Vitamin D receptor genotype is not associated with bone mineral density in three ethnic/regional groups. Academic Article uri icon

abstract

  • We report a cross-sectional study of 48 men, 56 premenopausal women, and 80 postmenopausal women who were of three ethnic/regional backgrounds: southern European (Greek, Italian), eastern European (Jewish, Polish, Hungarian), and western European (French, British). We determined bone mineral density (BMD) at four skeletal sites and assessed the vitamin D receptor (VDR) genotype by the Bsml restriction site polymorphism. Age and body mass index had significant effects on BMD by multiple regression analysis. In addition, ethnic/regional group had a significant effect on spinal BMD in premenopausal females (P = 0.014) and in males (P = 0.039). However, VDR genotype had no significant effect on BMD in any of the three study groups.

published proceedings

  • Calcif Tissue Int

author list (cited authors)

  • Spotila, L. D., Caminis, J., Johnston, R., Shimoya, K. S., O'Connor, M. P., Prockop, D. J., Tenenhouse, A., & Tenenhouse, H. S.

citation count

  • 30

complete list of authors

  • Spotila, LD||Caminis, J||Johnston, R||Shimoya, KS||O'Connor, MP||Prockop, DJ||Tenenhouse, A||Tenenhouse, HS

publication date

  • January 1996