HR job title
- Retired Professor
- Contact Info
- 1 979 436 9650
- Websites
Prockop, Darwin Professor
Positions
- Professor, Cell Biology and Genetics, School of Medicine
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- Publications
- Research
- Teaching
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Overview
Publications
selected publications
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academic article
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Choi, H., Phillips, C., Oh, J. Y., Potts, L., Reger, R. L., Prockop, D. J., & Fulcher, S.
(2019).
Absence of Therapeutic Benefit of the Anti-Inflammatory Protein TSG-6 for Corneal Alkali Injury in a Rat Model. Current Eye Research.
44(8), 873-881.
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Pacienza, N., Lee, R. H., Bae, E., Kim, D., Liu, Q., Prockop, D. J., & Yannarelli, G.
(2019).
InVitro Macrophage Assay Predicts the InVivo Anti-inflammatory Potential of Exosomes from Human Mesenchymal Stromal Cells. Molecular Therapy - Methods and Clinical Development.
13, 67-76.
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Nepal, S., Tiruppathi, C., Tsukasaki, Y., Farahany, J., Mittal, M., Rehman, J., Prockop, D. J., & Malik, A. B.
(2019).
STAT6 induces expression of Gas6 in macrophages to clear apoptotic neutrophils and resolve inflammation. Proceedings of the National Academy of Sciences of USA.
116(33), 16513-16518.
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Upadhya, D., Hattiangady, B., Castro, O. W., Shuai, B., Kodali, M., Attaluri, S., ... Shetty, A. K.
(2019).
Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration. Proceedings of the National Academy of Sciences of USA.
116(1), 287-296.
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Song, H. B., Park, S. Y., Ko, J. H., Park, J. W., Yoon, C. H., Kim, D. H., ... Oh, J. Y.
(2018).
Mesenchymal Stromal Cells Inhibit Inflammatory Lymphangiogenesis in the Cornea by Suppressing Macrophage in a TSG-6-Dependent Manner. MOLECULAR THERAPY.
26(1), 162-172.
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Snyderman, R., Koopman, W. J., & Prockop, D. J.
(2018).
Review of the national arthritis advisory board symposium, molecular biology: its potential for advancing rheumatology research. 30(10), 1191-1194.
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Long, Q., Upadhya, D., Hattiangady, B., Kim, D., An, S. Y., Shuai, B., Prockop, D. J., & Shetty, A. K.
(2017).
Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus. Proceedings of the National Academy of Sciences of USA.
114(17), E3536-E3545.
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Yun, Y. I., Park, S. Y., Lee, H. J., Ko, J. H., Kim, M. K., Wee, W. R., ... Oh, J. Y.
(2017).
Comparison of the anti-inflammatory effects of induced pluripotent stem cell-derived and bone marrow-derived mesenchymal stromal cells in a murine model of corneal injury. Cytotherapy.
19(1), 28-35.
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Prockop, D. J., Oh, J. Y., & Lee, R. H.
(2017).
Data against a Common Assumption: Xenogeneic Mouse Models Can Be Used to Assay Suppression of Immunity by Human MSCs. MOLECULAR THERAPY.
25(8), 1748-1756.
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Shigemoto-Kuroda, T., Oh, J. Y., Kim, D., Jeong, H. J., Park, S. Y., Lee, H. J., ... Lee, R. H.
(2017).
MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis. Stem Cell Reports.
8(5), 1214-1225.
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Prockop, D. J.
(2017).
The exciting prospects of new therapies with mesenchymal stromal cells. Cytotherapy.
19(1), 1-8.
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Ullah, M., Kuroda, Y., Bartosh, T. J., Liu, F., Zhao, Q., Gregory, C., ... Prockop, D. J.
(2017).
iPS-derived MSCs from an expandable bank to deliver a prodrug-converting enzyme that limits growth and metastases of human breast cancers. Cell Death Discovery.
3(1), 16064.
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Bartosh, T. J., Ullah, M., Zeitouni, S., Beaver, J., & Prockop, D. J.
(2016).
Cancer cells enter dormancy after cannibalizing mesenchymal stem/stromal cells (MSCs). Proceedings of the National Academy of Sciences of USA.
113(42), E6447-E6456.
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Prockop, D. J.
(2016).
Inflammation, fibrosis, and modulation of the process by mesenchymal stem/stromal cells. Matrix Biol.
51, 7-13.
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Bazhanov, N., Ylostalo, J. H., Bartosh, T. J., Tiblow, A., Mohammadipoor, A., Foskett, A., & Prockop, D. J.
(2016).
Intraperitoneally infused human mesenchymal stem cells form aggregates with mouse immune cells and attach to peritoneal organs. Stem Cell Research and Therapy.
7(1), 27.
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Mohammadipoor, A., Lee, R. H., Prockop, D. J., & Bartosh, T. J.
(2016).
Stanniocalcin-1 attenuates ischemic cardiac injury and response of differentiating monocytes/macrophages to inflammatory stimuli. 177, 127-142.
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Kim, D., Nishida, H., An, S. Y., Shetty, A. K., Bartosh, T. J., & Prockop, D. J.
(2016).
Chromatographically isolated CD63+CD81+ extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI. Proceedings of the National Academy of Sciences of USA.
113(1), 170-175.
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Ko, J. H., Lee, H. J., Jeong, H. J., Kim, M. K., Wee, W. R., Yoon, S., ... Oh, J. Y.
(2016).
Mesenchymal stem/stromal cells precondition lung monocytes/macrophages to produce tolerance against allo- and autoimmunity in the eye. Proceedings of the National Academy of Sciences of USA.
113(1), 158-163.
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Kim, D., Choi, H., Nishida, H., Oh, J. Y., Gregory, C., Lee, R. H., ... Prockop, D. J.
(2016).
Scalable Production of a Multifunctional Protein (TSG-6) That Aggregates with Itself and the CHO Cells That Synthesize It. PLoS One.
11(1), e0147553-e0147553.
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Prockop, D. J.
(2015).
Hardly Tendentious--Repairing Like with Like. NEW ENGLAND JOURNAL OF MEDICINE.
373(14), 1371-1372.
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Weiss, D. J., Chambers, D., Giangreco, A., Keating, A., Kotton, D., Lelkes, P. I., ... ATS Subcommittee on Stem Cells and Cell Therapies.
(2015).
An official American Thoracic Society workshop report: stem cells and cell therapies in lung biology and diseases. Annals of the American Thoracic Society.
12(4), S79-S97.
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Xie, J., Broxmeyer, H. E., Feng, D., Schweitzer, K. S., Yi, R. u., Cook, T. G., ... March, K. L.
(2015).
Human adipose-derived stem cells ameliorate cigarette smoke-induced murine myelosuppression via secretion of TSG-6. Stem Cells.
33(2), 468-478.
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Beltran, S. R., Svoboda, K., Kerns, D. G., Sheth, A., & Prockop, D. J.
(2015).
Anti-inflammatory protein tumor necrosis factor--stimulated protein 6 (TSG-6) promotes early gingival wound healing: an in vivo study. JOURNAL OF PERIODONTOLOGY.
86(1), 62-71.
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Zhao, Q., Gregory, C. A., Lee, R. H., Reger, R. L., Qin, L., Hai, B. o., ... Liu, F.
(2015).
MSCs derived from iPSCs with a modified protocol are tumor-tropic but have much less potential to promote tumors than bone marrow MSCs. Proceedings of the National Academy of Sciences of USA.
112(2), 530-535.
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Prockop, D. J., Prockop, S. E., & Bertoncello, I.
(2014).
Are clinical trials with mesenchymal stem/progenitor cells too far ahead of the science? Lessons from experimental hematology. Stem Cells.
32(12), 3055-3061.
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Lee, R. H., Yu, J. M., Foskett, A. M., Peltier, G., Reneau, J. C., Bazhanov, N., Oh, J. Y., & Prockop, D. J.
(2014).
TSG-6 as a biomarker to predict efficacy of human mesenchymal stem/progenitor cells (hMSCs) in modulating sterile inflammation in vivo. Proceedings of the National Academy of Sciences of USA.
111(47), 16766-16771.
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McFerrin, H. E., Olson, S. D., Gutschow, M. V., Semon, J. A., Sullivan, D. E., & Prockop, D. J.
(2014).
Rapidly self-renewing human multipotent marrow stromal cells (hMSC) express sialyl Lewis X and actively adhere to arterial endothelium in a chick embryo model system. PLoS One.
9(8), e105411-e105411.
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Oh, J. Y., Ko, J. H., Lee, H. J., Yu, J. M., Choi, H., Kim, M. K., Wee, W. R., & Prockop, D. J.
(2014).
Mesenchymal stem/stromal cells inhibit the NLRP3 inflammasome by decreasing mitochondrial reactive oxygen species. Stem Cells.
32(6), 1553-1563.
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Reger, R. L., & Prockop, D. J.
(2014).
Should publications on mesenchymal stem/progenitor cells include in-process data on the preparation of the cells?. Stem Cells Translational Medicine.
3(5), 632-635.
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Kim, H., Darwish, I., Monroy, M., Prockop, D. J., Liles, W. C., & Kain, K. C.
(2014).
Mesenchymal stromal (stem) cells suppress pro-inflammatory cytokine production but fail to improve survival in experimental staphylococcal toxic shock syndrome. BMC Immunology.
15(1), 1.
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Viswanathan, S., Keating, A., Deans, R., Hematti, P., Prockop, D., Stroncek, D. F., ... Rao, M. S.
(2014).
Soliciting strategies for developing cell-based reference materials to advance mesenchymal stromal cell research and clinical translation. Stem Cells and Development.
23(11), 1157-1167.
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Ylostalo, J. H., Bartosh, T. J., Tiblow, A., & Prockop, D. J.
(2014).
Unique characteristics of human mesenchymal stromal/progenitor cells pre-activated in 3-dimensional cultures under different conditions. Cytotherapy.
16(11), 1486-1500.
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Foskett, A. M., Bazhanov, N., Ti, X., Tiblow, A., Bartosh, T. J., & Prockop, D. J.
(2014).
Phase-directed therapy: TSG-6 targeted to early inflammation improves bleomycin-injured lungs. American Journal of Physiology: Lung Cellular and Molecular Physiology.
306(2), L120-L131.
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Bartosh, T. J., Ylstalo, J. H., Bazhanov, N., Kuhlman, J., & Prockop, D. J.
(2013).
Dynamic compaction of human mesenchymal stem/precursor cells into spheres self-activates caspase-dependent IL1 signaling to enhance secretion of modulators of inflammation and immunity (PGE2, TSG6, and STC1). Stem Cells.
31(11), 2443-2456.
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Prockop, D. J.
(2013).
Concise review: two negative feedback loops place mesenchymal stem/stromal cells at the center of early regulators of inflammation. Stem Cells.
31(10), 2042-2046.
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Watanabe, J., Shetty, A. K., Hattiangady, B., Kim, D., Foraker, J. E., Nishida, H., & Prockop, D. J.
(2013).
Administration of TSG-6 improves memory after traumatic brain injury in mice. NEUROBIOLOGY OF DISEASE.
59, 86-99.
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Prockop, D. J.
(2013).
Further proof for an unpopular concept: a single cell from bone marrow can serve as a stem cell for both hematopoiesis and osteogenesis. MOLECULAR THERAPY.
21(6), 1116-1117.
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Weiss, D. J., Bates, J., Gilbert, T., Liles, W. C., Lutzko, C., Rajagopal, J., & Prockop, D.
(2013).
Stem cells and cell therapies in lung biology and diseases: conference report. Annals of the American Thoracic Society.
10(5), S25-S44.
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Cibelli, J., Emborg, M. E., Prockop, D. J., Roberts, M., Schatten, G., Rao, M., Harding, J., & Mirochnitchenko, O.
(2013).
Strategies for improving animal models for regenerative medicine. Cell Stem Cell.
12(3), 271-274.
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Prockop, D. J.
(2012).
New targets for osteoporosis. NEW ENGLAND JOURNAL OF MEDICINE.
367(24), 2353-2354.
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Ylstalo, J. H., Bartosh, T. J., Coble, K., & Prockop, D. J.
(2012).
Human mesenchymal stem/stromal cells cultured as spheroids are self-activated to produce prostaglandin E2 that directs stimulated macrophages into an anti-inflammatory phenotype. Stem Cells.
30(10), 2283-2296.
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Prockop, D. J., & Keating, A.
(2012).
Relearning the lessons of genomic stability of human cells during expansion in culture: implications for clinical research. Stem Cells.
30(6), 1051-1052.
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Oh, J. Y., Choi, H., Lee, R. H., Roddy, G. W., Ylstalo, J. H., Wawrousek, E., & Prockop, D. J.
(2012).
Identification of the HSPB4/TLR2/NF-B axis in macrophage as a therapeutic target for sterile inflammation of the cornea. EMBO Molecular Medicine.
4(5), 435-448.
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Prockop, D. J., & Oh, J. Y.
(2012).
Medical therapies with adult stem/progenitor cells (MSCs): a backward journey from dramatic results in vivo to the cellular and molecular explanations. Journal of Cellular Biochemistry.
113(5), 1460-1469.
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Roddy, G. W., Rosa, R. H., Oh, J. Y., Ylostalo, J. H., Bartosh, T. J., Choi, H., ... Prockop, D. J.
(2012).
Stanniocalcin-1 rescued photoreceptor degeneration in two rat models of inherited retinal degeneration. MOLECULAR THERAPY.
20(4), 788-797.
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Prockop, D. J.
(2012).
A long-awaited discovery: hypoxia prevents mouse cells from undergoing spontaneous p53-dependent transformation. Cytotherapy.
14(9), 1029-1031.
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Tuo, J., Cao, X., Shen, D., Wang, Y., Zhang, J., Oh, J. Y., Prockop, D. J., & Chan, C.
(2012).
Anti-inflammatory recombinant TSG-6 stabilizes the progression of focal retinal degeneration in a murine model. Journal of Neuroinflammation.
9(1), 59.
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Horie, M., Driscoll, M. D., Sampson, H. W., Sekiya, I., Caroom, C. T., Prockop, D. J., & Thomas, D. B.
(2012).
Implantation of allogenic synovial stem cells promotes meniscal regeneration in a rabbit meniscal defect model. 94(8), 701-712.
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Horie, M., Choi, H., Lee, R. H., Reger, R. L., Ylostalo, J., Muneta, T., Sekiya, I., & Prockop, D. J.
(2012).
Intra-articular injection of human mesenchymal stem cells (MSCs) promote rat meniscal regeneration by being activated to express Indian hedgehog that enhances expression of type II collagen. Osteoarthritis and Cartilage.
20(10), 1197-1207.
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Oh, J. Y., Lee, R. H., Yu, J. M., Ko, J. H., Lee, H. J., Ko, A. Y., Roddy, G. W., & Prockop, D. J.
(2012).
Intravenous mesenchymal stem cells prevented rejection of allogeneic corneal transplants by aborting the early inflammatory response. MOLECULAR THERAPY.
20(11), 2143-2152.
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Prockop, D. J., & Oh, J. Y.
(2012).
Mesenchymal stem/stromal cells (MSCs): role as guardians of inflammation. MOLECULAR THERAPY.
20(1), 14-20.
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Ohkouchi, S., Block, G. J., Katsha, A. M., Kanehira, M., Ebina, M., Kikuchi, T., ... Prockop, D. J.
(2012).
Mesenchymal stromal cells protect cancer cells from ROS-induced apoptosis and enhance the Warburg effect by secreting STC1. MOLECULAR THERAPY.
20(2), 417-423.
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Prockop, D. J.
(2012).
Mitochondria to the rescue. Nature Medicine.
18(5), 653-654.
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Scheibe, F., Gladow, N., Mergenthaler, P., Tucker, A. H., Meisel, A., Prockop, D. J., & Priller, J.
(2012).
Nonviral gene delivery of erythropoietin by mesenchymal stromal cells. Gene Therapy (Basingstoke).
19(5), 550-560.
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Lee, R. H., Yoon, N., Reneau, J. C., & Prockop, D. J.
(2012).
Preactivation of human MSCs with TNF- enhances tumor-suppressive activity. Cell Stem Cell.
11(6), 825-835.
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Mao, J. J., & Prockop, D. J.
(2012).
Stem Cells in the Face: Tooth Regeneration and Beyond. Cell Stem Cell.
11(4), 579-579.
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Mao, J. J., & Prockop, D. J.
(2012).
Stem cells in the face: tooth regeneration and beyond. Cell Stem Cell.
11(3), 291-301.
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Foraker, J. E., Oh, J. Y., Ylostalo, J. H., Lee, R. H., Watanabe, J., & Prockop, D. J.
(2011).
Cross-talk between human mesenchymal stem/progenitor cells (MSCs) and rat hippocampal slices in LPS-stimulated cocultures: the MSCs are activated to secrete prostaglandin E2. Journal of Neurochemistry.
119(5), 1052-1063.
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Roddy, G. W., Oh, J. Y., Lee, R. H., Bartosh, T. J., Ylostalo, J., Coble, K., Rosa, R. H., & Prockop, D. J.
(2011).
Action at a distance: systemically administered adult stem/progenitor cells (MSCs) reduce inflammatory damage to the cornea without engraftment and primarily by secretion of TNF- stimulated gene/protein 6. Stem Cells.
29(10), 1572-1579.
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Choi, H., Lee, R. H., Bazhanov, N., Oh, J. Y., & Prockop, D. J.
(2011).
Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-B signaling in resident macrophages. Blood.
118(2), 330-338.
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Shoji, M., Oskowitz, A., Malone, C. D., Prockop, D. J., & Pochampally, R.
(2011).
Human mesenchymal stromal cells (MSCs) reduce neointimal hyperplasia in a mouse model of flow-restriction by transient suppression of anti-inflammatory cytokines. Journal of Atherosclerosis and Thrombosis.
18(6), 464-474.
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Oskowitz, A. Z., Penfornis, P., Tucker, A., Prockop, D. J., & Pochampally, R.
(2011).
Drosha regulates hMSCs cell cycle progression through a miRNA independent mechanism. The International Journal of Biochemistry and Cell Biology.
43(11), 1563-1572.
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Danchuk, S., Ylostalo, J. H., Hossain, F., Sorge, R., Ramsey, A., Bonvillain, R. W., ... Sullivan, D. E.
(2011).
Human multipotent stromal cells attenuate lipopolysaccharide-induced acute lung injury in mice via secretion of tumor necrosis factor--induced protein 6. Stem Cell Research and Therapy.
2(3), 27.
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Robinson, A. P., Foraker, J. E., Ylostalo, J., & Prockop, D. J.
(2011).
Human stem/progenitor cells from bone marrow enhance glial differentiation of rat neural stem cells: a role for transforming growth factor and Notch signaling. Stem Cells and Development.
20(2), 289-300.
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Weiss, D. J., Bertoncello, I., Borok, Z., Kim, C., Panoskaltsis-Mortari, A., Reynolds, S., ... Prockop, D. J.
(2011).
Stem cells and cell therapies in lung biology and lung diseases. Annals of the American Thoracic Society.
8(3), 223-272.
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Oh, J. Y., Roddy, G. W., Choi, H., Lee, R. H., Ylstalo, J. H., Rosa, R. H., & Prockop, D. J.
(2010).
Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury. Proceedings of the National Academy of Sciences of USA.
107(39), 16875-16880.
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Prockop, D. J., Kota, D. J., Bazhanov, N., & Reger, R. L.
(2010).
Evolving paradigms for repair of tissues by adult stem/progenitor cells (MSCs). Journal of Cellular and Molecular Medicine.
14(9), 2190-2199.
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Bartosh, T. J., Ylstalo, J. H., Mohammadipoor, A., Bazhanov, N., Coble, K., Claypool, K., ... Prockop, D. J.
(2010).
Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties. Proceedings of the National Academy of Sciences of USA.
107(31), 13724-13729.
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Block, G. J., DiMattia, G. D., & Prockop, D. J.
(2010).
Stanniocalcin-1 regulates extracellular ATP-induced calcium waves in human epithelial cancer cells by stimulating ATP release from bystander cells. PLoS One.
5(4), e10237-e10237.
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Snyder, B. R., Chiu, A. M., Prockop, D. J., & Chan, A.
(2010).
Human multipotent stromal cells (MSCs) increase neurogenesis and decrease atrophy of the striatum in a transgenic mouse model for Huntington's disease. PLoS One.
5(2), e9347-e9347.
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Prockop, D. J.
(2010).
Defining the probability that a cell therapy will produce a malignancy. MOLECULAR THERAPY.
18(7), 1249-1250.
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Prockop, D. J., Brenner, M., Fibbe, W. E., Horwitz, E., Le Blanc, K., Phinney, D. G., ... Keating, A.
(2010).
Defining the risks of mesenchymal stromal cell therapy. Cytotherapy.
12(5), 576-578.
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Semon, J. A., Nagy, L. H., Llamas, C. B., Tucker, H. A., Lee, R. H., & Prockop, D. J.
(2010).
Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels. Cell and Tissue Research.
341(1), 147-158.
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Fischer-Valuck, B. W., Barrilleaux, B. L., Phinney, D. G., Russell, K. C., Prockop, D. J., & O'Connor, K. C.
(2010).
Migratory response of mesenchymal stem cells to macrophage migration inhibitory factor and its antagonist as a function of colony-forming efficiency. Biotechnology Letters.
32(1), 19-27.
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Larson, B. L., Ylostalo, J., Lee, R. H., Gregory, C., & Prockop, D. J.
(2010).
Sox11 is expressed in early progenitor human multipotent stromal cells and decreases with extensive expansion of the cells. Tissue Engineering Part A.
16(11), 3385-3394.
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Uccelli, A., & Prockop, D. J.
(2010).
Why should mesenchymal stem cells (MSCs) cure autoimmune diseases?. Current Opinion in Immunology.
22(6), 768-774.
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Prockop, D. J.
(2009).
Repair of tissues by adult stem/progenitor cells (MSCs): controversies, myths, and changing paradigms. MOLECULAR THERAPY.
17(6), 939-946.
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Block, G. J., Ohkouchi, S., Fung, F., Frenkel, J., Gregory, C., Pochampally, R., ... Prockop, D. J.
(2009).
Multipotent stromal cells are activated to reduce apoptosis in part by upregulation and secretion of stanniocalcin-1. Stem Cells.
27(3), 670-681.
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Belmadani, S., Matrougui, K., Kolz, C., Pung, Y. F., Palen, D., Prockop, D. J., & Chilian, W. M.
(2009).
Amplification of coronary arteriogenic capacity of multipotent stromal cells by epidermal growth factor. Arteriosclerosis, Thrombosis and Vascular Biology.
29(6), 802-808.
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Garnero, P., Schott, A., Prockop, D., & Chevrel, G.
(2009).
Bone turnover and type I collagen C-telopeptide isomerization in adult osteogenesis imperfecta: associations with collagen gene mutations. BONE.
44(3), 461-466.
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Lee, R. H., Pulin, A. A., Seo, M. J., Kota, D. J., Ylostalo, J., Larson, B. L., ... Prockop, D. J.
(2009).
Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6. Cell Stem Cell.
5(1), 54-63.
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Prockop, D. J., Sieron, A. L., & Li, S. W.
(2009).
Procollagen N-proteinase and procollagen C-proteinase. Two unusual metalloproteinases that are essential for procollagen processing probably have important roles in development and cell signaling. Matrix Biol.
16(7), 399-408.
-
Barrilleaux, B. L., Phinney, D. G., Fischer-Valuck, B. W., Russell, K. C., Wang, G., Prockop, D. J., & O'Connor, K. C.
(2009).
Small-molecule antagonist of macrophage migration inhibitory factor enhances migratory response of mesenchymal stem cells to bronchial epithelial cells. Tissue Engineering Part A.
15(9), 2335-2346.
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Khillan, J. S., Olsen, A. S., Kontusaari, S., Sokolov, B., & Prockop, D. J.
(2009).
Transgenic mice that express a mini-gene version of the human gene for type I procollagen (COL1A1) develop a phenotype resembling a lethal form of osteogenesis imperfecta. Journal of Biological Chemistry.
266(34), 23373-23379.
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Abrams, M. B., Dominguez, C., Pernold, K., Reger, R., Wiesenfeld-Hallin, Z., Olson, L., & Prockop, D.
(2009).
Multipotent mesenchymal stromal cells attenuate chronic inflammation and injury-induced sensitivity to mechanical stimuli in experimental spinal cord injury. Restorative Neurology and Neuroscience.
27(4), 307-321.
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Lee, R. H., Seo, M. J., Pulin, A. A., Gregory, C. A., Ylostalo, J., & Prockop, D. J.
(2009).
The CD34-like protein PODXL and alpha6-integrin (CD49f) identify early progenitor MSCs with increased clonogenicity and migration to infarcted heart in mice. Blood.
113(4), 816-826.
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Oskowitz, A. Z., Lu, J., Penfornis, P., Ylostalo, J., McBride, J., Flemington, E. K., Prockop, D. J., & Pochampally, R.
(2008).
Human multipotent stromal cells from bone marrow and microRNA: regulation of differentiation and leukemia inhibitory factor expression. Proceedings of the National Academy of Sciences of USA.
105(47), 18372-18377.
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Ohtaki, H., Ylostalo, J. H., Foraker, J. E., Robinson, A. P., Reger, R. L., Shioda, S., & Prockop, D. J.
(2008).
Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses. Proceedings of the National Academy of Sciences of USA.
105(38), 14638-14643.
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Weiss, D. J., Kolls, J. K., Ortiz, L. A., Panoskaltsis-Mortari, A., & Prockop, D. J.
(2008).
Stem cells and cell therapies in lung biology and lung diseases. Annals of the American Thoracic Society.
5(5), 637-667.
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Spees, J. L., Whitney, M. J., Sullivan, D. E., Lasky, J. A., Laboy, M., Ylostalo, J., & Prockop, D. J.
(2008).
Bone marrow progenitor cells contribute to repair and remodeling of the lung and heart in a rat model of progressive pulmonary hypertension. The FASEB Journal.
22(4), 1226-1236.
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Ylstalo, J., Pochampally, R., & Prockop, D. J.
(2008).
Assays of MSCs with microarrays. Methods in Molecular Biology.
449, 133-151.
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Zeitouni, S., Ford, B. S., Harris, S. M., Whitney, M. J., Gregory, C. A., & Prockop, D. J.
(2008).
Pharmaceutical induction of ApoE secretion by multipotent mesenchymal stromal cells (MSCs). BMC Biotechnology.
8(1), 75.
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Ylstalo, J., Bazhanov, N., & Prockop, D. J.
(2008).
Reversible commitment to differentiation by human multipotent stromal cells in single-cell-derived colonies. Experimental Hematology.
36(10), 1390-1402.
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Larson, B. L., Ylstalo, J., & Prockop, D. J.
(2008).
Human multipotent stromal cells undergo sharp transition from division to development in culture. Stem Cells.
26(1), 193-201.
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Prockop, D. J., Phinney, D. G., & Bunnell, B. A.
(2008).
Methods and protocols. Preface. Methods in Molecular Biology.
449, v-vii.
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Phinney, D. G., & Prockop, D. J.
(2007).
Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair--current views. Stem Cells.
25(11), 2896-2902.
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Hung, S., Pochampally, R. R., Chen, S., Hsu, S., & Prockop, D. J.
(2007).
Angiogenic effects of human multipotent stromal cell conditioned medium activate the PI3K-Akt pathway in hypoxic endothelial cells to inhibit apoptosis, increase survival, and stimulate angiogenesis. Stem Cells.
25(9), 2363-2370.
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Pochampally, R. R., Ylostalo, J., Penfornis, P., Matz, R. R., Smith, J. R., & Prockop, D. J.
(2007).
Histamine receptor H1 and dermatopontin: new downstream targets of the vitamin D receptor. Journal of Bone and Mineral Research.
22(9), 1338-1349.
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Spees, J. L., Pociask, D. A., Sullivan, D. E., Whitney, M. J., Lasky, J. A., Prockop, D. J., & Brody, A. R.
(2007).
Engraftment of bone marrow progenitor cells in a rat model of asbestos-induced pulmonary fibrosis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
176(4), 385-394.
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Hung, S., Pochampally, R. R., Hsu, S., Sanchez, C., Chen, S., Spees, J., & Prockop, D. J.
(2007).
Short-term exposure of multipotent stromal cells to low oxygen increases their expression of CX3CR1 and CXCR4 and their engraftment in vivo. PLoS One.
2(5), e416-e416.
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Prockop, D. J., & Olson, S. D.
(2007).
Clinical trials with adult stem/progenitor cells for tissue repair: let's not overlook some essential precautions. Blood.
109(8), 3147-3151.
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Tolar, J., Nauta, A. J., Osborn, M. J., Panoskaltsis Mortari, A., McElmurry, R. T., Bell, S., ... Blazar, B. R.
(2007).
Sarcoma derived from cultured mesenchymal stem cells. Stem Cells.
25(2), 371-379.
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Prockop, D. J.
(2007).
"Stemness" does not explain the repair of many tissues by mesenchymal stem/multipotent stromal cells (MSCs). Clinical Pharmacology and Therapeutics.
82(3), 241-243.
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Lee, N., Smolarz, A. J., Olson, S., David, O., Reiser, J., Kutner, R., ... Gregory, C. A.
(2007).
A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies. British Journal of Cancer.
97(11), 1552-1559.
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Kesteloot, F., Desmoulire, A., Leclercq, I., Thiry, M., Arrese, J. E., Prockop, D. J., ... Colige, A.
(2007).
ADAM metallopeptidase with thrombospondin type 1 motif 2 inactivation reduces the extent and stability of carbon tetrachloride-induced hepatic fibrosis in mice. HEPATOLOGY.
46(5), 1620-1631.
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Marini, J. C., Forlino, A., Cabral, W. A., Barnes, A. M., San Antonio, J. D., Milgrom, S., ... Byers, P. H.
(2007).
Consortium for osteogenesis imperfecta mutations in the helical domain of type I collagen: regions rich in lethal mutations align with collagen binding sites for integrins and proteoglycans. Human Mutation.
28(3), 209-221.
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Iso, Y., Spees, J. L., Serrano, C., Bakondi, B., Pochampally, R., Song, Y., ... Prockop, D. J.
(2007).
Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment. Biochemical and Biophysical Research Communications.
354(3), 700-706.
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Prockop, D. J.
(2006).
MSCs roll into the mainstream. Blood.
108(12), 3626-3627.
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Lee, R. H., Seo, M. J., Reger, R. L., Spees, J. L., Pulin, A. A., Olson, S. D., & Prockop, D. J.
(2006).
Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice. Proceedings of the National Academy of Sciences of USA.
103(46), 17438-17443.
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Weiss, D. J., Berberich, M. A., Borok, Z., Gail, D. B., Kolls, J. K., Penland, C., & Prockop, D. J.
(2006).
Adult stem cells, lung biology, and lung disease. NHLBI/Cystic Fibrosis Foundation Workshop. Annals of the American Thoracic Society.
3(3), 193-207.
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Gunn, W. G., Conley, A., Deininger, L., Olson, S. D., Prockop, D. J., & Gregory, C. A.
(2006).
A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: a potential role in the development of lytic bone disease and tumor progression in multiple myeloma. Stem Cells.
24(4), 986-991.
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Lee, R. H., Hsu, S. C., Munoz, J., Jung, J. S., Lee, N. R., Pochampally, R., & Prockop, D. J.
(2006).
A subset of human rapidly self-renewing marrow stromal cells preferentially engraft in mice. Blood.
107(5), 2153-2161.
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Ylstalo, J., Smith, J. R., Pochampally, R. R., Matz, R., Sekiya, I., Larson, B. L., Vuoristo, J. T., & Prockop, D. J.
(2006).
Use of differentiating adult stem cells (marrow stromal cells) to identify new downstream target genes for transcription factors. Stem Cells.
24(3), 642-652.
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Munoz, J. R., Stoutenger, B. R., Robinson, A. P., Spees, J. L., & Prockop, D. J.
(2006).
Correction for Munoz et al., Human steprogenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice. Proceedings of the National Academy of Sciences of USA.
103(6), 2000-2002.
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Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F. c., Krause, D. s., ... Horwitz, E. m.
(2006).
Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy.
8(4), 315-317.
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Peister, A., Zeitouni, S., Pfankuch, T., Reger, R. L., Prockop, D. J., & Raber, J.
(2006).
Novel object recognition in Apoe(-/-) mice improved by neonatal implantation of wild-type multipotential stromal cells. Experimental Neurology.
201(1), 266-269.
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Barrilleaux, B., Phinney, D. G., Prockop, D. J., & O'Connor, K. C.
(2006).
Review: ex vivo engineering of living tissues with adult stem cells. Tissue Engineering.
12(11), 3007-3019.
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Spees, J. L., Olson, S. D., Whitney, M. J., & Prockop, D. J.
(2006).
Mitochondrial transfer between cells can rescue aerobic respiration. Proceedings of the National Academy of Sciences of USA.
103(5), 1283-1288.
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Munoz, J. R., Stoutenger, B. R., Robinson, A. P., Spees, J. L., & Prockop, D. J.
(2005).
Human stem/progenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice. Proceedings of the National Academy of Sciences of USA.
102(50), 18171-18176.
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Gregory, C. A., Ylostalo, J., & Prockop, D. J.
(2005).
Adult bone marrow stem/progenitor cells (MSCs) are preconditioned by microenvironmental "niches" in culture: a two-stage hypothesis for regulation of MSC fate. 2005(294), pe37.
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Prockop, D. J.
(2005).
Type II collagen and avascular necrosis of the femoral head. NEW ENGLAND JOURNAL OF MEDICINE.
352(22), 2268-2270.
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Nieminen, J., Sahlman, J., Hirvonen, T., Jms, T., Tuukkanen, J., Kovanen, V., ... Puustjrvi, K.
(2005).
Abnormal response to physical activity in femurs after heterozygous inactivation of one allele of the Col2a1 gene for type II collagen in mice. Calcified Tissue International.
77(2), 104-112.
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Sekiya, I., Larson, B. L., Vuoristo, J. T., Reger, R. L., & Prockop, D. J.
(2005).
Comparison of effect of BMP-2, -4, and -6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma. Cell and Tissue Research.
320(2), 269-276.
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Pochampally, R. R., Horwitz, E. M., DiGirolamo, C. M., Stokes, D. S., & Prockop, D. J.
(2005).
Correction of a mineralization defect by overexpression of a wild-type cDNA for COL1A1 in marrow stromal cells (MSCs) from a patient with osteogenesis imperfecta: a strategy for rescuing mutations that produce dominant-negative protein defects. Gene Therapy (Basingstoke).
12(14), 1119-1125.
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Gregory, C. A., Perry, A. S., Reyes, E., Conley, A., Gunn, W. G., & Prockop, D. J.
(2005).
Dkk-1-derived synthetic peptides and lithium chloride for the control and recovery of adult stem cells from bone marrow. Journal of Biological Chemistry.
280(3), 2309-2323.
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Gregory, C. A., Prockop, D. J., & Spees, J. L.
(2005).
Non-hematopoietic bone marrow stem cells: molecular control of expansion and differentiation. Experimental Cell Research.
306(2), 330-335.
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Devoto, M., Spotila, L. D., Stabley, D. L., Wharton, G. N., Rydbeck, H., Korkko, J., ... Sol-Church, K.
(2005).
Univariate and bivariate variance component linkage analysis of a whole-genome scan for loci contributing to bone mineral density. European Journal of Human Genetics.
13(6), 781-788.
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Wang, G., Bunnell, B. A., Painter, R. G., Quiniones, B. C., Tom, S., Lanson, N. A., ... Kolls, J. K.
(2005).
Adult stem cells from bone marrow stroma differentiate into airway epithelial cells: potential therapy for cystic fibrosis. Proceedings of the National Academy of Sciences of USA.
102(1), 186-191.
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Sahlman, J., Pitknen, M. T., Prockop, D. J., Arita, M., Li, S., Helminen, H. J., ... Lammi, M. J.
(2004).
A human COL2A1 gene with an Arg519Cys mutation causes osteochondrodysplasia in transgenic mice. ARTHRITIS AND RHEUMATISM.
50(10), 3153-3160.
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Smith, J. R., Pochampally, R., Perry, A., Hsu, S., & Prockop, D. J.
(2004).
Isolation of a highly clonogenic and multipotential subfraction of adult stem cells from bone marrow stroma. Stem Cells.
22(5), 823-831.
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Pochampally, R. R., Neville, B. T., Schwarz, E. J., Li, M. M., & Prockop, D. J.
(2004).
Rat adult stem cells (marrow stromal cells) engraft and differentiate in chick embryos without evidence of cell fusion. Proceedings of the National Academy of Sciences of USA.
101(25), 9282-9285.
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Prockop, D. J.
(2004).
Targeting gene therapy for osteogenesis imperfecta. NEW ENGLAND JOURNAL OF MEDICINE.
350(22), 2302-2304.
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Peister, A., Mellad, J. A., Larson, B. L., Hall, B. M., Gibson, L. F., & Prockop, D. J.
(2004).
Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potential. Blood.
103(5), 1662-1668.
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Pochampally, R. R., Smith, J. R., Ylostalo, J., & Prockop, D. J.
(2004).
Serum deprivation of human marrow stromal cells (hMSCs) selects for a subpopulation of early progenitor cells with enhanced expression of OCT-4 and other embryonic genes. Blood.
103(5), 1647-1652.
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Sekiya, I., Larson, B. L., Vuoristo, J. T., Cui, J., & Prockop, D. J.
(2004).
Adipogenic differentiation of human adult stem cells from bone marrow stroma (MSCs). Journal of Bone and Mineral Research.
19(2), 256-264.
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Schouten, J. W., Fulp, C. T., Royo, N. C., Saatman, K. E., Watson, D. J., Snyder, E. Y., ... McIntosh, T. K.
(2004).
A review and rationale for the use of cellular transplantation as a therapeutic strategy for traumatic brain injury. JOURNAL OF NEUROTRAUMA.
21(11), 1501-1538.
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Gregory, C. A., Gunn, W. G., Peister, A., & Prockop, D. J.
(2004).
An Alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction. Analytical Biochemistry.
329(1), 77-84.
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Spees, J. L., Gregory, C. A., Singh, H., Tucker, H. A., Peister, A., Lynch, P. J., ... Prockop, D. J.
(2004).
Internalized antigens must be removed to prepare hypoimmunogenic mesenchymal stem cells for cell and gene therapy. MOLECULAR THERAPY.
9(5), 747-756.
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Peister, A., Mellad, J. A., Wang, M., Tucker, H. A., & Prockop, D. J.
(2004).
Stable transfection of MSCs by electroporation. Gene Therapy (Basingstoke).
11(2), 224-228.
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Spees, J. L., Olson, S. D., Ylostalo, J., Lynch, P. J., Smith, J., Perry, A., ... Prockop, D. J.
(2003).
Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma. Proceedings of the National Academy of Sciences of USA.
100(5), 2397-2402.
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Prockop, D. J.
(2003).
Further proof of the plasticity of adult stem cells and their role in tissue repair. The Journal of Cell Biology.
160(6), 807-809.
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Gregory, C. A., Singh, H., Perry, A. S., & Prockop, D. J.
(2003).
The Wnt signaling inhibitor dickkopf-1 is required for reentry into the cell cycle of human adult stem cells from bone marrow. Journal of Biological Chemistry.
278(30), 28067-28078.
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Sekiya, I., Larson, B. L., Smith, J. R., Pochampally, R., Cui, J., & Prockop, D. J.
(2002).
Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality. Stem Cells.
20(6), 530-541.
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Sekiya, I., Vuoristo, J. T., Larson, B. L., & Prockop, D. J.
(2002).
In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis. Proceedings of the National Academy of Sciences of USA.
99(7), 4397-4402.
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Hofstetter, C. P., Schwarz, E. J., Hess, D., Widenfalk, J., El Manira, A., Prockop, D. J., & Olson, L.
(2002).
Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery. Proceedings of the National Academy of Sciences of USA.
99(4), 2199-2204.
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Prockop, D. J.
(2002).
Adult stem cells gradually come of age. Nature Biotechnology.
20(8), 791-792.
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Colige, A., Vandenberghe, I., Thiry, M., Lambert, C. A., Van Beeumen, J., Li, S., ... Nusgens, B. V.
(2002).
Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3. Journal of Biological Chemistry.
277(8), 5756-5766.
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Li, S. W., Takanosu, M., Arita, M., Bao, Y., Ren, Z. X., Maier, A., Prockop, D. J., & Mayne, R.
(2001).
Targeted disruption of Col11a2 produces a mild cartilage phenotype in transgenic mice: comparison with the human disorder otospondylomegaepiphyseal dysplasia (OSMED). Developmental Dynamics.
222(2), 141-152.
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Colter, D. C., Sekiya, I., & Prockop, D. J.
(2001).
Identification of a subpopulation of rapidly self-renewing and multipotential adult stem cells in colonies of human marrow stromal cells. Proceedings of the National Academy of Sciences of USA.
98(14), 7841-7845.
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Prockop, D. J.
(2001).
Stem cell research has only just begun. Science.
293(5528), 211-212.
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Javazon, E. H., Colter, D. C., Schwarz, E. J., & Prockop, D. J.
(2001).
Rat marrow stromal cells are more sensitive to plating density and expand more rapidly from single-cell-derived colonies than human marrow stromal cells. Stem Cells.
19(3), 219-225.
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LI, S., ARITA, M., FERTALA, A., BAO, Y., KOPEN, G. C., LNGSJ, T. K., ... PROCKOP, D. J.
(2001).
Transgenic mice with inactive alleles for procollagen N-proteinase (ADAMTS-2) develop fragile skin and male sterility. Biochemical Journal.
355(2), 271-271.
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Horwitz, E. M., Prockop, D. J., Gordon, P. L., Koo, W. W., Fitzpatrick, L. A., Neel, M. D., ... Brenner, M. K.
(2001).
Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta. Blood.
97(5), 1227-1231.
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Hyttinen, M. M., Tyrs, J., Lapvetelinen, T., Lindblom, J., Prockop, D. J., Li, S. W., ... Helminen, H. J.
(2001).
Inactivation of one allele of the type II collagen gene alters the collagen network in murine articular cartilage and makes cartilage softer. ANNALS OF THE RHEUMATIC DISEASES.
60(3), 262-268.
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Sekiya, I., Colter, D. C., & Prockop, D. J.
(2001).
BMP-6 enhances chondrogenesis in a subpopulation of human marrow stromal cells. Biochemical and Biophysical Research Communications.
284(2), 411-418.
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Deng, W., Obrocka, M., Fischer, I., & Prockop, D. J.
(2001).
In vitro differentiation of human marrow stromal cells into early progenitors of neural cells by conditions that increase intracellular cyclic AMP. Biochemical and Biophysical Research Communications.
282(1), 148-152.
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Prockop, D. J., Sekiya, I., & Colter, D. C.
(2001).
Isolation and characterization of rapidly self-renewing stem cells from cultures of human marrow stromal cells. Cytotherapy.
3(5), 393-396.
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Horwitz, E., Prockop, D., Keating, A., Butcher, B., & Brenner, M.
(2001).
Meeting Report: Mesenchymal and nonhematopoietic stem cells: recent progress and current controversies. Cytotherapy.
3(5), 391-392.
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Lapvetelinen, T., Hyttinen, M., Lindblom, J., Lngsj, T. K., Sironen, R., Li, S. W., ... Helminen, H. J.
(2001).
More knee joint osteoarthritis (OA) in mice after inactivation of one allele of type II procollagen gene but less OA after lifelong voluntary wheel running exercise. Osteoarthritis and Cartilage.
9(2), 152-160.
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Sahlman, J., Inkinen, R., Hirvonen, T., Lammi, M. J., Lammi, P. E., Nieminen, J., ... Puustjrvi, K.
(2001).
Premature vertebral endplate ossification and mild disc degeneration in mice after inactivation of one allele belonging to the Col2a1 gene for Type II collagen. 26(23), 2558-2565.
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Schwarz, E. J., Reger, R. L., Alexander, G. M., Class, R., Azizi, S. A., & Prockop, D. J.
(2001).
Rat marrow stromal cells rapidly transduced with a self-inactivating retrovirus synthesize L-DOPA in vitro. Gene Therapy (Basingstoke).
8(16), 1214-1223.
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Li, S. W., Arita, M., Fertala, A., Bao, Y., Kopen, G. C., Lngsj, T. K., ... Prockop, D. J.
(2001).
Transgenic mice with inactive alleles for procollagen N-proteinase (ADAMTS-2) develop fragile skin and male sterility. Biochemical Journal.
355(Pt 2), 271-278.
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Kramerova, I. A., Kawaguchi, N., Fessler, L. I., Nelson, R. E., Chen, Y., Kramerov, A. A., ... Fessler, J. H.
(2000).
Papilin in development; a pericellular protein with a homology to the ADAMTS metalloproteinases. Development (Cambridge).
127(24), 5475-5485.
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Woodbury, D., Schwarz, E. J., Prockop, D. J., & Black, I. B.
(2000).
Adult rat and human bone marrow stromal cells differentiate into neurons. Journal of Neuroscience Research.
61(4), 364-370.
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Krkk, J., Cohn, D. H., Ala-Kokko, L., Krakow, D., & Prockop, D. J.
(2000).
Widely distributed mutations in the COL2A1 gene produce achondrogenesis type II/hypochondrogenesis. American Journal of Medical Genetics Part A.
92(2), 95-100.
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Yuan, C. M., Ala-Kokko, L., Le Guellec, D., Franc, S., Fertala, A., Khillan, J. S., Sokolov, B. P., & Prockop, D. J.
(2000).
Lack of a phenotype in transgenic mice aberrantly expressing COL2A1 mRNA because of highly selective post-transcriptional down-regulation. Biochemical Journal.
345+Pt+2(Pt 2), 377-384.
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Prockop, D. J., Azizi, S. A., Colter, D., Digirolamo, C., Kopen, G., & Phinney, D. G.
(2000).
Potential use of stem cells from bone marrow to repair the extracellular matrix and the central nervous system. Biochemical Society Transactions.
28(4), 341-345.
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Colter, D. C., Class, R., DiGirolamo, C. M., & Prockop, D. J.
(2000).
Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow. Proceedings of the National Academy of Sciences of USA.
97(7), 3213-3218.
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Vuoristo, J. T., Berrettini, W. H., Overhauser, J., Prockop, D. J., Ferraro, T. N., & Ala-Kokko, L.
(2000).
Sequence and genomic organization of the human G-protein Golfalpha gene (GNAL) on chromosome 18p11, a susceptibility region for bipolar disorder and schizophrenia. Molecular Psychiatry.
5(5), 495-501.
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Prockop, D. J., Azizi, S. A., Phinney, D. G., Kopen, G. C., & Schwarz, E. J.
(2000).
Potential use of marrow stromal cells as therapeutic vectors for diseases of the central nervous system. Progress in Brain Research.
128, 293-297.
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Phinney, D. G., Kopen, G., Righter, W., Webster, S., Tremain, N., & Prockop, D. J.
(1999).
Donor variation in the growth properties and osteogenic potential of human marrow stromal cells. Journal of Cellular Biochemistry.
75(3), 424-436.
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Prockop, D. J.
(1999).
Genetic trail of osteoporosis: candidate genes versus genome Screens? small families versus large families?. Journal of Bone and Mineral Research.
14(12), 2000-2001.
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Digirolamo, C. M., Stokes, D., Colter, D., Phinney, D. G., Class, R., & Prockop, D. J.
(1999).
Propagation and senescence of human marrow stromal cells in culture: a simple colony-forming assay identifies samples with the greatest potential to propagate and differentiate. British Journal of Haematology.
107(2), 275-281.
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Kopen, G. C., Prockop, D. J., & Phinney, D. G.
(1999).
Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proceedings of the National Academy of Sciences of USA.
96(19), 10711-10716.
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Annunen, S., Paassilta, P., Lohiniva, J., Perl, M., Pihlajamaa, T., Karppinen, J., ... Ala-Kokko, L.
(1999).
An allele of COL9A2 associated with intervertebral disc disease. Science.
285(5426), 409-412.
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Kopen, G. C., Prockop, D. J., & Phinney, D. G.
(1999).
Enhanced in situ detection of beta-glucuronidase activity in murine tissue. Journal of Histochemistry and Cytochemistry: imaging the spectrum of cell biology.
47(7), 965-968.
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Kulkosky, J., Laptev, A., Shetty, S., Srinivasan, A., BouHamdan, M., Prockop, D. J., & Pomerantz, R. J.
(1999).
Human immunodeficiency virus type 1 Vpr alters bone marrow cell function. Blood.
93(6), 1906-1915.
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Phinney, D. G., Kopen, G., Isaacson, R. L., & Prockop, D. J.
(1999).
Plastic adherent stromal cells from the bone marrow of commonly used strains of inbred mice: variations in yield, growth, and differentiation. Journal of Cellular Biochemistry.
72(4), 570-585.
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Adachi, E., Katsumata, O., Yamashina, S., Prockop, D. J., & Fertala, A.
(1999).
Collagen II containing a Cys substitution for Arg-alpha1-519. Analysis by atomic force microscopy demonstrates that mutated monomers alter the topography of the surface of collagen II fibrils. Matrix Biol.
18(2), 189-196.
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Paassilta, P., Pihlajamaa, T., Annunen, S., Brewton, R. G., Wood, B. M., Johnson, C. C., ... Ala-Kokko, L.
(1999).
Complete sequence of the 23-kilobase human COL9A3 gene. Detection of Gly-X-Y triplet deletions that represent neutral variants. Journal of Biological Chemistry.
274(32), 22469-22475.
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Prockop, D. J.
(1999).
Heritable osteoarthritis. Diagnosis and possible modes of cell and gene therapy. Osteoarthritis and Cartilage.
7(4), 364-366.
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Prockop, D. J.
(1999).
Hopkins Memorial Medal lecture. Pleasant surprises en route from the biochemistry of collagen to attempts at gene therapy. Biochemical Society Transactions.
27(2), 15-31.
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Colige, A., Sieron, A. L., Li, S. W., Schwarze, U., Petty, E., Wertelecki, W., ... Nusgens, B. V.
(1999).
Human Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis are caused by mutations in the procollagen I N-proteinase gene. American Journal of Human Genetics.
65(2), 308-317.
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Schwarz, E. J., Alexander, G. M., Prockop, D. J., & Azizi, S. A.
(1999).
Multipotential marrow stromal cells transduced to produce L-DOPA: engraftment in a rat model of Parkinson disease. HUMAN GENE THERAPY.
10(15), 2539-2549.
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McGuirt, W. T., Prasad, S. D., Griffith, A. J., Kunst, H. P., Green, G. E., Shpargel, K. B., ... Smith, R. J.
(1999).
Mutations in COL11A2 cause non-syndromic hearing loss (DFNA13). Nature Genetics.
23(4), 413-419.
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Bishop, N. J.
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Osteogenesis imperfecta calls for caution. Nature Medicine.
5(5), 466-467.
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Andrew, L. J., Brancolini, V., de la Pena, L. S., Devoto, M., Caeiro, F., Marchegiani, R., ... Williams, C. J.
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Refinement of the chromosome 5p locus for familial calcium pyrophosphate dihydrate deposition disease. American Journal of Human Genetics.
64(1), 136-145.
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Annunen, S., Krkk, J., Czarny, M., Warman, M. L., Brunner, H. G., Kriinen, H., ... Ala-Kokko, L.
(1999).
Splicing mutations of 54-bp exons in the COL11A1 gene cause Marshall syndrome, but other mutations cause overlapping Marshall/Stickler phenotypes. American Journal of Human Genetics.
65(4), 974-983.
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Horwitz, E. M., Prockop, D. J., Fitzpatrick, L. A., Koo, W. W., Gordon, P. L., Neel, M., ... Brenner, M. K.
(1999).
Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nature Medicine.
5(3), 309-313.
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Myers, L. K., Brand, D. D., Ye, X. J., Cremer, M. A., Rosloniec, E. F., Bodo, M., ... Kang, A. H.
(1998).
Characterization of recombinant type II collagen: arthritogenicity and tolerogenicity in DBA/1 mice. Immunology.
95(4), 631-639.
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Pihlajamaa, T., Prockop, D. J., Faber, J., Winterpacht, A., Zabel, B., Giedion, A., ... Ala-Kokko, L.
(1998).
Heterozygous glycine substitution in the COL11A2 gene in the original patient with the Weissenbacher-Zweymller syndrome demonstrates its identity with heterozygous OSMED (nonocular Stickler syndrome). American Journal of Medical Genetics Part A.
80(2), 115-120.
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Prockop, D. J.
(1998).
The genetic trail of osteoporosis. NEW ENGLAND JOURNAL OF MEDICINE.
338(15), 1061-1062.
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Azizi, S. A., Stokes, D., Augelli, B. J., DiGirolamo, C., & Prockop, D. J.
(1998).
Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats--similarities to astrocyte grafts. Proceedings of the National Academy of Sciences of USA.
95(7), 3908-3913.
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Krkk, J., Annunen, S., Pihlajamaa, T., Prockop, D. J., & Ala-Kokko, L.
(1998).
Conformation sensitive gel electrophoresis for simple and accurate detection of mutations: comparison with denaturing gradient gel electrophoresis and nucleotide sequencing. Proceedings of the National Academy of Sciences of USA.
95(4), 1681-1685.
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Pereira, R. F., O'Hara, M. D., Laptev, A. V., Halford, K. W., Pollard, M. D., Class, R., ... Prockop, D. J.
(1998).
Marrow stromal cells as a source of progenitor cells for nonhematopoietic tissues in transgenic mice with a phenotype of osteogenesis imperfecta. Proceedings of the National Academy of Sciences of USA.
95(3), 1142-1147.
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Li, S. W., Arita, M., Kopen, G. C., Phinney, D. G., & Prockop, D. J.
(1998).
A 1,064 bp fragment from the promoter region of the Col11a2 gene drives lacZ expression not only in cartilage but also in osteoblasts adjacent to regions undergoing both endochondral and intramembranous ossification in mouse embryos. Matrix Biol.
17(3), 213-221.
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Krkk, J., Ala-Kokko, L., De Paepe, A., Nuytinck, L., Earley, J., & Prockop, D. J.
(1998).
Analysis of the COL1A1 and COL1A2 genes by PCR amplification and scanning by conformation-sensitive gel electrophoresis identifies only COL1A1 mutations in 15 patients with osteogenesis imperfecta type I: identification of common sequences of null-allele mutations. American Journal of Human Genetics.
62(1), 98-110.
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Engel, J., & Prockop, D. J.
(1998).
Does bound water contribute to the stability of collagen?. Matrix Biol.
17(8-9), 679-680.
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Devoto, M., Shimoya, K., Caminis, J., Ott, J., Tenenhouse, A., Whyte, M. P., ... Spotila, L. D.
(1998).
First-stage autosomal genome screen in extended pedigrees suggests genes predisposing to low bone mineral density on chromosomes 1p, 2p and 4q. European Journal of Human Genetics.
6(2), 151-157.
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Bleasel, J. F., Holderbaum, D., Brancolini, V., Moskowitz, R. W., Considine, E. L., Prockop, D. J., Devoto, M., & Williams, C. J.
(1998).
Five families with arginine 519-cysteine mutation in COL2A1: evidence for three distinct founders. Human Mutation.
12(3), 172-176.
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Pihlajamaa, T., Vuoristo, M. M., Annunen, S., Perl, M., Prockop, D. J., & Ala-Kokko, L.
(1998).
Human COL9A1 and COL9A2 genes. Two genes of 90 and 15 kb code for similar polypeptides of the same collagen molecule. Matrix Biol.
17(3), 237-241.
-
Prockop, D. J., & Fertala, A.
(1998).
Inhibition of the self-assembly of collagen I into fibrils with synthetic peptides. Demonstration that assembly is driven by specific binding sites on the monomers. Journal of Biological Chemistry.
273(25), 15598-15604.
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Prockop, D. J.
(1998).
Marrow stromal cells as stem cells for continual renewal of nonhematopoietic tissues and as potential vectors for gene therapy. Journal of cellular biochemistry. Supplement.
30-31(S30‒31), 284-285.
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Prockop, D. J.
(1998).
Marrow stromal cells as stem cells for continual renewal of nonhematopoietic tissues and as potential vectors for gene therapy. 30-31, 284-285.
-
Arnold, W. V., Fertala, A., Sieron, A. L., Hattori, H., Mechling, D., Bchinger, H. P., & Prockop, D. J.
(1998).
Recombinant procollagen II: Deletion of D period segments identifies sequences that are required for helix stabilization and generates a temperature-sensitive N-proteinase cleavage site. Journal of Biological Chemistry.
273(48), 31822-31828.
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Prockop, D. J., & Fertala, A.
(1998).
The collagen fibril: the almost crystalline structure. Journal of Structural Biology.
122(1-2), 111-118.
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Krkk, J., Milunsky, J., Prockop, D. J., & Ala-Kokko, L.
(1998).
Use of conformation sensitive gel electrophoresis to detect single-base changes in the gene for COL10A1. Human Mutation.
Suppl 1(S1), S201-S203.
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Prockop, D. J., Ala-Kokko, L., McLain, D. A., & Williams, C.
(1997).
Can mutated genes cause common osteoarthritis?. British journal of rheumatology.
36(8), 827-829.
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Prockop, D. J.
(1997).
Marrow stromal cells as stem cells for nonhematopoietic tissues. Science.
276(5309), 71-74.
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Tsuneyoshi, T., Ishikawa, K., Koga, Y., Naito, Y., Baba, S., Terunuma, H., Arakawa, R., & Prockop, D. J.
(1997).
Mass spectrometric gene diagnosis of one-base substitution from polymerase chain reaction amplified human DNA. Rapid Communications in Mass Spectrometry.
11(7), 719-722.
-
Colige, A., Li, S. W., Sieron, A. L., Nusgens, B. V., Prockop, D. J., & Lapire, C. M.
(1997).
cDNA cloning and expression of bovine procollagen I N-proteinase: a new member of the superfamily of zinc-metalloproteinases with binding sites for cells and other matrix components. Proceedings of the National Academy of Sciences of USA.
94(6), 2374-2379.
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Arnold, W. V., Sieron, A. L., Fertala, A., Bchinger, H. P., Mechling, D., & Prockop, D. J.
(1997).
A cDNA cassette system for the synthesis of recombinant procollagens. Variants of procollagen II lacking a D-period are secreted as triple-helical monomers. Matrix Biol.
16(3), 105-116.
-
Zafarullah, K., Sieron, A. L., Fertala, A., Tromp, G., Kuivaniemi, H., & Prockop, D. J.
(1997).
A recombinant homotrimer of type I procollagen that lacks the central two D-periods. The thermal stability of the triple helix is decreased by 2 to 4 degrees C. Matrix Biol.
16(5), 245-253.
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Yang, C., Li, S. W., Helminen, H. J., Khillan, J. S., Bao, Y., & Prockop, D. J.
(1997).
Apoptosis of chondrocytes in transgenic mice lacking collagen II. Experimental Cell Research.
235(2), 370-373.
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Jimenez, S. A., Ala-Kokko, L., Prockop, D. J., Merryman, C. F., Shepard, N., & Dodge, G. R.
(1997).
Characterization of human type II procollagen and collagen-specific antibodies and their application to the study of human type II collagen processing and ultrastructure. Matrix Biol.
16(1), 29-39.
-
Fertala, A., Ala-Kokko, L., Wiaderkiewicz, R., & Prockop, D. J.
(1997).
Collagen II containing a Cys substitution for arg-alpha1-519. Homotrimeric monomers containing the mutation do not assemble into fibrils but alter the self-assembly of the normal protein. Journal of Biological Chemistry.
272(10), 6457-6464.
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Kuivaniemi, H., Tromp, G., & Prockop, D. J.
(1997).
Mutations in fibrillar collagens (types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of diseases of bone, cartilage, and blood vessels. Human Mutation.
9(4), 300-315.
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Kuivaniemi, H., Tromp, G., & Prockop, D. J.
(1997).
Mutations in fibrillar collagens (types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of diseases of bone, cartilage, and blood vessels. Human Mutation.
9(4), 300-315.
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Zafarullah, K., Brown, E. M., Kuivaniemi, H., Tromp, G., Sieron, A. L., Fertala, A., & Prockop, D. J.
(1997).
Synthesis and conformational properties of a recombinant C-propeptide of human type III procollagen. Matrix Biol.
16(4), 201-209.
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Krkk, J., Kuivaniemi, H., Paassilta, P., Zhuang, J., Tromp, G., DePaepe, A., Prockop, D. J., & Ala-Kokko, L.
(1997).
Two new recurrent nucleotide mutations in the COL1A1 gene in four patients with osteogenesis imperfecta: about one-fifth are recurrent. Human Mutation.
9(2), 148-156.
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Fields, G. B., & Prockop, D. J.
(1996).
Perspectives on the synthesis and application of triple-helical, collagen-model peptides. Biopolymers.
40(4), 345-357.
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Ala-Kokko, L., Yuan, C. M., Le Guellec, D., Franc, S., Fertala, A., Khillan, J. S., Sokolov, B. P., & Prockop, D. J.
(1996).
A 1.9-Kb 5' fragment from the human COL1A1 gene drives inappropriate expression of the human COL2A1 gene in tissues of transgenic mice that normally express only the COL1A1 gene. Annals of the New York Academy of Sciences.
785(1), 202-203.
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Williams, C. J., Ganguly, A., Considine, E., McCarron, S., Prockop, D. J., Walsh-Vockley, C., & Michels, V. V.
(1996).
A-2-->G transition at the 3' acceptor splice site of IVS17 characterizes the COL2A1 gene mutation in the original Stickler syndrome kindred. American Journal of Medical Genetics Part A.
63(3), 461-467.
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Bleasel, J. F., Holderbaum, D., Brancolini, V., Moskowitz, R. W., Haqqi, T. M., Considine, E., ... Williams, C. J.
(1996).
Arg519-Cys mutation in COL2A1: evidence for multiple founders. Annals of the New York Academy of Sciences.
785(1), 215-218.
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Fertala, A., Ala-Kokko, L., & Prockop, D. J.
(1996).
Characterization of recombinant human collagen II with Arg519-to-Cys substitution. Annals of the New York Academy of Sciences.
785(1), 251-253.
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Vuoristo, M. M., Pihlajamaa, T., Vandenberg, P., Krkk, J., Prockop, D. J., & Ala-Kokko, L.
(1996).
Complete structure of the human COL11A2 gene: the exon sizes and other features indicate the gene has not evolved with genes for other fibriller collagens. Annals of the New York Academy of Sciences.
785(1), 343-344.
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Arnold, W. V., Sieron, A. L., & Prockop, D. J.
(1996).
Creation of a system for the assembly and expression of DNA constructs encoding novel recombinant human procollagen II. Annals of the New York Academy of Sciences.
785(1), 204-205.
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Li, S. W., Sieron, A. L., Fertala, A., Hojima, Y., Arnold, W. V., & Prockop, D. J.
(1996).
The C-proteinase that processes procollagens to fibrillar collagens is identical to the protein previously identified as bone morphogenic protein-1. Proceedings of the National Academy of Sciences of USA.
93(10), 5127-5130.
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Fertala, A., Holmes, D. F., Kadler, K. E., Sieron, A. L., & Prockop, D. J.
(1996).
Assembly in vitro of thin and thick fibrils of collagen II from recombinant procollagen II. The monomers in the tips of thick fibrils have the opposite orientation from monomers in the growing tips of collagen I fibrils. Journal of Biological Chemistry.
271(25), 14864-14869.
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Zhuang, J., Tromp, G., Kuivaniemi, H., Castells, S., Bugge, M., & Prockop, D. J.
(1996).
Direct sequencing of PCR products derived from cDNAs for the pro alpha 1 and pro alpha 2 chains of type I procollagen as a screening method to detect mutations in patients with osteogenesis imperfecta. Human Mutation.
7(2), 89-99.
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Li, S. W., Nembhard, K. M., Prockop, D. J., & Khillan, J. S.
(1996).
Identification and cloning of integration site of DNA by PCR. BioTechniques: the journal of laboratory technology for bioresearch.
20(3), 356-358.
-
Scott, I. C., Halila, R., Jenkins, J. M., Mehan, S., Apostolou, S., Winqvist, R., ... Kadler, K. E.
(1996).
Molecular cloning, expression and chromosomal localization of a human gene encoding a 33 kDa putative metallopeptidase (PRSM1). Gene.
174(1), 135-143.
-
Spotila, L. D., Caminis, J., Devoto, M., Shimoya, K., Sereda, L., Ott, J., ... Prockop, D. J.
(1996).
Osteopenia in 37 members of seven families: analysis based on a model of dominant inheritance. Molecular Medicine.
2(3), 313-324.
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Prockop, D. J.
(1996).
Role of the first intron in the regulation of the COL 1A1 gene. Matrix Biol.
15(2), 68-69.
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Vandenberg, P., Vuoristo, M. M., Ala-Kokko, L., & Prockop, D. J.
(1996).
The mouse col11a2 gene. Some transcripts from the adjacent rxr-beta gene extend into the col11a2 gene. Matrix Biol.
15(5), 359-367.
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Spotila, L. D., Caminis, J., Johnston, R., Shimoya, K. S., O'Connor, M. P., Prockop, D. J., Tenenhouse, A., & Tenenhouse, H. S.
(1996).
Vitamin D receptor genotype is not associated with bone mineral density in three ethnic/regional groups. Calcified Tissue International.
59(4), 235-237.
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Laptev, A., Li, S. U., Rouda, S., Qin, H., Kennedy, S. H., Prockop, D. J., & Tan, E.
(1996).
Inhibition of type i collagen expression by antisense oligonucleotides in keloid fibroblast cultures. Journal of Investigative Medicine.
44(3),
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Fields, G. B., & Prockop, D. J.
(1996).
Perspectives on the synthesis and application of triple-helical, collagen-model peptides. Biopolymers.
40(4), 345-357.
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Zhuang, J., Tromp, G., Kuivaniemi, H., Castells, S., & Prockop, D. J.
(1996).
Substitution of arginine for glycine at position 154 of the 1 chain of type I collagen in a variant of osteogenesis imperfecta: Comparison to previous cases with the same mutation. American Journal of Medical Genetics Part A.
61(2), 111-116.
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Zhuang, J., Tromp, G., Kuivaniemi, H., Castells, S., & Prockop, D. J.
(1996).
Substitution of arginine for glycine at position 154 of the alpha 1 chain of type I collagen in a variant of osteogenesis imperfecta: comparison to previous cases with the same mutation. American Journal of Medical Genetics Part A.
61(2), 111-116.
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Pereira, R. F., Hume, E. L., Halford, K. W., & Prockop, D. J.
(1995).
Bone fragility in transgenic mice expressing a mutated gene for type I procollagen (COL1A1) parallels the age-dependent phenotype of human osteogenesis imperfecta. Journal of Bone and Mineral Research.
10(12), 1837-1843.
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Li, S. W., Prockop, D. J., Helminen, H., Fssler, R., Lapvetelinen, T., Kiraly, K., ... Arita, M.
(1995).
Transgenic mice with targeted inactivation of the Col2 alpha 1 gene for collagen II develop a skeleton with membranous and periosteal bone but no endochondral bone. Genes and Development.
9(22), 2821-2830.
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Ganguly, A., & Prockop, D. J.
(1995).
Detection of mismatched bases in double stranded DNA by gel electrophoresis. Electrophoresis.
16(10), 1830-1835.
-
Ritvaniemi, P., Krkk, J., Bonaventure, J., Vikkula, M., Hyland, J., Paassilta, P., ... Hakala, M.
(1995).
Identification of COL2A1 gene mutations in patients with chondrodysplasias and familial osteoarthritis. ARTHRITIS AND RHEUMATISM.
38(7), 999-1004.
-
Prockop, D. J., & Kivirikko, K. I.
(1995).
Collagens: molecular biology, diseases, and potentials for therapy. Annual Review of Biochemistry.
64(1), 403-434.
-
Pereira, R. F., Halford, K. W., O'Hara, M. D., Leeper, D. B., Sokolov, B. P., Pollard, M. D., Bagasra, O., & Prockop, D. J.
(1995).
Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice. Proceedings of the National Academy of Sciences of USA.
92(11), 4857-4861.
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Williams, C. J., Rock, M., Considine, E., McCarron, S., Gow, P., Ladda, R., ... Prockop, D. J.
(1995).
Three new point mutations in type II procollagen (COL2A1) and identification of a fourth family with the COL2A1 Arg519-->Cys base substitution using conformation sensitive gel electrophoresis. Human Molecular Genetics.
4(2), 309-312.
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Ala-Kokko, L., Kvist, A. P., Metsranta, M., Kivirikko, K. I., de Crombrugghe, B., Prockop, D. J., & Vuorio, E.
(1995).
Conservation of the sizes of 53 introns and over 100 intronic sequences for the binding of common transcription factors in the human and mouse genes for type II procollagen (COL2A1). Biochemical Journal.
308+%28+Pt+3%29(Pt 3), 923-929.
-
Hulmes, D. J., Wess, T. J., Prockop, D. J., & Fratzl, P.
(1995).
Radial packing, order, and disorder in collagen fibrils. Biophysical Journal.
68(5), 1661-1670.
-
Bonaventure, J., Cohen-Solal, L., Ritvaniemi, P., Van Maldergem, L., Kadhom, N., Delezoide, A. L., ... Ala-Kokko, L.
(1995).
Substitution of aspartic acid for glycine at position 310 in type II collagen produces achondrogenesis II, and substitution of serine at position 805 produces hypochondrogenesis: analysis of genotype-phenotype relationships. Biochemical Journal.
307+%28+Pt+3%29(Pt 3), 823-830.
-
Li, S. W., Khillan, J., & Prockop, D. J.
(1995).
The complete cDNA coding sequence for the mouse pro alpha 1(I) chain of type I procollagen. Matrix Biol.
14(7), 593-595.
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Vuristo, M. M., Pihlajamaa, T., Vandenberg, P., Prockop, D. J., & Ala-Kokko, L.
(1995).
The human COL11A2 gene structure indicates that the gene has not evolved with the genes for the major fibrillar collagens. Journal of Biological Chemistry.
270(39), 22873-22881.
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Sokolov, B. P., Ala-Kokko, L., Dhulipala, R., Arita, M., Khillan, J. S., & Prockop, D. J.
(1995).
Tissue-specific expression of the gene for type I procollagen (COL1A1) in transgenic mice. Only 476 base pairs of the promoter are required if collagen genes are used as reporters. Journal of Biological Chemistry.
270(16), 9622-9629.
-
Sokolov, B. P., & Prockop, D. J.
(1994).
A rapid and simple PCR-based method for isolation of cDNAs from differentially expressed genes. Nucleic Acids Research.
22(19), 4009-4015.
-
Laptev, A. V., Lu, Z., Colige, A., & Prockop, D. J.
(1994).
Specific inhibition of expression of a human collagen gene (COL1A1) with modified antisense oligonucleotides. The most effective target sites are clustered in double-stranded regions of the predicted secondary structure for the mRNA. Biochemistry.
33(36), 11033-11039.
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Khillan, J. S., Li, S. W., & Prockop, D. J.
(1994).
Partial rescue of a lethal phenotype of fragile bones in transgenic mice with a chimeric antisense gene directed against a mutated collagen gene. Proceedings of the National Academy of Sciences of USA.
91(14), 6298-6302.
-
Earley, J. J., Kuivaniemi, H., Prockop, D. J., & Tromp, G.
(1994).
Robotic automation of dideoxyribonucleotide sequencing reactions. BioTechniques: the journal of laboratory technology for bioresearch.
17(1), 156-165.
-
Ganguly, A., Smelt, S., Mewar, R., Fertala, A., Sieron, A. L., Overhauser, J., & Prockop, D. J.
(1994).
Targeted insertions of two exogenous collagen genes into both alleles of their endogenous loci in cultured human cells: the insertions are directed by relatively short fragments containing the promoters and the 5' ends of the genes. Proceedings of the National Academy of Sciences of USA.
91(15), 7365-7369.
-
Spotila, L. D., Colige, A., Sereda, L., Constantinou-Deltas, C. D., Whyte, M. P., Riggs, B. L., ... Olsen, N.
(1994).
Mutation analysis of coding sequences for type I procollagen in individuals with low bone density. Journal of Bone and Mineral Research.
9(6), 923-932.
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Pereira, R., Halford, K., Sokolov, B. P., Khillan, J. S., & Prockop, D. J.
(1994).
Phenotypic variability and incomplete penetrance of spontaneous fractures in an inbred strain of transgenic mice expressing a mutated collagen gene (COL1A1). Journal of Clinical Investigation.
93(4), 1765-1769.
-
Ritvaniemi, P., Sokolov, B. P., Williams, C. J., Considine, E., Yurgenev, L., Meerson, E. M., Ala-Kokko, L., & Prockop, D. J.
(1994).
A single base mutation in the type II procollagen gene (COL2A1) that converts glycine alpha 1-247 to serine in a family with late-onset spondyloepiphyseal dysplasia. Human Mutation.
3(3), 261-267.
-
Cassella, J. P., Pereira, R., Khillan, J. S., Prockop, D. J., Garrington, N., & Ali, S. Y.
(1994).
An ultrastructural, microanalytical, and spectroscopic study of bone from a transgenic mouse with a COL1.A1 pro-alpha-1 mutation. BONE.
15(6), 611-619.
-
Hojima, Y., Behta, B., Romanic, A. M., & Prockop, D. J.
(1994).
Cadmium ions inhibit procollagen C-proteinase and cupric ions inhibit procollagen N-proteinase. Matrix Biol.
14(2), 113-120.
-
Hojima, Y., Mrgelin, M. M., Engel, J., Boutillon, M. M., van der Rest, M., McKenzie, J., ... Prockop, D. J.
(1994).
Characterization of type I procollagen N-proteinase from fetal bovine tendon and skin. Purification of the 500-kilodalton form of the enzyme from bovine tendon. Journal of Biological Chemistry.
269(15), 11381-11390.
-
Hojima, Y., Behta, B., Romanic, A. M., & Prockop, D. J.
(1994).
Cleavage of type I procollagen by C- and N-proteinases is more rapid if the substrate is aggregated with dextran sulfate or polyethylene glycol. Analytical Biochemistry.
223(2), 173-180.
-
Prockop, D. J., Kuivaniemi, H., & Tromp, G.
(1994).
Molecular basis of osteogenesis imperfecta and related disorders of bone. Clinics in Plastic Surgery.
21(3), 407-413.
-
Freisinger, P., Ala-Kokko, L., LeGuellec, D., Franc, S., Bouvier, R., Ritvaniemi, P., Prockop, D. J., & Bonaventure, J.
(1994).
Mutation in the COL2A1 gene in a patient with hypochondrogenesis. Expression of mutated COL2A1 gene is accompanied by expression of genes for type I procollagen in chondrocytes. Journal of Biological Chemistry.
269(18), 13663-13669.
-
Fertala, A., Sieron, A. L., Hojima, Y., Ganguly, A., & Prockop, D. J.
(1994).
Self-assembly into fibrils of collagen II by enzymic cleavage of recombinant procollagen II. Lag period, critical concentration, and morphology of fibrils differ from collagen I. Journal of Biological Chemistry.
269(15), 11584-11589.
-
Romanic, A. M., Spotila, L. D., Adachi, E., Engel, J., Hojima, Y., & Prockop, D. J.
(1994).
Self-assembly of collagen I from a proband homozygous for a mutation that substituted serine for glycine at position 661 in the alpha 2(I) chain. Possible relationship between the effects of mutations on critical concentration and the severity of the phenotype. Journal of Biological Chemistry.
269(15), 11614-11619.
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Fertala, A., Sieron, A. L., Ganguly, A., Li, S. W., Ala-Kokko, L., Anumula, K. R., & Prockop, D. J.
(1994).
Synthesis of recombinant human procollagen II in a stably transfected tumour cell line (HT1080). Biochemical Journal.
298+%28+Pt+1%29(Pt 1), 31-37.
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Ganguly, A., Rock, M. J., & Prockop, D. J.
(1994).
Erratum: Conformation-sensitive gel electrophoresis for rapid detection of single-base differences in double-stranded PCR products and DNA fragments: Evidence for solvent-induced bends in DNA heteroduplexes (Proceedings of the National Academy of Sciences of the United States of America (November 1, 1993) 90:21 (10325-10329)). Proceedings of the National Academy of Sciences of USA.
91(11), 5217.
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Prockop, D. J., Colige, A., Helminen, H., Khillan, J. S., Pereira, R., & Vandenberg, P.
(1993).
Mutations in type 1 procollagen that cause osteogenesis imperfecta: effects of the mutations on the assembly of collagen into fibrils, the basis of phenotypic variations, and potential antisense therapies. Journal of Bone and Mineral Research.
8 Suppl 2(S2), S489-S492.
-
Ganguly, A., Rock, M. J., & Prockop, D. J.
(1993).
Conformation-sensitive gel electrophoresis for rapid detection of single-base differences in double-stranded PCR products and DNA fragments: evidence for solvent-induced bends in DNA heteroduplexes. Proceedings of the National Academy of Sciences of USA.
90(21), 10325-10329.
-
Sokolov, B. P., Mays, P. K., Khillan, J. S., & Prockop, D. J.
(1993).
Tissue- and development-specific expression in transgenic mice of a type I procollagen (COL1A1) minigene construct with 2.3 kb of the promoter region and 2 kb of the 3'-flanking region. Specificity is independent of the putative regulatory sequences in the first intron. Biochemistry.
32(35), 9242-9249.
-
Helminen, H. J., Kiraly, K., Pelttari, A., Tammi, M. I., Vandenberg, P., Pereira, R., ... Hume, E. L.
(1993).
An inbred line of transgenic mice expressing an internally deleted gene for type II procollagen (COL2A1). Young mice have a variable phenotype of a chondrodysplasia and older mice have osteoarthritic changes in joints. Journal of Clinical Investigation.
92(2), 582-595.
-
Tromp, G., Wu, Y., Prockop, D. J., Madhatheri, S. L., Kleinert, C., Earley, J. J., ... Abbott, W. M.
(1993).
Sequencing of cDNA from 50 unrelated patients reveals that mutations in the triple-helical domain of type III procollagen are an infrequent cause of aortic aneurysms. Journal of Clinical Investigation.
91(6), 2539-2545.
-
Pereira, R., Khillan, J. S., Helminen, H. J., Hume, E. L., & Prockop, D. J.
(1993).
Transgenic mice expressing a partially deleted gene for type I procollagen (COL1A1). A breeding line with a phenotype of spontaneous fractures and decreased bone collagen and mineral. Journal of Clinical Investigation.
91(2), 709-716.
-
Ritvaniemi, P., Hyland, J., Ignatius, J., Kivirikko, K. I., Prockop, D. J., & Ala-Kokko, L.
(1993).
A fourth example suggests that premature termination codons in the COL2A1 gene are a common cause of the Stickler syndrome: analysis of the COL2A1 gene by denaturing gradient gel electrophoresis. Genomics.
17(1), 218-221.
-
Zhuang, J., Tromp, G., Kuivaniemi, H., Nakayasu, K., & Prockop, D. J.
(1993).
Deletion of 19 base pairs in intron 13 of the gene for the pro alpha 2(I) chain of type-I procollagen (COL1A2) causes exon skipping in a proband with type-I osteogenesis imperfecta. Human Genetics.
91(3), 210-216.
-
Sieron, A. L., Fertala, A., Ala-Kokko, L., & Prockop, D. J.
(1993).
Deletion of a large domain in recombinant human procollagen II does not alter the thermal stability of the triple helix. Journal of Biological Chemistry.
268(28), 21232-21237.
-
Earley, J. J., Kuivaniemi, H., Prockop, D. J., & Tromp, G.
(1993).
Efficient DNA sequencing on microtiter plates using dried reagents and Bst DNA polymerase. Mitochondrial DNA.
4(2), 79-85.
-
Kuivaniemi, H., Prockop, D. J., Wu, Y., Madhatheri, S. L., Kleinert, C., Earley, J. J., ... Myllyl, V. V.
(1993).
Exclusion of mutations in the gene for type III collagen (COL3A1) as a common cause of intracranial aneurysms or cervical artery dissections: results from sequence analysis of the coding sequences of type III collagen from 55 unrelated patients. Neurology.
43(12), 2652-2658.
-
Geddis, A. E., & Prockop, D. J.
(1993).
Expression of human COL1A1 gene in stably transfected HT1080 cells: the production of a thermostable homotrimer of type I collagen in a recombinant system. 13(5), 399-405.
-
Krkk, J., Ritvaniemi, P., Haataja, L., Kriinen, H., Kivirikko, K. I., Prockop, D. J., & Ala-Kokko, L.
(1993).
Mutation in type II procollagen (COL2A1) that substitutes aspartate for glycine alpha 1-67 and that causes cataracts and retinal detachment: evidence for molecular heterogeneity in the Wagner syndrome and the Stickler syndrome (arthro-ophthalmopathy). American Journal of Human Genetics.
53(1), 55-61.
-
Williams, C. J., Considine, E. L., Knowlton, R. G., Reginato, A., Neumann, G., Harrison, D., ... Prockop, D. J.
(1993).
Spondyloepiphyseal dysplasia and precocious osteoarthritis in a family with an Arg75-->Cys mutation in the procollagen type II gene (COL2A1). Human Genetics.
92(5), 499-505.
-
Wu, Y., Kuivaniemi, H., Tromp, G., Strobel, D., Romanic, A. M., & Prockop, D. J.
(1993).
Temperature sensitivity of aberrant RNA splicing with a mutation in the G+5 position of intron 37 of the gene for type III procollagen from a patient with Ehlers-Danlos syndrome type IV. Human Mutation.
2(1), 28-36.
-
Fertala, A., Westerhausen, A., Morris, G., Rooney, J. E., & Prockop, D. J.
(1993).
Two cysteine substitutions in procollagen I: a glycine replacement near the N-terminus of alpha 1(I) chain causes lethal osteogenesis imperfecta and a glycine replacement in the alpha 2(I) chain markedly destabilizes the triple helix. Biochemical Journal.
289+%28+Pt+1%29(Pt 1), 195-199.
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Ahmad, N. N., McDonald-McGinn, D. M., Zackai, E. H., Knowlton, R. G., LaRossa, D., DiMascio, J., & Prockop, D. J.
(1993).
A second mutation in the type II procollagen gene (COL2AI) causing stickler syndrome (arthro-ophthalmopathy) is also a premature termination codon. American Journal of Human Genetics.
52(1), 39-45.
-
Constantinou-Deltas, C. D., Ladda, R. L., & Prockop, D. J.
(1993).
Somatic cell mosaicism: another source of phenotypic heterogeneity in nuclear families with osteogenesis imperfecta. American Journal of Medical Genetics Part A.
45(2), 246-251.
-
Colige, A., Sokolov, B. P., Nugent, P., Baserga, R., & Prockop, D. J.
(1993).
Use of an antisense oligonucleotide to inhibit expression of a mutated human procollagen gene (COL1A1) in transfected mouse 3T3 cells. Biochemistry.
32(1), 7-11.
-
Harrison, D., Baldwin, C., & Prockop, D. J.
(1993).
Use of an automated workstation to facilitate PCR amplification, loading agarose gels and sequencing of DNA templates. BioTechniques: the journal of laboratory technology for bioresearch.
14(1), 88-97.
-
Spotila, L. D., Sereda, L., & Prockop, D. J.
(1992).
Partial isodisomy for maternal chromosome 7 and short stature in an individual with a mutation at the COL1A2 locus. American Journal of Human Genetics.
51(6), 1396-1405.
-
Holmes, D. F., Chapman, J. A., Prockop, D. J., & Kadler, K. E.
(1992).
Growing tips of type I collagen fibrils formed in vitro are near-paraboloidal in shape, implying a reciprocal relationship between accretion and diameter. Proceedings of the National Academy of Sciences of USA.
89(20), 9855-9859.
-
Silver, D., Miller, J., Harrison, R., & Prockop, D. J.
(1992).
Helical model of nucleation and propagation to account for the growth of type I collagen fibrils from symmetrical pointed tips: a special example of self-assembly of rod-like monomers. Proceedings of the National Academy of Sciences of USA.
89(20), 9860-9864.
-
Kontusaari, S., Tromp, G., Kuivaniemi, H., Stolle, C., Pope, F. M., & Prockop, D. J.
(1992).
Substitution of aspartate for glycine 1018 in the type III procollagen (COL3A1) gene causes type IV Ehlers-Danlos syndrome: the mutated allele is present in most blood leukocytes of the asymptomatic and mosaic mother. American Journal of Human Genetics.
51(3), 497-507.
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Prockop, D. J.
(1992).
Seminars in medicine of the Beth Israel Hospital, Boston. Mutations in collagen genes as a cause of connective-tissue diseases. NEW ENGLAND JOURNAL OF MEDICINE.
326(8), 540-546.
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Mays, P. K., Tromp, G., Kuivaniemi, H., Ryynnen, M., & Prockop, D. J.
(1992).
A 15 base-pair AT-rich variable number tandem repeat in the type III procollagen gene (COL3A1) as an informative marker for 2q31-2q32.3. 12(1), 44-49.
-
Torre-Blanco, A., Adachi, E., Romanic, A. M., & Prockop, D. J.
(1992).
Copolymerization of normal type I collagen with three mutated type I collagens containing substitutions of cysteine at different glycine positions in the alpha 1 (I) chain. Journal of Biological Chemistry.
267(7), 4968-4973.
-
Williams, C. J., Harrison, D. A., Hopkinson, I., Baldwin, C. T., Ahmad, N. N., Ala-Kokko, L., ... Considine, E. L.
(1992).
Detection of sequence variants in the gene for human type II procollagen (COL2A1) by direct sequencing of polymerase chain reaction-amplified genomic DNA. Human Mutation.
1(5), 403-416.
-
Ala-Kokko, L., Gnzler, V., Hoek, J. B., Rubin, E., & Prockop, D. J.
(1992).
Hepatic fibrosis in rats produced by carbon tetrachloride and dimethylnitrosamine: observations suggesting immunoassays of serum for the 7S fragment of type IV collagen are a more sensitive index of liver damage than immunoassays for the NH2-terminal propeptide of type III procollagen. HEPATOLOGY.
16(1), 167-172.
-
Romanic, A. M., Adachi, E., Hojima, Y., Engel, J., & Prockop, D. J.
(1992).
Polymerization of pNcollagen I and copolymerization of pNcollagen I with collagen I. A kinetic, thermodynamic, and morphologic study. Journal of Biological Chemistry.
267(31), 22265-22271.
-
McBride, D. J., Kadler, K. E., Hojima, Y., & Prockop, D. J.
(1992).
Self-assembly into fibrils of a homotrimer of type I collagen. 12(4), 256-263.
-
Torre-Blanco, A., Adachi, E., Hojima, Y., Wootton, J. A., Minor, R. R., & Prockop, D. J.
(1992).
Temperature-induced post-translational over-modification of type I procollagen. Effects of over-modification of the protein on the rate of cleavage by procollagen N-proteinase and on self-assembly of collagen into fibrils. Journal of Biological Chemistry.
267(4), 2650-2655.
-
Strobel, D., Tsuneyoshi, T., Kuivaniemi, H., Tromp, G., Spotila, L. D., Baldwin, C. T., ... Sokolov, B. P.
(1992).
Three new polymorphisms at the COL1A2 locus. 12(2), 87-91.
-
Hojima, Y., McKenzie, J., Kadler, K. E., McBride, D. J., van der Rest, M., Mrgelin, M. M., Engel, J., & Prockop, D. J.
(1992).
A new 500-kDa form of type I procollagen N-proteinase from chick embryo tendons. Matrix (Stuttgart, Germany). Supplement.
1, 97-98.
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Prockop, D. J.
(1991).
Mutations in collagen genes as a cause of rare and perhaps common diseases of connective tissue. Acta paediatrica Scandinavica. Supplement.
379(s379), 55-57.
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Kuivaniemi, H., Tromp, G., & Prockop, D. J.
(1991).
Genetic causes of aortic aneurysms. Unlearning at least part of what the textbooks say. Journal of Clinical Investigation.
88(5), 1441-1444.
-
Vandenberg, P., Khillan, J. S., Prockop, D. J., Helminen, H., Kontusaari, S., & Ala-Kokko, L.
(1991).
Expression of a partially deleted gene of human type II procollagen (COL2A1) in transgenic mice produces a chondrodysplasia. Proceedings of the National Academy of Sciences of USA.
88(17), 7640-7644.
-
Tromp, G., Christiano, A., Goldstein, N., Indik, Z., Boyd, C., Rosenbloom, J., ... Kuivaniemi, H.
(1991).
A to G polymorphism in ELN gene. Nucleic Acids Research.
19(15), 4314-4314.
-
Sokolov, B. P., Constantinou, C. D., Tsuneyoshi, T., Zhuang, J. P., & Prockop, D. J.
(1991).
G to A polymorphism in exon 45 of the COL1A1 gene. Nucleic Acids Research.
19(15), 4302-4302.
-
Tsuneyoshi, T., Sokolov, B. P., & Prockop, D. J.
(1991).
PCR detection of a HindIII polymorphism in the human gene for type II procollagen (COL2A1). Nucleic Acids Research.
19(16), 4571-4571.
-
Ahmad, N. N., Ala-Kokko, L., Knowlton, R. G., Jimenez, S. A., Weaver, E. J., Maguire, J. I., Tasman, W., & Prockop, D. J.
(1991).
Stop codon in the procollagen II gene (COL2A1) in a family with the Stickler syndrome (arthro-ophthalmopathy). Proceedings of the National Academy of Sciences of USA.
88(15), 6624-6627.
-
Zhuang, J. P., Constantinou, C. D., Ganguly, A., & Prockop, D. J.
(1991).
A single base mutation in type I procollagen (COL1A1) that converts glycine alpha 1-541 to aspartate in a lethal variant of osteogenesis imperfecta: detection of the mutation with a carbodiimide reaction of DNA heteroduplexes and direct sequencing of products of the PCR. American Journal of Human Genetics.
48(6), 1186-1191.
-
Spotila, L. D., Constantinou, C. D., Sereda, L., Ganguly, A., Riggs, B. L., & Prockop, D. J.
(1991).
Mutation in a gene for type I procollagen (COL1A2) in a woman with postmenopausal osteoporosis: evidence for phenotypic and genotypic overlap with mild osteogenesis imperfecta. Proceedings of the National Academy of Sciences of USA.
88(12), 5423-5427.
-
Engel, J., & Prockop, D. J.
(1991).
The zipper-like folding of collagen triple helices and the effects of mutations that disrupt the zipper. Annual review of biophysics and biophysical chemistry.
20(1), 137-152.
-
Kadler, K. E., Torre-Blanco, A., Adachi, E., Vogel, B. E., Hojima, Y., & Prockop, D. J.
(1991).
A type I collagen with substitution of a cysteine for glycine-748 in the alpha 1(I) chain copolymerizes with normal type I collagen and can generate fractallike structures. Biochemistry.
30(20), 5081-5088.
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Kuivaniemi, H., Tromp, G., & Prockop, D. J.
(1991).
Mutations in collagen genes: causes of rare and some common diseases in humans. The FASEB Journal.
5(7), 2052-2060.
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Vasan, N. S., Kuivaniemi, H., Vogel, B. E., Minor, R. R., Wootton, J. A., Tromp, G., Weksberg, R., & Prockop, D. J.
(1991).
A mutation in the pro alpha 2(I) gene (COL1A2) for type I procollagen in Ehlers-Danlos syndrome type VII: evidence suggesting that skipping of exon 6 in RNA splicing may be a common cause of the phenotype. American Journal of Human Genetics.
48(2), 305-317.
-
Tromp, G., Kleinert, C., Kuivaniemi, H., & Prockop, D. J.
(1991).
C to T polymorphism in exon 33 of the COL3A1 gene. Nucleic Acids Research.
19(3), 681-681.
-
Westerhausen, A., Constantinou, C. D., Pack, M., Peng, M. Z., Hanning, C., Olsen, A. S., & Prockop, D. J.
(1991).
Completion of the last half of the structure of the human gene for the Pro alpha 1 (I) chain of type I procollagen (COL1A1). 11(6), 375-379.
-
Romanic, A. M., Adachi, E., Kadler, K. E., Hojima, Y., & Prockop, D. J.
(1991).
Copolymerization of pNcollagen III and collagen I. pNcollagen III decreases the rate of incorporation of collagen I into fibrils, the amount of collagen I incorporated, and the diameter of the fibrils formed. Journal of Biological Chemistry.
266(19), 12703-12709.
-
Sokolov, B. P., Prytkov, A. N., Tromp, G., Knowlton, R. G., & Prockop, D. J.
(1991).
Exclusion of COL1A1, COL1A2, and COL3A1 genes as candidate genes for Ehlers-Danlos syndrome type I in one large family. Human Genetics.
88(2), 125-129.
-
Ala-Kokko, L., Hyland, J., Smith, C., Kivirikko, K. I., Jimenez, S. A., & Prockop, D. J.
(1991).
Expression of a human cartilage procollagen gene (COL2A1) in mouse 3T3 cells. Journal of Biological Chemistry.
266(22), 14175-14178.
-
Ganguly, A., Baldwin, C. T., Strobel, D., Conway, D., Horton, W., & Prockop, D. J.
(1991).
Heterozygous mutation in the G+5 position of intron 33 of the pro-alpha 2(I) gene (COL1A2) that causes aberrant RNA splicing and lethal osteogenesis imperfecta. Use of carbodiimide methods that decrease the extent of DNA sequencing necessary to define an unusual mutation. Journal of Biological Chemistry.
266(18), 12035-12040.
-
Olsen, A. S., Geddis, A. E., & Prockop, D. J.
(1991).
High levels of expression of a minigene version of the human pro alpha 1 (I) collagen gene in stably transfected mouse fibroblasts. Effects of deleting putative regulatory sequences in the first intron. Journal of Biological Chemistry.
266(2), 1117-1121.
-
Steinmann, B., Westerhausen, A., Constantinou, C. D., Superti-Furga, A., & Prockop, D. J.
(1991).
Substitution of cysteine for glycine-alpha 1-691 in the pro alpha 1(I) chain of type I procollagen in a proband with lethal osteogenesis imperfecta destabilizes the triple helix at a site C-terminal to the substitution. Biochemical Journal.
279+%28+Pt+3%29(Pt 3), 747-752.
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Tsuneyoshi, T., Westerhausen, A., Constantinou, C. D., & Prockop, D. J.
(1991).
Substitutions for glycine alpha 1-637 and glycine alpha 2-694 of type I procollagen in lethal osteogenesis imperfecta. The conformational strain on the triple helix introduced by a glycine substitution can be transmitted along the helix. Journal of Biological Chemistry.
266(24), 15608-15613.
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Kontusaari, S., Tromp, G., Kuivaniemi, H., Romanic, A. M., & Prockop, D. J.
(1990).
A mutation in the gene for type III procollagen (COL3A1) in a family with aortic aneurysms. Journal of Clinical Investigation.
86(5), 1465-1473.
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Zafarullah, K., Kleinert, C., Tromp, G., Kuivaniemi, H., Kontusaari, S., Wu, Y. L., Ganguly, A., & Prockop, D. J.
(1990).
G to A polymorphism in exon 31 of the COL3A1 gene. Nucleic Acids Research.
18(20), 6180-6180.
-
Constantinou, C. D., Pack, M., Young, S. B., & Prockop, D. J.
(1990).
Phenotypic heterogeneity in osteogenesis imperfecta: the mildly affected mother of a proband with a lethal variant has the same mutation substituting cysteine for alpha 1-glycine 904 in a type I procollagen gene (COL1A1). American Journal of Human Genetics.
47(4), 670-679.
-
Constantinou, C. D., Spotila, L. D., Zhuang, J., Sereda, L., Hanning, C., & Prockop, D. J.
(1990).
PvuII polymorphism at the COL1A2 locus. Nucleic Acids Research.
18(18), 5577-5577.
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Ala-Kokko, L., Baldwin, C. T., Moskowitz, R. W., & Prockop, D. J.
(1990).
Single base mutation in the type II procollagen gene (COL2A1) as a cause of primary osteoarthritis associated with a mild chondrodysplasia. Proceedings of the National Academy of Sciences of USA.
87(17), 6565-6568.
-
Westerhausen, A. I., Constantinou, C. D., & Prockop, D. J.
(1990).
A sequence polymorphism in the 3'-nontranslated region of the pro alpha 1 chain of type I procollagen. Nucleic Acids Research.
18(16), 4968-4968.
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Ganguly, A., & Prockop, D. J.
(1990).
Detection of single-base mutations by reaction of DNA heteroduplexes with a water-soluble carbodiimide followed by primer extension: application to products from the polymerase chain reaction. Nucleic Acids Research.
18(13), 3933-3939.
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Kontusaari, S., Tromp, G., Kuivaniemi, H., Ladda, R. L., & Prockop, D. J.
(1990).
Inheritance of an RNA splicing mutation (G+ 1 IVS20) in the type III procollagen gene (COL3A1) in a family having aortic aneurysms and easy bruisability: phenotypic overlap between familial arterial aneurysms and Ehlers-Danlos syndrome type IV. American Journal of Human Genetics.
47(1), 112-120.
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Danne, T., Poulsom, R., Schuppan, D., Prockop, D. J., & Boot-Handford, R. P.
(1990).
Streptozotocin-diabetes but not galactose-feeding increases the serum concentration of type IV collagen antigens in rats. Diabetes research (Edinburgh, Scotland).
14(1), 1-4.
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Knowlton, R. G., Katzenstein, P. L., Moskowitz, R. W., Weaver, E. J., Malemud, C. J., Pathria, M. N., Jimenez, S. A., & Prockop, D. J.
(1990).
Genetic linkage of a polymorphism in the type II procollagen gene (COL2A1) to primary osteoarthritis associated with mild chondrodysplasia. NEW ENGLAND JOURNAL OF MEDICINE.
322(8), 526-530.
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Kadler, K. E., Hulmes, D. J., Hojima, Y., & Prockop, D. J.
(1990).
Assembly of type I collagen fibrils de novo by the specific enzymic cleavage of pC collagen. The fibrils formed at about 37 degrees C are similar in diameter, roundness, and apparent flexibility to the collagen fibrils seen in connective tissue. Annals of the New York Academy of Sciences.
580(1), 214-224.
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Kadler, K. E., Hojima, Y., & Prockop, D. J.
(1990).
Collagen fibrils in vitro grow from pointed tips in the C- to N-terminal direction. Biochemical Journal.
268(2), 339-343.
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Ala-Kokko, L., & Prockop, D. J.
(1990).
Completion of the intron-exon structure of the gene for human type II procollagen (COL2A1): variations in the nucleotide sequences of the alleles from three chromosomes. Genomics.
8(3), 454-460.
-
Poulsom, R., Prockop, D. J., & Boot-Handford, R. P.
(1990).
Effects of long-term diabetes and galactosaemia upon lens and retinal mRNA levels in the rat. Experimental Eye Research.
51(1), 27-32.
-
Ala-Kokko, L., & Prockop, D. J.
(1990).
Efficient procedure for preparing cosmid libraries from microgram quantities of genomic DNA fragments size fractionated by gel electrophoresis. 10(5), 279-284.
-
Kuivaniemi, H., Kontusaari, S., Tromp, G., Zhao, M. J., Sabol, C., & Prockop, D. J.
(1990).
Identical G+1 to A mutations in three different introns of the type III procollagen gene (COL3A1) produce different patterns of RNA splicing in three variants of Ehlers-Danlos syndrome. IV. An explanation for exon skipping some mutations and not others. Journal of Biological Chemistry.
265(20), 12067-12074.
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Prockop, D. J., Olsen, A., Kontusaari, S., Hyland, J., Ala-Kokko, L., Vasan, N. S., ... Brent, R. L.
(1990).
Mutations in human procollagen genes. Consequences of the mutations in man and in transgenic mice. Annals of the New York Academy of Sciences.
580(1), 330-339.
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Prockop, D. J., Baldwin, C. T., & Constantinou, C. D.
(1990).
Mutations in type I procollagen genes that cause osteogenesis imperfecta. Advances in human genetics.
19, 105-132.
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Prockop, D. J.
(1990).
Mutations that alter the primary structure of type I collagen. The perils of a system for generating large structures by the principle of nucleated growth. Journal of Biological Chemistry.
265(26), 15349-15352.
-
Westerhausen, A., Kishi, J., & Prockop, D. J.
(1990).
Mutations that substitute serine for glycine alpha 1-598 and glycine alpha 1-631 in type I procollagen. The effects on thermal unfolding of the triple helix are position-specific and demonstrate that the protein unfolds through a series of cooperative blocks. Journal of Biological Chemistry.
265(23), 13995-14000.
-
Tryggvason, K., Soininen, R., Hostikka, S. L., Ganguly, A., Huotari, M., & Prockop, D. J.
(1990).
Structure of the human type IV collagen genes. Annals of the New York Academy of Sciences.
580(1), 97-111.
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Prockop, D. J.
(1990).
Mutations in type I procollagen genes: An explanation for brittle bones and a paradigm for other diseases of connective tissue. ANNALS OF THE RHEUMATIC DISEASES.
49(SUPPL. 1), 440-444.
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Knowlton, R. G., Weaver, E. J., Struyk, A. F., Knobloch, W. H., King, R. A., Norris, K., ... Prockop, D. J.
(1989).
Genetic linkage analysis of hereditary arthro-ophthalmopathy (Stickler syndrome) and the type II procollagen gene. American Journal of Human Genetics.
45(5), 681-688.
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Prockop, D. J., Constantinou, C. D., Dombrowski, K. E., Hojima, Y., Kadler, K. E., Kuivaniemi, H., Tromp, G., & Vogel, B. E.
(1989).
Type I procollagen: the gene-protein system that harbors most of the mutations causing osteogenesis imperfecta and probably more common heritable disorders of connective tissue. American Journal of Medical Genetics Part A.
34(1), 60-67.
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Dombrowski, K. E., Vogel, B. E., & Prockop, D. J.
(1989).
Mutations that alter the primary structure of type I procollagen have long-range effects on its cleavage by procollagen N-proteinase. Biochemistry.
28(17), 7107-7112.
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Constantinou, C. D., Nielsen, K. B., & Prockop, D. J.
(1989).
A lethal variant of osteogenesis imperfecta has a single base mutation that substitutes cysteine for glycine 904 of the alpha 1(I) chain of type I procollagen. The asymptomatic mother has an unidentified mutation producing an overmodified and unstable type I procollagen. Journal of Clinical Investigation.
83(2), 574-584.
-
Baldwin, C. T., Reginato, A. M., & Prockop, D. J.
(1989).
A new epidermal growth factor-like domain in the human core protein for the large cartilage-specific proteoglycan. Evidence for alternative splicing of the domain. Journal of Biological Chemistry.
264(27), 15747-15750.
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Baldwin, C. T., Constantinou, C. D., Dumars, K. W., & Prockop, D. J.
(1989).
A single base mutation that converts glycine 907 of the alpha 2(I) chain of type I procollagen to aspartate in a lethal variant of osteogenesis imperfecta. The single amino acid substitution near the carboxyl terminus destabilizes the whole triple helix. Journal of Biological Chemistry.
264(5), 3002-3006.
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Tromp, G., Kuivaniemi, H., Shikata, H., & Prockop, D. J.
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A single base mutation that substitutes serine for glycine 790 of the alpha 1 (III) chain of type III procollagen exposes an arginine and causes Ehlers-Danlos syndrome IV. Journal of Biological Chemistry.
264(3), 1349-1352.
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Shows, T. B., Tikka, L., Byers, M. G., Eddy, R. L., Haley, L. L., Henry, W. M., Prockop, D. J., & Tryggvason, K.
(1989).
Assignment of the human collagen alpha 1 (XIII) chain gene (COL13A1) to the q22 region of chromosome 10. Genomics.
5(1), 128-133.
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Ganguly, A., Rooney, J. E., Hosomi, S., Zeiger, A. R., & Prockop, D. J.
(1989).
Detection and location of single-base mutations in large DNA fragments by immunomicroscopy. Genomics.
4(4), 530-538.
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Pihlajaniemi, T., McKeon, J., Gay, S., Gay, R., de Wet, W. J., Myers, J. C., & Prockop, D. J.
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Increased expression of the gene for the pro alpha 1(IV) chain of basement-membrane procollagen in cultured skin fibroblasts from two variants of osteogenesis imperfecta. Biochemical Journal.
257(2), 439-445.
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Hulmes, D. J., Kadler, K. E., Mould, A. P., Hojima, Y., Holmes, D. F., Cummings, C., Chapman, J. A., & Prockop, D. J.
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Pleomorphism in type I collagen fibrils produced by persistence of the procollagen N-propeptide. JOURNAL OF MOLECULAR BIOLOGY.
210(2), 337-345.
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Tromp, G., Kuivaniemi, H., Stolle, C., Pope, F. M., & Prockop, D. J.
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Single base mutation in the type III procollagen gene that converts the codon for glycine 883 to aspartate in a mild variant of Ehlers-Danlos syndrome IV. Journal of Biological Chemistry.
264(32), 19313-19317.
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Soininen, R., Huotari, M., Ganguly, A., Prockop, D. J., & Tryggvason, K.
(1989).
Structural organization of the gene for the alpha 1 chain of human type IV collagen. Journal of Biological Chemistry.
264(23), 13565-13571.
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Baldwin, C. T., Reginato, A. M., Smith, C., Jimenez, S. A., & Prockop, D. J.
(1989).
Structure of cDNA clones coding for human type II procollagen. The alpha 1(II) chain is more similar to the alpha 1(I) chain than two other alpha chains of fibrillar collagens. Biochemical Journal.
262(2), 521-528.
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Pack, M., Constantinou, C. D., Kalia, K., Nielsen, K. B., & Prockop, D. J.
(1989).
Substitution of serine for alpha 1(I)-glycine 844 in a severe variant of osteogenesis imperfecta minimally destabilizes the triple helix of type I procollagen. The effects of glycine substitutions on thermal stability are either position of amino acid specific. Journal of Biological Chemistry.
264(33), 19694-19699.
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Olsen, A. S., & Prockop, D. J.
(1989).
Transcription of human type I collagen genes. Variation in the relative rates of transcription of the pro alpha 1 and pro alpha 2 genes. 9(2), 73-81.
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Hojima, Y., McKenzie, J. A., van der Rest, M., & Prockop, D. J.
(1989).
Type I procollagen N-proteinase from chick embryo tendons. Purification of a new 500-kDa form of the enzyme and identification of the catalytically active polypeptides. Journal of Biological Chemistry.
264(19), 11336-11345.
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Prockop, D. J.
(1989).
The Gordon Wilson lecture. Mutations in type I procollagen genes. An explanation for brittle bones and a paradigm for other diseases of connective tissue. Transactions of the American Clinical and Climatological Association.
100, 70-80.
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Tikka, L., Pihlajaniemi, T., Henttu, P., Prockop, D. J., & Tryggvason, K.
(1988).
Gene structure for the alpha 1 chain of a human short-chain collagen (type XIII) with alternatively spliced transcripts and translation termination codon at the 5' end of the last exon. Proceedings of the National Academy of Sciences of USA.
85(20), 7491-7495.
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Tromp, G., & Prockop, D. J.
(1988).
Single base mutation in the pro alpha 2(I) collagen gene that causes efficient splicing of RNA from exon 27 to exon 29 and synthesis of a shortened but in-frame pro alpha 2(I) chain. Proceedings of the National Academy of Sciences of USA.
85(14), 5254-5258.
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Kuivaniemi, H., Sabol, C., Tromp, G., Sippola-Thiele, M., & Prockop, D. J.
(1988).
A 19-base pair deletion in the pro-alpha 2(I) gene of type I procollagen that causes in-frame RNA splicing from exon 10 to exon 12 in a proband with atypical osteogenesis imperfecta and in his asymptomatic mother. Journal of Biological Chemistry.
263(23), 11407-11413.
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Vogel, B. E., Doelz, R., Kadler, K. E., Hojima, Y., Engel, J., & Prockop, D. J.
(1988).
A substitution of cysteine for glycine 748 of the alpha 1 chain produces a kink at this site in the procollagen I molecule and an altered N-proteinase cleavage site over 225 nm away. Journal of Biological Chemistry.
263(35), 19249-19255.
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Prockop, D. J.
(1988).
Abstracts from the Second International Conference on Molecular Biology and Pathology of Matrix. Philadelphia, Pennsylvania, June 15-18, 1988. Matrix Biology.
8(6), 471-557.
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Kadler, K. E., Hojima, Y., & Prockop, D. J.
(1988).
Assembly of type I collagen fibrils de novo. Between 37 and 41 degrees C the process is limited by micro-unfolding of monomers. Journal of Biological Chemistry.
263(21), 10517-10523.
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Dombrowski, K. E., & Prockop, D. J.
(1988).
Cleavage of type I and type II procollagens by type I/II procollagen N-proteinase. Correlation of kinetic constants with the predicted conformations of procollagen substrates. Journal of Biological Chemistry.
263(32), 16545-16552.
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Prockop, D. J., Kadler, K. E., Hojima, Y., Constantinou, C. D., Dombrowski, K. E., Kuivaniemi, H., Tromp, G., & Vogel, B.
(1988).
Expression of type I procollagen genes. Ciba Foundation symposium.
136, 142-160.
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Poulsom, R., Kurkinen, M., Prockop, D. J., & Boot-Handford, R. P.
(1988).
Increased steady-state levels of laminin B1 mRNA in kidneys of long-term streptozotocin-diabetic rats. No effect of an aldose reductase inhibitor. Journal of Biological Chemistry.
263(21), 10072-10076.
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Tromp, G., Kuivaniemi, H., Stacey, A., Shikata, H., Baldwin, C. T., Jaenisch, R., & Prockop, D. J.
(1988).
Structure of a full-length cDNA clone for the prepro alpha 1(I) chain of human type I procollagen. Biochemical Journal.
253(3), 919-922.
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Kuivaniemi, H., Tromp, G., Chu, M. L., & Prockop, D. J.
(1988).
Structure of a full-length cDNA clone for the prepro alpha 2(I) chain of human type I procollagen. Comparison with the chicken gene confirms unusual patterns of gene conservation. Biochemical Journal.
252(3), 633-640.
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Soininen, R., Huotari, M., Hostikka, S. L., Prockop, D. J., & Tryggvason, K.
(1988).
The structural genes for alpha 1 and alpha 2 chains of human type IV collagen are divergently encoded on opposite DNA strands and have an overlapping promoter region. Journal of Biological Chemistry.
263(33), 17217-17220.
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Prockop, D. J.
(1988).
Osteogenesis imperfecta. A model for genetic causes of osteoporosis and perhaps several other common diseases of connective tissue. ARTHRITIS AND RHEUMATISM.
31(1), 1-8.
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Soininen, R., Haka-Risku, T., Prockop, D. J., & Tryggvason, K.
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Complete primary structure of the alpha 1-chain of human basement membrane (type IV) collagen. FEBS Letters.
225(1-2), 188-194.
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Tikka, L., Roiko, K., Soininen, R., Prockop, D. J., & Tryggvason, K.
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A HindIII polymorphism in the 3' end of the human alpha 1(IV) collagen gene. Nucleic Acids Research.
15(13), 5497-5497.
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Constantinou, C. D., Vogel, B. E., Jeffrey, J. J., & Prockop, D. J.
(1987).
The A and B fragments of normal type I procollagen have a similar thermal stability to proteinase digestion but are selectively destabilized by structural mutations. European Journal of Biochemistry.
163(2), 247-251.
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Pihlajaniemi, T., Myllyl, R., Seyer, J., Kurkinen, M., & Prockop, D. J.
(1987).
Partial characterization of a low molecular weight human collagen that undergoes alternative splicing. Proceedings of the National Academy of Sciences of USA.
84(4), 940-944.
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Vogel, B. E., Minor, R. R., Freund, M., & Prockop, D. J.
(1987).
A point mutation in a type I procollagen gene converts glycine 748 of the alpha 1 chain to cysteine and destabilizes the triple helix in a lethal variant of osteogenesis imperfecta. Journal of Biological Chemistry.
262(30), 14737-14744.
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Kadler, K. E., Hojima, Y., & Prockop, D. J.
(1987).
Assembly of collagen fibrils de novo by cleavage of the type I pC-collagen with procollagen C-proteinase. Assay of critical concentration demonstrates that collagen self-assembly is a classical example of an entropy-driven process. Journal of Biological Chemistry.
262(32), 15696-15701.
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Minor, R. R., Wootton, J. A., Prockop, D. J., & Patterson, D. F.
(1987).
Genetic diseases of connective tissues in animals. Current problems in dermatology.
17, 199-215.
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Kadler, K., & Prockop, D. J.
(1987).
Protein structure and the specific heat of water. Nature.
325(6103), 395-395.
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Boot-Handford, R. P., Kurkinen, M., & Prockop, D. J.
(1987).
Steady-state levels of mRNAs coding for the type IV collagen and laminin polypeptide chains of basement membranes exhibit marked tissue-specific stoichiometric variations in the rat. Journal of Biological Chemistry.
262(26), 12475-12478.
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Olsen, A. S., & Prockop, D. J.
(1987).
Relative transcription rates and mRNA levels for the two chains of type I procollagen. METHODS IN ENZYMOLOGY.
144(C), 74-83.
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Goldkorn, T., & Prockop, D. J.
(1986).
A simple and efficient enzymatic method for covalent attachment of DNA to cellulose. Application for hybridization-restriction analysis and for in vitro synthesis of DNA probes. Nucleic Acids Research.
14(22), 9171-9191.
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Soininen, R., Chow, L., Kurkinen, M., Tryggvason, K., & Prockop, D. J.
(1986).
The gene for the alpha 1(IV) chain of human type IV procollagen: the exon structures do not coincide with the two structural subdomains in the globular carboxy-terminus of the protein. The EMBO Journal.
5(11), 2821-2823.
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Dombrowski, K. E., Sheats, J. E., & Prockop, D. J.
(1986).
Iron-containing metallocenes as active site directed inhibitors of the proteinase that cleaves the NH2-terminal propeptides from type I procollagen. Biochemistry.
25(15), 4302-4309.
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Soininen, R., Tikka, L., Chow, L., Pihlajaniemi, T., Kurkinen, M., Prockop, D. J., Boyd, C. D., & Tryggvason, K.
(1986).
Large introns in the 3' end of the gene for the pro alpha 1 (IV) chain of human basement membrane collagen. Proceedings of the National Academy of Sciences of USA.
83(6), 1568-1572.
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Sippola-Thiele, M., Tromp, G. C., Prockop, D. J., & Ramirez, F.
(1986).
Assessment of small polymorphisms in defined human collagen gene segments. Human Genetics.
72(3), 245-247.
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Uitto, J., Matsuoka, L. Y., Chu, M. L., Pihlajaniemi, T., & Prockop, D. J.
(1986).
Connective tissue biochemistry of neurofibromas. Annals of the New York Academy of Sciences.
486(1), 271-286.
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Minor, R. R., Sippola-Thiele, M., McKeon, J., Berger, J., & Prockop, D. J.
(1986).
Defects in the processing of procollagen to collagen are demonstrable in cultured fibroblasts from patients with the Ehlers-Danlos and osteogenesis imperfecta syndromes. Journal of Biological Chemistry.
261(21), 10006-10014.
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Prockop, D. J.
(1986).
Genetic defects of collagen. Hospital practice (Office ed.).
21(2), 125-140.
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Seibold, J. R., Uitto, J., Dorwart, B. B., & Prockop, D. J.
(1985).
Collagen synthesis and collagenase activity in dermal fibroblasts from patients with diabetes and digital sclerosis. Translational Research: the journal of laboratory and clinical medicine.
105(6), 664-667.
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Oikarinen, H., Oikarinen, A. I., Tan, E. M., Abergel, R. P., Meeker, C. A., Chu, M. L., Prockop, D. J., & Uitto, J.
(1985).
Modulation of procollagen gene expression by retinoids. Inhibition of collagen production by retinoic acid accompanied by reduced type I procollagen messenger ribonucleic acid levels in human skin fibroblast cultures. Journal of Clinical Investigation.
75(5), 1545-1553.
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Prockop, D. J.
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Mutations in collagen genes. Consequences for rare and common diseases. Journal of Clinical Investigation.
75(3), 783-787.
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MYERS, J. C., DICKSON, L. A., POPE, F. M., KORHONEN, V. R., NICHOLLS, A., PROCKOP, D. J., & PIHLAJANIEMI, T.
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A Homozygous Frameshift Mutation in the Pro2(I) Collagen COOHPropeptide Results in Osteogenesis Imperfecta. Annals of the New York Academy of Sciences.
460(1), 482-485.
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Deak, S. B., van der Rest, M., & Prockop, D. J.
(1985).
Altered helical structure of a homotrimer of alpha 1(I)chains synthesized by fibroblasts from a variant of osteogenesis imperfecta. Matrix Biology.
5(4), 305-313.
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WET, W., SIPPOLA, M., BERNARD, M., PROCKOP, D., CHU, M., & RAMIREZ, F.
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Electronmicroscopic Localization of Deletions in the Human Pro2(I) Collagen Genea. Annals of the New York Academy of Sciences.
460(1), 415-418.
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Prockop, D. J., Chu, M. L., de Wet, W., Myers, J. C., Pihlajaniemi, T., Ramirez, F., & Sippola, M.
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Mutations in osteogenesis imperfecta leading to the synthesis of abnormal type I procollagens. Annals of the New York Academy of Sciences.
460(1), 289-297.
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Stolle, C. A., Pyeritz, R. E., Myers, J. C., & Prockop, D. J.
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Synthesis of an altered type III procollagen in a patient with type IV Ehlers-Danlos syndrome. A structural change in the alpha 1(III) chain which makes the protein more susceptible to proteinases. Journal of Biological Chemistry.
260(3), 1937-1944.
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Tanzawa, K., Berger, J., & Prockop, D. J.
(1985).
Type I procollagen N-proteinase from whole chick embryos. Cleavage of a homotrimer of pro-alpha 1(I) chains and the requirement for procollagen with a triple-helical conformation. Journal of Biological Chemistry.
260(2), 1120-1126.
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Pihlajaniemi, T., Tryggvason, K., Myers, J. C., Kurkinen, M., Lebo, R., Cheung, M. C., Prockop, D. J., & Boyd, C. D.
(1985).
cDNA clones coding for the pro-alpha1(IV) chain of human type IV procollagen reveal an unusual homology of amino acid sequences in two halves of the carboxyl-terminal domain. Journal of Biological Chemistry.
260(12), 7681-7687.
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Brresen, A. L., Berg, K., Tsipouras, P., Dickson, L. A., Prockop, D. J., & Ramirez, F.
(1985).
DNA polymorphisms in collagen genes: potential use in the study of disease. Progress in clinical and biological research.
177, 37-51.
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Berger, J., Tanzawa, K., & Prockop, D. J.
(1985).
Sequential cleavage of type I procollagen by procollagen N-proteinase. An intermediate containing an uncleaved pro alpha 1(I) chain. Biochemistry.
24(3), 600-605.
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Tsipouras, P., Brresen, A. L., Dickson, L. A., Berg, K., Prockop, D. J., & Ramirez, F.
(1984).
Molecular heterogeneity in the mild autosomal dominant forms of osteogenesis imperfecta. American Journal of Human Genetics.
36(6), 1172-1179.
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Prockop, D. J., & Kivirikko, K. I.
(1984).
Heritable diseases of collagen. NEW ENGLAND JOURNAL OF MEDICINE.
311(6), 376-386.
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Nicholls, A. C., Osse, G., Schloon, H. G., Lenard, H. G., Deak, S., Myers, J. C., ... Pope, F. M.
(1984).
The clinical features of homozygous alpha 2(I) collagen deficient osteogenesis imperfecta. Journal of Medical Genetics.
21(4), 257-262.
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Dickson, L. A., Pihlajaniemi, T., Deak, S., Pope, F. M., Nicholls, A., Prockop, D. J., & Myers, J. C.
(1984).
Nuclease S1 mapping of a homozygous mutation in the carboxyl-propeptide-coding region of the pro alpha 2(I) collagen gene in a patient with osteogenesis imperfecta. Proceedings of the National Academy of Sciences of USA.
81(14), 4524-4528.
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Prockop, D. J.
(1984).
Osteogenesis imperfecta: phenotypic heterogeneity, protein suicide, short and long collagen. American Journal of Human Genetics.
36(3), 499-505.
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Curran, S., & Prockop, D. J.
(1984).
Isolation and partial characterization of the carboxy-terminal propeptide of type II procollagen from chick embryos. Biochemistry.
23(4), 741-746.
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Sippola, M., Kaffe, S., & Prockop, D. J.
(1984).
A heterozygous defect for structurally altered pro-alpha 2 chain of type I procollagen in a mild variant of osteogenesis imperfecta. The altered structure decreases the thermal stability of procollagen and makes it resistant to procollagen N-proteinase. Journal of Biological Chemistry.
259(22), 14094-14100.
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Miyahara, M., Hayashi, K., Berger, J., Tanzawa, K., Njieha, F. K., Trelstad, R. L., & Prockop, D. J.
(1984).
Formation of collagen fibrils by enzymic cleavage of precursors of type I collagen in vitro. Journal of Biological Chemistry.
259(15), 9891-9898.
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Hoffmann, H. P., Schwartz, N. B., Rodn, L., & Prockop, D. J.
(1984).
Location of xylosyltransferase in the cisternae of the rough endoplasmic reticulum of embryonic cartilage cells. Connective Tissue Research.
12(2), 151-163.
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Dickson, L. A., Pihlajaniemi, T., Deak, S., Pope, F. M., Nicholls, A., Prockop, D. J., & Myers, J. C.
(1984).
Nuclease S1 mapping of a homozygous mutation in the carboxyl-propeptide-coding region of the pro alpha 2(I) collagen gene in a patient with osteogenesis imperfecta. Proceedings of the National Academy of Sciences of USA.
81(14), 4524-4528.
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Pihlajaniemi, T., Dickson, L. A., Pope, F. M., Korhonen, V. R., Nicholls, A., Prockop, D. J., & Myers, J. C.
(1984).
Osteogenesis imperfecta: cloning of a pro-alpha 2(I) collagen gene with a frameshift mutation. Journal of Biological Chemistry.
259(21), 12941-12944.
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Chu, M. L., Rowe, D., Nicholls, A. C., Pope, F. M., & Prockop, D. J.
(1984).
Presence of translatable mRNA for pro alpha 2(I) chains in fibroblasts from a patient with osteogenesis imperfecta whose type I collagen does not contain alpha 2(I) chains. Matrix Biology.
4(5), 389-394.
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Prockop, D. J.
(1984).
The synthesis of type I collagen fibers and potential inhibitors of the process. Progress in clinical and biological research.
154, 81-88.
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Bernard, M. P., Chu, M. L., Myers, J. C., Ramirez, F., Eikenberry, E. F., & Prockop, D. J.
(1983).
Nucleotide sequences of complementary deoxyribonucleic acids for the pro alpha 1 chain of human type I procollagen. Statistical evaluation of structures that are conserved during evolution. Biochemistry.
22(22), 5213-5223.
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Tsipouras, P., Myers, J. C., Ramirez, F., & Prockop, D. J.
(1983).
Restriction fragment length polymorphism associated with the pro alpha 2(I) gene of human type I procollagen. Application to a family with an autosomal dominant form of osteogenesis imperfecta. Journal of Clinical Investigation.
72(4), 1262-1267.
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Bernard, M. P., Myers, J. C., Chu, M. L., Ramirez, F., Eikenberry, E. F., & Prockop, D. J.
(1983).
Structure of a cDNA for the pro alpha 2 chain of human type I procollagen. Comparison with chick cDNA for pro alpha 2(I) identifies structurally conserved features of the protein and the gene. Biochemistry.
22(5), 1139-1145.
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Miyahara, M., Bruckner, P., Helle, O., & Prockop, D. J.
(1983).
Aggregation of a type I collagen precursor containing N-terminal propeptides. Matrix Biology.
3(4), 279-293.
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Chu, M. L., Williams, C. J., Pepe, G., Hirsch, J. L., Prockop, D. J., & Ramirez, F.
(1983).
Internal deletion in a collagen gene in a perinatal lethal form of osteogenesis imperfecta. Nature.
304(5921), 78-80.
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Synthesis and processing of a type I procollagen containing shortened pro-alpha 1(I) chains by fibroblasts from a patient with osteogenesis imperfecta. Journal of Biological Chemistry.
258(9), 5915-5921.
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de Wet, W. J., Pihlajaniemi, T., Myers, J., Kelly, T. E., & Prockop, D. J.
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Synthesis of a shortened pro-alpha 2(I) chain and decreased synthesis of pro-alpha 2(I) chains in a proband with osteogenesis imperfecta. Journal of Biological Chemistry.
258(12), 7721-7728.
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de Wet, W. J., Chu, M. L., & Prockop, D. J.
(1983).
The mRNAs for the pro-alpha 1(I) and pro-alpha 2(I) chains of type I procollagen are translated at the same rate in normal human fibroblasts and in fibroblasts from two variants of osteogenesis imperfecta with altered steady state ratios of the two mRNAs. Journal of Biological Chemistry.
258(23), 14385-14389.
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Deak, S. B., Nicholls, A., Pope, F. M., & Prockop, D. J.
(1983).
The molecular defect in a nonlethal variant of osteogenesis imperfecta. Synthesis of pro-alpha 2(I) chains which are not incorporated into trimers of type I procollagen. Journal of Biological Chemistry.
258(24), 15192-15197.
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Huerre, C., Junien, C., Weil, D., Chu, M. L., Morabito, M., Van Cong, N., ... Ramirez, F.
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Human type I procollagen genes are located on different chromosomes. Proceedings of the National Academy of Sciences of USA.
79(21 I), 6627-6630.
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Huerre, C., Junien, C., Weil, D., Chu, M. L., Morabito, M., Van Cong, N., ... Ramirez, F.
(1982).
Human type I procollagen genes are located on different chromosomes. Proceedings of the National Academy of Sciences of USA.
79(21), 6627-6630.
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Kimura, T., & Prockop, D. J.
(1982).
Hydroxylation of prolyl residues in type II procollagen in vitro and in cellulo. Lack of preferential hydroxylation of specific regions of the protein. Biochemistry.
21(22), 5482-5488.
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Tuderman, L., & Prockop, D. J.
(1982).
Procollagen N-proteinase. Properties of the enzyme purified from chick embryo tendons. European Journal of Biochemistry.
125(3), 545-549.
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Junien, C., Weil, D., Myers, J. C., Van Cong, N., Chu, M. L., Foubert, C., ... Ramirez, F.
(1982).
Assignment of the human pro alpha 2(I) collagen structural gene (COLIA2) to chromosome 7 by molecular hybridization. American Journal of Human Genetics.
34(3), 381-387.
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Curran, S., & Prockop, D. J.
(1982).
Isolation and partial characterization of the amino-terminal propeptide of type II procollagen from chick embryos. Biochemistry.
21(7), 1482-1487.
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Njieha, F. K., Morikawa, T., Tuderman, L., & Prockop, D. J.
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Partial purification of a procollagen C-proteinase. Inhibition by synthetic peptides and sequential cleavage of type I procollagen. Biochemistry.
21(4), 757-764.
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Miyahara, M., Njieha, F. K., & Prockop, D. J.
(1982).
Formation of collagen fibrils in vitro by cleavage of procollagen with procollagen proteinases. Journal of Biological Chemistry.
257(14), 8442-8448.
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Prockop, D. J.
(1982).
How does a skin fibroblast make type I collagen fibers?. Journal of Investigative Dermatology.
79+Suppl+1(s1), 3s-6s.
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Kao, W. W., Bressan, G. M., & Prockop, D. J.
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Kinetics of the incorporation of tropoelastin into elastic fibers in embryonic chick aorta. Connective Tissue Research.
10(3-4), 263-274.
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Guzman, N. A., Oronsky, A. L., Suarez, G., Meyerson, L. R., Cutroneo, K. R., Olsen, B. R., & Prockop, D. J.
(1982).
Prolyl 4-Hydroxylase from Human Placenta. Simultaneous Isolation of Immunoglobulin G which Binds to Ascaris Cuticle Collagen. Matrix Biology.
2(5), 365-380.
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Van der Rest, M., Stolle, C. A., Prockop, D. J., & Fietzek, P. P.
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Separation of human pro alpha 1 (I) and pro alpha 2 (I) procollagen chains by reverse phase high performance liquid chromatography. Matrix Biology.
2(4), 281-285.
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Inouye, K., Kobayashi, Y., Kyogoku, Y., Kishida, Y., Sakakibara, S., & Prockop, D. J.
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Synthesis and physical properties of (hydroxyproline-proline-glycine)10: hydroxyproline in the X-position decreases the melting temperature of the collagen triple helix. Archives of Biochemistry and Biophysics.
219(1), 198-203.
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Prockop, D. J., & Tuderman, L.
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Posttranslational enzymes in the biosynthesis of collagen: extracellular enzymes. METHODS IN ENZYMOLOGY.
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Prockop, D. J., & Williams, C. J.
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Structure of the organic matrix: collagen structure (chemical). 161-177.
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Riley, D. J., Kerr, J. S., Berg, R. A., Ianni, B. D., Pietra, G. G., Edelman, N. H., & Prockop, D. J.
(1982).
beta-Aminopropionitrile prevents bleomycin-induced pulmonary fibrosis in the hamster. The American review of respiratory disease.
125(1), 67-73.
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Prockop, D. J.
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Recombinant DNA and collagen research. Is amino acid sequencing obsolete? Can we study diseases involving collagen by analysis of the genes?. Matrix Biology.
1(1), 129-135.
-
Bruckner, P., Eikenberry, E. F., & Prockop, D. J.
(1981).
Formation of the triple helix of type I procollagen in cellulo. A kinetic model based on cis-trans isomerization of peptide bonds. European Journal of Biochemistry.
118(3), 607-613.
-
Graves, P. N., Olsen, B. R., Fietzek, P. P., Prockop, D. J., & Monson, J. M.
(1981).
Comparison of the NH2-Terminal sequences of chick Type I preprocollagen chains synthesized in an nRNA-dependent reticulocyte lysate. European Journal of Biochemistry.
118(2), 363-369.
-
Riley, D. J., Kerr, J. S., Berg, R. A., Ianni, B. D., Pietra, G. G., Edelman, N. H., & Prockop, D. J.
(1981).
Prevention of bleomycin-induced pulmonary fibrosis in the hamster by Cis-4-hydroxy-L-proline. The American review of respiratory disease.
123(4), 388-393.
-
Myers, J. C., Chu, M. L., Faro, S. H., Clark, W. J., Prockop, D. J., & Ramirez, F.
(1981).
Cloning a cDNA for the pro-alpha 2 chain of human type I collagen. Proceedings of the National Academy of Sciences of USA.
78(6), 3516-3520.
-
Riley, D. J., Kerr, J. S., Berg, R. A., Ianni, B. D., Pietra, G. G., Edelman, N. H., & Prockop, D. J.
(1981).
Prevention of bleomycin-induced pulmonary fibrosis in the hamster by cis-4-hydroxy-l-proline. The American review of respiratory disease.
123(4 Pt 1), 388-393.
-
Riley, D. J., Kerr, J. S., Berg, R. A., Ianni, B., Edelman, N. H., & Prockop, D. J.
(1981).
Effect of cis-4-hydroxy-L-proline on lung mechanics and collagen content of bleomycin-treated hamsters. Chest.
80(1 Suppl), 49-50.
-
Fiedler-Nagy, C., Bruckner, P., Hayashi, T., & Prockop, D. J.
(1981).
Isolation of unhydroxylated type I procollagen folding of the protein in vitro. Archives of Biochemistry and Biophysics.
212(2), 668-677.
-
Bruckner, P., & Prockop, D. J.
(1981).
Proteolytic enzymes as probes for the triple-helical conformation of procollagen. Analytical Biochemistry.
110(2), 360-368.
-
Uitto, V. J., Uitto, J., & Prockop, D. J.
(1981).
Synthesis of type I procollagen: formation of interchain disulfide bonds before complete hydroxylation of the protein. Archives of Biochemistry and Biophysics.
210(2), 445-454.
-
Riley, R. J., Kerr, J. S., Berg, R. A., Ianni, B., Edelman, N. H., & Prockop, D. J.
(1981).
Effect of Cis-4- hydroxy-L-proline on lung mechanics and collagen content of bleomycin-treated hamsters. Chest.
80(suppl.1), 49S-50S.
-
Prockop, D. J.
(1980).
Present and future research on collagen and genes for collagen. Medical Biology.
58(6), 289-292.
-
Prockop, D. J.
(1980).
Recombinant DNA and collagen research. Is amino acid sequencing obsolete? Can we study diseases involving collagen by analysis of the genes?. Matrix Biology.
1(1), 129-135.
-
Peltonen, L., Palotie, A., & Prockop, D. J.
(1980).
A defect in the structure of type I procollagen in a patient who had osteogenesis imperfecta: excess mannose in the COOH-terminal propeptide. Proceedings of the National Academy of Sciences of USA.
77(10), 6179-6183.
-
Morikawa, T., Tuderman, L., & Prockop, D. J.
(1980).
Inhibitors of procollagen N-protease. Synthetic peptides with sequences similar to the cleavage site in the pro alpha 1(I) chain. Biochemistry.
19(12), 2646-2650.
-
Bchinger, H. P., Bruckner, P., Timpl, R., Prockop, D. J., & Engel, J.
(1980).
Folding mechanism of the triple helix in type-III collagen and type-III pN-collagen. Role of disulfide bridges and peptide bond isomerization. European Journal of Biochemistry.
106(2), 619-632.
-
Riley, D. J., Berg, R. A., Edelman, N. H., & Prockop, D. J.
(1980).
Prevention of collagen deposition following pulmonary oxygen toxicity in the rat by cis-4-hydroxy-L-proline. Journal of Clinical Investigation.
65(3), 643-651.
-
Steinmann, B., Tuderman, L., Peltonen, L., Martin, G. R., McKusick, V. A., & Prockop, D. J.
(1980).
Evidence for a structural mutation of procollagen type I in a patient with the Ehlers-Danlos syndrome type VII. Journal of Biological Chemistry.
255(18), 8887-8893.
-
Kao, W. W., & Prockop, D. J.
(1980).
Can proline analogues be used to prevent fibroblasts from overgrowing cultures of epithelial cells?. Birth defects original article series.
16(2), 53-59.
-
Kao, W. W., Gay, S., Bressan, G. M., & Prockop, D. J.
(1980).
Demonstration by immunofluorescence that the same cells from chick embryo aortas synthesize elastin and collagen types I and III. Artery.
7(3), 176-190.
-
Peltonen, L., Palotie, A., Hayashi, T., & Prockop, D. J.
(1980).
Thermal stability of type I and type III procollagens from normal human fibroblasts and from a patient with osteogenesis imperfecta. Proceedings of the National Academy of Sciences of USA.
77(1), 162-166.
-
Hyashi, T., Curran-Patel, S., & Prockop, D. J.
(1979).
Thermal stability of the triple helix of type I procollagen and collagen. Precautions for minimizing ultraviolet damage to proteins during circular dichroism studies. Biochemistry.
18(19), 4182-4187.
-
Prockop, D. J., Kivirikko, K. I., Tuderman, L., & Guzman, N. A.
(1979).
The biosynthesis of collagen and its disorders (first of two parts). NEW ENGLAND JOURNAL OF MEDICINE.
301(1), 13-23.
-
Prockop, D. J., Kivirikko, K. I., Tuderman, L., & Guzman, N. A.
(1979).
The biosynthesis of collagen and its disorders (second of two parts). NEW ENGLAND JOURNAL OF MEDICINE.
301(2), 77-85.
-
Kao, W. W., Prockop, D. J., & Berg, R. A.
(1979).
Kinetics for the secretion of nonhelical procollagen by freshly isolated tendon cells. Journal of Biological Chemistry.
254(7), 2234-2243.
-
Riley, D. J., Edelman, N. H., Berg, R. A., & Prockop, D. J.
(1979).
Use of a proline analogue to prevent lung injury following oxygen toxicity in rats. The American review of respiratory disease.
119(4 Suppl.), 353.
-
Tuderman, L., Kivirikko, K. I., & Prockop, D. J.
(1978).
Partial purification and characterization of a neutral protease which cleaves the N-terminal propeptides from procollagen. Biochemistry.
17(15), 2948-2954.
-
Guzman, N. A., Graves, P. N., & Prockop, D. J.
(1978).
Addition of mannose to both the amino- and carboxy-terminal properties of type II procollagen occurs without formation of a triple helix. Biochemical and Biophysical Research Communications.
84(3), 691-698.
-
Uitto, V. J., Uitto, J., Kao, W. W., & Prockop, D. J.
(1978).
Procollagen polypeptides containing cis-4-hydroxy-L-proline are overglycosylated and secreted as nonhelical pro-gamma-chains. Archives of Biochemistry and Biophysics.
185(1), 214-221.
-
Ryhnen, L., Graves, P. N., Bressan, G. M., & Prockop, D. J.
(1978).
Synthesis of an elastin component of molecular weight about 70,000 by polysomes from chick embryo aortas. Archives of Biochemistry and Biophysics.
185(2), 344-351.
-
Berg, R. A., Kishida, Y., Sakakibara, S., & Prockop, D. J.
(1977).
Hydroxylation of (Pro-Pro-Gly)5 and (Pro-Pro-Gly)10 by prolyl hydroxylase. Evidence for an asymmetric active site in the enzyme. Biochemistry.
16(8), 1615-1621.
-
Bressan, G. M., & Prockop, D. J.
(1977).
Synthesis of elastin in aortas from chick embryos. Conversion of newly secreted elastin to cross-linked elastin without apparent proteolysis of the molecule. Biochemistry.
16(7), 1406-1412.
-
Engel, J., Chen, H. T., Prockop, D. J., & Klump, H.
(1977).
The triple helix in equilibrium with coil conversion of collagen-like polytripeptides in aqueous and nonaqueous solvents. Comparison of the thermodynamic parameters and the binding of water to (L-Pro-L-Pro-Gly)n and (L-Pro-L-Hyp-Gly)n. Biopolymers.
16(3), 601-622.
-
Prockop, D. J., & Guzman, N. A.
(1977).
Collagen diseases and the biosynthesis of collagen. Hospital practice.
12(12), 61-68.
-
Uitto, J., & Prockop, D. J.
(1977).
Incorporation of proline analogs into procollagen. Assay for replacement of imino acids by cis-4-hydroxy-L-proline and cis-4-fluoro-L-proline. Archives of Biochemistry and Biophysics.
181(1), 293-299.
-
Bressan, G. M., & Prockop, D. J.
(1977).
Is newly-secreted elastin cleaved to a smaller molecule before being incorporated into crosslinked elastin fibers?. Advances in Experimental Medicine and Biology.
79, 443-451.
-
Kao, W. W., Berg, R. A., & Prockop, D. J.
(1977).
Kinetics for the secretion of procollagen by freshly isolated tendon cells. Journal of Biological Chemistry.
252(23), 8391-8397.
-
Kao, W. W., & Prockop, D. J.
(1977).
Proline analogue removes fibroblasts from cultured mixed cell populations. Nature.
266(5597), 63-64.
-
Uitto, J., Hoffmann, H. P., & Prockop, D. J.
(1977).
Purification and partial characterization of the type II procollagen synthesized by embryonic cartilage cells. Archives of Biochemistry and Biophysics.
179(2), 654-662.
-
Whei-Yang Kao, W., Guzman, N. A., & Prockop, D. J.
(1977).
Use of glutaraldehyde-fixed Escherichia coli cells as a convenient support for radioimmune assays. Analytical Biochemistry.
81(1), 209-219.
-
Hoffmann, H. P., Olsen, B. R., Chen, H. T., & Prockop, D. J.
(1976).
Segment-long-spacing aggregates and isolation of COOH-terminal peptides from type I procollagen. Proceedings of the National Academy of Sciences of USA.
73(12), 4304-4308.
-
Becker, U., & Timpl, R.
(1976).
NH2-terminal extensions on skin collagen from sheep with a genetic defect in conversion of procollagen into collagen. Biochemistry.
15(13), 2853-2862.
-
Guzman, N. A., Berg, R. A., & Prockop, D. J.
(1976).
Concanavalin A binds of purified prolyl hydroxylase and partially inhibits its enzymic activity. Biochemical and Biophysical Research Communications.
73(2), 279-285.
-
Inouye, K., Sakakibara, S., & Prockop, D. J.
(1976).
Effects of the stereo-configuration of the hydroxyl group in 4-hydroxyproline on the triple-helical structures formed by homogenous peptides resembling collagen. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
420(1), 133-141.
-
Olsen, B. R., Hoffmann, H., & Prockop, D. J.
(1976).
Interchain disulfide bonds at the COOH-terminal end of procollagen synthesized by matrix-free cells from chick embryonic tendon and cartilage. Archives of Biochemistry and Biophysics.
175(1), 341-350.
-
Kao, W. W., Flaks, J. G., & Prockop, D. J.
(1976).
Primary and secondary effects of ascorbate on procollagen synthesis and protein synthesis by primary cultures of tendon fibroblasts. Archives of Biochemistry and Biophysics.
173(2), 638-648.
-
Berg, R. A., Kao, W., & Prockop, D. J.
(1976).
Prolyl hydroxylase activity in L-929 fibroblasts incubated with and without ascorbate. BBA: General Subjects.
444(3), 756-764.
-
Uitto, J., Hoffmann H-P, .., & Prockop, D. J.
(1976).
Synthesis of elastin and procallagen by cells from embryonic aorta. Differences in the role of hydroxyproline and the effects of proline analogs on the secretion of the two proteins. Archives of Biochemistry and Biophysics.
173(1), 187-200.
-
Uitto, J., & Prockop, D. J.
(1976).
Inhibition of collagen formation by proline analogues: degree of replacement and specificity of action. Clinical research.
24(3),
-
Uitto, J., Hoffman, H., & Prockop, D. J.
(1975).
Retention of nonhelical procollagen containing cis-hydroxyproline in rough endoplasmic reticulum. Science.
190(4220), 1202-1204.
-
Olsen, B. R., Berg, R. A., Kishida, Y., & Prockop, D. J.
(1975).
Further characterization of embryonic tendon fibroblasts and the use of immunoferritin techniques to study collagen biosynthesis. The Journal of Cell Biology.
64(2), 340-355.
-
Kishida, Y., Olsen, B. R., Berg, R. A., & Prockop, D. J.
(1975).
Two improved methods for preparing ferritin-protein conjugates for electron microscopy. The Journal of Cell Biology.
64(2), 331-339.
-
Kao, W. W., Berg, R. A., & Prockop, D. J.
(1975).
Ascorbate increases the synthesis of procollagen hydroxyproline by cultured fibroblasts from chick embryo tendons without activation of prolyl hydroxyla. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
411(2), 202-215.
-
Kao, W., Berg, R. A., Flaks, J. G., & Prockop, D. J.
(1975).
Ascorbate can increase hydroxyproline synthesis in cultured fibroblasts without activation of prolyl hydroxylase. FEDERATION PROCEEDINGS.
34(3),
-
Uitto, J., & Prockop, D. J.
(1974).
Biosynthesis of cartilage procollagen. Influence of chain association and hydroxylation of prolyl residues on the folding of the polypeptides into the triple-helical conformation. Biochemistry.
13(22), 4586-4591.
-
Dehm, P., Olsen, B. R., & Prockop, D. J.
(1974).
Antibodies to chick-tendon procollagen. Affinity purification with the isolated disulfide-linded NH2-terminal extensions and reactivity with a component in embryonic serum. European Journal of Biochemistry.
46(1), 107-116.
-
Olsen, B. R., & Prockop, D. J.
(1974).
Ferritin-conjugated antibodies used for labeling of organelles involved in the cellular synthesis and transport of procollagen. Proceedings of the National Academy of Sciences of USA.
71(5), 2033-2037.
-
Schofield, J. D., Uitto, J., & Prockop, D. J.
(1974).
Formation of interchain disulfide bonds and helical structure during biosynthesis of procollagen by embryonic tendon cells. Biochemistry.
13(9), 1801-1806.
-
Uitto, J., & Prockop, D. J.
(1974).
Intracellular hydroxylation of non-helical protocollagen to form triple-helical procollagen and subsequent secretion of the molecule. European Journal of Biochemistry.
43(2), 221-230.
-
Uitto, J., & Prockop, D. J.
(1974).
Hydroxylation of peptide-bound proline and lysine before and after chain completion of the polypeptide chains of procollagen. Archives of Biochemistry and Biophysics.
164(1), 210-217.
-
Uitto, J., & Prockop, D. J.
(1974).
Incorporation of proline analogues into collagen polypeptides Effects on the production of extracellular procollagen and on the stability of the triple-helical structure of the molecule. Biochimica et Biophysica Acta - Protein Structure.
336(2), 234-251.
-
SCHOFIELD, J. D., UITTO, J. J., & PROCKOP, D. J.
(1974).
Interchain Disulphide Bonding in Procollagen from Embryonic Chick Tendon Cells and the Formation of the Triple-Helical Structure. Biochemical Society Transactions.
2(1), 90-93.
-
Uitto, J., & Prockop, D. J.
(1974).
Synthesis and secretion of under-hydroxylated procollagen at various temperatures by cells subject to temporary anoxia. Biochemical and Biophysical Research Communications.
60(1), 414-423.
-
GRANT, M. E., SCHOFIELD, J. D., KEFALIDES, N. A., & PROCKOP, D. J.
(1974).
Triple-Helix Formation and Disulphide Bonding during the Biosynthesis of Lens Basement-Membrane Collagen. Biochemical Society Transactions.
2(1), 93-95.
-
Olsen, B. R., Berg, R. A., Kishida, Y., & Prockop, D. J.
(1973).
Collagen synthesis: localization of prolyl hydroxylase in tendon cells detected with ferritin-labeled antibodies. Science.
182(4114), 825-827.
-
Kivirikko, K. I., Ryhnen, L., Anttinen, H., Bornstein, P., & Prockop, D. J.
(1973).
Further hydroxylation of lysyl residues in collagen by protocollagen lysyl hydroxylase in vitro. Biochemistry.
12(24), 4966-4971.
-
Berg, R. A., & Prockop, D. J.
(1973).
Purification of (14C) protocollagen and its hydroxylation by prolyl-hydroxylase. Biochemistry.
12(18), 3395-3401.
-
Dehm, P., & Prockop, D. J.
(1973).
Biosynthesis of cartilage procollagen. European Journal of Biochemistry.
35(1), 159-166.
-
Olsen, B. R., Berg, R. A., Kivirikko, K. T., & Prockop, D. J.
(1973).
Structure of protocollagen proline hydroxylase from chick embryos. European Journal of Biochemistry.
35(1), 135-147.
-
Berg, R. A., Kishida, Y., Kobayashi, Y., Inouye, K., Tonelli, A. E., Sakakibara, S., & Prockop, D. J.
(1973).
A model for the triple-helical structure of (Pro-Hyp-Gly)10 involving a cis peptide bond and inter-chain hydrogen-bonding to the hydroxyl group of hydroxyproline. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
328(2), 553-559.
-
Berg, R. A., & Prockop, D. J.
(1973).
Affinity column purification of protocollagen proline hydroxylase from chick embryos and further characterization of the enzyme. Journal of Biological Chemistry.
248(4), 1175-1182.
-
Daly, J. M., Steiger, E., Prockop, D. J., & Dudrick, S. J.
(1973).
Inhibition of collagen synthesis by the proline analogue cis-4-hydroxyproline. Journal of Surgical Research.
14(6), 551-555.
-
Schofield, J. D., & Prockop, D. J.
(1973).
Procollagen-a precursor form of collagen. Clinical Orthopaedics and Related Research.
97(97), 175-195.
-
Uitto, J., & Prockop, D. J.
(1973).
Rate of helix formation by intracellular procollagen and protocollagen. Evidence for a role for disulfide bonds. Biochemical and Biophysical Research Communications.
55(3), 904-911.
-
Sakakibara, S., Inouye, K., Shudo, K., Kishida, Y., Kobayashi, Y., & Prockop, D. J.
(1973).
Synthesis of (Pro-Hyp-Gly) n of defined molecular weights. Evidence for the stabilization of collagen triple helix by hydroxypyroline. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
303(1), 198-202.
-
Grant, M. E., Schofield, J. D., Kefalides, N. A., & Prockop, D. J.
(1973).
The biosynthesis of basement membrane collagen in embryonic chick lens. 3. Intracellular formation of the triple helix and the formation of aggregates through disulfide bonds. Journal of Biological Chemistry.
248(21), 7432-7437.
-
Berg, R. A., & Prockop, D. J.
(1973).
The thermal transition of a non-hydroxylated form of collagen. Evidence for a role for hydroxyproline in stabilizing the triple-helix of collagen. Biochemical and Biophysical Research Communications.
52(1), 115-120.
-
Pleasure, D. E., Feldmann, B., & Prockop, D. J.
(1973).
Diphtheria toxin inhibits the synthesis of myelin proteolipid and basic proteins by peripheral nerve in vitro. Journal of Neurochemistry.
20(1), 81-90.
-
Uitto, J., & Prockop, D. J.
(1973).
Proline analogues inhibit the formation of helical collagen. Clinical research.
21(3), 742.
-
Uitto, J., Dehm, P., & Prockop, D. J.
(1972).
Incorporation of cis-hydroxyproline into collagen by tendon cells. Failure of the intracellular collagen to assume a triple-helical conformation. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
278(3), 601-605.
-
Uitto, J., Jimenez, S. A., Dehm, P., & Prockop, D. J.
(1972).
Characterization of the precursor forms of the 1 and 2 chains of collagen from matrix-free tendon cells. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
278(1), 198-205.
-
Prockop, D. J.
(1972).
A subtle disease and a dilemma: can cells secrete collagen that does not contain a sugar-tag?. NEW ENGLAND JOURNAL OF MEDICINE.
286(19), 1055-1056.
-
Pleasure, D. E., & Prockop, D. J.
(1972).
Myelin synthesis in peripheral nerve in vitro: sulphatide incorporation requires a transport lipoprotein. Journal of Neurochemistry.
19(2), 283-295.
-
Grant, M. E., & Prockop, D. J.
(1972).
The biosynthesis of collagen. 2. NEW ENGLAND JOURNAL OF MEDICINE.
286(5), 242-249.
-
Grant, M. E., & Prockop, D. J.
(1972).
The biosynthesis of collagen. 3. NEW ENGLAND JOURNAL OF MEDICINE.
286(6), 291-300.
-
Kivirikko, K. I., Kishida, Y., Sakakibara, S., & Prockop, D. J.
(1972).
Hydroxylation of (X-Pro-Gly)n by protocollagen proline hydroxylase. Effect of chain length, helical conformation and amino acid sequence in the substrate. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
271(2), 347-356.
-
Lane, J. M., Bora, F. W., Prockop, D. J., Heppenstall, R. B., & Black, J.
(1972).
Inhibition of scar formation by the proline analog cis-hydroxyproline. Journal of Surgical Research.
13(3), 135-137.
-
Bora, F. W., Lane, J. M., & Prockop, D. J.
(1972).
Inhibitors of collagen biosynthesis as a means of controlling scar formation in tendon injury. 54(7), 1501-1508.
-
Berg, R. A., Olsen, B. R., & Prockop, D. J.
(1972).
Labeled antibodies to protocollagen proline hydroxylase from chick embryos for intracellular localization of the enzyme. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
285(1), 167-175.
-
Kivirikko, K. I., & Prockop, D. J.
(1972).
Partial purification and characterization of protocollagen lysine hydroxylase from chick embryos. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
258(2), 366-379.
-
Kivirikko, K. I., Shudo, K., Sakakibara, S., & Prockop, D. J.
(1972).
Studies on protocollagen lysine hydroxylase. Hydroxylation of synthetic peptides and the stoichiometric decarboxylation of -ketoglutarate. Biochemistry.
11(1), 122-129.
-
Grant, M. E., Kefalides, N. A., & Prockop, D. J.
(1972).
The biosynthesis of basement membrane collagen in embryonic chick lens. I. Delay between the synthesis of polypeptide chains and the secretion of collagen by matrix-free cells. Journal of Biological Chemistry.
247(11), 3539-3544.
-
Grant, M. E., Kefalides, N. A., & Prockop, D. J.
(1972).
The biosynthesis of basement membrane collagen in embryonic chick lens. II. Synthesis of a precursor form by matrix-free cells and a time-dependent conversion to chains in intact lens. Journal of Biological Chemistry.
247(11), 3545-3551.
-
Dehm, P., & Prockop, D. J.
(1972).
Time lag in the secretion of collagen by matrix-free tendon cells and inhibition of the secretory process by colchicine and vinblastine. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
264(2), 375-382.
-
Dehm, P., Jimenez, S. A., Olsen, B. R., & Prockop, D. J.
(1972).
A transport form of collagen from embryonic tendon: electron microscopic demonstration of an NH 2 -terminal extension and evidence suggesting the presence of cystine in the molecule (chick embryo-tropocollagen-gel filtration). Proceedings of the National Academy of Sciences of USA.
69(1), 60-64.
-
Grant, M. E., & Prockop, D. J.
(1972).
The biosynthesis of collagen. 1. NEW ENGLAND JOURNAL OF MEDICINE.
286(4), 194-199.
-
Jimenez, S. A., Dehm, P., & Prockop, D. J.
(1971).
Further evidence for a transport form of collagen. Its extrusion and extracellular conversion to tropocollagen in embryonic tendon. FEBS Letters.
17(2), 245-248.
-
Kivirikko, K. I., Suga, K., Kishida, Y., Sakakibara, S., & Prockop, D. J.
(1971).
Asymmetry in the hydroxylation of (Pro-Pro-Gly) 5 by protocollagen proline hydroxylase. Biochemical and Biophysical Research Communications.
45(6), 1591-1596.
-
Lane, J. M., Dehm, P., & Prockop, D. J.
(1971).
Effect of the proline analogue azetidine-2-carboxylic acid on collagen synthesis in vivo. I. Arrest of collagen accumulation in growing chick embryos. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
236(3), 517-527.
-
Lane, J. M., Parkes, L. J., & Prockop, D. J.
(1971).
Effect of the proline analogue azetidine-2-carboxylic acid on collagen synthesis in vivo. II. Morphological and physical properties of collagen containing the analogue. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
236(3), 528-541.
-
Rosenbloom, J., & Prockop, D. J.
(1971).
Incorporation of cis-hydroxyproline into protocollagen and collagen. Collagen containing cis-hydroxyproline in place of proline and trans-hydroxyproline is not extruded at a normal rate. Journal of Biological Chemistry.
246(6), 1549-1555.
-
Lane, J., Rosenbloom, J., & Prockop, D. J.
(1971).
Lag between incorporation of proline into protocollagen and synthesis of hydroxyproline during collagen biosynthesis in vitro and in vivo. 232(2), 191-192.
-
Blumenkrantz, N., & Prockop, D. J.
(1971).
Quantitative assay for hydroxylysine in protein hydrolyzates. Analytical Biochemistry.
39(1), 59-64.
-
Prockop, D. J.
(1971).
Role of iron in the synthesis of collagen in connective tissue. FEDERATION PROCEEDINGS.
30(3), 984-990.
-
Dehm, P., & Prockop, D. J.
(1971).
Synthesis and extrusion of collagen by freshly isolated cells from chick embryo tendon. Biochimica et Biophysica Acta - Section Nucleic Acids And Protein Synthesis.
240(3), 358-369.
-
Olsen, B. R., Berg, R. A., Sakakibara, S., Kishida, Y., & Prockop, D. J.
(1971).
The synthetic polytripeptides (Pro-Pro-Gly)10 and (Pro-Pro-Gly)20 form micro-crystalline structures similar to segmental structures formed by collagen. JOURNAL OF MOLECULAR BIOLOGY.
57(3), 589-595.
-
Prockop, D. J.
(1970).
Hydroxyprolinemia as an illustration of nonessential enzymes in man. NEW ENGLAND JOURNAL OF MEDICINE.
283(9), 487-487.
-
Olsen, B. R., Jimenez, S. A., Kivirikko, K. I., & Prockop, D. J.
(1970).
Electron microscopy of protocollagen proline hydroxylase from chick embryos. Journal of Biological Chemistry.
245(10), 2649-2655.
-
Rosenbloom, J., & Prockop, D. J.
(1970).
Incorporation of 3,4-dehydroproline into protocollagen and collagen. Limited hydroxylation of proline and lysine in the same polypeptide. Journal of Biological Chemistry.
245(13), 3361-3368.
-
Berg, R. A., Olsen, B. R., & Prockop, D. J.
(1970).
Titration and melting curves of the collagen-like triple helices formed from (Pro-Pro-Gly) in aqueous solution. Journal of Biological Chemistry.
245(21), 5759-5763.
-
Blumenkrantz, N., & Prockop, D. J.
(1970).
Variations in the glycosylation of the collagen synthesized by chick embryo cartilage. Effects of development and several hormones. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
208(3), 461-466.
-
Kitridou, R., McCarty, D. J., Prockop, D. J., & Hummeler, K.
(1969).
Identification of collagen in synovial fluid. ARTHRITIS AND RHEUMATISM.
12(6), 580-588.
-
Prockop, D. J.
(1969).
The intracellular biosynthesis of collagen. Some possible implications for diseases of bone and other connective tissues. Archives of Internal Medicine.
124(5), 563-570.
-
Blumenkrantz, N., & Prockop, D. J.
(1969).
A rapid assay for 14C-labeled hydroxylysine in collagen and related materials. Analytical Biochemistry.
30(3), 377-385.
-
Takeuchi, T., & Prockop, D. J.
(1969).
Biosynthesis of abnormal collagens with amino acid analogues. I. Incorporation of L-azetidine-2-carboxylic acid and cis-4-fluoro-L-proline into protocollagen and collagen. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
175(1), 142-155.
-
Takeuchi, T., Rosenbloom, J., & Prockop, D. J.
(1969).
Biosynthesis of abnormal collagens with amino acid analogues. II. Inability of cartilage cells to extrude collagen polypeptides containing L-azetidine-2-carboxylic acid or cis-4-fluoro-L-proline. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
175(1), 156-164.
-
Prockop, D. J., & Kivirikko, K. I.
(1969).
Effect of polymer size on the inhibition of protocollagen proline hydroxylase by polyproline II. Journal of Biological Chemistry.
244(18), 4838-4842.
-
Juva, K., & Prockop, D. J.
(1969).
Formation of enzyme-substrate complexes with protocollagen proline hydroxylase and large polypeptide substrates. Journal of Biological Chemistry.
244(23), 6486-6492.
-
Weinstein, E., Blumenkrantz, N., & Prockop, D. J.
(1969).
Hydroxylation of proline and lysine in protocollagen involves two separate enzymatic sites. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
191(3), 747-750.
-
Lorenzi, G. P., Blout, E. R., Kivirikko, K. I., & Prockop, D. J.
(1969).
Oligopeptides with the sequences ala-pro-gly and gly-pro-gly as substrates or inhibitors for protocollagen proline hydroxylase. Journal of Biological Chemistry.
244(10), 2755-2760.
-
Fujimoto, D., & Prockop, D. J.
(1969).
Protocollagen proline hydroxylase from Ascaris lumbricoides. Journal of Biological Chemistry.
244(1), 205-210.
-
Takeuchi, T., & Prockop, D. J.
(1969).
Protocollagen proline hydroxylase in normal liver and in hepatic fibrosis. GASTROENTEROLOGY.
56(4), 744-750.
-
Blumenkrantz, N., Rosenbloom, J., & Prockop, D. J.
(1969).
Sequential steps in the synthesis of hydroxylysine and the glycosylation of hydroxylysine during the biosynthesis of collagen. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
192(1), 81-89.
-
Cooper, G. W., & Prockop, D. J.
(1968).
Intracellular accumulation of protocollagen and extrusion of collagen by embryonic cartilage cells. The Journal of Cell Biology.
38(3), 523-537.
-
Fujimoto, D., & Prockop, D. J.
(1968).
Denatured collagen from the cuticle of Ascaris lumbricoides as a substrate for protocollagen proline hydroxylase. Journal of Biological Chemistry.
243(15), 4138-4142.
-
Cerda, J. J., Brooks, F. P., & Prockop, D. J.
(1968).
Intraduodenal hydrolysis of gelatin as a measure of protein digestion in normal subjects and in patients with malabsorption syndromes. GASTROENTEROLOGY.
54(3), 358-365.
-
Kivirikko, K. I., Bright, H. J., & Prockop, D. J.
(1968).
Kinetic patterns of protocollagen hydroxylase and further studies on the polypeptide substrate. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
151(3), 558-567.
-
Rosenbloom, J., Blumenkrantz, N., & Prockop, D. J.
(1968).
Sequential hydroxylation of lysine and glycosylation of hydroxylysine during the biosynthesis of collagen in isolated cartilage. Biochemical and Biophysical Research Communications.
31(5), 792-797.
-
Bhatnagar, R. S., Kivirikko, K. I., & Prockop, D. J.
(1968).
Studies on the synthesis and intracellular accumulation of protocollagen in organ culture of embryonic cartilage. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
154(1), 196-207.
-
Morrow, G., Kivirikko, K. I., & Prockop, D. J.
(1967).
Catabolism and excretion of free hydroxyproline in infancy. Journal of Clinical Endocrinology and Metabolism.
27(10), 1365-1371.
-
Prockop, D. J., Juva, K., & Engel, J.
(1967).
Enzymatic synthesis of hydroxyproline by the hydroxylation of poly(L-propyl-glycyl-L-prolyl). The Journal of antibiotics. Ser. B.
20(5), 553-560.
-
Bhatnagar, R. S., Prockop, D. J., & Rosenbloom, J.
(1967).
Intracellular pool of unhydroxylated polypeptide precursors of collagen. Science.
158(3800), 492-494.
-
Bhatnagar, R. S., Kivirikko, K., Rosenbloom, J., & Prockop, D. J.
(1967).
Transfer of puromycin-containing polypeptides through the plasma membrane of cartilage cells synthesizing collagen. Proceedings of the National Academy of Sciences of USA.
58(1), 248-255.
-
Prockop, D. J., Juva, K., & Engel, J.
(1967).
Enzymatic synthesis of hydroxyproline by the hydroxylation of poly(L-propyl-glycyl-L-prolyl). Hoppe-Seyler's Zeitschrift fur physiologische Chemie.
348(5), 553-560.
-
Avioli, L. V., & Prockop, D. J.
(1967).
Collagen degradation and the response to parathyroid extract in the intact rhesus monkey. Journal of Clinical Investigation.
46(2), 217-224.
-
Kivirikko, K. I., Ganser, V., Engel, J., & Prockop, D. J.
(1967).
Comparison of poly-L-proline I and II as inhibitors of protocollagen hydroxylase. Hoppe-Seyler's Zeitschrift fur physiologische Chemie.
348(11), 1341-1344.
-
Bhatnagar, R. S., Rosenbloom, J., Kivrikko, K. I., & Prockop, D. J.
(1967).
Effect of cycloheximide on collagen biosynthesis as evidence for a post-ribosomal site for the hydroxylation of proline. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
149(1), 273-281.
-
PROCKOP, D. J., JUVA, K., & ENGEL, J.
(1967).
Enzymatic Synthesis of Hydroxyproline by the Hydroxylation of Poly(L-prolyl-glycyl-L-prolyl). Hoppe-Seyler's Zeitschrift fur physiologische Chemie.
348(1), 553-560.
-
Rosenbloom, J., Bhatnagar, R. S., & Prockop, D. J.
(1967).
Hydroxylation of proline after the release of proline-rich polypeptides from ribosomal complexes during uninhibited collagen biosynthesis. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
149(1), 259-272.
-
Kivirikko, K. I., & Prockop, D. J.
(1967).
Hydroxylation of proline in synthetic polypeptides with purified protocollagen hydroxylase. Journal of Biological Chemistry.
242(18), 4007-4012.
-
Takeuchi, T., Kivirikko, K. I., & Prockop, D. J.
(1967).
Increased protocollagen hydroxylase activity in the livers of rats with hepatic fibrosis. Biochemical and Biophysical Research Communications.
28(6), 940-944.
-
Ebert, P. S., & Prockop, D. J.
(1967).
Influence of cortisol on the synthesis of sulfated mucopolysaccharides and collagen in chick embryos. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
136(1), 45-55.
-
Kivirikko, K. I., Laitinen, O., & Prockop, D. J.
(1967).
Modifications of a specific assay for hydroxyproline in urine. Analytical Biochemistry.
19(2), 249-255.
-
Kivirikko, K. I., & Prockop, D. J.
(1967).
Partial characterization of protocollagen from embryonic cartilage. Biochemical Journal.
102(2), 432-442.
-
Kivirikko, K. I., & Prockop, D. J.
(1967).
Purification and partial characterization of the enzyme for the hydroxylation of proline in protocollagen. Archives of Biochemistry and Biophysics.
118(3), 611-618.
-
Phelps, P., Prockop, D. J., & McCarty, D. J.
(1966).
Crystal induced inflammation in canine joints. 3. Evidence against bradykinin as a mediator of inflammation. Translational Research: the journal of laboratory and clinical medicine.
68(3), 433-444.
-
Morrow, G., Kivitikko, K. I., & Prockop, D. J.
(1966).
Hydroxyprolinemia and increased excretion of free hydroxyproline in early infancy. Journal of Clinical Endocrinology and Metabolism.
26(9), 1012-1014.
-
Juva, K., Prockop, D. J., Cooper, G. W., & Lash, J. W.
(1966).
Hydroxylation of proline and the intracellular accumulation of a polypeptide precursor of collagen. Science.
152(3718), 92-94.
-
Juva, K., & Prockop, D. J.
(1966).
An effect of puromycin on the synthesis of collagen by embryonic cartilage in vitro. Journal of Biological Chemistry.
241(19), 4419-4425.
-
Bhatnagar, R. S., & Prockop, D. J.
(1966).
Dissociation of the synthesis of sulphated mucopolysaccharides and the synthesis of collagen in embryonic cartilage. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
130(2), 383-392.
-
Prockop, D. J., Weinstein, E., & Mulveny, T.
(1966).
Hydroxylation of lysine in a polypeptide precursor of collagen. Biochemical and Biophysical Research Communications.
22(1), 124-128.
-
Juva, K., & Prockop, D. J.
(1966).
Modified procedure for the assay of H-3-or C-14-labeled hydroxyproline. Analytical Biochemistry.
15(1), 77-83.
-
PROCKOP, D. J., & JUVA, K.
(1965).
SYNTHESIS OF HYDROXYPROLINE IN VITRO BY THE HYDROXYLATION OF PROLINE IN A PRECURSOR OF COLLAGEN. Proceedings of the National Academy of Sciences of USA.
53(3), 661-668.
-
PROCKOP, D. J., & JUVA, K.
(1965).
HYDROXYLATION OF PROLINE IN PARTICULATE FRACTIONS FROM CARTILAGE. Biochemical and Biophysical Research Communications.
18(1), 54-59.
-
JUVA, K., & PROCKOP, D. J.
(1964).
PUROMYCIN INHIBITION OF COLLAGEN SYNTHESIS AS EVIDENCE FOR A RIBOSOMAT. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
91, 174-176.
-
PROCKOP, D. J.
(1964).
ISOTOPIC STUDIES ON COLLAGEN DEGRADATION AND THE URINE EXCRETION OF HYDROXYPROLINE. Journal of Clinical Investigation.
43(3), 453-460.
-
Prockop, D. J.
(1964).
Isotopic Studies on Collagen Degradation and the Urine Excretion of Hydroxyproline *. Journal of Clinical Investigation.
43(3), 453-460.
-
PROCKOP, D. J., & DAVIDSON, W. D.
(1964).
A STUDY OF URINARY AND SERUM LYSOZYME IN PATIENTS WITH RENAL DISEASE. NEW ENGLAND JOURNAL OF MEDICINE.
270(6), 269-274.
-
PROCKOP, D. J., PETTENGILL, O., & HOLTZER, H.
(1964).
INCORPORATION OF SULFATE AND THE SYNTHESIS OF COLLAGEN BY CULTURES OF EMBRYONIC CHONDROCYTES. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
83(2), 189-196.
-
JUVA, K., & PROCKOP, D. J.
(1964).
PUROMYCIN INHIBITION OF COLLAGEN SYNTHESIS AS EVIDENCE FOR A RIBOSOMAT OR POST-RIBOSOMAL SITE FOR THE HYDROXYLATION OF PROLINE. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
91(1), 174-176.
-
SEBESTA, D. G., BRADSHAW, F. J., & PROCKOP, D. J.
(1964).
SOURCE OF THE ELEVATED SERUM ALKALINE PHOSPHATASE ACTIVITY IN BILIARY OBSTRUCTION: STUDIES UTILIZING ISOLATED LIVER PERFUSION. GASTROENTEROLOGY.
47(2), 166-170.
-
PROCKOP, D. J., EBERT, P. S., & SHAPIRO, B. M.
(1964).
STUDIES WITH PROLINE-3,4,-H3 ON THE HYDROXYLATION OF PROLINE DURING COLLAGEN SYNTHESIS IN CHICK EMBRYOS. Archives of Biochemistry and Biophysics.
106(C), 112-122.
-
PROCKOP, D. J., & SMITH, B.
(1963).
L-Tryptophan. NEW ENGLAND JOURNAL OF MEDICINE.
268(12), 685-685.
-
PROCKOP, D. J., & EBERT, P. S.
(1963).
A SIMPLE METHOD FOR DIFFERENTIAL ASSAY OF TRITIUM AND CARBON-14 IN WATER-SOLUBLE BIOLOGICAL MATERIALS. Analytical Biochemistry.
6(3), 263-271.
-
EBERT, P. S., & PROCKOP, D. J.
(1963).
EFFECTS OF HYDROCORTISONE ON THE SYNTHESIS OF SULPHATED MUCOPOLYSACCHARIDES AND COLLAGEN IN CHICK EMBRYOS. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics.
78(2), 390-392.
-
PROCKOP, D., KAPLAN, A., & UDENFRIEND, S.
(1963).
Oxygen-18 studies on the conversion of proline to collagen hydroxyproline. Archives of Biochemistry and Biophysics.
101(3), 499-503.
-
SMITH, B., & PROCKOP, D. J.
(1962).
Central-nervous-system effects of ingestin of L-tryptophan by normal subjects. NEW ENGLAND JOURNAL OF MEDICINE.
267(26), 1338-1341.
-
Prockop, D. J., Keiser, H. R., & Sjoerdsma, A.
(1962).
GASTROINTESTINAL ABSORPTION AND RENAL EXCRETION OF HYDROXYPROLINE PEPTIDES. The Lancet.
280(7255), 527-528.
-
PETERKOFSKY, B., & PROCKOP, D. J.
(1962).
A method for the simultaneous measurement of the radioactivity of proline-C14 and hydroxyproline-C14 in biological materials. Analytical Biochemistry.
4(5), 400-406.
-
PROCKOP, D. J., KEISER, H. R., & SJOERDSMA, A.
(1962).
Gastrointestinal absorption and renal excretion of hydroxyproline peptides. The Lancet.
2(7255), 527-528.
-
PROCKOP, D., KAPLAN, A., & UDENFRIEND, S.
(1962).
Oxygen-18 studies on the conversion of proline to hydroxyproline. Biochemical and Biophysical Research Communications.
9(1-2), 162-166.
-
KATZ, E., PROCKOP, D. J., & UNDENFRIEND, S.
(1962).
Precursors of the hydroxyproline and ketoproline in actinomycin. Journal of Biological Chemistry.
237(5), 1585-1588.
-
PROCKOP, D. J., PETERKOFSKY, B., & UDENFRIENDS.
(1962).
Studies on the intracellular localization of collagen synthesis in the intact chick embryo. Journal of Biological Chemistry.
237(5), 1581-1584.
-
PROCKOP, D. J.
(1962).
Synthesis of collagen. Nature.
194(4827), 477-477.
-
EBERT, P. S., & PROCKOP, D. J.
(1962).
The hydroxylation of proline to hydroxyproline during the synthesis of collagen in chick embryos. Biochemical and Biophysical Research Communications.
8(4), 305-309.
-
PROCKOP, D. J., & SJOERDSMA, A.
(1961).
Significance of urinary hydroxyproline in man. Journal of Clinical Investigation.
40(5), 843-849.
-
PROCKOP, D. J., UDENFRIEND, S., & LINDSTEDT, S.
(1961).
A simple technique for measuring the specific activity of labeled hydroxyproline in biological materials. Journal of Biological Chemistry.
236(5), 1395-1398.
-
MARTIN, G. R., MERGENHAGEN, S. E., & PROCKOP, D. J.
(1961).
Influence of scurvy and lathyrism (odoratism) on hydroxyproline excretion. Nature.
191(4792), 1008-1009.
-
LINDSTEDT, S., & PROCKOP, D. J.
(1961).
Isotopic studies on urinary hydroxyproline as evidence for rapidly catabolized forms of collagen in the young rat. Journal of Biological Chemistry.
236(5), 1399-1403.
-
PROCKOP, D. J., & UDENFRIEND, S.
(1960).
A specific method for the analysis of hydroxyproline in tissues and urine. Analytical Biochemistry.
1(3), 228-239.
-
PROCKOP, D. J., SHORE, P. A., & BRODIE, B. B.
(1959).
Anticonvulsant properties of monoamine oxidase inhibitors. Annals of the New York Academy of Sciences.
80(3), 643-651.
-
PROCKOP, D. J., SHORE, P. A., & BRODIE, B. B.
(1959).
An anticonvulsant effect of monoamine oxidase inhibitors. Experientia.
15(4), 145-147.
-
CLARKSON, B., & PROCKOP, D. J.
(1958).
Aregenerative anemia associated with benign thymoma. NEW ENGLAND JOURNAL OF MEDICINE.
259(6), 253-258.
-
SHORE, P. A., & BRODIE, B. B.
(1958).
Effect of iproniazid on brain levels of norepinephrine and serotonin. Science.
127(3300), 704-704.
-
BRODIE, B. B., PROCKOP, D. J., & SHORE, P. A.
(1958).
An interpretation of the action of psychotropic drugs. Postgraduate medicine.
24(3), 296-304.
-
Shore, P. A., Gillespie, L., Spector, S., & Prockop, D.
(1958).
Increase in blood serotonin levels induced by iproniazid in man and rabbits. Naturwissenschaften.
45(14), 340-341.
-
Pleasure, D., Bora, F. W., Lane, J., & Prockop, D.
Regeneration after nerve transection: effect of inhibition of collagen synthesis. Experimental Neurology.
45(1), 72-78.
-
Ala-Kokko, L., Kontusaari, S., Baldwin, C. T., Kuivaniemi, H., & Prockop, D. J.
Structure of cDNA clones coding for the entire prepro alpha 1 (III) chain of human type III procollagen. Differences in protein structure from type I procollagen and conservation of codon preferences. Biochemical Journal.
260(2), 509-516.
-
Hojima, Y., van der Rest, M., & Prockop, D. J.
Type I procollagen carboxyl-terminal proteinase from chick embryo tendons. Purification and characterization. Journal of Biological Chemistry.
260(29), 15996-16003.
-
Choi, H., Phillips, C., Oh, J. Y., Potts, L., Reger, R. L., Prockop, D. J., & Fulcher, S.
(2019).
Absence of Therapeutic Benefit of the Anti-Inflammatory Protein TSG-6 for Corneal Alkali Injury in a Rat Model. Current Eye Research.
44(8), 873-881.
-
book
-
Prockop, D. J., Phinney, D. G., & Bunnell, B. A.
(2008).
Methods in Molecular Biology: Preface. Ed. 449.
-
Prockop, D. J.
(2004).
Embryonic Stem Cells Versus Adults Stem Cells. Ed. 1-2.
Elsevier.
-
Prockop, D. J., Phinney, D. G., & Bunnell, B. A.
(2008).
Methods in Molecular Biology: Preface. Ed. 449.
-
chapter
-
Prockop, D. J.
(2016).
Use of a natural modulator of inflammation (TSG-6) for the therapy of traumatic brain injury. Cellular Therapy for Neurological Injury.
(pp. 253-262).
-
Prockop, D. J.
(2013).
Collagens. Encyclopedia of Biological Chemistry.
(pp. 545-549).
Elsevier.
-
Prockop, D. J., & Reger, R. L.
(2012).
MSCs: Changing Hypotheses, Paradigms, and Controversies on Mechanisms of Action in Repairing Tissues. Mesenchymal Stromal Cells.
(pp. 17-42).
Springer Nature.
-
Zeitouni, S., Ford, B., Harris, S., Whitney, M., Gregory, C., & Prockop, D.
(2011).
Pharmaceutical Induction of ApoE Secretion. Current Research in Pharmaceutical Technology.
(pp. 192-210).
Taylor & Francis.
-
Gregory, C. A., & Prockop, D. J.
(2007).
Fundamentals of Culture and Characterization of Mesenchymal Stem/Progenitor Cells (MSCs) from Bone Marrow Stroma. Culture of Human Stem Cells.
(pp. 207-232).
Wiley.
-
Prockop, D. J.
(2016).
Use of a natural modulator of inflammation (TSG-6) for the therapy of traumatic brain injury. Cellular Therapy for Neurological Injury.
(pp. 253-262).
-
conference paper
-
Mittal, M., Tiruppathi, C., Nepal, S., Zhao, Y., Grzych, D., Soni, D., Prockop, D. J., & Malik, A. B.
(2016).
TNF-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury. Proceedings of the National Academy of Sciences of USA.
E8151-E8158.
-
Mishra, V., Hattiangady, B., Robbins, A. B., Shuai, B., Moreno, M. R., Prockop, D. J., & Shetty, A. K.
(2014).
Mild Traumatic Brain Injury Induced Through an Exposure to Blast Shock Waves Causes Lasting Hippocampus-Dependent and Hippocampus-Independent Memory Dysfunction and Depression. Cell Transplantation.
778-778.
-
Oconnor, K. C., Barrilleaux, B., Fischer-Valuck, B., Prockop, D., & Phinney, D.
(2008).
Regulating migration of bone marrow stromal cells to injured bronchial epithelium
-
Witek, M. A., Chen, G., Shadpour, H., Khaterpal, I., Prockop, D., Gregory, C. A., McCarley, R. L., & Soper, S. A.
(2006).
Integrated microfluidic system for the processing of membrane proteins isolated from stem cells. 1456-1458.
-
Gregory, C. A., Gunn, W. G., Reyes, E., Smolarz, A. J., Munoz, J., Spees, J. L., & Prockop, D. J.
(2005).
How Wnt signaling affects bone repair by mesenchymal stem cells from the bone marrow. Annals of the New York Academy of Sciences.
97-106.
-
Prockop, D. J., Gregory, C. A., & Spees, J. L.
(2003).
One strategy for cell and gene therapy: harnessing the power of adult stem cells to repair tissues. Proceedings of the National Academy of Sciences of USA.
11917-11923.
-
KONTUSAARI, S., KUIVANIEMI, H., TROMP, G., GRIMWOOD, R., & PROCKOP, D. J.
(1990).
A Single Base Mutation in Type III Procollagen That Converts the Codon for Glycine 619 to Arginine in a Family with Familial Aneurysms and Mild Bleeding Tendenciesa. Annals of the New York Academy of Sciences.
556-557.
-
CONSTANTINOU, C. D., PACK, M. A., YOUNG, S. B., & PROCKOP, D. J.
(1990).
A Substitution of Cysteine for Glycine 904 in COL1A1 in a Proband with Lethal Osteogenesis Imperfecta and in Her Asymptomatic Mother. Annals of the New York Academy of Sciences.
540-541.
-
TROMP, G., KUIVANIEMI, H., STOLLE, C., POPE, F. M., & PROCKOP, D. J.
(1990).
Single Base Mutation in the Type III Procollagen Gene That Converts the Codon for Glycine 883 to Aspartate in a Proband with Mild Symptoms of EhlersDanlos Syndrome IVa. Annals of the New York Academy of Sciences.
558-559.
-
ZHAO, M., KONTUSAARI, S., KUIVANIEMI, H., TROMP, G., SABOL, C., ALAKOKKO, L., ... PROCKOP, D. J.
(1990).
Three Single Base Mutations in Type III Procollagen Gene That Prevent Correct RNA Splicing in Variants of EhlersDanlos Syndrome IVa. Annals of the New York Academy of Sciences.
554-555.
-
Mittal, M., Tiruppathi, C., Nepal, S., Zhao, Y., Grzych, D., Soni, D., Prockop, D. J., & Malik, A. B.
(2016).
TNF-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury. Proceedings of the National Academy of Sciences of USA.
E8151-E8158.
Research
principal investigator on
- Preparation and Distribution of Adult Stem Cells awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2014 - 2019
- IPA for Jing Xu awarded by Central Texas Veterans Health Care System - (Waco, Texas, United States) 2017 - 2018
- IPA for Raghavendra Upadhya awarded by Central Texas Veterans Health Care System - (Waco, Texas, United States) 2017 - 2018
co-principal investigator on
Teaching
teaching activities
- MSCI691 Research Credit: Medical Sci Instructor
Background
education and training
- Ph.D. in Biochemistry, George Washington University - (Washington D.C., District of Columbia, United States) 1961
- M.D. in Medicine, University of Pennsylvania - (Philadelphia, Pennsylvania, United States) 1956
- M.A. in Animal Physiology, University of Oxford - (Oxford, Oxfordshire, United Kingdom) 1953
- A.B. in Philosophy, Haverford College - (Philadelphia, Pennsylvania, United States) 1951
- Polytechnic of Medimurje in Cakovec - (Čakovec, Croatia) 1957
awards and honors
- NAI Fellow, conferred by National Academy of Inventors - (Tampa, Florida, United States), 2014
- Hopkins Medal, conferred by Biochemical Society - (London, United Kingdom), 1998
- Lee C. Howley Sr. Prize for Arthritis Scientific Research, conferred by Arthritis Foundation - (Atlanta, Georgia, United States), 1992
- Member, conferred by National Academy of Medicine - (Washington D.C., District of Columbia, United States), 1992
- Members/Foreign Associates, conferred by National Academy of Sciences - (Washington D.C., District of Columbia, United States), 1991
- Academician, conferred by Academy of Finland - (Helsinki, Finland), 1990
- AAAS Fellow, conferred by American Association For The Advancement of Science - (Washington D.C., District of Columbia, United States), 1985
Contact
first name
- Darwin
has last name
- Prockop
mailing address
-
Texas A&M Health Science Center
Molecular And Cellular Medicine
1114 TAMUS
College Station, TX 77845
USA
Other
- prockop@tamu.edu