., Kramer, G. L., ... Young, K. A.
(2001).
Olanzapine treatment for post-traumatic stress disorder: an open-label study. INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY.
16(6), 331-337.
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Tsuang, M. T., Faraone, S. V., Bingham, S., Young, K., Prabhudesai, S., Haverstock, S. L., ... Collins, J.
(2000).
Department of Veterans Affairs Cooperative Studies Program genetic linkage study of schizophrenia: ascertainment methods and sample description. American Journal of Medical Genetics Part A.
96(3), 342-347.
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Young, K. A., Manaye, K. F., Liang, C., Hicks, P. B., & German, D. C.
(2000).
Reduced number of mediodorsal and anterior thalamic neurons in schizophrenia. Biological Psychiatry.
47(11), 944-953.
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Barwick, V. S., Jones, D. H., Richter, J. T., Hicks, P. B., & Young, K. A.
(2000).
Subthalamic nucleus microinjections of 5-HT2 receptor antagonists suppress stereotypy in rats. NeuroReport.
11(2), 267-270.
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Wadenberg, M. L., Young, K. A., Richter, J. T., & Hicks, P. B.
(1999).
Effects of local application of 5-hydroxytryptamine into the dorsal or median raphe nuclei on haloperidol-induced catalepsy in the rat. Neuropharmacology.
38(1), 151-156.
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Wadenberg, M. L., Hicks, P. B., Richter, J. T., & Young, K. A.
(1998).
Enhancement of antipsychoticlike properties of raclopride in rats using the selective serotonin2A receptor antagonist MDL 100,907. Biological Psychiatry.
44(6), 508-515.
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Wadenberg, M. L., Young, K. A., Trompler, R. A., Zavodny, R. A., Richter, T. J., & Hicks, P. B.
(1997).
A novel computer-controlled conditioned avoidance apparatus for rats. Journal of Pharmacological and Toxicological Methods.
38(4), 211-215.
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Renazco, M. A., Rawls, T., Smith, M., Kaiser, S., Davis, M., Russell, I. S., & Young, K. A.
(1997).
336 Associative learning, neuropsychological performance and psychophysiologic responses in inpatient and outpatient schizophrenics. Schizophrenia Research.
24(1-2), 122-123.
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Young, K. A., Randall, P. K., & Wilcox, R. E.
(1995).
Startle and sensorimotor correlates of ventral thalamic dopamine and GABA in rodents. NeuroReport.
6(18), 2495-2499.
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Young, K. A., Hicks, P. B., Randall, P. K., & Wilcox, R. E.
(1994).
Behavioral and frontal cortical metabolic effects of apomorphine and muscimol microinjections into the mediodorsal thalamic nucleus. JOURNAL OF NEURAL TRANSMISSION.
98(2), 119-132.
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Hicks, P., Young, K., & Zavodny, R.
(1993).
Further evidence for a 5-HT-1C modulation of apomorphine-induced locomotor activity. 9(2-3), 238-238.
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Young, K. A., Zavodny, R., & Hicks, P. B.
(1993).
Effects of serotonergic agents on apomorphine-induced locomotor activity. 110(1-2), 97-102.
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Young, K. A., Zavodny, R., & Hicks, P. B.
(1991).
Subchronic buspirone, mesulergine, and ICS 205-930 lack effects on D1 and D2 dopamine binding in the rat striatum during chronic haloperidol treatment. 86(3), 223-228.
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Young, K. A., Randall, P. K., & Wilcox, R. E.
(1991).
Dose and time response analysis of apomorphine's effect on prepulse inhibition of acoustic startle. Behavioural Brain Research.
42(1), 43-48.
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Young, K. A., & Wilcox, R. E.
(1991).
Characterization of D2 receptors and dopamine levels in the thalamus of the rat. LIFE SCIENCES.
48(19), 1845-1852.
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Nievergelt, C. M., Maihofer, A. X., Atkinson, E. G., Chen, C., Choi, K. W., Coleman, J. R., ... Koenen, K. C.
(2023).
Discovery of 95 PTSD loci provides insight into genetic architecture and neurobiology of trauma and stress-related disorders. 4(09-08), 2023.08.31.23294915.
-
conference paper
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Young, K. A., Bonkale, W., Sachsenmaier, S., & Hicks, P.
(2009).
VA/VL THALAMIC CELL NUMBER IN SCHIZOPHRENIA AND MOOD DISORDERS. Schizophrenia Bulletin.
226-227.
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Young, K. A., Holcomb, L. A., Bonkale, W. L., & Hicks, P. B.
(2007).
Normal oligodendrocyte cell numbers in anterior thalamus in schizophrenia Normal oligodendrocyte cell numbers in anterior thalamus in schizophrenia. Schizophrenia Bulletin.
274-274.
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Holcomb, L. A., Dhanasekaran, M., Young, K. A., & Manyam, B. V.
(2004).
The effect of Bacopa monniera extract on neuropathology in the doubly transgenic PSAPP Alzheimer's disease mouse model. Neurobiology of Aging.
S244-S244.
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Holcomb, L., Reichenbach, R. R., Stitt, D. A., & Young, K. A.
(2003).
Antigliosis in schizophrenia. Schizophrenia Research.
72-72.
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Young, K. A., Skol, A. S., Tsuang, D. W., Faraone, S. V., Bingham, S., Prabhudesai, S., ... Tsuang, M. T.
(2003).
Association of NOTCH4 with schizophrenia in VA Coop Study # 366. Schizophrenia Research.
92-92.
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Holcomb, L. A., Hicks, P. B., Metz, D. S., Stepp, S., & Young, K. A.
(2001).
Anterior thalamic volume in schizophrenia and mood disorders. Schizophrenia Research.
61-61.
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Young, K. A., Russell, I. S., & Hicks, P. B.
(2001).
Changes in evoked potential latency variation over time are associated with changes in EP and startle gating in schizophrenic patients. Schizophrenia Research.
126-126.
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Browning, J. L., Patel, T., Brandt, P. C., Young, K. A., & Hicks, P. B.
(2001).
Is the mechanism of action of antipsychotic agents mediated through the MAP kinase signal transduction system?. Schizophrenia Research.
87-88.
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Holcomb, L. A., Manaye, E. F., German, D. C., Hicks, P. B., & Young, K. A.
(1999).
GFAP and Rab3a immunoreactivity in the thalamus of schizophrenics. Schizophrenia Research.
81-81.
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Young, K. A., Smith, M., Clark, W., Hicks, P. B., & Russell, I. S.
(1999).
Incidence of startle prepulse inhibition deficits in schizophrenics. Schizophrenia Research.
188-188.
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Barwick, V. S., Manaye, K. F., Brandt, A., German, D. C., Hicks, P. B., & Young, K. A.
(1999).
Stereological estimate of total thalamic neuron number in schizophrenics. Schizophrenia Research.
79-79.
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Young, K. A.
(1999).
Thalamic anatomy in schizophrenia. Schizophrenia Research.
86-86.
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Wadenberg, M., Hicks, P. B., Young, K. A., & Richter, J. T.
(1997).
Further evidence for a role of the 5-HT2A receptor in the mediation of antipsychotic activity. Schizophrenia Research.
83-83.
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YOUNG, K. A., BRADY, M. D., & HICKS, P. B.
(1995).
PSYCHOPHYSIOLOGICAL EVIDENCE FOR NEUROLEPTIC-INDUCED DEPOLARIZATION BLOCK IN SCHIZOPHRENICS. Schizophrenia Research.
170-171.
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Young, K. A., Bonkale, W., Sachsenmaier, S., & Hicks, P.
(2009).
VA/VL THALAMIC CELL NUMBER IN SCHIZOPHRENIA AND MOOD DISORDERS. Schizophrenia Bulletin.
226-227.
-
institutional repository document
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Jaffe, A. E., Tao, R., Tran, M. N., Page, S. C., Maynard, K. R., Pattie, E. A., ... Kleinman, J. E.
(2021).
Decoding shared versus divergent transcriptomic signatures across cortico-amygdala circuitry in PTSD and depressive disorders
-
Girgenti, M. J., Wang, J., Ji, D., Cruz, D., Group, T., Program, t., ... Duman, R. S.
(2020).
Transcriptomic Organization of Human Posttraumatic Stress Disorder
-
Nievergelt, C. M., Maihofer, A. X., Klengel, T., Atkinson, E. G., Chen, C., Choi, K. W., ... Koenen, K. C.
(2018).
Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways
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Tran, L., Lasher, B. K., Young, K. A., & Keele, N. B.
(2013).
Depletion of serotonin in the basolateral amygdala elevates glutamate receptors and facilitates fear-potentiated startle. Translational Psychiatry.
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Roltsch, E., Holcomb, L., Young, K. A., Marks, A., & Zimmer, D. B.
(2010).
PSAPP mice exhibit regionally selective reductions in gliosis and plaque deposition in response to S100B ablation. Journal of Neuroinflammation.
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Jaffe, A. E., Tao, R., Tran, M. N., Page, S. C., Maynard, K. R., Pattie, E. A., ... Kleinman, J. E.
(2021).
Decoding shared versus divergent transcriptomic signatures across cortico-amygdala circuitry in PTSD and depressive disorders
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thesis
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Young, K. L.
(2018).
Biogeochemistry of Urban, Suburban, and Rural Ponds and Lakes in South-Central Texas
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Young, K. L.
(2018).
Biogeochemistry of Urban, Suburban, and Rural Ponds and Lakes in South-Central Texas
Teaching
teaching activities
- MSCI691 Research Credit: Medical Sci Instructor
Background
awards and honors
Contact
first name
- Keith
has last name
- Young
Other
- kayoung@tamu.edu