HR job title
- Research Assistant Professor
- Contact Info
- ORCiD
- 0000-0003-0102-0612
Powell, Reid Research Assistant Professor
Positions
- Research Assistant Professor, Institute of Biosciences and Technology, Texas A&M University Naresh K. Vashisht College of Medicine
- Overview
- Publications
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Overview
Publications
selected publications
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academic article
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Powell, R. T., Rinkenbaugh, A. L., Guo, L., Cai, S., Shao, J., Zhou, X., ... Piwnica-Worms, H.
(2024).
Targeting neddylation and sumoylation in chemoresistant triple negative breast cancer. npj Breast Cancer.
10(1), 37.
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Ghosh, S., Fan, F., Powell, R., Park, Y. S., Stephan, C., Roszik, J., Ellis, L. M., & Bhattacharya, R.
(2023).
Abstract B171: BX-795 enhances the efficacy of crizotinib in colorectal cancer cells by altering the activity of aurora kinases. 22(12_Supplement), b171-b171.
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Junco, J. J., Rashid, R., Terrell, M., Alozie, M., Rochette, M., Zorman, B., ... Rabin, K. R.
(2023).
A Novel Transgenic Mouse Model of Down Syndrome Acute Lymphoblastic Leukemia Identifies Targetable Vulnerabilities. 142(Supplement 1), 2981-2981.
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Carter, B. Z., Mak, P. Y., Muftuoglu, M., Tao, W., Ke, B., Pei, J., ... Andreeff, M.
(2023).
Epichaperome inhibition targets TP53-mutant AML and AML stem/progenitor cells. Blood.
142(12), 1056-1070.
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Ghosh, S., Fan, F., Powell, R. T., Roszik, J., Park, Y. S., Stephan, C., ... Bhattacharya, R.
(2023).
Vincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal Cancer. MOLECULAR CANCER THERAPEUTICS.
22(8), 962-975.
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Yu, W., Chen, Y., Putluri, N., Osman, A., Coarfa, C., Putluri, V., ... Sandulache, V. C.
(2023).
Evolution of cisplatin resistance through coordinated metabolic reprogramming of the cellular reductive state. British Journal of Cancer.
128(11), 2013-2024.
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Foster, K., Dasari, S. K., Powell, R. T., Nguyen, N. D., Sobieski, M., Stephan, C., ... Sood, A. K.
(2023).
Systematic high-throughput combination drug screen to enhance poly (ADP-ribose) polymerase (PARP) inhibitor efficacy in ovarian cancer. 41(16_suppl), 5546-5546.
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Shah, P. A., Mazumdar, T., Powell, R. T., Shen, L. i., Wang, J., Stephen, C. C., Frederick, M. J., & Johnson, F. M.
(2023).
Abstract 2847: Concurrent inactivation of PI3K and PLK1 is synergistic and overcomes acquired resistance to PI3K inhibitors in NOTCH1 MUT HNSCC. Cancer Research.
83(7_Supplement), 2847-2847.
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Welte, T., Vuttaradhi, V., Khlebus, E., Lawson, B., Hillman, R. T., Nguyen, N., ... Stephan, C.
(2023).
Abstract 453: Targeting FOXL2C402G vulnerabilities in adult type ovarian granulosa cell tumors. Cancer Research.
83(7_Supplement), 453-453.
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Ghosh, S., Fan, F., Roszik, J., Powell, R., Park, Y., Stephan, C., Ellis, L. M., & Bhattacharya, R.
(2023).
Abstract 4994: Crizotinib enhances the efficacy of BX-795 identified by high-throughput screening of pan-active drugs in colorectal cancer cells. Cancer Research.
83(7_Supplement), 4994-4994.
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Abdulkareem, N., Bhat, R., Powell, R., Chikermane, S., Yande, S., Trinh, L., ... Trivedi, M.
(2023).
Abstract P6-10-19: Screening of GPCR-targeting drugs for repositioning in breast cancer. Cancer Research.
83(5_Supplement), p6-10-19-p6-10-19.
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Dasari, S. K., Joseph, R., Umamaheswaran, S., Mangala, L. S., Bayraktar, E., Rodriguez-Aguayo, C., ... Sood, A. K.
(2023).
Combination of EphA2- and Wee1-Targeted Therapies in Endometrial Cancer. 24(4), 3915-3915.
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Fan, F., Ghosh, S., Powell, R., Roszik, J., Park, Y., Sobieski, M., ... Bhattacharya, R.
(2023).
Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo. PLoS ONE.
18(3), e0281063-e0281063.
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Ghosh, S., Mazumdar, T., Xu, W., Powell, R. T., Stephan, C., Shen, L. i., ... Johnson, F. M.
(2022).
Combined TRIP13 and Aurora Kinase Inhibition Induces Apoptosis in Human Papillomavirus-Driven Cancers. CLINICAL CANCER RESEARCH.
28(20), 4479-4493.
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Ghosh, S., Mazumdar, T., Xu, W., Powell, R. T., Stephan, C., Shen, L. i., ... Johnson, F. M.
(2022).
Abstract 1858: Rb deficient HPV+ HNSCC experienced enhanced sensitivity to aurora kinase inhibitors by altering the balance of MAD2 and TRIP13 levels. Cancer Research.
82(12_Supplement), 1858-1858.
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Braun, F. K., Brabetz, S., Qi, L., Du, Y., Kogiso, M., Zhang, H. Y., ... Li, X.
(2022).
MODL-29. Molecular Landscape of a comprehensive panel of pediatric brain cancer Patient-derived orthotopic xenograft (PDOX) models inform unique targets for drug responsiveness. Neuro-Oncology.
24(Supplement_1), i175-i175.
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Tahaney, W. M., Qian, J., Powell, R., Moyer, C. L., Ma, Y., Nguyen, N., ... Brown, P. H.
(2022).
Abstract GS1-09: Inhibition of GPX4 induces preferential death of p53-mutant triple-negative breast cancer cells. Cancer Research.
82(4_Supplement), gs1-09-gs1-09.
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Kumar, A., Aglyamova, G., Yim, Y. Y., Bailey, A. O., Lynch, H. M., Powell, R. T., ... Rudenko, G.
(2022).
Chemically targeting the redox switch in AP1 transcription factor FOSB. Nucleic Acids Research (NAR).
50(16), 9548-9567.
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de Groot, E., Varghese, S., Tan, L., Knighton, B., Sobieski, M., Nguyen, N., ... Gopal, Y.
(2022).
Combined inhibition of HMGCoA reductase and mitochondrial complex I induces tumor regression of BRAF inhibitor-resistant melanomas. Cancer & Metabolism.
10(1), 6.
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Tang, Y., Powell, R. T., & Gottlieb, A.
(2022).
Molecular pathways enhance drug response prediction using transfer learning from cell lines to tumors and patient-derived xenografts. Scientific Reports.
12(1), 16109.
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Powell, R. T., Moussalli, M. J., Guo, L., Bae, G., Singh, P., Stephan, C., Shureiqi, I., & Davies, P. J.
(2022).
deepOrganoid: A brightfield cell viability model for screening matrix-embedded organoids. Slas Discovery.
27(3), 175-184.
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Abdulkareem, N. M., Bhat, R., Powell, R. T., Chikermane, S., Yande, S., Trinh, L., ... Trivedi, M. V.
(2022).
Screening of GPCR drugs for repurposing in breast cancer. Frontiers in Pharmacology.
13, 1049640.
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Handley, K. F., Rodriguez-Aguayo, C., Ma, S., Stur, E., Joseph, R., Bayraktar, E., ... Sood, A. K.
(2021).
Rational Combination of CRM1 Inhibitor Selinexor and Olaparib Shows Synergy in Ovarian Cancer Cell Lines and Mouse Models. MOLECULAR CANCER THERAPEUTICS.
20(12), 2352-2361.
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Bolt, M. J., Singh, P., Obkirchner, C. E., Powell, R. T., Mancini, M. G., Szafran, A. T., Stossi, F., & Mancini, M. A.
(2021).
Endocrine disrupting chemicals differentially alter intranuclear dynamics and transcriptional activation of estrogen receptor-. iScience.
24(11), 103227-103227.
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Henderson, Y. C., Mohamed, A., Maniakas, A., Chen, Y., Powell, R. T., Peng, S., ... Lai, S. Y.
(2021).
A High-throughput Approach to Identify Effective Systemic Agents for the Treatment of Anaplastic Thyroid Carcinoma. Journal of Clinical Endocrinology and Metabolism.
106(10), 2962-2978.
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Mazumdar, T., Shen, L. i., Xu, W., Ghosh, S., Powell, R. T., Stephan, C., ... Johnson, F. M.
(2021).
Abstract 368: Aurora kinase inhibitors cause cell death in HPV+ cells: A plausible treatment option for HPV+ cancers. Cancer Research.
81(13_Supplement), 368-368.
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Shah, P. A., Mazumdar, T., Powell, R. T., Shen, L. i., Wang, J., Stephen, C. C., Frederick, M. J., & Johnson, F. M.
(2021).
Abstract 369: Identification of pathways that enhance cell death in NOTCH1-mutant HNSCC. Cancer Research.
81(13_Supplement), 369-369.
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Chowdhury, P., Perera, D., Powell, R. T., Talley, T., Tripathi, D. N., Park, Y. S., ... Dere, R.
(2021).
Author Correction: Therapeutically actionable signaling node to rescue AURKA driven loss of primary cilia in VHL-deficient cells. Scientific Reports.
11(1), 17657.
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Shah, V. V., Duncan, A. D., Jiang, S., Stratton, S. A., Allton, K. L., Yam, C., ... Barton, M. C.
(2021).
Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer. Nature Communications.
12(1), 5389.
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Zhao, N. a., Powell, R. T., Yuan, X., Bae, G., Roarty, K. P., Stossi, F., ... Rosen, J. M.
(2021).
Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition. Nature Communications.
12(1), 4262.
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Post, S. M., Malaney, P., Chan, L., Zhang, X., Link, T., Cho, E., ... Dalby, K.
(2021).
Targeting the Oncogenic Functions of an RNA-Binding Protein Involved in Hematologic Malignancies. Blood.
138(Supplement 1), 2226-2226.
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Chowdhury, P., Perera, D., Powell, R. T., Talley, T., Tripathi, D. N., Park, Y. S., ... Dere, R.
(2021).
Therapeutically actionable signaling node to rescue AURKA driven loss of primary cilia in VHL-deficient cells. Scientific Reports.
11(1), 10461.
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Powell, R., Fan, F., Sobieski, M., Brunell, D., Wang, R., Ye, X., ... Bhattacharya, R.
(2020).
Abstract B20: Unbiased high-throughput screenings to identify combination therapies targeting RAS-mutated colorectal cancer. Molecular Cancer Research.
18(5_Supplement), b20-b20.
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Tahaney, W. M., Powell, R., Nguyen, N., Bollu, L. R., Qian, J., Mazumdar, A., ... Brown, P. H.
(2020).
Abstract P3-03-08: Identification of drugs that induce the death or suppress the growth of p53-mutant breast cancer. Cancer Research.
80(4_Supplement), p3-03-08-p3-03-08.
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Powell, R. T., Redwood, A., Liu, X., Guo, L., Cai, S., Zhou, X., ... Piwnica-Worms, H.
(2020).
Pharmacologic profiling of patient-derived xenograft models of primary treatment-nave triple-negative breast cancer. Scientific Reports.
10(1), 17899.
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Xia, J., Chiu, L., Nehring, R. B., Bravo Nez, M. A., Mei, Q., Perez, M., ... Rosenberg, S. M.
(2019).
Bacteria-to-Human Protein Networks Reveal Origins of Endogenous DNA Damage. Cell.
176(1-2), 127-143.e24.
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Wadsworth, P. A., Folorunso, O., Nguyen, N., Singh, A. K., D'Amico, D., Powell, R. T., ... Laezza, F.
(2019).
High-throughput screening against protein:protein interaction interfaces reveals anti-cancer therapeutics as potent modulators of the voltage-gated Na+ channel complex. Scientific Reports.
9(1), 16890.
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Chowdhury, P., Powell, R. T., Stephan, C., Uray, I. P., Talley, T., Karki, M., ... Dere, R.
(2018).
Bexarotene - a novel modulator of AURKA and the primary cilium in VHL-deficient cells. Journal of Cell Science.
131(24), jcs219923.
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Puli, O. R., Danysh, B. P., McBeath, E., Sinha, D. K., Hoang, N. M., Powell, R. T., ... Hofmann, M.
(2018).
The Transcription Factor ETV5 Mediates BRAFV600E-Induced Proliferation and TWIST1 Expression in Papillary Thyroid Cancer Cells. Neoplasia.
20(11), 1121-1134.
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Chiang, Y., Park, I., Terzo, E. A., Tripathi, D. N., Mason, F. M., Fahey, C. C., ... Rathmell, W. K.
(2018).
SETD2 Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma. 78(12), 3135-3146.
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Cooper, L. A., Demicco, E. G., Saltz, J. H., Powell, R. T., Rao, A., & Lazar, A. J.
(2018).
PanCancer insights from The Cancer Genome Atlas: the pathologist's perspective. Journal of Pathology.
244(5), 512-524.
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Sun, M., Tong, P., Kong, W., Dong, B., Huang, Y., Park, I. Y., ... Jonasch, E.
(2017).
HNF1B Loss Exacerbates the Development of Chromophobe Renal Cell Carcinomas. Cancer Research.
77(19), 5313-5326.
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Jonasch, E., Fuller, G., McCutcheon, I., Ding, Z., Zhou, L., Liu, X., ... Sun, M.
(2017).
1723P The role of hepatocyte nuclear factor 1 homeobox B (HNF1B) loss in chromophobe RCC (ChRCC) development. ANNALS OF ONCOLOGY.
28, v602-v602.
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Powell, R. T., Olar, A., Narang, S., Rao, G., Sulman, E., Fuller, G. N., & Rao, A.
(2017).
Identification of Histological Correlates of Overall Survival in Lower Grade Gliomas Using a Bag-of-words Paradigm: A Preliminary Analysis Based on Hematoxylin & Eosin Stained Slides from the Lower Grade Glioma Cohort of The Cancer Genome Atlas. Journal of Pathology Informatics.
8(1), 9-9.
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Park, I. Y., Chowdhury, P., Tripathi, D. N., Powell, R. T., Dere, R., Terzo, E. A., Rathmell, W. K., & Walker, C. L.
(2016).
Methylated -tubulin antibodies recognize a new microtubule modification on mitotic microtubules. 8(8), 1590-1597.
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Park, I. Y., Powell, R. T., Tripathi, D. N., Dere, R., Ho, T. H., Blasius, T. L., ... Walker, C. L.
(2016).
Dual Chromatin and Cytoskeletal Remodeling by SETD2. Cell.
166(4), 950-962.
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Zhang, J., Tripathi, D. N., Jing, J. i., Alexander, A., Kim, J., Powell, R. T., ... Walker, C. L.
(2015).
ATM functions at the peroxisome to induce pexophagy in response to ROS. Nature Cell Biology.
17(10), 1259-1269.
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Stossi, F., Bolt, M. J., Ashcroft, F. J., Lamerdin, J. E., Melnick, J. S., Powell, R. T., ... Mancini, M. A.
(2014).
Defining estrogenic mechanisms of bisphenol A analogs through high throughput microscopy-based contextual assays. Chemistry and Biology.
21(6), 743-753.
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Welte, T., Vuttaradhi, V. K., Khlebus, E. Y., Brodsky, A., Flores Legarreta, A., Celestino, J., ... Hillman, R. T.
Gain-of-Function Chromatin Remodeling Activity of Oncogenic FOXL2-C134W Reprograms Glucocorticoid Receptor Occupancy to Drive Granulosa Cell Tumors. Cancer Research.
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Johnson, S. J., Johnson, H. L., Powell, R. T., Stephan, C., Stossi, F., & Cooper, T. A.
Small Molecule Screening Identifies HSP90 as a Modifier of RNA Foci in Myotonic Dystrophy Type 1. Molecular and Cellular Biology.
ahead-of-print(ahead-of-print), 1-13.
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Powell, R. T., Rinkenbaugh, A. L., Guo, L., Cai, S., Shao, J., Zhou, X., ... Piwnica-Worms, H.
(2024).
Targeting neddylation and sumoylation in chemoresistant triple negative breast cancer. npj Breast Cancer.
10(1), 37.
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chapter
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Powell, R. T.
(2024).
Computational precision therapeutics and drug repositioning. Comprehensive Precision Medicine.
(pp. 57-74).
Elsevier.
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Lehrer, M., Powell, R. T., Barua, S., Kim, D., Narang, S., & Rao, A.
(2017).
Radiogenomics and Histomics in Glioblastoma: The Promise of Linking Image-Derived Phenotype with Genomic Information. ADVANCES IN BIOLOGY AND TREATMENT OF GLIOBLASTOMA.
(pp. 143-159).
Springer Nature.
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Powell, R. T.
(2024).
Computational precision therapeutics and drug repositioning. Comprehensive Precision Medicine.
(pp. 57-74).
Elsevier.
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conference paper
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Foster, K., Dasari, S. K., Powell, R. T., Nguyen, N. D., Sobieski, M., Stephan, C., ... Sood, A. K.
(2023).
Systematic high-throughput combination drug screen to enhance poly (ADP-ribose) polymerase (PARP) inhibitor efficacy in ovarian cancer. Journal of Clinical Oncology.
-
Braun, F. K., Brabetz, S., Qi, L., Du, Y., Kogiso, M., Zhang, H. Y., ... Li, X.
(2022).
MOLECULAR LANDSCAPE OF A COMPREHENSIVE PANEL OF PEDIATRIC BRAIN CANCER PATIENT-DERIVED ORTHOTOPIC XENOGRAFT (PDOX) MODELS INFORM UNIQUE TARGETS FOR DRUG RESPONSIVENESS. Neuro-Oncology.
175-175.
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Ghosh, S., Fan, F., Roszik, J., Powell, R., Park, Y., Stephan, C., Ellis, L. M., & Bhattacharya, R.
(2022).
Determining efficacy of combining the MEK inhibitor trametinib with vincristine identified by unbiased high throughput screening in RAS-mutated colorectal cancer cells. Cancer Research.
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Ghosh, S., Mazumdar, T., Xu, W., Powell, R. T., Stephan, C., Shen, L. i., ... Johnson, F. M.
(2022).
Rb deficient HPV plus HNSCC experienced enhanced sensitivity to aurora kinase inhibitors by altering the balance of MAD2 and TRIP13 levels. Cancer Research.
-
Mazumdar, T., Shen, L. i., Xu, W., Ghosh, S., Powell, R. T., Stephan, C., ... Johnson, F. M.
(2021).
Aurora kinase inhibitors cause cell death in HPV plus cells: A plausible treatment option for HPV plus cancers. Cancer Research.
-
Shah, P. A., Mazumdar, T., Powell, R. T., Shen, L. i., Wang, J., Stephen, C. C., Frederick, M. J., & Johnson, F. M.
(2021).
Identification of pathways that enhance cell death in NOTCH1-mutant HNSCC. Cancer Research.
-
Dvorak, N. M., Wadsworth, P. A., Engelke, D. S., Singh, A. K., Nguyen, N., Aceto, G., ... Laezza, F.
(2021).
Pharmacological Targeting of FGF14 Modulates Motivated Behavior by Increasing Medium Spiny Neuron Firing. Neuropsychopharmacology.
237-238.
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Fan, F., Powell, R., Roszik, J., Wang, R., Ye, X., Stephan, C., Ellis, L., & Bhattacharya, R.
(2020).
Determining efficacy of drug combinations identified by unbiased high throughput screening for RAS-mutated colorectal cancer. Cancer Research.
550-550.
-
Powell, R. T., Redwood, A., Guo, L., Cai, S., Tu, Y., Jiang, Y., ... Piwnica-Worms, H.
(2020).
High throughput chemical profiling of chemoresistant triple negative breast cancer. Cancer Research.
4106-4106.
-
Powell, R., Fan, F., Sobieski, M., Brunell, D., Wang, R., Ye, X., ... Bhattacharya, R.
(2020).
Unbiased high-throughput screenings to identify combination therapies targeting RAS-mutated colorectal cancer. Molecular Cancer Research.
63-63.
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Bernard, V., San Lucas, F. A., Huang, J., Powell, R. T., Guerrero, P. A., Semaan, A., ... Maitra, A.
(2019).
Single cell transcriptomic profiling of ex vivo tumoroid models reveal therapeutic vulnerabilities of pancreatic ductal adenocarcinoma. Cancer Research.
1402-1402.
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Foster, K., Dasari, S. K., Powell, R. T., Nguyen, N. D., Sobieski, M., Stephan, C., ... Sood, A. K.
(2023).
Systematic high-throughput combination drug screen to enhance poly (ADP-ribose) polymerase (PARP) inhibitor efficacy in ovarian cancer. Journal of Clinical Oncology.
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institutional repository document
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Marreddy, R., Picker, J., Phelps, G. A., Powell, R., Cherian, P. T., Bowling, J. J., ... Hurdle, J. G.
(2022).
The licorice metabolite enoxolone attenuates Clostridioides difficile pathophysiology by corrupting its metabolic and toxin production networks
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Tahaney, W. M., Qian, J., Moyer, C. L., Nguyen, N., Lanier, A., Ma, Y., ... Brown, P. H.
(2022).
Inhibition of GPX4 Induces the Death of p53-Mutant Triple-Negative Breast Cancer
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Xia, J., Chiu, L., Nehring, R. B., Nez, M., Mei, Q., Perez, M., ... Rosenberg, S. M.
(2018).
Bacteria-to-human protein networks reveal origins of endogenous DNA damage
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Marreddy, R., Picker, J., Phelps, G. A., Powell, R., Cherian, P. T., Bowling, J. J., ... Hurdle, J. G.
(2022).
The licorice metabolite enoxolone attenuates Clostridioides difficile pathophysiology by corrupting its metabolic and toxin production networks
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thesis
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Powell, R. T.
(2018).
Extracting Biological Knowledge from High Throughput Phenotypic Screens
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Powell, R. T.
(2018).
Extracting Biological Knowledge from High Throughput Phenotypic Screens
Contact
first name
- Reid
has last name
- Powell
Other
- repowell@tamu.edu