A carcinogenesis model describing mutational events at the DNA adduct level. Academic Article

abstract

• A stochastic carcinogenesis model is proposed to describe a sequence of component mutational changes that constitute the G:C-->A:T base substitution. This paper provides the biological basis and mathematical formulation underlying the proposed model. In addition, the paper elaborates on a numerical approach for studying the cumulant functions, survival functions, and hazard functions of the model. Several numerical examples are given of potential applications of the model.

authors

• Zheng, Qi

published proceedings

• Math Biosci

author list (cited authors)

• Zheng, O., Lutz, W. K., & Gaylor, D. W.

citation count

• 10

complete list of authors

• Zheng, O||Lutz, WK||Gaylor, DW

publication date

• January 1997

publisher

• Elsevier  Publisher

published in

• Mathematical Biosciences  Journal

keywords

• Base Composition
• Carcinogens
• DNA Adducts
• Humans
• Models, Theoretical
• Mutation
• Neoplasms
• Poisson Distribution
• Stochastic Processes

Digital Object Identifier (DOI)

• 10.1016/s0025-5564(97)00005-9

start page

• 23

end page

• 44

volume

• 144

issue

• 1

URL

• http://dx.doi.org/10.1016/s0025-5564(97)00005-9