Stem cells in the face: tooth regeneration and beyond.

abstract

• The face distinguishes one person from another. Postnatal orofacial tissues harbor rare cells that exhibit stem cell properties. Despite unmet clinical needs for reconstruction of tissues lost in congenital anomalies, infections, trauma, or tumor resection, how orofacial stem/progenitor cells contribute to tissue development, pathogenesis, and regeneration is largely obscure. This perspective article critically analyzes the current status of our understanding of orofacial stem/progenitor cells, identifies gaps in our knowledge, and highlights pathways for the development of regenerative therapies.

published proceedings

• Cell Stem Cell

altmetric score

• 18.45

author list (cited authors)

• Mao, J. J., & Prockop, D. J.

citation count

• 98

complete list of authors

• Mao, Jeremy J||Prockop, Darwin J

publication date

• January 2012

publisher

• Elsevier  Publisher

published in

• Cell Stem Cell  Journal

keywords

• Animals
• Connective Tissue Cells
• Epithelial Cells
• Face
• Humans
• Regeneration
• Stem Cells
• Tooth

Digital Object Identifier (DOI)

• 10.1016/j.stem.2012.08.010

start page

• 291

end page

• 301

volume

• 11

issue

• 3

URL

• http://dx.doi.org/10.1016/j.stem.2012.08.010