A carcinogenesis model describing mutational events at the DNA adduct level. Academic Article uri icon


  • A stochastic carcinogenesis model is proposed to describe a sequence of component mutational changes that constitute the G:C-->A:T base substitution. This paper provides the biological basis and mathematical formulation underlying the proposed model. In addition, the paper elaborates on a numerical approach for studying the cumulant functions, survival functions, and hazard functions of the model. Several numerical examples are given of potential applications of the model.

published proceedings

  • Math Biosci

author list (cited authors)

  • Zheng, O., Lutz, W. K., & Gaylor, D. W.

citation count

  • 10

complete list of authors

  • Zheng, O||Lutz, WK||Gaylor, DW

publication date

  • January 1997