selected publications academic article Cruz, A. M., Spencer, H. F., Kim, T. H., Jhou, T. C., & Smith, R. J (2021). Prelimbic cortical projections to rostromedial tegmental nucleus play a suppressive role in cue-induced reinstatement of cocaine seeking. Neuropsychopharmacology. 46(8), 1399-1406. Smith, R. J., Anderson, R. I., Haun, H. L., Mulholland, P. J., Griffin, W. C., Lopez, M. F., & Becker, H. C (2020). Dynamic c-Fos changes in mouse brain during acute and protracted withdrawal from chronic intermittent ethanol exposure and relapse drinking. Addiction Biology. 25(6), e12804. Smith, R. J., Vento, P. J., Chao, Y. S., Good, C. H., & Jhou, T. C (2019). Gene expression and neurochemical characterization of the rostromedial tegmental nucleus (RMTg) in rats and mice. Brain Struct Funct. 224(1), 219-238. Smith, R. J., & Laiks, L. S (2018). Behavioral and neural mechanisms underlying habitual and compulsive drug seeking. Prog Neuropsychopharmacol Biol Psychiatry. 87(Pt A), 11-21. Scofield, M. D., Boger, H. A., Smith, R. J., Li, H., Haydon, P. G., & Kalivas, P. W (2015). Gq-DREADD Selectively Initiates Glial Glutamate Release and Inhibits Cue-induced Cocaine Seeking. BIOLOGICAL PSYCHIATRY. 78(7), 441-451. Mahler, S. V., Moorman, D. E., Smith, R. J., James, M. H., & Aston-Jones, G (2014). Motivational activation: a unifying hypothesis of orexin/hypocretin function. Nat Neurosci. 17(10), 1298-1303. Smith, R. J., Lobo, M. K., Spencer, S., & Kalivas, P. W (2013). Cocaine-induced adaptations in D1 and D2 accumbens projection neurons (a dichotomy not necessarily synonymous with direct and indirect pathways). Current Opinion in Neurobiology. 23(4), 546-552. Mahler, S. V., Smith, R. J., & Aston-Jones, G (2013). Interactions between VTA orexin and glutamate in cue-induced reinstatement of cocaine seeking in rats. Psychopharmacology. 226(4), 687-698. Smith, R. J., & Aston-Jones, G. (2012). Orexin/hypocretin 1 receptor antagonist reduces heroin self-administration and cue-induced heroin seeking. Eur J Neurosci. Mahler, S. V., Smith, R. J., Moorman, D. E., Sartor, G. C., & Aston-Jones, G (2012). Multiple roles for orexin/hypocretin in addiction. FINE ARTS, NEUROLOGY, AND NEUROSCIENCE: NEURO-HISTORICAL DIMENSIONS. 198, 79-121. Smith, R. J., & Aston-Jones, G. (2011). (2) Adrenergic and imidazoline receptor agonists prevent cue-induced cocaine seeking Cason, A. M., Smith, R. J., Tahsili-Fahadan, P., Moorman, D. E., Sartor, G. C., & Aston-Jones, G (2010). Role of orexin/hypocretin in reward-seeking and addiction: implications for obesity. Physiology and Behavior. 100(5), 419-428. Smith, R. J., Tahsili-Fahadan, P., & Aston-Jones, G (2010). Orexin/hypocretin is necessary for context-driven cocaine-seeking. Neuropharmacology. 58(1), 179-184. Smith, R. J., See, R. E., & Aston-Jones, G (2009). Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking. Eur J Neurosci. 30(3), 493-503. Smith, R. J., & Aston-Jones, G (2008). Noradrenergic transmission in the extended amygdala: role in increased drug-seeking and relapse during protracted drug abstinence. Brain Struct Funct. 213(1-2), 43-61. Smith, R. J., Doyle, G. A., Han, A. M., Crowley, J. J., Oslin, D. W., Patkar, A. A., ... Berrettini, W. H (2005). Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependence. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS. 133B(1), 105-109. Talbot, K., Eidem, W. L., Tinsley, C. L., Benson, M. A., Thompson, E. W., Smith, R. J., ... Arnold, S. E (2004). Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia. JOURNAL OF CLINICAL INVESTIGATION. 113(9), 1353-1363. conference paper Aston-Jones, G., Mahler, S., Sartor, G., Smith, R., & Moorman, D (2014). Seeking reward. 173-174. Evans, S. M., & Smith, R (1999). Effects of regulating the use of TBT-based antifouling paints on TBT contamination. 2012 OCEANS. 1119-1122.
principal investigator on Establishing a Link Between Habits and Punishment Resistance awarded by National Institute on Drug Abuse - (Bethesda, Maryland, United States) 2019 - 2023 Opposing Roles of Distinct Output Projections From Prefrontal Cortex awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2015 - 2017
teaching activities NRSC235 Intro Beh & Cog Neuroscience Instructor NRSC335 Physiological Psych Instructor NRSC336 Drugs & Behavior Instructor NRSC485 Directed Studies Instructor NRSC491 Hnr-research Instructor NRSC649 Sem In Behav Neurosci Instructor NRSC691 Research Instructor PSYC235 Intro Beh & Cog Neuroscience Instructor PSYC335 Physiological Psych Instructor PSYC336 Drugs & Behavior Instructor PSYC485 Directed Studies Instructor PSYC491 Hnr-research Instructor PSYC649 Sem In Behav Neurosci Instructor PSYC685 Directed Studies Instructor PSYC691 Research Instructor
education and training Ph.D. in Neuroscience, University of Pennsylvania - (Philadelphia, Pennsylvania, United States) 2008 B.S. in Biopsychology, University of California, Santa Barbara - (Santa Barbara, California, United States) 2002