HR job title
- Research Associate Professor
- Contact Info
- 1 713 677 7680
- ORCiD
- 0000-0002-4648-5993
Martinez-Moczygemba, Margarita Research Associate Professor
Positions
- Associate Director for Academic Affairs, Institute of Biosciences and Technology, School of Medicine
The research focus of our laboratory is to understand the molecular mechanisms controlling interleukin-5 receptor endocytosis and signal termination. Currently, we are investigating how the ubiquitin/proteasome degradation pathway controls the endocytic trafficking of the IL-5 receptor, and how this process contributes to "shutting off" IL-5-mediated signaling. In a related project, we aim to understand the significance of differential compartmentalization of the IL-5R into lipid rafts and clathrin-containing vesicles.
- Overview
- Publications
- Teaching
- Background
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Overview
Publications
selected publications
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academic article
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Hoden, B., DeRubeis, D., Martinez-Moczygemba, M., Ramos, K. S., & Zhang, D.
(2022).
Understanding the role of Toll-like receptors in lung cancer immunity and immunotherapy. Frontiers in Immunology.
13, 1033483.
-
Goldblatt, D. L., Valverde Ha, G., Wali, S., Kulkarni, V. V., Longmire, M. K., Jaramillo, A. M., ... Evans, S. E.
(2022).
Epithelial immunomodulation by aerosolized Toll-like receptor agonists prevents allergic inflammation in airway mucosa in mice. Frontiers in Pharmacology.
13, 833380.
-
Fang, S., Cui, D., Hong, T., Guo, L., Lee, Y., Lee, M., ... Huang, Y.
(2022).
Ten-Eleven Translocation Ablation Impairs Cardiac Differentiation of Mouse Embryonic Stem Cells. Stem Cells.
40(3), 260-272.
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Liu, X., Kong, W., Peterson, C. B., McGrail, D. J., Hoang, A., Zhang, X., ... Jonasch, E.
(2020).
PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma. Nature Communications.
11(1), 2135.
-
Wang, Y., Jenkins, S. A., Gu, C., Shree, A., Martinez-Moczygemba, M., Herold, J., ... Xu, Y. i.
(2019).
Correction: Bacillus anthracis Spore Surface Protein BclA Mediates Complement Factor H Binding to Spores and Promotes Spore Persistence. PLOS Pathogens.
15(2), e1007579-e1007579.
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Post, A., Isgandarova, S., Martinez-Moczygemba, M., Hahn, M., Russell, B., Hook, M., & Cosgriff-Hernandez, E.
(2019).
Elucidation of Endothelial Cell Hemostatic Regulation with Integrin-Targeting Hydrogels. Annals of Biomedical Engineering.
47(3), 866-877.
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Nguyen, N. T., He, L., Martinez-Moczygemba, M., Huang, Y., & Zhou, Y.
(2018).
Rewiring Calcium Signaling for Precise Transcriptional Reprogramming. ACS Synthetic Biology.
7(3), 814-821.
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Kumar, R., Herold, J. L., Schady, D., Davis, J., Kopetz, S., Martinez-Moczygemba, M., ... Xu, Y. i.
(2017).
Streptococcus gallolyticus subsp. gallolyticus promotes colorectal tumor development. PLOS Pathogens.
13(7), e1006440-e1006440.
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Wang, Y., Jenkins, S. A., Gu, C., Shree, A., Martinez-Moczygemba, M., Herold, J., ... Xu, Y. i.
(2016).
Bacillus anthracis Spore Surface Protein BclA Mediates Complement Factor H Binding to Spores and Promotes Spore Persistence. PLOS Pathogens.
12(6), e1005678-e1005678.
-
Wang, Y., Jenkins, S. A., Gu, C., Shree, A., Martinez-Moczygemba, M., Herold, J., ... Xu, Y. i.
(2016).
Correction: Bacillus anthracis Spore Surface Protein BclA Mediates Complement Factor H Binding to Spores and Promotes Spore Persistence. PLOS Pathogens.
12(10), e1005968-e1005968.
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Amini-Vaughan, Z. J., Martinez-Moczygemba, M., & Huston, D. P.
(2012).
Therapeutic strategies for harnessing human eosinophils in allergic inflammation, hypereosinophilic disorders, and cancer. Current Allergy and Asthma Reports.
12(5), 402-412.
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Lee, M., Cherla, R. P., Jenson, M. H., Leyva-Illades, D., Martinez-Moczygemba, M., & Tesh, V. L.
(2011).
Shiga toxins induce autophagy leading to differential signalling pathways in toxin-sensitive and toxin-resistant human cells. Cellular Microbiology.
13(10), 1479-1496.
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Lei, J. T., Mazumdar, T., & Martinez-Moczygemba, M.
(2011).
Three lysine residues in the common chain of the interleukin-5 receptor are required for Janus kinase (JAK)-dependent receptor ubiquitination, endocytosis, and signaling. Journal of Biological Chemistry.
286(46), 40091-40103.
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Martinez-Moczygemba, M., & Huston, D. P.
(2010).
Immune dysregulation in the pathogenesis of pulmonary alveolar proteinosis. Current Allergy and Asthma Reports.
10(5), 320-325.
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Martinez-Moczygemba, M., Doan, M. L., Elidemir, O., Fan, L. L., Cheung, S. W., Lei, J. T., ... Huston, D. P.
(2008).
Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRalpha gene in the X chromosome pseudoautosomal region 1. Journal of Experimental Medicine.
205(12), 2711-2716.
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Lei, J. T., & Martinez-Moczygemba, M.
(2008).
Separate endocytic pathways regulate IL-5 receptor internalization and signaling. Journal of Leukocyte Biology.
84(2), 499-509.
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Martinez-Moczygemba, M., Huston, D. P., & Lei, J. T.
(2007).
JAK kinases control IL-5 receptor ubiquitination, degradation, and internalization. Journal of Leukocyte Biology.
81(4), 1137-1148.
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Nguyen, A. P., Martinez-Moczygemba, M., Tavana, G., Moore, J. P., Shanks, R. A., Rohani, P., & Huston, D. P.
(2005).
Alternative strategies for antagonism of IL-5. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY.
115(2), s119-S119.
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Martinez-Moczygemba, M., & Huston, D. P.
(2004).
Biology of common beta receptor-signaling cytokines: IL-3, IL-5, and GM-CSF. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY.
112(4), 653-665.
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Martinez-Moczygemba, M., Lei, J. T., & Philip, B.
(2004).
Regulatory signals mediating down-regulation of the common beta chain of the IL-5, IL-3, and GM-CSF receptors. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY.
113(2), s334-S334.
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Martinez-Moczygemba, M.
(2003).
Molecular mechanism of IL-5 receptor proteasome degradation. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY.
111(2), s149-S149.
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Foster, P. S., Martinez-Moczygemba, M., Huston, D. P., & Corry, D. B.
(2002).
Interleukins-4, -5, and -13: emerging therapeutic targets in allergic disease. Pharmacology and Therapeutics.
94(3), 253-264.
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Martinez-Moczygemba, M., & Huston, D. P.
(2001).
Proteasomal regulation of betac signaling reveals a novel mechanism for cytokine receptor heterotypic desensitization. Journal of Clinical Investigation.
108(12), 1797-1806.
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Huston, D. P., Huston, M. M., Dickason, R. R., & Martinez-Moczygemba, M.
(2000).
Interleukin-5, a therapeutic target in allergic inflammation. Transactions of the American Clinical and Climatological Association.
111, 46-59.
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Martinez-Moczygemba, M., Gutch, M. J., French, D. L., & Reich, N. C.
(1997).
Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3. Journal of Biological Chemistry.
272(32), 20070-20076.
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Hoden, B., DeRubeis, D., Martinez-Moczygemba, M., Ramos, K. S., & Zhang, D.
(2022).
Understanding the role of Toll-like receptors in lung cancer immunity and immunotherapy. Frontiers in Immunology.
13, 1033483.
-
chapter
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Huang, J. C., Martinez-Moczygemba, M., Nguyen, A. P., & Huston, D. P.
(2003).
Modulating the interleukin-5 response in asthma. Eissa, N. T., & Huston, D. P. (Eds.),
Therapeutic Targets in Airway Inflammation.
(pp. 495-518).
CRC Press.
-
Huang, J. C., Martinez-Moczygemba, M., Nguyen, A. P., & Huston, D. P.
(2003).
Modulating the interleukin-5 response in asthma. Eissa, N. T., & Huston, D. P. (Eds.),
Therapeutic Targets in Airway Inflammation.
(pp. 495-518).
CRC Press.
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conference paper
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Lee, M., Li, J., Li, J., Fang, S., Zhang, J., Vo, A., ... Huang, Y.
(2021).
Tet2 Inactivation Enhances the Antitumor Activity of Tumor-Infiltrating Lymphocytes. CANCER RESEARCH.
1965-1976.
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Goldblatt, D. L., Fouts, A., Valverde-Ha, G., Martinez-Moczygemba, M., Huston, D., Tuvim, M. J., Dickey, B. F., & Evans, S. E.
(2021).
Aerosolized Toll-Like Receptor Agonists Modulate Type 2 Allergic Inflammation. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
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Goldblatt, D. L., Ha, G. V., Fouts, A., Wali, S., Martinez-Moczygemba, M., Huston, D. P., ... Evans, S. E.
(2020).
Aerosolized Toll-Like Receptor Agonists Suppress Allergic Inflammation. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
a4271-a4271.
-
Goldblatt, D., Fouts, A., Wali, S. M., Valverde-Ha, G., Moczygemba-Martinez, M., Huston, D. P., ... Evans, S.
(2020).
Aerosolized Toll-like Receptor Agonists Suppress Allergic Inflammation. JOURNAL OF IMMUNOLOGY.
a1347-a1347.
-
Liu, X., Kong, W., Anh, H., Zhang, X., Zhou, L., Pilie, P. G., ... Jonasch, E.
(2020).
PBRM1 loss promotes resistance to immunotherapy in RCC. CANCER IMMUNOLOGY RESEARCH.
105-105.
-
Liu, X., Kong, W., Peterson, C., McGrail, D., Anh, H., Zhang, X., ... Jonasch, E.
(2019).
PBRM1 loss defines distinct tumor phenotype associated with immunotherapy resistance in renal cell carcinoma. Journal for ImmunoTherapy of Cancer.
-
Martinez-Moczygemba, M., Lei, J. T., & Mazumdar, T.
(2011).
The Common Beta Chain Phosphorylation Axis Controls IL-5 Receptor Sub-cellular Distribution. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY.
AB165-AB165.
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Martinez-Moczygemba, M., & Huston, D. P.
(2000).
Cytokine regulation of IL-5 receptor alpha chain (IL-5Ra) and beta chain (bc) isoform expression. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY.
S75-S75.
-
Lee, M., Li, J., Li, J., Fang, S., Zhang, J., Vo, A., ... Huang, Y.
(2021).
Tet2 Inactivation Enhances the Antitumor Activity of Tumor-Infiltrating Lymphocytes. CANCER RESEARCH.
1965-1976.
-
institutional repository document
-
Goldblatt, D. L., Ha, G. V., Wali, S., Kulkarni, V. V., Longmire, M. K., Jaramillo, A. M., ... Evans, S. E.
(2021).
Epithelial Immunomodulation by Aerosolized Toll-like Receptor Agonists Attenuates Allergic Responsiveness in Mice
-
Lee, M., Li, J., Fang, S., Zhang, J., Vo, A., Han, W., ... Huang, Y.
(2020).
Tet2 inactivation enhances the anti-tumor activity of tumor-infiltrating lymphocytes (TILs) to curtail melanoma growth
-
Goldblatt, D. L., Ha, G. V., Wali, S., Kulkarni, V. V., Longmire, M. K., Jaramillo, A. M., ... Evans, S. E.
(2021).
Epithelial Immunomodulation by Aerosolized Toll-like Receptor Agonists Attenuates Allergic Responsiveness in Mice
Teaching
teaching activities
- MSCI689 Sptp: Foundations In Biotechno Instructor
- MSCI691 Research Credit: Medical Sci Instructor
Background
education and training
- B.S. in Biology, Texas A&M University - Kingsville - (Kingsville, Texas, United States) 1997
- Ph.D. in Molecular Immunology and Pathology, Stony Brook University - (Stony Brook, New York, United States) 1997
- M.S. in Biology, Texas A&M University - Kingsville - (Kingsville, Texas, United States) 1989
- Baylor College of Medicine - (Houston, Texas, United States) , Postdoctoral Training 2002
Contact
first name
- Margarita
has last name
- Martinez-Moczygemba
mailing address
-
Texas A&M Health Science Center
Ibt-Ciid-Hook
1201 TAMUS
Houston, TX 77030
USA
Other
- mmoczygemba@tamu.edu